Outputs (17)

An ancient family of lytic polysaccharide monooxygenases with roles in arthropod development and biomass digestion (2018)
Journal Article

Thermobia domestica belongs to an ancient group of insects and has a remarkable ability to digest crystalline cellulose without microbial assistance. By investigating the digestive proteome of Thermobia, we have identified over 20 members of an uncha... Read More about An ancient family of lytic polysaccharide monooxygenases with roles in arthropod development and biomass digestion.

Lytic xylan oxidases from wood-decay fungi unlock biomass degradation (2018)
Journal Article

Wood biomass is the most abundant feedstock envisioned for the development of modern biorefineries. However, the cost-effective conversion of this form of biomass into commodity products is limited by its resistance to enzymatic degradation. Here we... Read More about Lytic xylan oxidases from wood-decay fungi unlock biomass degradation.

Structural and electronic determinants of lytic polysaccharide monooxygenase reactivity on polysaccharide substrates (2017)
Journal Article

Lytic polysaccharide monooxygenases (LPMOs) are industrially important copper-dependent enzymes that oxidatively cleave polysaccharides. Here we present a functional and structural characterization of two closely related AA9-family LPMOs from Lentinu... Read More about Structural and electronic determinants of lytic polysaccharide monooxygenase reactivity on polysaccharide substrates.

The molecular basis of polysaccharide cleavage by lytic polysaccharide monooxygenases (2016)
Journal Article

Lytic polysaccharide monooxygenases (LPMOs) are copper-containing enzymes that oxidatively break down recalcitrant polysaccharides such as cellulose and chitin. Since their discovery, LPMOs have become integral factors in the industrial utilization o... Read More about The molecular basis of polysaccharide cleavage by lytic polysaccharide monooxygenases.

Structure–function characterization reveals new catalytic diversity in the galactose oxidase and glyoxal oxidase family (2015)
Journal Article

Alcohol oxidases, including carbohydrate oxidases, have a long history of research that has generated fundamental biological understanding and biotechnological applications. Despite a long history of study, the galactose 6-oxidase/glyoxal oxidase fam... Read More about Structure–function characterization reveals new catalytic diversity in the galactose oxidase and glyoxal oxidase family.

Dispersion, solvent and metal effects in the binding of gold cations to alkynyl ligands: implications for Au(i) catalysis (2015)
Journal Article

An investigation into the cytotoxicity of cis,cis-triaminocyclohexane derivatives (2014)
Thesis

N,N’,N’’-Tris(2-pyridylmethyl)-cis,cis-1,3,5-triaminocyclohexane, tachpyr, has been studied for several years for its potential application in cancer therapy. Several studies have been carried out to understand the mechanism of action of this molecul... Read More about An investigation into the cytotoxicity of cis,cis-triaminocyclohexane derivatives.