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Chondrocyte channel transcriptomics: do microarray data fit with expression and functional data?

Lewis, Rebecca; May, Hannah; Mobasheri, Ali; Barrett-Jolley, Richard

Authors

Rebecca Lewis

Hannah May

Ali Mobasheri ali.mobasheri@nottingham.ac.uk

Richard Barrett-Jolley rbj@liv.ac.uk



Abstract

To date, a range of ion channels have been identified in chondrocytes using a number of different techniques, predominantly electrophysiological and/or biomolecular; each of these has its advantages and disadvantages. Here we aim to compare and contrast the data available from biophysical and microarray experiments. This letter analyses recent transcriptomics datasets from chondrocytes, accessible from the European Bioinformatics Institute (EBI). We discuss whether such bioinformatic analysis of microarray datasets can potentially accelerate identification and discovery of ion channels in chondrocytes. The ion channels which appear most frequently across these microarray datasets are discussed, along with their possible functions. We discuss whether functional or protein data exist which support the microarray data. A microarray experiment comparing gene expression in osteoarthritis and healthy cartilage is also discussed and we verify the differential expression of 2 of these genes, namely the genes encoding the BK and aquaporin channels.

Journal Article Type Article
Publication Date Nov 1, 2013
Journal Channels
Print ISSN 1933-6950
Electronic ISSN 1933-6950
Publisher Taylor & Francis
Peer Reviewed Peer Reviewed
Volume 7
Issue 6
APA6 Citation Lewis, R., May, H., Mobasheri, A., & Barrett-Jolley, R. (2013). Chondrocyte channel transcriptomics: do microarray data fit with expression and functional data?. Channels, 7(6), doi:10.4161/chan.26071
DOI https://doi.org/10.4161/chan.26071
Publisher URL https://www.landesbioscience.com/journals/channels/article/26071/?nocache=1249964648
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc/4.0





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