Outputs (173)

A nanoluciferase biosensor to investigate endogenous chemokine secretion and receptor binding (2020)
Journal Article
White, C. W., Kilpatrick, L. E., Pfleger, K. D., & Hill, S. J. (2021). A nanoluciferase biosensor to investigate endogenous chemokine secretion and receptor binding. iScience, 24(1), Article 102011. https://doi.org/10.1016/j.isci.2020.102011

© 2020 The Author(s) Secreted chemokines are critical mediators of cellular communication that elicit intracellular signaling by binding membrane-bound receptors. Here we demonstrate the development and use of a sensitive real-time approach to quanti... Read More about A nanoluciferase biosensor to investigate endogenous chemokine secretion and receptor binding.

Perceptions and Experiences of the University of Nottingham Pilot SARS-CoV-2 Asymptomatic Testing Service: A Mixed-Methods Study (2020)
Journal Article
Blake, H., Corner, J., Cirelli, C., Hassard, J., Briggs, L., Daly, J. M., …Ball, J. (2021). Perceptions and Experiences of the University of Nottingham Pilot SARS-CoV-2 Asymptomatic Testing Service: A Mixed-Methods Study. International Journal of Environmental Research and Public Health, 18(1), 1-26. https://doi.org/10.3390/ijerph18010188

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. We aimed to explore student and staff perceptions and experiences of a pilot SARS-CoV-2 asymptomatic testing service (P-ATS) in a UK university campus setting. This was a mixed-method study co... Read More about Perceptions and Experiences of the University of Nottingham Pilot SARS-CoV-2 Asymptomatic Testing Service: A Mixed-Methods Study.

Phenylbutyrate, a branched-chain amino acid keto dehydrogenase activator, promotes branched-chain amino acid metabolism and induces muscle catabolism in C2C12 cells (2020)
Journal Article
Crossland, H., Smith, K., Idris, I., Phillips, B. E., Atherton, P. J., & Wilkinson, D. J. (2021). Phenylbutyrate, a branched-chain amino acid keto dehydrogenase activator, promotes branched-chain amino acid metabolism and induces muscle catabolism in C2C12 cells. Experimental Physiology, 106(3), 585-592. https://doi.org/10.1113/EP089223

New Findings: What is the central question of this study? The compound sodium phenylbutyrate (PB) has been shown to promote branched-chain amino acid (BCAA) catabolism, and as such has been proposed as a treatment for disorders with enhanced BCAA lev... Read More about Phenylbutyrate, a branched-chain amino acid keto dehydrogenase activator, promotes branched-chain amino acid metabolism and induces muscle catabolism in C2C12 cells.

Transmission, Tropism, and Biological Impacts of Torix Rickettsia in the Common Bed Bug Cimex lectularius (Hemiptera: Cimicidae) (2020)
Journal Article
Thongprem, P., Evison, S. E. F., Hurst, G. D. D., & Otti, O. (2020). Transmission, Tropism, and Biological Impacts of Torix Rickettsia in the Common Bed Bug Cimex lectularius (Hemiptera: Cimicidae). Frontiers in Microbiology, 11, Article 608763. https://doi.org/10.3389/fmicb.2020.608763

The torix group of Rickettsia have been recorded from a wide assemblage of invertebrates, but details of transmission and biological impacts on the host have rarely been established. The common bed bug (Cimex lectularius) is a hemipteran insect which... Read More about Transmission, Tropism, and Biological Impacts of Torix Rickettsia in the Common Bed Bug Cimex lectularius (Hemiptera: Cimicidae).

Corrigendum to ‘LC-MS metabolomics comparisons of cancer cell and macrophage responses to methotrexate and polymer-encapsulated methotrexate’ [International Journal of Pharmaceutics: X Volume 1 (2019) 100036] (2020)
Journal Article
Al-Natour, M. A., Alazzo, A., Ghaemmaghami, A. M., Kim, D. H., & Alexander, C. (2020). Corrigendum to ‘LC-MS metabolomics comparisons of cancer cell and macrophage responses to methotrexate and polymer-encapsulated methotrexate’ [International Journal of Pharmaceutics: X Volume 1 (2019) 100036]. International Journal of Pharmaceutics: X, 2, Article 100044. https://doi.org/10.1016/j.ijpx.2020.100044

© 2020 The Author(s) The authors regret that the original version of Fig. 3 incorrect. The updated figure is below for reference. [Figure presented] Fig. 3 Super-resolution microscopy image of methotrexate loaded PLGA nanoparticles (green) (92 μg/mL,... Read More about Corrigendum to ‘LC-MS metabolomics comparisons of cancer cell and macrophage responses to methotrexate and polymer-encapsulated methotrexate’ [International Journal of Pharmaceutics: X Volume 1 (2019) 100036].

The Evolutionary Genomics of Serpentine Adaptation (2020)
Journal Article
Konečná, V., Yant, L., & Kolář, F. (2020). The Evolutionary Genomics of Serpentine Adaptation. Frontiers in Plant Science, 11, Article 574616. https://doi.org/10.3389/fpls.2020.574616

© Copyright © 2020 Konečná, Yant and Kolář. Serpentine barrens are among the most challenging settings for plant life. Representing a perfect storm of hazards, serpentines consist of broadly skewed elemental profiles, including abundant toxic metals... Read More about The Evolutionary Genomics of Serpentine Adaptation.

Association between serum urate, gout and comorbidities: a case–control study using data from the UK Biobank (2020)
Journal Article
Sandoval-Plata, G., Nakafero, G., Chakravorty, M., Morgan, K., & Abhishek, A. (2021). Association between serum urate, gout and comorbidities: a case–control study using data from the UK Biobank. Rheumatology, 60(7), 3243-3251. https://doi.org/10.1093/rheumatology/keaa773

Objectives To examine the association between comorbidities and serum urate (SU), gout and comorbidities, and to determine whether the association between gout and comorbidities is independent of SU. Methods We performed a case-control study using UK... Read More about Association between serum urate, gout and comorbidities: a case–control study using data from the UK Biobank.

The Relationship of the Mechanisms of the Pathogenesis of Multiple Sclerosis and the Expression of Endogenous Retroviruses (2020)
Journal Article
Lezhnyova, V. R., Martynova, E. V., Khaiboullin, T. I., Urbanowicz, R. A., Khaiboullina, S. F., & Rizvanov, A. A. (2020). The Relationship of the Mechanisms of the Pathogenesis of Multiple Sclerosis and the Expression of Endogenous Retroviruses. Biology, 9(12), 1-16. https://doi.org/10.3390/biology9120464

Two human endogenous retroviruses of the HERV‐W family can act as cofactors triggering multiple sclerosis (MS): MS‐associated retrovirus (MSRV) and ERVWE1. Endogenous retroviral elements are believed to have integrated in our ancestors’ DNA millions... Read More about The Relationship of the Mechanisms of the Pathogenesis of Multiple Sclerosis and the Expression of Endogenous Retroviruses.

Physical inactivity and health inequality during coronavirus: a novel opportunity or total lockdown? (2020)
Journal Article
Shur, N., Johns, . D., Kluzek, S., & Peirce, N. (2020). Physical inactivity and health inequality during coronavirus: a novel opportunity or total lockdown?. BMJ Open Sport and Exercise Medicine, 6(1), Article e000903. https://doi.org/10.1136/bmjsem-2020-000903

Government-restricted movement during the coronavirus pandemic in various countries around the world has led to rapid and fundamental changes in our health behaviour. As well as being at a higher risk of contracting and being hospitalised with COVID-... Read More about Physical inactivity and health inequality during coronavirus: a novel opportunity or total lockdown?.

Skeletal muscle anabolic and insulin sensitivity responses to a mixed meal in adult patients with active Crohn's disease (2020)
Journal Article
Davies, A., Nixon, A., Tsintzas, K., Stephens, F. B., & Moran, G. W. (2021). Skeletal muscle anabolic and insulin sensitivity responses to a mixed meal in adult patients with active Crohn's disease. Clinical Nutrition ESPEN, 41, 305-313. https://doi.org/10.1016/j.clnesp.2020.11.014

© 2020 European Society for Clinical Nutrition and Metabolism Background and aims: We have previously shown reduced protein balance in response to nutrition in paediatric Crohn's disease (CD) in remission, associated with reduced lean mass (sarcopeni... Read More about Skeletal muscle anabolic and insulin sensitivity responses to a mixed meal in adult patients with active Crohn's disease.