Bacteriophages, gut bacteria, and microbial pathways interplay in cardiometabolic health

Kirk, Daniel; Costeira, Ricardo; Visconti, Alessia; Khan Mirzaei, Mohammadali; Deng, Li; Valdes, Ana M; Menni, Cristina

Abstract

Cardiometabolic diseases are leading causes of mortality in Western countries. Well-established risk factors include host genetics, lifestyle, diet, and the gut microbiome. Moreover, gut bacterial communities and their activities can be altered by bacteriophages (also known simply as phages), bacteria-infecting viruses, making these biological entities key regulators of human cardiometabolic health. The manipulation of bacterial populations by phages enables the possibility of using phages in the treatment of cardiometabolic diseases through phage therapy and fecal viral transplants. First, however, a deeper understanding of the role of the phageome in cardiometabolic diseases is required. In this review, we first introduce the phageome as a component of the gut microbiome and discuss fecal viral transplants and phage therapy in relation to cardiometabolic diseases. We then summarize the current state of phageome research in cardiometabolic diseases and propose how the phageome might indirectly influence cardiometabolic health through gut bacteria and their metabolites.

Citation

Kirk, D., Costeira, R., Visconti, A., Khan Mirzaei, M., Deng, L., Valdes, A. M., & Menni, C. (2024). Bacteriophages, gut bacteria, and microbial pathways interplay in cardiometabolic health. Cell Reports, 43(2), Article 113728. https://doi.org/10.1016/j.celrep.2024.113728

• Journal Article Type: Review
• Acceptance Date: Jan 16, 2024
• Online Publication Date: Jan 31, 2024
• Publication Date: Feb 27, 2024
• Deposit Date: Apr 2, 2024
• Publicly Available Date: Apr 3, 2024
• Journal: Cell Reports
• Print ISSN: 2211-1247
• Electronic ISSN: 2211-1247
• Publisher: Cell Press
• Peer Reviewed: Peer Reviewed
• Volume: 43
• Issue: 2
• Article Number: 113728
• DOI: https://doi.org/10.1016/j.celrep.2024.113728
• Keywords: microbiome, bacteriophage, CP: Metabolism, CP: Microbiology, phage therapy, phageome, obesity, fecal virome transplant, cardiometabolic diseases
• Public URL: https://nottingham-repository.worktribe.com/output/31602880
• Publisher URL: https://www.cell.com/cell-reports/fulltext/S2211-1247(24)00056-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124724000561%3Fshowall%3Dtrue
• Additional Information: This article is maintained by: Elsevier; Article Title: Bacteriophages, gut bacteria, and microbial pathways interplay in cardiometabolic health; Journal Title: Cell Reports; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.celrep.2024.113728; Content Type: article; Copyright: © 2024 The Author(s).