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Outputs (571)

Optimising the performance and interpretation of small bowel capsule endoscopy (2017)
Journal Article
Beg, S., Parra-Blanco, A., & Ragunath, K. (in press). Optimising the performance and interpretation of small bowel capsule endoscopy. Frontline Gastroenterology, https://doi.org/10.1136/flgastro-2017-100878

Small bowel capsule endoscopy has become a commonly used tool in the investigation of gastrointestinal symptoms and is now widely available in clinical practice. In contrast to conventional endoscopy, there is a lack of clear consensus on when compet... Read More about Optimising the performance and interpretation of small bowel capsule endoscopy.

Development and characterization of a human monoclonal antibody targeting the N-terminal region of hepatitis C virus envelope glycoprotein E1 (2017)
Journal Article
Mesalam, A. A., Desombere, I., Farhoudi, A., Van Houtte, F., Verhoye, L., Ball, J., …Meuleman, P. (2018). Development and characterization of a human monoclonal antibody targeting the N-terminal region of hepatitis C virus envelope glycoprotein E1. Virology, 514, https://doi.org/10.1016/j.virol.2017.10.019

Monoclonal antibodies (mAbs) targeting the hepatitis C virus (HCV) envelope have been raised mainly against envelope protein 2 (E2), while the antigenic epitopes of envelope protein 1 (E1) are not fully identified. Here we describe the detailed chara... Read More about Development and characterization of a human monoclonal antibody targeting the N-terminal region of hepatitis C virus envelope glycoprotein E1.

SOX9 predicts progression towards cirrhosis in patients while its loss protects against liver fibrosis (2017)
Journal Article
Athwal, V. S., Pritchett, J., Llewellyn, J., Martin, K., Camacho, E., Raza, S. M., …Hanley, K. P. (in press). SOX9 predicts progression towards cirrhosis in patients while its loss protects against liver fibrosis. EMBO Molecular Medicine, 9(12), https://doi.org/10.15252/emmm.201707860

Fibrosis and organ failure is a common endpoint for many chronic liver diseases. Much is known about the upstream inflammatory mechanisms provoking fibrosis and downstream potential for tissue remodeling. However, less is known about the transcriptio... Read More about SOX9 predicts progression towards cirrhosis in patients while its loss protects against liver fibrosis.

Development, content validity and cross-cultural adaptation of a Patient-Reported Outcome Measure for Real-time Symptom Assessment in Irritable Bowel Syndrome (2017)
Journal Article
Vork, L., Keszthely, D., Mujagic, Z., Kruimel, J., Leue, C., Pontén, I., …Masclee, A. (in press). Development, content validity and cross-cultural adaptation of a Patient-Reported Outcome Measure for Real-time Symptom Assessment in Irritable Bowel Syndrome. Neurogastroenterology and Motility, 30(3), Article e13244. https://doi.org/10.1111/nmo.13244

BACKGROUND: End-of-day questionnaires, which are considered the gold standard for assessing abdominal pain and other gastrointestinal (GI) symptoms in irritable bowel syndrome (IBS), are influenced by recall and ecological bias. The Experience Sampli... Read More about Development, content validity and cross-cultural adaptation of a Patient-Reported Outcome Measure for Real-time Symptom Assessment in Irritable Bowel Syndrome.

Surgical rates for Crohn’s Disease are decreasing: a population-based time trend analysis and validation study (2017)
Journal Article
Ma, C., Moran, G. W., Benchimol, E. I., Targownik, L. E., Heitman, S. J., Hubbard, J. N., …Kaplan, G. G. (2017). Surgical rates for Crohn’s Disease are decreasing: a population-based time trend analysis and validation study. American Journal of Gastroenterology, 112, https://doi.org/10.1038/ajg.2017.394

Objectives: Temporal changes for intestinal resections for Crohn’s disease (CD) are controversial. We validated administrative database codes for CD diagnosis and surgery in hospitalized patients and then evaluated temporal trends in CD surgical res... Read More about Surgical rates for Crohn’s Disease are decreasing: a population-based time trend analysis and validation study.

A novel neutralizing human monoclonal antibody broadly abrogates hepatitis C virus infection in vitro and in vivo (2017)
Journal Article
Desombere, I., Mesalam, A. A., Urbanowicz, R. A., Van Houtte, F., Verhoye, L., Keck, Z.-Y., …Meuleman, P. (2017). A novel neutralizing human monoclonal antibody broadly abrogates hepatitis C virus infection in vitro and in vivo. Antiviral Research, 148, https://doi.org/10.1016/j.antiviral.2017.10.015

Infections with hepatitis C virus (HCV) represent a worldwide health burden and a prophylactic vaccine is still not available. Liver transplantation (LT) is often the only option for patients with HCV-induced end-stage liver disease. However, immedia... Read More about A novel neutralizing human monoclonal antibody broadly abrogates hepatitis C virus infection in vitro and in vivo.

Mechanistic Fluid Transport Model to Estimate Gastrointestinal Fluid Volume and Its Dynamic Change Over Time (2017)
Journal Article
Yu, A., Jackson, T., Tsume, Y., Koenigsknecht, M., Wysocki, J., Marciani, L., …Sun, D. (2017). Mechanistic Fluid Transport Model to Estimate Gastrointestinal Fluid Volume and Its Dynamic Change Over Time. AAPS Journal, 19(6), 1682-1690. https://doi.org/10.1208/s12248-017-0145-x

Gastrointestinal (GI) fluid volume and its dynamic change are integral to study drug disintegration, dissolution, transit, and absorption. However, key questions regarding the local volume and its absorption, secretion, and transit remain unanswered.... Read More about Mechanistic Fluid Transport Model to Estimate Gastrointestinal Fluid Volume and Its Dynamic Change Over Time.

The management of functional dyspepsia in clinical practice: what lessons can be learnt from recent literature? (2017)
Journal Article
Corsetti, M., & Fox, M. (2017). The management of functional dyspepsia in clinical practice: what lessons can be learnt from recent literature?. F1000Research, 6, Article 1778. https://doi.org/10.12688/f1000research.12089.1

© 2017 Corsetti M and Fox M. Functional dyspepsia is a prevalent functional gastrointestinal disorder that can significantly erode the quality of life of sufferers and places a major cost burden on healthcare services. In this article, we review the... Read More about The management of functional dyspepsia in clinical practice: what lessons can be learnt from recent literature?.

Development of a telehealth monitoring service after colorectal surgery: a feasibility study (2017)
Journal Article
Bragg, D. D., Edis, H., Clark, S., Parsons, S. L., Perumpalath, B., Lobo, D. N., & Maxwell-Armstrong, C. A. (in press). Development of a telehealth monitoring service after colorectal surgery: a feasibility study. World Journal of Gastroenterology, 9(9), https://doi.org/10.4240/wjgs.v9.i9.193

AIM: To evaluate the feasibility of a text-messaging system to remotely monitor and support patients after discharge following elective colorectal surgery, within an enhanced recovery protocol. METHODS: Florence (FLO) is a National Health Service te... Read More about Development of a telehealth monitoring service after colorectal surgery: a feasibility study.