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Patient reported outcome measures in the recovery of adults hospitalised with community-acquired pneumonia: a systematic review (2019)
Journal Article
Pick, H. J., Bolton, C. E., Lim, W. S., & McKeever, T. M. (2019). Patient reported outcome measures in the recovery of adults hospitalised with community-acquired pneumonia: a systematic review. European Respiratory Journal, 53(3), Article 1802165. https://doi.org/10.1183/13993003.02165-2018

Symptomatic and functional recovery are important patient-reported outcome measures (PROMs) in community-acquired pneumonia (CAP) that are increasingly used as trial endpoints. This systematic review summarises the literature on PROMs in CAP.

Comp... Read More about Patient reported outcome measures in the recovery of adults hospitalised with community-acquired pneumonia: a systematic review.

Hip fracture outcomes in patients with COPD (2018)
Journal Article
Buss, L., McKeever, T. M., Nightingale, J., Akyea, R., Ollivere, B., Moppett, I., & Bolton, C. E. (2018). Hip fracture outcomes in patients with COPD. British Journal of Anaesthesia, 121(6), 1377-1379. https://doi.org/10.1016/j.bja.2018.09.008+hideArticle+Info

Hip fractures are common in patients with COPD and contemporary outcome data is needed. Patients admitted with a hip fracture to one acute trust (2010-2015) were assessed prospectively (UK National Hip Fracture Database audit) and mortality data col... Read More about Hip fracture outcomes in patients with COPD.

Risk of fall in patients with COPD (2018)
Journal Article
Hakamy, A., Bolton, C. E., Gibson, J. E., & McKeever, T. M. (2018). Risk of fall in patients with COPD. Thorax, 73(11), 1079-1080. https://doi.org/10.1136/thoraxjnl-2017-211008

A matched cohort study was conducted to determine the incidence of falls in patients following a diagnosis of COPD using a UK primary care database. 44 400 patients with COPD and 175 545 non-COPD subjects were identified. The incidence rate of fall p... Read More about Risk of fall in patients with COPD.

Variation in lung function and alterations in cardiac 1 structure and function: analysis of the UK Biobank 2 cardiovascular magnetic resonance imaging substudy (2018)
Journal Article
Thomson, R. J., Aung, N., Sanghvi, M. M., Paiva, J. M., Lee, A. M., Fung, K., …Petersen, S. E. (2018). Variation in lung function and alterations in cardiac 1 structure and function: analysis of the UK Biobank 2 cardiovascular magnetic resonance imaging substudy. PLoS ONE, 13(3), Article e0194434. https://doi.org/10.1371/journal.pone.0194434

Background

Reduced lung function is common and associated with increased cardiovascular morbidity and mortality, even in asymptomatic individuals without diagnosed respiratory disease. Previous studies have identified relationships between lung fu... Read More about Variation in lung function and alterations in cardiac 1 structure and function: analysis of the UK Biobank 2 cardiovascular magnetic resonance imaging substudy.

Quadrupling inhaled glucocorticoid dose to abort asthma exacerbations (2018)
Journal Article
McKeever, T., Mortimer, K., Wilson, A., Walker, S., Brightling, C., Skeggs, A., …Harrison, T. (2018). Quadrupling inhaled glucocorticoid dose to abort asthma exacerbations. New England Journal of Medicine, 378(10), 902-910. https://doi.org/10.1056/NEJMoa1714257

Copyright © 2018 Massachusetts Medical Society. BACKGROUND Asthma exacerbations are frightening for patients and are occasionally fatal. We tested the concept that a plan for patients to manage their asthma (self-management plan), which included a te... Read More about Quadrupling inhaled glucocorticoid dose to abort asthma exacerbations.

The recording and characteristics of pulmonary rehabilitation in patients with COPD using The Health Information Network (THIN) primary care database (2017)
Journal Article
Hakamy, A., McKeever, T. M., Gibson, J. E., & Bolton, C. E. (in press). The recording and characteristics of pulmonary rehabilitation in patients with COPD using The Health Information Network (THIN) primary care database. npj Primary Care Respiratory Medicine, 27(1), Article 58. https://doi.org/10.1038/s41533-017-0058-2

Pulmonary rehabilitation is recommended for patients with COPD to improve physical function, breathlessness and quality of life. Using The Health Information Network (THIN) primary care database in UK, we compared the demographic and clinical paramet... Read More about The recording and characteristics of pulmonary rehabilitation in patients with COPD using The Health Information Network (THIN) primary care database.

The use of the practice walk test in pulmonary rehabilitation program: National COPD Audit Pulmonary Rehabilitation Workstream (2017)
Journal Article
Hakamy, A., McKeever, T. M., Steiner, M. C., Roberts, C. M., Singh, S. J., & Bolton, C. E. (in press). The use of the practice walk test in pulmonary rehabilitation program: National COPD Audit Pulmonary Rehabilitation Workstream. International Journal of Chronic Obstructive Pulmonary Disease, 12, https://doi.org/10.2147/COPD.S141620

Our aim was to evaluate the use and impact of the practice walk test on enrolment, completion, and clinical functional response to pulmonary rehabilitation (PR) using the 2015 UK National Chronic Obstructive Pulmonary Disease (COPD) Pulmonary Rehabil... Read More about The use of the practice walk test in pulmonary rehabilitation program: National COPD Audit Pulmonary Rehabilitation Workstream.

Targeted sequencing of lung function loci in chronic obstructive pulmonary disease cases and controls (2017)
Journal Article
Artigas, M. S., Wain, L. V., Shrine, N., McKeever, T. M., Sayers, I., Hall, I. P., & Tobin, M. D. (2017). Targeted sequencing of lung function loci in chronic obstructive pulmonary disease cases and controls. PLoS ONE, 12(1), Article e0170222. https://doi.org/10.1371/journal.pone.0170222

Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide; smoking is the main risk factor for COPD, but genetic factors are also relevant contributors. Genome-wide association studies (GWAS) of the lung function meas... Read More about Targeted sequencing of lung function loci in chronic obstructive pulmonary disease cases and controls.

FourFold Asthma Study (FAST): a study protocol for a randomised controlled trial evaluating the clinical cost-effectiveness of temporarily quadrupling the dose of inhaled steroid to prevent asthma exacerbations (2016)
Journal Article
Skeggs, A., McKeever, T. M., Duley, L., Mitchell, E., Bradshaw, L., Mortimer, K., …Haydock, R. (2016). FourFold Asthma Study (FAST): a study protocol for a randomised controlled trial evaluating the clinical cost-effectiveness of temporarily quadrupling the dose of inhaled steroid to prevent asthma exacerbations. Trials, 17, https://doi.org/10.1186/s13063-016-1608-6

BACKGROUND: Asthma is one of the commonest chronic diseases in the UK. Acute exacerbations of asthma are unpredictable, disruptive and frightening. They cause considerable morbidity and account for a large component of the health service costs of ast... Read More about FourFold Asthma Study (FAST): a study protocol for a randomised controlled trial evaluating the clinical cost-effectiveness of temporarily quadrupling the dose of inhaled steroid to prevent asthma exacerbations.