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Professor ANA VALDES's Outputs (119)

Temporary 2-week suspension of methotrexate treatment to enhance COVID-19 vaccine response in people with immune-mediated inflammatory diseases: the VROOM RCT (2025)
Journal Article
Abhishek, A., Peckham, N., Pade, C., Gibbons, J. M., Cureton, L., Reynolds, C. J., Francis, A., Barber, V., Williams, J., Appelbe, D., Eldridge, L., Julier, P., Altmann, D. M., Bluett, J., Brooks, T., Coates, L. C., Rombach, I., Semper, A., Otter, A., Valdes, A. M., …Cook, J. A. (2025). Temporary 2-week suspension of methotrexate treatment to enhance COVID-19 vaccine response in people with immune-mediated inflammatory diseases: the VROOM RCT. Efficacy and Mechanism Evaluation, 1-42. https://doi.org/10.3310/kytk6537

Objective
Methotrexate is first-line treatment for many immune-mediated inflammatory diseases. However, it inhibits vaccine-induced immunity – a major concern for this vulnerable group of patients. We evaluated if a 2-week interruption of methotrexa... Read More about Temporary 2-week suspension of methotrexate treatment to enhance COVID-19 vaccine response in people with immune-mediated inflammatory diseases: the VROOM RCT.

Monocyte eukaryotic initiation factor 2 (EIF2) signalling differentiates 17-hydroxy-docosahexaenoic acid levels and pain (2025)
Journal Article
Gowler, P. R., Arendt-Tranholm, A., Turnbull, J., Jha, R. R., Onion, D., Kelly, T., Kouraki, A., Millns, P., Gohir, S., Franks, S., Barrett, D. A., Valdes, A. M., & Chapman, V. (2025). Monocyte eukaryotic initiation factor 2 (EIF2) signalling differentiates 17-hydroxy-docosahexaenoic acid levels and pain. iScience, 28(2), Article 111862. https://doi.org/10.1016/j.isci.2025.111862

Our goal was to probe the potential transcriptomic basis for the relationship between plasma levels of the specialized pro-resolving precursor, 17-hydroxy-docosahexaenoic acid (17-HDHA) and chronic pain. Participants with osteoarthritis (average age... Read More about Monocyte eukaryotic initiation factor 2 (EIF2) signalling differentiates 17-hydroxy-docosahexaenoic acid levels and pain.

Gut Microbiome Diversity and Composition Correlates With Time in the Therapeutic Range in Patients on Warfarin Treatment: A Pilot Study (2024)
Journal Article
Agosti, P., Kouraki, A., Dionisi, T., Addolorato, G., D’Innocenzo, L., Sorrentino, S., De Maio, F., De Candia, E., Blanco-Miguez, A., Bazzani, D., Bonadiman, A., Tonidandel, G., Bolzan, M., Gianniello, F., Passamonti, S. M., Abbattista, M., Valdes, A. M., Bucciarelli, P., Peyvandi, F., & Menni, C. (2024). Gut Microbiome Diversity and Composition Correlates With Time in the Therapeutic Range in Patients on Warfarin Treatment: A Pilot Study. Arteriosclerosis, Thrombosis, and Vascular Biology, https://doi.org/10.1161/ATVBAHA.124.321490

Supplementation with Citrus Low-Methoxy Pectin Reduces Levels of Inflammation and Anxiety in Healthy Volunteers: A Pilot Controlled Dietary Intervention Study (2024)
Journal Article
Vijay, A., Kelly, A., Miller, S., Marshall, M., Alonso, A., Kouraki, A., Probert, C., Simpson, E. J., & Valdes, A. M. (2024). Supplementation with Citrus Low-Methoxy Pectin Reduces Levels of Inflammation and Anxiety in Healthy Volunteers: A Pilot Controlled Dietary Intervention Study. Nutrients, 16(19), Article 3326. https://doi.org/10.3390/nu16193326

Background/Objective: Although low-methoxy (LM) pectin (polysaccharides extracted from citrus peels) can reduce inflammation by binding to and inhibiting the TLR-2 pathway in animal models and in vitro studies, the anti-inflammatory effects of LM pec... Read More about Supplementation with Citrus Low-Methoxy Pectin Reduces Levels of Inflammation and Anxiety in Healthy Volunteers: A Pilot Controlled Dietary Intervention Study.

Metagenomic changes in response to antibiotic treatment in severe orthopedic trauma patients (2024)
Journal Article
Kouraki, A., Zheng, A. S., Miller, S., Kelly, A., Ashraf, W., Bazzani, D., Bonadiman, A., Tonidandel, G., Bolzan, M., Vijay, A., Nightingale, J., Menni, C., Ollivere, B. J., & Valdes, A. M. (2024). Metagenomic changes in response to antibiotic treatment in severe orthopedic trauma patients. iScience, 27(9), Article 110783. https://doi.org/10.1016/j.isci.2024.110783

We investigated changes in microbiome composition and abundance of antimicrobial resistance (AMR) genes post-antibiotic treatment in severe trauma patients. Shotgun sequencing revealed beta diversity (Bray-Curtis) differences between 16 hospitalized... Read More about Metagenomic changes in response to antibiotic treatment in severe orthopedic trauma patients.

Vitamin A carotenoids, but not retinoids, mediate the impact of a healthy diet on gut microbial diversity (2024)
Journal Article
Valdes, A. M., Louca, P., Visconti, A., Asnicar, F., Bermingham, K., Nogal, A., Wong, K., Michelotti, G. A., Wolf, J., Segata, N., Spector, T. D., Berry, S. E., Falchi, M., & Menni, C. (2024). Vitamin A carotenoids, but not retinoids, mediate the impact of a healthy diet on gut microbial diversity. BMC Medicine, 22(1), Article 321. https://doi.org/10.1186/s12916-024-03543-4

Background: Vitamin A is essential for physiological processes like vision and immunity. Vitamin A’s effect on gut microbiome composition, which affects absorption and metabolism of other vitamins, is still unknown. Here we examined the relationship... Read More about Vitamin A carotenoids, but not retinoids, mediate the impact of a healthy diet on gut microbial diversity.

Association of serum biomarkers with radiographic knee osteoarthritis, knee pain and function in a young, male, trauma-exposed population – Findings from the ADVANCE study (2024)
Journal Article
O'Sullivan, O., Stocks, J., Schofield, S., Bilzon, J., Boos, C. J., Bull, A. M., Fear, N. T., Watt, F. E., Bennett, A. N., Kluzek, S., & Valdes, A. M. (2024). Association of serum biomarkers with radiographic knee osteoarthritis, knee pain and function in a young, male, trauma-exposed population – Findings from the ADVANCE study. Osteoarthritis and Cartilage, 32(12), 1636-1646. https://doi.org/10.1016/j.joca.2024.07.016

Objective: The ArmeD SerVices TrAuma RehabilitatioN OutComE (ADVANCE) study is investigating long-term combat-injury outcomes; this sub-study aims to understand the association of osteoarthritis (OA) biomarkers with knee radiographic OA (rOA), pain a... Read More about Association of serum biomarkers with radiographic knee osteoarthritis, knee pain and function in a young, male, trauma-exposed population – Findings from the ADVANCE study.

Modelling the role of enzymatic pathways in the metabolism of docosahexaenoic acid by monocytes and its association with osteoarthritic pain (2024)
Journal Article
Franks, S. J., Gowler, P. R., Dunster, J. L., Turnbull, J., Gohir, S. A., Kelly, A., Valdes, A. M., King, J. R., Barrett, D. A., Chapman, V., & Preston, S. (2024). Modelling the role of enzymatic pathways in the metabolism of docosahexaenoic acid by monocytes and its association with osteoarthritic pain. Mathematical Biosciences, 374, Article 109228. https://doi.org/10.1016/j.mbs.2024.109228

Chronic pain is a major cause of disability and suffering in osteoarthritis (OA) patients. Endogenous specialised pro-resolving molecules (SPMs) curtail pro-inflammatory responses. One of the SPM intermediate oxylipins, 17-hydroxydocasahexaenoic acid... Read More about Modelling the role of enzymatic pathways in the metabolism of docosahexaenoic acid by monocytes and its association with osteoarthritic pain.

Machine Learning Metabolomics Profiling of Dietary Interventions from a Six-Week Randomised Trial (2024)
Journal Article
Kouraki, A., Nogal, A., Nocun, W., Louca, P., Vijay, A., Wong, K., Michelotti, G. A., Menni, C., & Valdes, A. M. (2024). Machine Learning Metabolomics Profiling of Dietary Interventions from a Six-Week Randomised Trial. Metabolites, 14(6), Article 311. https://doi.org/10.3390/metabo14060311

Metabolomics can uncover physiological responses to prebiotic fibre and omega-3 fatty acid supplements with known health benefits and identify response-specific metabolites. We profiled 534 stool and 799 serum metabolites in 64 healthy adults followi... Read More about Machine Learning Metabolomics Profiling of Dietary Interventions from a Six-Week Randomised Trial.

Effects of a personalized nutrition program on cardiometabolic health: a randomized controlled trial (2024)
Journal Article
Bermingham, K. M., Linenberg, I., Polidori, L., Asnicar, F., Arrè, A., Wolf, J., Badri, F., Bernard, H., Capdevila, J., Bulsiewicz, W. J., Gardner, C. D., Ordovas, J. M., Davies, R., Hadjigeorgiou, G., Hall, W. L., Delahanty, L. M., Valdes, A. M., Segata, N., Spector, T. D., & Berry, S. E. (2024). Effects of a personalized nutrition program on cardiometabolic health: a randomized controlled trial. Nature Medicine, 30, 1888-1897. https://doi.org/10.1038/s41591-024-02951-6

Large variability exists in people’s responses to foods. However, the efficacy of personalized dietary advice for health remains understudied. We compared a personalized dietary program (PDP) versus general advice (control) on cardiometabolic health... Read More about Effects of a personalized nutrition program on cardiometabolic health: a randomized controlled trial.

Serum levels of hydroxylated metabolites of arachidonic acid cross-sectionally and longitudinally predict knee pain progression: an observational cohort study (2024)
Journal Article
Turnbull, J., Jha, R. R., Gowler, P. R., Ferrands-Bentley, R., Kim, D.-H., Barrett, D. A., Sarmanova, A., Fernandes, G. S., Doherty, M., Zhang, W., Walsh, D. A., Valdes, A. M., & Chapman, V. (2024). Serum levels of hydroxylated metabolites of arachidonic acid cross-sectionally and longitudinally predict knee pain progression: an observational cohort study. Osteoarthritis and Cartilage, 32(8), 990-1000. https://doi.org/10.1016/j.joca.2024.04.006

Objective: To examine associations between serum oxylipins, which regulate tissue repair and pain signalling, and knee pain/radiographic osteoarthritis (OA) at baseline and knee pain at 3 year follow-up.

Method: Baseline, and 3 year follow-up, kne... Read More about Serum levels of hydroxylated metabolites of arachidonic acid cross-sectionally and longitudinally predict knee pain progression: an observational cohort study.

Bacteriophages, gut bacteria, and microbial pathways interplay in cardiometabolic health (2024)
Journal Article
Kirk, D., Costeira, R., Visconti, A., Khan Mirzaei, M., Deng, L., Valdes, A. M., & Menni, C. (2024). Bacteriophages, gut bacteria, and microbial pathways interplay in cardiometabolic health. Cell Reports, 43(2), Article 113728. https://doi.org/10.1016/j.celrep.2024.113728

Cardiometabolic diseases are leading causes of mortality in Western countries. Well-established risk factors include host genetics, lifestyle, diet, and the gut microbiome. Moreover, gut bacterial communities and their activities can be altered by ba... Read More about Bacteriophages, gut bacteria, and microbial pathways interplay in cardiometabolic health.

Two-week break in methotrexate treatment and COVID-19 vaccine response: a prospective, open label, two-arm parallel-group, multicentre, superiority, randomised controlled trial (2023)
Journal Article
Abhishek, A., Peckham, N., Pade, C., Gibbons, J. M., Cureton, L., Francis, A., Barber, V., Williams, J. A. E., Appelbe, D., Eldridge, L., Julier, P., Altmann, D. M., Bluett, J., Brooks, T., Coates, L. C., Rombach, I., Semper, A., Otter, A., Valdes, A. M., Nguyen-Van-Tam, J. S., …Study investigators, V. (2024). Two-week break in methotrexate treatment and COVID-19 vaccine response: a prospective, open label, two-arm parallel-group, multicentre, superiority, randomised controlled trial. The Lancet Rheumatology, 6(2), E92-E104. https://doi.org/10.1016/S2665-9913%2823%2900298-9

Background
Methotrexate is the first-line treatment for immune-mediated inflammatory diseases and reduces vaccine-induced immunity. We evaluated if a 2-week interruption of methotrexate treatment immediately after COVID-19 booster vaccination improv... Read More about Two-week break in methotrexate treatment and COVID-19 vaccine response: a prospective, open label, two-arm parallel-group, multicentre, superiority, randomised controlled trial.

Effect of a 2-week interruption in methotrexate treatment on COVID-19 vaccine response in people with immune-mediated inflammatory diseases (VROOM study): a randomised, open label, superiority trial (2023)
Journal Article
Abhishek, A., Peckham, N., Pade, C., Gibbons, J. M., Cureton, L., Francis, A., Barber, V., Williams, J. A. E., Appelbe, D., Eldridge, L., Julier, P., Altmann, D. M., Bluett, J., Brooks, T., Coates, L. C., Rombach, I., Semper, A., Otter, A., Valdes, A. M., Nguyen-Van-Tam, J. S., …Cook, J. A. (2023). Effect of a 2-week interruption in methotrexate treatment on COVID-19 vaccine response in people with immune-mediated inflammatory diseases (VROOM study): a randomised, open label, superiority trial. The Lancet Rheumatology, 6(2), e92-e104. https://doi.org/10.1016/s2665-9913%2823%2900298-9

Background: Methotrexate is the first-line treatment for immune-mediated inflammatory diseases and reduces vaccine-induced immunity. We evaluated if a 2-week interruption of methotrexate treatment immediately after COVID-19 booster vaccination improv... Read More about Effect of a 2-week interruption in methotrexate treatment on COVID-19 vaccine response in people with immune-mediated inflammatory diseases (VROOM study): a randomised, open label, superiority trial.

Associations of Muscle Strength with Central Aspects of Pain: Data from the Knee Pain and Related Health in the Community (KPIC) Cohort (2023)
Journal Article
McWilliams, D. F., Yue, B., Smith, S. L., Stocks, J., Doherty, M., Valdes, A. M., Zhang, W., Sarmanova, A., Fernandes, G. S., Akin-Akinyosoye, K., Hall, M., & Walsh, D. A. (2023). Associations of Muscle Strength with Central Aspects of Pain: Data from the Knee Pain and Related Health in the Community (KPIC) Cohort. Journal of Personalized Medicine, 13(10), Article 1450. https://doi.org/10.3390/jpm13101450

Knee pain is associated with lower muscle strength, and both contribute to disability. Peripheral and central neurological mechanisms contribute to OA pain. Understanding the relative contributions of pain mechanisms to muscle strength might help fut... Read More about Associations of Muscle Strength with Central Aspects of Pain: Data from the Knee Pain and Related Health in the Community (KPIC) Cohort.

A Fecal Metabolite Signature of Impaired Fasting Glucose: Results From Two Independent Population-Based Cohorts (2023)
Journal Article
Nogal, A., Tettamanzi, F., Dong, Q., Louca, P., Visconti, A., Christiansen, C., Breuninger, T., Linseisen, J., Grallert, H., Wawro, N., Asnicar, F., Wong, K., Baleanu, A.-F., Michelotti, G. A., Segata, N., Falchi, M., Peters, A., Franks, P. W., Bagnardi, V., Spector, T. D., …Menni, C. (2023). A Fecal Metabolite Signature of Impaired Fasting Glucose: Results From Two Independent Population-Based Cohorts. Diabetes, 72(12), 1870–1880. https://doi.org/10.2337/db23-0170

Prediabetes is a metabolic condition associated with gut microbiome composition, though mechanisms remain elusive. We searched for faecal metabolites, a readout of gut microbiome function, associated with impaired fasting glucose (IFG) in 142 individ... Read More about A Fecal Metabolite Signature of Impaired Fasting Glucose: Results From Two Independent Population-Based Cohorts.

Feasibility of conducting a cohort randomized controlled trial assessing the effectiveness of a nurse-led package of care for knee pain (2023)
Journal Article
Fuller, A., Hall, M., Nomikos, P. A., Millar, B., Ogollah, R., Valdes, A., Greenhaff, P., das Nair, R., Doherty, M., Walsh, D. A., & Abhishek, A. (2024). Feasibility of conducting a cohort randomized controlled trial assessing the effectiveness of a nurse-led package of care for knee pain. Rheumatology, 63(6), 1582-1592. https://doi.org/10.1093/rheumatology/kead432

Objective
To evaluate the feasibility of conducting a cohort randomized controlled trial (RCT) of a nurse-led package of care for knee pain and determining a treatment sequence for use in a future trial.

Methods
This study was an open-label, thr... Read More about Feasibility of conducting a cohort randomized controlled trial assessing the effectiveness of a nurse-led package of care for knee pain.

Knee MRI biomarkers associated with structural, functional and symptomatic changes at least a year from ACL injury - A systematic review (2023)
Journal Article
O’Sullivan, O., Ladlow, P., Steiner, K., Kuyser, D., Ali, O., Stocks, J., Valdes, A. M., Bennett, A. N., & Kluzek, S. (2023). Knee MRI biomarkers associated with structural, functional and symptomatic changes at least a year from ACL injury - A systematic review. Osteoarthritis and Cartilage Open, 5(3), Article 100385. https://doi.org/10.1016/j.ocarto.2023.100385

Introduction
Osteoarthritis (OA) results from various aetiologies, including joint morphology, biomechanics, inflammation, and injury. The latter is implicated in post-traumatic OA, which offers a paradigm to identify potential biomarkers enabling e... Read More about Knee MRI biomarkers associated with structural, functional and symptomatic changes at least a year from ACL injury - A systematic review.

Osteoarthritis in the UK Armed Forces: a review of its impact, treatment and future research (2023)
Journal Article
O'Sullivan, O., Behan, F. P., Coppack, R. J., Stocks, J., Kluzek, S., Valdes, A. M., & Bennett, A. N. (2024). Osteoarthritis in the UK Armed Forces: a review of its impact, treatment and future research. BMJ Military Health, 170(4), 359-364. https://doi.org/10.1136/military-2023-002390

Within the UK Armed Forces, musculoskeletal injuries account for over half of all medical downgrades and discharges. Data from other Armed Forces show that osteoarthritis (OA), more common in military personnel, is likely to contribute to this, both... Read More about Osteoarthritis in the UK Armed Forces: a review of its impact, treatment and future research.