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Outputs (794)

The recognition of local DNA conformation by the human papillomavirus type 6 E2 protein (2006)
Journal Article
Hooley, E., Fairweather, V., Clarke, A. R., Gaston, K., & Brady, R. L. (2006). The recognition of local DNA conformation by the human papillomavirus type 6 E2 protein. Nucleic Acids Research, 34(14), 3897-3908. https://doi.org/10.1093/nar/gkl466

The E2 proteins are transcription/replication factors from papillomaviruses. Human papillomaviruses (HPVs) can be broadly divided in two groups; low-risk HPV subtypes cause benign warts while high-risk HPVs give rise to cervical cancer. Although a ra... Read More about The recognition of local DNA conformation by the human papillomavirus type 6 E2 protein.

Oligomerisation of the developmental regulator proline rich homeodomain (PRH/Hex) is mediated by a novel proline-rich dimerisation domain (2006)
Journal Article
Soufi, A., Smith, C., Clarke, A. R., Gaston, K., & Jayaraman, P. (2006). Oligomerisation of the developmental regulator proline rich homeodomain (PRH/Hex) is mediated by a novel proline-rich dimerisation domain. Journal of Molecular Biology, 358(4), 943-962. https://doi.org/10.1016/j.jmb.2006.02.020

Homeodomain proteins regulate multiple developmental pathways by altering gene expression temporally and in a tissue-specific fashion. The Proline Rich Homeodomain protein (PRH/Hex) is a transcription factor and an essential regulator of embryonic de... Read More about Oligomerisation of the developmental regulator proline rich homeodomain (PRH/Hex) is mediated by a novel proline-rich dimerisation domain.

Diffusible VP22-E2 protein kills bystander cells and offers a route for cervical cancer gene therapy (2006)
Journal Article
Green, K. L., Southgate, T. D., Mulryan, K., Fairbairn, L. J., Stern, P. L., & Gaston, K. (2006). Diffusible VP22-E2 protein kills bystander cells and offers a route for cervical cancer gene therapy. Human Gene Therapy, 17(2), 147-157. https://doi.org/10.1089/hum.2006.17.147

Human papillomaviruses (HPVs) are a causative agent of cervical cancer and are implicated in several other types of malignant disease including cancer of the vulva, oral cancer, and skin cancer. In HPV-transformed cells, expression of the viral E6 an... Read More about Diffusible VP22-E2 protein kills bystander cells and offers a route for cervical cancer gene therapy.

Purification and characterisation of the PRH homeodomain: removal of the N-terminal domain of PRH increases the PRH homeodomain-DNA interaction (2006)
Journal Article
Soufi, A., Gaston, K., & Jayaraman, P. (2006). Purification and characterisation of the PRH homeodomain: removal of the N-terminal domain of PRH increases the PRH homeodomain-DNA interaction. International Journal of Biological Macromolecules, 39(1-3), 45-50. https://doi.org/10.1016/j.ijbiomac.2006.01.004

The Proline-Rich Homeodomain (PRH) protein is a regulator of transcription and translation and plays a key role in the control of cell proliferation and cell differentiation. PRH contains an N-terminal proline-rich domain that can repress transcripti... Read More about Purification and characterisation of the PRH homeodomain: removal of the N-terminal domain of PRH increases the PRH homeodomain-DNA interaction.

Measuring the induction or inhibition of apoptosis by HPV proteins (2005)
Book Chapter
Kowalczyk, A. M., Roeder, G. E., Green, K., Stephens, D. J., & Gaston, K. (2005). Measuring the induction or inhibition of apoptosis by HPV proteins. In C. Davy, & J. Doorbar (Eds.), Human Papillomaviruses: methods and protocols (419 -- 432). Totowa, NJ: Humana Press. https://doi.org/10.1385/1-59259-982-6%3A419

Many viral proteins influence the cellular pathways that control cell proliferation and cell death. Some viral proteins trigger apoptotic cell death, and this may be important in host defense and viral spread. In other cases, viral proteins inhibit a... Read More about Measuring the induction or inhibition of apoptosis by HPV proteins.

Vascular endothelial growth factor induction by prostaglandin E2 in human airway smooth muscle cells is mediated by E prostanoid EP 2/EP4 receptors and SP-1 transcription factor binding sites (2005)
Journal Article
Bradbury, D., Clarke, D., Seedhouse, C., Corbettt, L., Stocks, J., & Knox, A. (2005). Vascular endothelial growth factor induction by prostaglandin E2 in human airway smooth muscle cells is mediated by E prostanoid EP 2/EP4 receptors and SP-1 transcription factor binding sites. Journal of Biological Chemistry, 280(34), 29993-30000. https://doi.org/10.1074/jbc.M414530200

Prostaglandin E2 (PGE2) can increase vascular endothelial growth factor A (VEGF-A) production but the mechanisms involved are unclear. Here we characterized the transcriptional mechanisms involved in human airway smooth muscle cells (HASMC). PGE2 inc... Read More about Vascular endothelial growth factor induction by prostaglandin E2 in human airway smooth muscle cells is mediated by E prostanoid EP 2/EP4 receptors and SP-1 transcription factor binding sites.

Tagged polymerase chain reaction subtractive hybridization for the enrichment of phage display random peptide libraries (2005)
Journal Article
Tarr, A. W., Boneham, S. P., Grabowska, A. M., & Ball, J. K. (2005). Tagged polymerase chain reaction subtractive hybridization for the enrichment of phage display random peptide libraries. Analytical Biochemistry, 339(1), 61-68. https://doi.org/10.1016/j.ab.2004.12.020

Affinity selection of phage display peptide libraries is routinely used for isolating peptides capable of binding a range of molecules, including antibodies and receptors. This process is most successful when the selecting molecule is relatively pure... Read More about Tagged polymerase chain reaction subtractive hybridization for the enrichment of phage display random peptide libraries.

Herpes simplex virus VP22-human papillomavirus E2 fusion proteins produced in mammalian or bacterial cells enter mammalian cells and induce apoptotic cell death (2004)
Journal Article
Roeder, G. E., Parish, J. L., Stern, P. L., & Gaston, K. (2004). Herpes simplex virus VP22-human papillomavirus E2 fusion proteins produced in mammalian or bacterial cells enter mammalian cells and induce apoptotic cell death. Biotechnology and Applied Biochemistry, 40(2), 157-165. https://doi.org/10.1042/BA20030172

Infection by high‐risk HPV (human papillomavirus) is supposed to be the primary cause of cervical cancer. The HPV E2 protein (E2) is a DNA‐binding protein that regulates viral gene expression and is required for efficient viral replication. Overexpre... Read More about Herpes simplex virus VP22-human papillomavirus E2 fusion proteins produced in mammalian or bacterial cells enter mammalian cells and induce apoptotic cell death.

Comparison of the structure and DNA-binding properties of the E2 proteins from an oncogenic and a non-oncogenic human papillomavirus (2003)
Journal Article
Dell, G., Wilkinson, K. W., Tranter, R., Parish, J., Brady, R. L., & Gaston, K. (2003). Comparison of the structure and DNA-binding properties of the E2 proteins from an oncogenic and a non-oncogenic human papillomavirus. Journal of Molecular Biology, 334(5), 979-991. https://doi.org/10.1016/j.jmb.2003.10.009

Human papillomaviruses (HPVs) that infect the genital tract can be divided into two groups: high-risk HPV types, such as HPV 16 and HPV 18, are associated with cancer, low-risk HPV types, such as HPV 6, are associated with benign warts. In both high-... Read More about Comparison of the structure and DNA-binding properties of the E2 proteins from an oncogenic and a non-oncogenic human papillomavirus.