Vinca alkaloid binding to P-glycoprotein occurs in a processive manner
(2022)
Journal Article
Iqbal, S., Flux, C., Briggs, D. A., Deplazes, E., Long, J., Skrzypek, R., …Callaghan, R. (2022). Vinca alkaloid binding to P-glycoprotein occurs in a processive manner. BBA - Biomembranes, 1864(10), Article 184005. https://doi.org/10.1016/j.bbamem.2022.184005
A mechanistic understanding of how P-glycoprotein (Pgp) is able to bind and transport its astonishing range of substrates remains elusive. Pharmacological data demonstrated the presence of at least four distinct binding sites, but their locations hav... Read More about Vinca alkaloid binding to P-glycoprotein occurs in a processive manner.