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Outputs (12)

Dipyridamole plus aspirin versus aspirin alone in the secondary prevention after TIA or stroke: a meta-analysis by risk (2008)
Journal Article
Halkes, P., Gray, L. J., Bath, P. M., Diener, H.-C., & Guiraud-Chaumeil, B. (2008). Dipyridamole plus aspirin versus aspirin alone in the secondary prevention after TIA or stroke: a meta-analysis by risk. Journal of Neurology, Neurosurgery and Psychiatry, 79(11), https://doi.org/10.1136/jnnp.2008.143875

Objectives: Our aim was to study the effect of combination therapy with aspirin and dipyridamole (A+D) over aspirin alone (ASA) in secondary prevention after transient ischemic attack or minor stroke of presumed arterial origin and to perform subgr... Read More about Dipyridamole plus aspirin versus aspirin alone in the secondary prevention after TIA or stroke: a meta-analysis by risk.

Telmisartan to Prevent Recurrent Stroke and Cardiovascular Events (2008)
Journal Article
Yusuf, S., Diener, H.-C., Sacco, R. L., Cotton, D., Ounpuu, S., Lawton, W. A., …Yoon, B.-W. (2008). Telmisartan to Prevent Recurrent Stroke and Cardiovascular Events. New England Journal of Medicine, 359(12), 1225-1237. https://doi.org/10.1056/nejmoa0804593

Background Prolonged lowering of blood pressure after a stroke reduces the risk of recurrent stroke. In addition, inhibition of the renin–angiotensin system in high-risk patients reduces the rate of subsequent cardiovascular events, including str... Read More about Telmisartan to Prevent Recurrent Stroke and Cardiovascular Events.

Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke (2008)
Journal Article
Sacco, R. L., Diener, H.-C., Yusuf, S., Cotton, D., Ounpuu, S., Lawton, W. A., …Yoon, B.-W. (2008). Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke. New England Journal of Medicine, 359(12), 1238-1251. https://doi.org/10.1056/NEJMoa0805002

Background: Recurrent stroke is a frequent, disabling event after ischemic stroke. This study compared the efficacy and safety of two antiplatelet regimens — aspirin plus extended release dipyridamole (ASA–ERDP) versus clopidogrel. Methods: In this... Read More about Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke.

Use of ordinal outcomes in vascular prevention trials: comparison with binary outcomes in published trials (2008)
Journal Article
Bath, P. M., Geeganage, C., Gray, L. J., Collier, T., & Pocock, S. (2008). Use of ordinal outcomes in vascular prevention trials: comparison with binary outcomes in published trials. Stroke, 39(10), https://doi.org/10.1161/STROKEAHA.107.509893

Background and Purpose—Vascular prevention trials mostly count “yes/no” (binary) outcome events, eg, stroke/no stroke. Analysis of ordered categorical vascular events (eg, fatal stroke/nonfatal stroke/no stroke) is clinically relevant and could be... Read More about Use of ordinal outcomes in vascular prevention trials: comparison with binary outcomes in published trials.

Calculation of sample size for stroke trials assessing functional outcome: comparison of binary and ordinal approaches (2008)
Journal Article
The Optimising Analysis of Stroke Trials Collaboration, O. (2008). Calculation of sample size for stroke trials assessing functional outcome: comparison of binary and ordinal approaches. International Journal of Stroke, 3(2),

Background Many acute stroke trials have given neutral results. Sub-optimal statistical analyses may be failing to detect efficacy. Methods which take account of the ordinal nature of functional outcome data are more efficient. We compare sample... Read More about Calculation of sample size for stroke trials assessing functional outcome: comparison of binary and ordinal approaches.

Empirical evidence of bias in the design of experimental stroke studies: a metaepidemiologic approach (2008)
Journal Article
Crossley, N. A., Sena, E. S., Goehler, J., Horn, J., van der Worp, H. B., Bath, P. M., …Dirnagl, U. (2008). Empirical evidence of bias in the design of experimental stroke studies: a metaepidemiologic approach. Stroke, 39, https://doi.org/10.1161/STROKEAHA.107.498725

Background and Purpose: At least part of the failure in the transition from experimental to clinical studies in stroke has been attributed to the imprecision introduced by problems in the design of experimental stroke studies. Using a metaepidemiolog... Read More about Empirical evidence of bias in the design of experimental stroke studies: a metaepidemiologic approach.

Stroke outcome in clinical trial patients deriving from different countries (2008)
Journal Article
Ali, M., Atula, S., Bath, P. M., Grotta, J., Hacke, W., Lyden, P. D., …Lees, K. R. (2008). Stroke outcome in clinical trial patients deriving from different countries. Stroke, 40(1), https://doi.org/10.1161/STROKEAHA.108.518035

Background and Purpose—Stroke incidence and outcome vary widely within and across geographical locations. We examined whether differences in index stroke severity, stroke risk factors, mortality, and stroke outcome across geographical locations rem... Read More about Stroke outcome in clinical trial patients deriving from different countries.

A novel antimicrobial peptide on the ocular surface shows decreased expression in inflammation and infection (2008)
Journal Article
Abedin, A., Mohammed, I., Hopkinson, A., & Dua, H. S. (2008). A novel antimicrobial peptide on the ocular surface shows decreased expression in inflammation and infection. Investigative Ophthalmology & Visual Science, 49(1), 28-33. https://doi.org/10.1167/iovs.07-0645

PURPOSE: Antimicrobial peptides (AMPs) are cationic host defense peptides with microbicidal and cell-signaling properties. They show promise as potential therapeutic agents. In the present study, a beta-defensin AMP gene was isolated from the ocular... Read More about A novel antimicrobial peptide on the ocular surface shows decreased expression in inflammation and infection.