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Outputs (173)

Identifying the ischaemic penumbra using pH-weighted magnetic resonance imaging (2014)
Journal Article
Harston, G. W. J., Tee, Y. K., Blockley, N., Okell, T. W., Thandeswaran, S., Shaya, G., …Kennedy, J. (2015). Identifying the ischaemic penumbra using pH-weighted magnetic resonance imaging. Brain, 138(1), 36-42. https://doi.org/10.1093/brain/awu374

© 2014 The Author. The original concept of the ischaemic penumbra suggested imaging of regional cerebral blood flow and metabolism would be required to identify tissue that may benefit from intervention. Amide proton transfer magnetic resonance imagi... Read More about Identifying the ischaemic penumbra using pH-weighted magnetic resonance imaging.

'Partial' competition of heterobivalent ligand binding may be mistaken for allosteric interactions: a comparison of different target interaction models (2014)
Journal Article

© 2014 The British Pharmacological Society. Background and Purpose Non-competitive drugs that confer allosteric modulation of orthosteric ligand binding are of increasing interest as therapeutic agents. Sought-after advantages include a ceiling level... Read More about 'Partial' competition of heterobivalent ligand binding may be mistaken for allosteric interactions: a comparison of different target interaction models.

Characterisation of chlorinated, brominated and mixed halogenated dioxins, furans and biphenyls as potent and as partial agonists of the Aryl hydrocarbon receptor (2014)
Journal Article
Wall, R. J., Fernades, A., Rose, M., Bell, D. R., & Mellor, I. R. (2015). Characterisation of chlorinated, brominated and mixed halogenated dioxins, furans and biphenyls as potent and as partial agonists of the Aryl hydrocarbon receptor. Environment International, 76, 49-56. https://doi.org/10.1016/j.envint.2014.12.002

The Aryl hydrocarbon receptor (AhR) binds a variety of chlorinated and brominated dioxins, furans and biphenyls. Mixed halogenated variants have been recently identified in food at significant levels but full characterisation requires potency data in... Read More about Characterisation of chlorinated, brominated and mixed halogenated dioxins, furans and biphenyls as potent and as partial agonists of the Aryl hydrocarbon receptor.

TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1α degradation (2014)
Journal Article
Melino, G., Amelio, I., Mak, T. W., Inoue, S., Knight, R. A., Markert, E. K., & Levine, A. J. (2015). TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1α degradation. Proceedings of the National Academy of Sciences, 112(1), 226-231. https://doi.org/10.1073/pnas.1410609111

Tumor hypoxia and hypoxia-inducible factor 1 (HIF-1) activation are associated with cancer progression. Here, we demonstrate that the transcription factor TAp73 opposes HIF-1 activity through a nontranscriptional mechanism, thus affecting tumor angio... Read More about TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1α degradation.

Spatial complementarity and the coexistence of species (2014)
Journal Article
Velázquez, J., Garrahan, J. P., & Eichhorn, M. P. (2014). Spatial complementarity and the coexistence of species. PLoS ONE, 9(12), Article e114979. https://doi.org/10.1371/journal.pone.0114979

© 2014 Velázquez et al. Coexistence of apparently similar species remains an enduring paradox in ecology. Spatial structure has been predicted to enable coexistence even when population-level models predict competitive exclusion if it causes each spe... Read More about Spatial complementarity and the coexistence of species.

Convergent genetic and expression data implicate immunity in Alzheimer's disease (2014)
Journal Article
Bossù, P., Tsuang, D. W., Lleò, A., Wallon, D., Todd, S., Dufouil, C., …Holmans, P. (2015). Convergent genetic and expression data implicate immunity in Alzheimer's disease. Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 11(6), 658-671. https://doi.org/10.1016/j.jalz.2014.05.1757

© 2015, Elsevier Inc. All rights reserved. Background: Late-onset Alzheimer's disease (AD) is heritable with 20 genes showing genome-wide association in the International Genomics of Alzheimer's Project (IGAP). To identify the biology underly... Read More about Convergent genetic and expression data implicate immunity in Alzheimer's disease.

Contrasting patterns of turnover between plants, pollinators and their interactions (2014)
Journal Article
Norfolk, O., Eichhorn, M. P., & Gilbert, F. S. (2015). Contrasting patterns of turnover between plants, pollinators and their interactions. Diversity and Distributions, 21(4), https://doi.org/10.1111/ddi.12295

Aim: Biogeographers typically assess patterns of diversity across landscapes. As interacting groups often exhibit contrasting trends, this leads to variation in the structure of interaction networks and thereby influences ecosystem processes. Here we... Read More about Contrasting patterns of turnover between plants, pollinators and their interactions.

Migratory bird species benefit from traditional agricultural gardens in arid South Sinai (2014)
Journal Article
Norfolk, O., Power, A., Eichhorn, M. P., & Gilbert, F. (2015). Migratory bird species benefit from traditional agricultural gardens in arid South Sinai. Journal of Arid Environments, 114, 110-115. https://doi.org/10.1016/j.jaridenv.2014.12.004

In temperate and tropical regions agricultural conversion of natural habitat typically has negative impacts upon the diversity and functional complexity of bird communities. In arid environments however, the irrigation associated with agricultural ca... Read More about Migratory bird species benefit from traditional agricultural gardens in arid South Sinai.