Outputs (2)

The pharmacokinetics and toxicity of morning vs. evening tobramycin dosing for pulmonary exacerbations of cystic fibrosis: A randomised comparison (2015)
Journal Article
Smyth, A., Knox, A., Prayle, A., Jain, K., Touw, D., Koch, B., …Smyth, A. R. (2016). The pharmacokinetics and toxicity of morning vs. evening tobramycin dosing for pulmonary exacerbations of cystic fibrosis: A randomised comparison. Journal of Cystic Fibrosis, 15(4), 510-517. https://doi.org/10.1016/j.jcf.2015.07.012

Background: Circadian variation in renal toxicity of aminoglycosides has been demonstrated in animal and human studies. People with CF are frequently prescribed aminoglycosides. Altered pharmacokinetics of aminoglycosides are predictive of toxicity.... Read More about The pharmacokinetics and toxicity of morning vs. evening tobramycin dosing for pulmonary exacerbations of cystic fibrosis: A randomised comparison.

Intravenous antibiotics for pulmonary exacerbations in people with cystic fibrosis (2015)
Journal Article
Hurley, M., Prayle, A., & Flume, P. (in press). Intravenous antibiotics for pulmonary exacerbations in people with cystic fibrosis. Cochrane Database of Systematic Reviews, 2015(7), Article CD009730. https://doi.org/10.1002/14651858.CD009730.pub2

BACKGROUND: Cystic fibrosis is a multi-system disease characterised by the production of thick secretions causing recurrent pulmonary infection, often with unusual bacteria. Intravenous antibiotics are commonly used in the treatment of acute deterior... Read More about Intravenous antibiotics for pulmonary exacerbations in people with cystic fibrosis.