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MATTHEW BROOKES's Outputs (95)

A novel, robust, and portable platform for magnetoencephalography using optically-pumped magnetometers (2024)
Journal Article
Schofield, H., Hill, R. M., Feys, O., Holmes, N., Osborne, J., Doyle, C., Bobela, D., Corvilain, P., Wens, V., Rier, L., Bowtell, R., Ferez, M., Mullinger, K. J., Coleman, S., Rhodes, N., Rea, M., Tanner, Z., Boto, E., de Tiège, X., Shah, V., & Brookes, M. J. (2024). A novel, robust, and portable platform for magnetoencephalography using optically-pumped magnetometers. Imaging Neuroscience, 2, 1-22. https://doi.org/10.1162/imag_a_00283

Magnetoencephalography (MEG) measures brain function via assessment of magnetic fields generated by neural currents. Conventional MEG uses superconducting sensors, which place significant limitations on performance, practicality, and deployment; howe... Read More about A novel, robust, and portable platform for magnetoencephalography using optically-pumped magnetometers.

Tracking the neurodevelopmental trajectory of beta band oscillations with optically pumped magnetometer-based magnetoencephalography (2024)
Journal Article
Rier, L., Rhodes, N., Pakenham, D. O., Boto, E., Holmes, N., Hill, R. M., …Brookes, M. J. (2024). Tracking the neurodevelopmental trajectory of beta band oscillations with optically pumped magnetometer-based magnetoencephalography. eLife, 13, Article RP94561. https://doi.org/10.7554/elife.94561.3

Neural oscillations mediate the coordination of activity within and between brain networks, supporting cognition and behaviour. How these processes develop throughout childhood is not only an important neuroscientific question but could also shed lig... Read More about Tracking the neurodevelopmental trajectory of beta band oscillations with optically pumped magnetometer-based magnetoencephalography.

Simultaneous whole-head electrophysiological recordings using EEG and OPM-MEG (2024)
Journal Article
Seedat, Z. A., Pier, K. S., Holmes, N., Rea, M., Al-Hilaly, L., Tierney, T. M., …Brookes, M. J. (2024). Simultaneous whole-head electrophysiological recordings using EEG and OPM-MEG. Imaging Neuroscience, 2, 1-15. https://doi.org/10.1162/imag_a_00179

Electroencephalography (EEG) and magnetoencephalography (MEG) non-invasively measure human brain electrophysiology. They differ in nature; MEG offers better performance whilst EEG (a wearable platform) is more practical. They are also complementary,... Read More about Simultaneous whole-head electrophysiological recordings using EEG and OPM-MEG.

Post‐task responses following working memory and movement are driven by transient spectral bursts with similar characteristics (2024)
Journal Article
Coleman, S. C., Seedat, Z. A., Pakenham, D. O., Quinn, A. J., Brookes, M. J., Woolrich, M. W., & Mullinger, K. J. (2024). Post‐task responses following working memory and movement are driven by transient spectral bursts with similar characteristics. Human Brain Mapping, 45(7), Article e26700. https://doi.org/10.1002/hbm.26700

The post-movement beta rebound has been studied extensively using magnetoencephalography (MEG) and is reliably modulated by various task parameters as well as illness. Our recent study showed that rebounds, which we generalise as “post-task responses... Read More about Post‐task responses following working memory and movement are driven by transient spectral bursts with similar characteristics.

The neurodevelopmental trajectory of beta band oscillations: an OPM-MEG study (2024)
Journal Article
Rier, L., Rhodes, N., Pakenham, D., Boto, E., Holmes, N., Hill, R. M., …Brookes, M. J. (2024). The neurodevelopmental trajectory of beta band oscillations: an OPM-MEG study. eLife, Article 94561v1. https://doi.org/10.7554/eLife.94561.1

Neural oscillations mediate coordination of activity within and between brain networks, supporting cognition and behaviour. How these processes develop throughout childhood is not only a critical neuroscientific question but could also shed light on... Read More about The neurodevelopmental trajectory of beta band oscillations: an OPM-MEG study.

Designing Optimal Loop, Saddle, and Ellipse-Based Magnetic Coils by Spherical Harmonic Mapping (2023)
Journal Article
Hobson, P. J., Hardwicke, N. L., Davis, A., Smith, T. X., Morley, C., Packer, M., Holmes, N., Weil, M. A., Brookes, M. J., Bowtell, R., & Fromhold, M. (2023). Designing Optimal Loop, Saddle, and Ellipse-Based Magnetic Coils by Spherical Harmonic Mapping. IEEE Transactions on Instrumentation and Measurement, 72, Article 1005815. https://doi.org/10.1109/TIM.2023.3284138

Adaptable, low-cost, coils designed by carefully selecting the arrangements and geometries of simple primitive units are used to generate magnetic fields for diverse applications. These extend from magnetic resonance and fundamental physics experimen... Read More about Designing Optimal Loop, Saddle, and Ellipse-Based Magnetic Coils by Spherical Harmonic Mapping.

Tri-axial rubidium and helium optically pumped magnetometers for on-scalp magnetoencephalography recording of interictal epileptiform discharges: a case study (2023)
Journal Article
Feys, O., Corvilain, P., Labyt, E., Mahmoudzadeh, M., Routier, L., Sculier, C., …De Tiège, X. (2023). Tri-axial rubidium and helium optically pumped magnetometers for on-scalp magnetoencephalography recording of interictal epileptiform discharges: a case study. Frontiers in Neuroscience, 17, Article 1284262. https://doi.org/10.3389/fnins.2023.1284262

Cryogenic magnetoencephalography (MEG) enhances the presurgical assessment of refractory focal epilepsy (RFE). Optically pumped magnetometers (OPMs) are cryogen-free sensors that enable on-scalp MEG recordings. Here, we investigate the application of... Read More about Tri-axial rubidium and helium optically pumped magnetometers for on-scalp magnetoencephalography recording of interictal epileptiform discharges: a case study.

Portable single-beam cesium zero-field magnetometer for magnetocardiography (2023)
Journal Article
Dawson, R., O'Dwyer, C., Mrozowski, M. S., Irwin, E., McGilligan, J. P., Burt, D. P., …Riis, E. (2023). Portable single-beam cesium zero-field magnetometer for magnetocardiography. Journal of Optical Microsystems, 3(4), Article 044501. https://doi.org/10.1117/1.jom.3.4.044501

Optically pumped magnetometers (OPMs) are becoming common in the realm of biomagnetic measurements. We discuss the development of a prototype zero-field cesium portable OPM and its miniaturized components. Zero-field sensors operate in a very low sta... Read More about Portable single-beam cesium zero-field magnetometer for magnetocardiography.

Test-retest reliability of the human connectome: An OPM-MEG study (2023)
Journal Article
Rier, L., Michelmann, S., Ritz, H., Shah, V., Hill, R. M., Osborne, J., …Boto, E. (2023). Test-retest reliability of the human connectome: An OPM-MEG study. Imaging Neuroscience, 1, 1-20. https://doi.org/10.1162/imag_a_00020

Magnetoencephalography with optically pumped magnetometers (OPM-MEG) offers a new way to record electrophysiological brain function, with significant advantages over conventional MEG, including adaptability to head shape/size, free movement during sc... Read More about Test-retest reliability of the human connectome: An OPM-MEG study.

Benchtop magnetic shielding for benchmarking atomic magnetometers (2023)
Journal Article
Hobson, P. J., Holmes, N., Patel, P., Styles, B., Chalmers, J., Morley, C., Davis, A., Packer, M., Smith, T. X., Raudonyte, S., Holmes, D., Harrison, R., Woolger, D., Sims, D., Brookes, M. J., Bowtell, R., & Fromhold, M. (2023). Benchtop magnetic shielding for benchmarking atomic magnetometers. IEEE Transactions on Instrumentation and Measurement, 72, Article 6007309. https://doi.org/10.1109/tim.2023.3293540

Here, a benchtop hybrid magnetic shield containing four mumetal cylinders and nine internal flexible printed circuit boards is designed, constructed, tested, and operated. The shield is designed specifically as a test-bed for building and operating u... Read More about Benchtop magnetic shielding for benchmarking atomic magnetometers.

An Iterative Implementation of the Signal Space Separation Method for Magnetoencephalography Systems with Low Channel Counts (2023)
Journal Article
Holmes, N., Bowtell, R., Brookes, M. J., & Taulu, S. (2023). An Iterative Implementation of the Signal Space Separation Method for Magnetoencephalography Systems with Low Channel Counts. Sensors, 23(14), Article 6537. https://doi.org/10.3390/s23146537

The signal space separation (SSS) method is routinely employed in the analysis of multichannel magnetic field recordings (such as magnetoencephalography (MEG) data). In the SSS method, signal vectors are posed as a multipole expansion of the magnetic... Read More about An Iterative Implementation of the Signal Space Separation Method for Magnetoencephalography Systems with Low Channel Counts.

Naturalistic Hyperscanning with Wearable Magnetoencephalography (2023)
Journal Article
Holmes, N., Rea, M., Hill, R. M., Boto, E., Leggett, J., Edwards, L. J., …Bowtell, R. (2023). Naturalistic Hyperscanning with Wearable Magnetoencephalography. Sensors, 23(12), Article 5454. https://doi.org/10.3390/s23125454

The evolution of human cognitive function is reliant on complex social interactions which form the behavioural foundation of who we are. These social capacities are subject to dramatic change in disease and injury; yet their supporting neural substra... Read More about Naturalistic Hyperscanning with Wearable Magnetoencephalography.

Enabling ambulatory movement in wearable magnetoencephalography with matrix coil active magnetic shielding (2023)
Journal Article
Holmes, N., Rea, M., Hill, R. M., Leggett, J., Edwards, L. J., Hobson, P. J., …Bowtell, R. (2023). Enabling ambulatory movement in wearable magnetoencephalography with matrix coil active magnetic shielding. NeuroImage, 274, Article 120157. https://doi.org/10.1016/j.neuroimage.2023.120157

The ability to collect high-quality neuroimaging data during ambulatory participant movement would enable a wealth of neuroscientific paradigms. Wearable magnetoencephalography (MEG) based on optically pumped magnetometers (OPMs) has the potential to... Read More about Enabling ambulatory movement in wearable magnetoencephalography with matrix coil active magnetic shielding.

Non-invasive measurements of ictal and interictal epileptiform activity using optically pumped magnetometers (2023)
Journal Article
Hillebrand, A., Holmes, N., Sijsma, N., O’Neill, G. C., Tierney, T. M., Liberton, N., …Barnes, G. R. (2023). Non-invasive measurements of ictal and interictal epileptiform activity using optically pumped magnetometers. Scientific Reports, 13(1), Article 4623. https://doi.org/10.1038/s41598-023-31111-y

Magneto- and electroencephalography (MEG/EEG) are important techniques for the diagnosis and pre-surgical evaluation of epilepsy. Yet, in current cryogen-based MEG systems the sensors are offset from the scalp, which limits the signal-to-noise ratio... Read More about Non-invasive measurements of ictal and interictal epileptiform activity using optically pumped magnetometers.

Measurement of Frontal Midline Theta Oscillations using OPM-MEG (2023)
Journal Article
Rhodes, N., Rea, M., Boto, E., Rier, L., Shah, V., Hill, R. M., …Brookes, M. J. (2023). Measurement of Frontal Midline Theta Oscillations using OPM-MEG. NeuroImage, 271, Article 120024. https://doi.org/10.1016/j.neuroimage.2023.120024

Optically pumped magnetometers (OPMs) are an emerging lightweight and compact sensor that can measure magnetic fields generated by the human brain. OPMs enable construction of wearable magnetoencephalography (MEG) systems, which offer advantages over... Read More about Measurement of Frontal Midline Theta Oscillations using OPM-MEG.

Mapping Interictal activity in epilepsy using a hidden Markov model: A magnetoencephalography study (2022)
Journal Article
Seedat, Z. A., Rier, L., Gascoyne, L. E., Cook, H., Woolrich, M. W., Quinn, A. J., …Gaetz, W. (2022). Mapping Interictal activity in epilepsy using a hidden Markov model: A magnetoencephalography study. Human Brain Mapping, https://doi.org/10.1002/hbm.26118

Epilepsy is a highly heterogeneous neurological disorder with variable etiology, manifestation, and response to treatment. It is imperative that new models of epileptiform brain activity account for this variability, to identify individual needs and... Read More about Mapping Interictal activity in epilepsy using a hidden Markov model: A magnetoencephalography study.

Turning OPM-MEG into a Wearable Technology (2022)
Book Chapter
Rhodes, N., Holmes, N., Hill, R., Barnes, G., Bowtell, R., Brookes, M., & Boto, E. (2022). Turning OPM-MEG into a Wearable Technology. In E. Labyt, T. Sander, & R. Wakai (Eds.), Flexible High Performance Magnetic Field Sensors: On-Scalp Magnetoencephalography and Other Applications (195-223). Springer International Publishing. https://doi.org/10.1007/978-3-031-05363-4_11

This chapter explores the use of optically pumped magnetometers (OPMs) as a tool for magnetoencephalography (MEG). Conventional MEG systems use superconducting quantum interference devices (SQUIDs) to measure the femto-Tesla-level magnetic fields at... Read More about Turning OPM-MEG into a Wearable Technology.

A lightweight magnetically shielded room with active shielding (2022)
Journal Article
Holmes, N., Rea, M., Chalmers, J., Leggett, J., Edwards, L. J., Nell, P., …Bowtell, R. (2022). A lightweight magnetically shielded room with active shielding. Scientific Reports, 12, Article 13561. https://doi.org/10.1038/s41598-022-17346-1

Magnetically shielded rooms (MSRs) use multiple layers of materials such as MuMetal to screen external magnetic fields that would otherwise interfere with high precision magnetic field measurements such as magnetoencephalography (MEG). Optically pump... Read More about A lightweight magnetically shielded room with active shielding.

Predicting time-resolved electrophysiological brain networks from structural eigenmodes (2022)
Journal Article
Tewarie, P., Prasse, B., Meier, J., Mandke, K., Warrington, S., Stam, C. J., …Hillebrand, A. (2022). Predicting time-resolved electrophysiological brain networks from structural eigenmodes. Human Brain Mapping, https://doi.org/10.1002/hbm.25967

How temporal modulations in functional interactions are shaped by the underlying anatomical connections remains an open question. Here, we analyse the role of structural eigenmodes, in the formation and dissolution of temporally evolving functional b... Read More about Predicting time-resolved electrophysiological brain networks from structural eigenmodes.

On-Scalp Optically Pumped Magnetometers versus Cryogenic Magnetoencephalography for Diagnostic Evaluation of Epilepsy in School-aged Children (2022)
Journal Article
Feys, O., Corvilain, P., Aeby, A., Sculier, C., Holmes, N., Brookes, M., …De Tiège, X. (2022). On-Scalp Optically Pumped Magnetometers versus Cryogenic Magnetoencephalography for Diagnostic Evaluation of Epilepsy in School-aged Children. Radiology, 304(2), 429-434. https://doi.org/10.1148/radiol.212453

Background Magnetoencephalography (MEG) is an established method used to detect and localize focal interictal epileptiform discharges (IEDs). Current MEG systems house hundreds of cryogenic sensors in a rigid, one-size-fits-all helmet, which results... Read More about On-Scalp Optically Pumped Magnetometers versus Cryogenic Magnetoencephalography for Diagnostic Evaluation of Epilepsy in School-aged Children.

Using OPM-MEG in contrasting magnetic environments (2022)
Journal Article
Hill, R. M., Devasagayam, J., Holmes, N., Boto, E., Shah, V., Osborne, J., …Brookes, M. J. (2022). Using OPM-MEG in contrasting magnetic environments. NeuroImage, 253, Article 119084. https://doi.org/10.1016/j.neuroimage.2022.119084

Magnetoencephalography (MEG) has been revolutionised by optically pumped magnetometers (OPMs). “OPM-MEG” offers higher sensitivity, better spatial resolution, and lower cost than conventional instrumentation based on superconducting quantum interfere... Read More about Using OPM-MEG in contrasting magnetic environments.

Magnetic field design in a cylindrical high-permeability shield: The combination of simple building blocks and a genetic algorithm (2022)
Journal Article
Packer, M., Hobson, P. J., Davis, A., Holmes, N., Leggett, J., Glover, P., Hardwicke, N. L., Brookes, M. J., Bowtell, R., & Fromhold, T. M. (2022). Magnetic field design in a cylindrical high-permeability shield: The combination of simple building blocks and a genetic algorithm. Journal of Applied Physics, 131(9), Article 093902. https://doi.org/10.1063/5.0071986

Magnetically sensitive experiments and newly developed quantum technologies with integrated high-permeability magnetic shields require increasing control of their magnetic field environment and reductions in size, weight, power, and cost. However, ma... Read More about Magnetic field design in a cylindrical high-permeability shield: The combination of simple building blocks and a genetic algorithm.

Triaxial detection of the neuromagnetic field using optically-pumped magnetometry: feasibility and application in children (2022)
Journal Article
Boto, E., Shah, V., Hill, R. M., Rhodes, N., Osborne, J., Doyle, C., …Brookes, M. J. (2022). Triaxial detection of the neuromagnetic field using optically-pumped magnetometry: feasibility and application in children. NeuroImage, 252, Article 119027. https://doi.org/10.1016/j.neuroimage.2022.119027

Optically-pumped magnetometers (OPMs) are an established alternative to superconducting sensors for magnetoencephalography (MEG), offering significant advantages including flexibility to accommodate any head size, uniform coverage, free movement duri... Read More about Triaxial detection of the neuromagnetic field using optically-pumped magnetometry: feasibility and application in children.

The oscillatory effects of rhythmic median nerve stimulation (2022)
Journal Article
Houlgreave, M. S., Morera Maiquez, B., Brookes, M. J., & Jackson, S. R. (2022). The oscillatory effects of rhythmic median nerve stimulation. NeuroImage, 251, Article 118990. https://doi.org/10.1016/j.neuroimage.2022.118990

Entrainment of brain oscillations can be achieved using rhythmic non-invasive brain stimulation, and stimulation of the motor cortex at a frequency associated with sensorimotor inhibition can impair motor responses. Despite the potential for therapeu... Read More about The oscillatory effects of rhythmic median nerve stimulation.

Optimised hybrid shielding and magnetic field control for emerging quantum technologies (2021)
Presentation / Conference Contribution
Hobson, P. J., Packer, M., Holmes, N., Davis, A., Patel, P., Holmes, D., Harrison, R., Chalmers, J., Styles, B., Woolger, D., Sims, D., Brookes, M. J., & Fromhold, T. M. (2021, September). Optimised hybrid shielding and magnetic field control for emerging quantum technologies. Presented at SPIE PHOTONEX, Glasgow, United Kingdom

The accurate control of magnetic fields is a cornerstone of multiple emerging quantum technologies. These technologies often require passive high permeability magnetic shielding and internal active field-generating coils to create their own bespoke m... Read More about Optimised hybrid shielding and magnetic field control for emerging quantum technologies.

Mild traumatic brain injury impairs the coordination of intrinsic and motor-related neural dynamics (2021)
Journal Article
Rier, L., Zamyadi, R., Zhang, J., Emami, Z., Seedat, Z. A., Mocanu, S., …Dunkley, B. T. (2021). Mild traumatic brain injury impairs the coordination of intrinsic and motor-related neural dynamics. NeuroImage: Clinical, 32, Article 102841. https://doi.org/10.1016/j.nicl.2021.102841

Mild traumatic brain injury (mTBI) poses a considerable burden on healthcare systems. Whilst most patients recover quickly, a significant number suffer from sequelae that are not accompanied by measurable structural damage. Understanding the neural u... Read More about Mild traumatic brain injury impairs the coordination of intrinsic and motor-related neural dynamics.

Practical real-time MEG-based neural interfacing with optically pumped magnetometers (2021)
Journal Article
Wittevrongel, B., Holmes, N., Boto, E., Hill, R., Rea, M., Libert, A., …Brookes, M. J. (2021). Practical real-time MEG-based neural interfacing with optically pumped magnetometers. BMC Biology, 19(1), Article 158. https://doi.org/10.1186/s12915-021-01073-6

Background: Brain-computer interfaces decode intentions directly from the human brain with the aim to restore lost functionality, control external devices or augment daily experiences. To combine optimal performance with wide applicability, high-qual... Read More about Practical real-time MEG-based neural interfacing with optically pumped magnetometers.

Magnetic Field Mapping and Correction for Moving OP-MEG (2021)
Journal Article
Mellor, S., Tierney, T. M., O'Neill, G. C., Alexander, N., Seymour, R. A., Holmes, N., …Barnes, G. R. (2022). Magnetic Field Mapping and Correction for Moving OP-MEG. IEEE Transactions on Biomedical Engineering, 69(2), 528-536. https://doi.org/10.1109/TBME.2021.3100770

Background: Optically pumped magnetometers (OPMs) have made moving, wearable magnetoencephalography (MEG) possible. The OPMs typically used for MEG require a low background magnetic field to operate, which is achieved using both passive and active ma... Read More about Magnetic Field Mapping and Correction for Moving OP-MEG.

Precision magnetic field modelling and control for wearable magnetoencephalography (2021)
Journal Article
Rea, M., Holmes, N., Hill, R. M., Boto, E., Leggett, J., Edwards, L. J., …Brookes, M. J. (2021). Precision magnetic field modelling and control for wearable magnetoencephalography. NeuroImage, 241, Article 118401. https://doi.org/10.1016/j.neuroimage.2021.118401

Optically-pumped magnetometers (OPMs) are highly sensitive, compact magnetic field sensors, which offer a viable alternative to cryogenic sensors (superconducting quantum interference devices – SQUIDs) for magnetoencephalography (MEG). With the promi... Read More about Precision magnetic field modelling and control for wearable magnetoencephalography.

Interlayer connectivity reconstruction for multilayer brain networks using phase oscillator models (2021)
Journal Article
Tewarie, P., Prasse, B., Meier, J. M., Byrne, Á., De Domenico, M., Stam, C. J. (., …Van Mieghem, P. (2021). Interlayer connectivity reconstruction for multilayer brain networks using phase oscillator models. New Journal of Physics, 23(6), Article 063065. https://doi.org/10.1088/1367-2630/ac066d

Large-scale neurophysiological networks are often reconstructed from band-pass filtered time series derived from magnetoencephalography (MEG) data. Common practice is to reconstruct these networks separately for different frequency bands and to treat... Read More about Interlayer connectivity reconstruction for multilayer brain networks using phase oscillator models.

Theoretical advantages of a triaxial optically pumped magnetometer magnetoencephalography system (2021)
Journal Article
Brookes, M. J., Boto, E., Rea, M., Shah, V., Osborne, J., Holmes, N., …Bowtell, R. (2021). Theoretical advantages of a triaxial optically pumped magnetometer magnetoencephalography system. NeuroImage, 236, Article 118025. https://doi.org/10.1016/j.neuroimage.2021.118025

The optically pumped magnetometer (OPM) is a viable means to detect magnetic fields generated by human brain activity. Compared to conventional detectors (superconducting quantum interference devices) OPMs are small, lightweight, flexible, and operat... Read More about Theoretical advantages of a triaxial optically pumped magnetometer magnetoencephalography system.

Assessment, endoscopy, and treatment in patients with acute severe ulcerative colitis during the COVID-19 pandemic (PROTECT-ASUC): a multicentre, observational, case-control study (2021)
Journal Article
Sebastian, S., Walker, G. J., Kennedy, N. A., Conley, T. E., Patel, K. V., Subramanian, S., …Zafar, M. (2021). Assessment, endoscopy, and treatment in patients with acute severe ulcerative colitis during the COVID-19 pandemic (PROTECT-ASUC): a multicentre, observational, case-control study. Lancet Gastroenterology and Hepatology, 6(4), 271-281. https://doi.org/10.1016/s2468-1253%2821%2900016-9

Background
There is a paucity of evidence to support safe and effective management of patients with acute severe ulcerative colitis during the COVID-19 pandemic. We sought to identify alterations to established conventional evidence-based management... Read More about Assessment, endoscopy, and treatment in patients with acute severe ulcerative colitis during the COVID-19 pandemic (PROTECT-ASUC): a multicentre, observational, case-control study.

Motor-related oscillatory activity in schizophrenia according to phase of illness and clinical symptom severity (2020)
Journal Article
Gascoyne, L. E., Brookes, M. J., Rathnaiah, M., Zia Ul Haq Katshu, M., Koelewijn, L., Williams, G., …Morris, P. G. (2021). Motor-related oscillatory activity in schizophrenia according to phase of illness and clinical symptom severity. NeuroImage: Clinical, 29, Article 102524. https://doi.org/10.1016/j.nicl.2020.102524

Magnetoencephalography (MEG) measures magnetic fields generated by synchronised neural current flow and provides direct inference on brain electrophysiology and connectivity, with high spatial and temporal resolution. The movement-related beta decrea... Read More about Motor-related oscillatory activity in schizophrenia according to phase of illness and clinical symptom severity.

Optimal Inverse Design of Magnetic Field Profiles in a Magnetically Shielded Cylinder (2020)
Journal Article
Packer, M., Hobson, P., Holmes, N., Leggett, J., Glover, P., Brookes, M., …Fromhold, T. (2020). Optimal Inverse Design of Magnetic Field Profiles in a Magnetically Shielded Cylinder. Physical Review Applied, 14(5), Article 054004. https://doi.org/10.1103/PhysRevApplied.14.054004

Magnetic shields that use both active and passive components to enable the generation of a tailored low-field environment are required for many applications in science, engineering, and medical imaging. Until now, accurate field nulling, or field gen... Read More about Optimal Inverse Design of Magnetic Field Profiles in a Magnetically Shielded Cylinder.

Mouth magnetoencephalography: A unique perspective on the human hippocampus (2020)
Journal Article
Tierney, T. M., Levy, A., Barry, D. N., Meyer, S. S., Shigihara, Y., Everatt, M., …Barnes, G. R. (2021). Mouth magnetoencephalography: A unique perspective on the human hippocampus. NeuroImage, 225, Article 117443. https://doi.org/10.1016/j.neuroimage.2020.117443

Traditional magnetoencephalographic (MEG) brain imaging scanners consist of a rigid sensor array surrounding the head; this means that they are maximally sensitive to superficial brain structures. New technology based on optical pumping means that we... Read More about Mouth magnetoencephalography: A unique perspective on the human hippocampus.

Age-related differences in myeloarchitecture measured at 7 T (2020)
Journal Article
Carradus, A. J., Mougin, O., Hunt, B. A., Tewarie, P. K., Geades, N., Morris, P. G., …Madan, C. R. (2020). Age-related differences in myeloarchitecture measured at 7 T. Neurobiology of Aging, 96, 246-254. https://doi.org/10.1016/j.neurobiolaging.2020.08.009

We have used the magnetisation transfer (MT) MRI measure as a primary measure of myelination in both the grey matter (GM) of the 78 cortical automated anatomical labelling (AAL) regions of the brain, and the underlying white matter in each region, in... Read More about Age-related differences in myeloarchitecture measured at 7 T.

Quantifying the core deficit in classical schizophrenia (2020)
Journal Article
Rathnaiah, M., Liddle, E., Gascoyne, L., Kumar, J., Zia Ul Haq Katshu, M., Faruqi, C., …Liddle, P. F. (2020). Quantifying the core deficit in classical schizophrenia. Schizophrenia Bulletin Open, 1(1), Article sgaa031. https://doi.org/10.1093/schizbullopen/sgaa031

In the classical descriptions of schizophrenia, Kraepelin and Bleuler recognised disorganization and impoverishment of mental activity as fundamental symptoms. Their classical descriptions also included a tendency to persisting disability. The psycho... Read More about Quantifying the core deficit in classical schizophrenia.

Multi-channel whole-head OPM-MEG: Helmet design and a comparison with a conventional system (2020)
Journal Article
Hill, R. M., Boto, E., Rea, M., Holmes, N., Leggett, J., Coles, L. A., …Brookes, M. J. (2020). Multi-channel whole-head OPM-MEG: Helmet design and a comparison with a conventional system. NeuroImage, 219, Article 116995. https://doi.org/10.1016/j.neuroimage.2020.116995

© 2020 The Authors Magnetoencephalography (MEG) is a powerful technique for functional neuroimaging, offering a non-invasive window on brain electrophysiology. MEG systems have traditionally been based on cryogenic sensors which detect the small extr... Read More about Multi-channel whole-head OPM-MEG: Helmet design and a comparison with a conventional system.

A tool for functional brain imaging with lifespan compliance (2019)
Journal Article
Hill, R. M., Boto, E., Holmes, N., Hartley, C., Seedat, Z. A., Leggett, J., …Brookes, M. J. (2019). A tool for functional brain imaging with lifespan compliance. Nature Communications, 10, Article 4785. https://doi.org/10.1038/s41467-019-12486-x

The human brain undergoes significant functional and structural changes in the first decades of life, as the foundations for human cognition are laid down. However, non-invasive imaging techniques to investigate brain function throughout neurodevelop... Read More about A tool for functional brain imaging with lifespan compliance.

Post-stimulus beta responses are modulated by task duration (2019)
Journal Article
Pakenham, D. O., Quinn, A. J., Fry, A., Francis, S. T., Woolrich, M. W., Brookes, M. J., & Mullinger, K. J. (2020). Post-stimulus beta responses are modulated by task duration. NeuroImage, 206, Article 116288. https://doi.org/10.1016/j.neuroimage.2019.116288

Modulation of beta-band neural oscillations during and following movement is a robust marker of brain function. In particular, the post-movement beta rebound (PMBR), which occurs on movement cessation, has been related to inhibition and connectivity... Read More about Post-stimulus beta responses are modulated by task duration.

Balanced, bi-planar magnetic field and field gradient coils for field compensation in wearable magnetoencephalography (2019)
Journal Article
Holmes, N., Tierney, T. M., Leggett, J., Boto, E., Mellor, S., Roberts, G., …Bowtell, R. (2019). Balanced, bi-planar magnetic field and field gradient coils for field compensation in wearable magnetoencephalography. Scientific Reports, 9, Article 14196. https://doi.org/10.1038/s41598-019-50697-w

To allow wearable magnetoencephalography (MEG) recordings to be made on unconstrained subjects the spatially inhomogeneous remnant magnetic field inside the magnetically shielded room (MSR) must be nulled. Previously, a large bi-planar coil system wh... Read More about Balanced, bi-planar magnetic field and field gradient coils for field compensation in wearable magnetoencephalography.

How Sensitive Are Conventional MEG Functional Connectivity Metrics With Sliding Windows to Detect Genuine Fluctuations in Dynamic Functional Connectivity? (2019)
Journal Article
Liuzzi, L., Quinn, A. J., O'Neill, G. C., Woolrich, M. W., Brookes, M. J., Hillebrand, A., & Tewarie, P. (2019). How Sensitive Are Conventional MEG Functional Connectivity Metrics With Sliding Windows to Detect Genuine Fluctuations in Dynamic Functional Connectivity?. Frontiers in Neuroscience, 13, Article 797. https://doi.org/10.3389/fnins.2019.00797

Despite advances in the field of dynamic connectivity, fixed sliding window approaches for the detection of fluctuations in functional connectivity are still widely used. The use of conventional connectivity metrics in conjunction with a fixed slidin... Read More about How Sensitive Are Conventional MEG Functional Connectivity Metrics With Sliding Windows to Detect Genuine Fluctuations in Dynamic Functional Connectivity?.

Two spatially distinct posterior alpha sources fulfill different functional roles in attention (2019)
Journal Article
Sokoliuk, R., Mayhew, S., Aquino, K., Wilson, R., Brookes, M., Francis, S., …Mullinger, K. (2019). Two spatially distinct posterior alpha sources fulfill different functional roles in attention. Journal of Neuroscience, 39(36), 7183-7194. https://doi.org/10.1523/jneurosci.1993-18.2019

Directing attention helps extracting relevant information and suppressing distracters. Alpha brain oscillations (8-12Hz) are crucial for this process, with power decreases facilitating processing of important information and power increases inhibitin... Read More about Two spatially distinct posterior alpha sources fulfill different functional roles in attention.

Data‐driven model optimization for optically pumped magnetometer sensor arrays (2019)
Journal Article
Duque‐Muñoz, L., Tierney, T. M., Meyer, S. S., Boto, E., Holmes, N., Roberts, G., …Barnes, G. R. (2019). Data‐driven model optimization for optically pumped magnetometer sensor arrays. Human Brain Mapping, 40(15), 4357-4369. https://doi.org/10.1002/hbm.24707

© 2019 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc. Optically pumped magnetometers (OPMs) have reached sensitivity levels that make them viable portable alternatives to traditional superconducting technology for magnetoenceph... Read More about Data‐driven model optimization for optically pumped magnetometer sensor arrays.

Towards OPM-MEG in a virtual reality environment (2019)
Journal Article
Roberts, G., Holmes, N., Alexander, N., Boto, E., Leggett, J., Hill, R. M., …Brookes, M. J. (2019). Towards OPM-MEG in a virtual reality environment. NeuroImage, 199, 408-417. https://doi.org/10.1016/j.neuroimage.2019.06.010

Virtual reality (VR) provides an immersive environment in which a participant can experience a feeling of presence in a virtual world. Such environments generate strong emotional and physical responses and have been used for wide-ranging applications... Read More about Towards OPM-MEG in a virtual reality environment.

Optically pumped magnetometers: From quantum origins to multi-channel magnetoencephalography (2019)
Journal Article
Tierney, T. M., Holmes, N., Mellor, S., López, J. D., Roberts, G., Hill, R. M., …Barnes, G. R. (2019). Optically pumped magnetometers: From quantum origins to multi-channel magnetoencephalography. NeuroImage, 199, 598-608. https://doi.org/10.1016/j.neuroimage.2019.05.063

Optically Pumped Magnetometers (OPMs) have emerged as a viable and wearable alternative to cryogenic, superconducting MEG systems. This new generation of sensors has the advantage of not requiring cryogenic cooling and as a result can be flexibly pla... Read More about Optically pumped magnetometers: From quantum origins to multi-channel magnetoencephalography.

Imaging human cortical responses to intraneural microstimulation using magnetoencephalography (2019)
Journal Article
O'Neill, G. C., Watkins, R. H., Ackerley, R., Barratt, E. L., Sengupta, A., Asghar, M., …Francis, S. T. (2019). Imaging human cortical responses to intraneural microstimulation using magnetoencephalography. NeuroImage, 189, 329-340. https://doi.org/10.1016/j.neuroimage.2019.01.017

The sensation of touch in the glabrous skin of the human hand is conveyed by thousands of fast-conducting mechanoreceptive afferents, which can be categorised into four distinct types. The spiking properties of these afferents in the periphery in re... Read More about Imaging human cortical responses to intraneural microstimulation using magnetoencephalography.

Updating dynamic noise models with moving magnetoencephalographic (MEG) systems (2019)
Journal Article
Lopez, J. D., Tierney, T. M., Sucerquia, A., Valencia, F., Holmes, N., Mellor, S., …Barnes, G. R. (2019). Updating dynamic noise models with moving magnetoencephalographic (MEG) systems. IEEE Access, 7(1), 10093-10102. https://doi.org/10.1109/access.2019.2891162

Optically pumped magnetometers have opened many possibilities for the study of human brain function using wearable moveable technology. In order to fully exploit this capability, a stable low-field environment at the sensors is required. One way to a... Read More about Updating dynamic noise models with moving magnetoencephalographic (MEG) systems.

Development of human electrophysiological brain networks (2018)
Journal Article
Briley, P. M., Liddle, E. B., Groom, M. J., Smith, H. J. F., Morris, P. G., Colclough, G. L., …Liddle, P. F. (2018). Development of human electrophysiological brain networks. Journal of Neurophysiology, 120(6), 3122-3130. https://doi.org/10.1152/jn.00293.2018

Functional activity in the human brain is intrinsically organized into independently active, connected brain regions. These networks include sensorimotor systems, as well as higher-order cognitive networks such as the default mode network (DMN), whic... Read More about Development of human electrophysiological brain networks.

How do spatially distinct frequency specific MEG networks emerge from one underlying structural connectome? The role of the structural eigenmodes (2018)
Journal Article
Tewarie, P., Abeysuriya, R., Byrne, Á., O'Neill, G. C., Sotiropoulos, S. N., Brookes, M. J., & Coombes, S. (2019). How do spatially distinct frequency specific MEG networks emerge from one underlying structural connectome? The role of the structural eigenmodes. NeuroImage, 186, 211-220. https://doi.org/10.1016/j.neuroimage.2018.10.079

Functional networks obtained from magnetoencephalography (MEG) from different frequency bands show distinct spatial patterns. It remains to be elucidated how distinct spatial patterns in MEG networks emerge given a single underlying structural networ... Read More about How do spatially distinct frequency specific MEG networks emerge from one underlying structural connectome? The role of the structural eigenmodes.

Time to endoscopy for acute upper gastrointestinal bleeding: results from a prospective multicentre trainee-led audit (2018)
Journal Article
Siau, K., Hodson, J., Ingram, R., Baxter, A., Widlak, M. M., Sharratt, C., …Major, G. (2018). Time to endoscopy for acute upper gastrointestinal bleeding: results from a prospective multicentre trainee-led audit. United European Gastroenterology Journal, https://doi.org/10.1177/2050640618811491

Background: Endoscopy within 24 hours of admission (early endoscopy) is a quality standard in acute upper gastrointestinal bleeding (AUGIB). We aimed to audit time to endoscopy outcomes and identify factors affecting delayed endoscopy (>24h of admiss... Read More about Time to endoscopy for acute upper gastrointestinal bleeding: results from a prospective multicentre trainee-led audit.

Spontaneous cortical activity transiently organises into frequency specific phase-coupling networks (2018)
Journal Article
Vidaurre, D., Hunt, L. T., Quinn, A. J., Hunt, B. A. E., Brookes, M. J., Nobre, A. C., & Woolrich, M. W. (2018). Spontaneous cortical activity transiently organises into frequency specific phase-coupling networks. Nature Communications, 9(1), Article 2987. https://doi.org/10.1038/s41467-018-05316-z

© 2018, The Author(s). Frequency-specific oscillations and phase-coupling of neuronal populations are essential mechanisms for the coordination of activity between brain areas during cognitive tasks. Therefore, the ongoing activity ascribed to the di... Read More about Spontaneous cortical activity transiently organises into frequency specific phase-coupling networks.

Changes in electrophysiological markers of cognitive control after administration of galantamine (2018)
Journal Article
Robson, S. E., Gascoyne, L. E., Mullinger, K. J., Robson, S., Kumar, J., O'Neill, G. C., …Liddle, P. F. (2018). Changes in electrophysiological markers of cognitive control after administration of galantamine. NeuroImage: Clinical, 20, 228-235. https://doi.org/10.1016/j.nicl.2018.07.019

© 2018 The healthy brain is able to maintain a stable balance between bottom-up sensory processing and top-down cognitive control. The neurotransmitter acetylcholine plays a substantial role in this. Disruption of this balance could contribute to sym... Read More about Changes in electrophysiological markers of cognitive control after administration of galantamine.

Cognitive neuroscience using wearable magnetometer arrays: Non-invasive assessment of language function (2018)
Journal Article
Tierney, T. M., Holmes, N., Meyer, S. S., Boto, E., Roberts, G., Leggett, J., …Barnes, G. R. (2018). Cognitive neuroscience using wearable magnetometer arrays: Non-invasive assessment of language function. NeuroImage, 181, 513-520. https://doi.org/10.1016/j.neuroimage.2018.07.035

Recent work has demonstrated that Optically Pumped Magnetometers (OPMs) can be utilised to create a wearable Magnetoencephalography (MEG) system that is motion robust. In this study, we use this system to map eloquent cortex using a clinically valida... Read More about Cognitive neuroscience using wearable magnetometer arrays: Non-invasive assessment of language function.

A bi-planar coil system for nulling background magnetic fields in scalp mounted magnetoencephalography (2018)
Journal Article
Holmes, N., Leggett, J., Boto, E., Roberts, G., Hill, R. M., Tierney, T. M., …Bowtell, R. (2018). A bi-planar coil system for nulling background magnetic fields in scalp mounted magnetoencephalography. NeuroImage, 181, 760-774. https://doi.org/10.1016/j.neuroimage.2018.07.028

Small, commercially-available Optically Pumped Magnetometers (OPMs) can be used to construct a wearable Magnetoencephalography (MEG) system that allows large head movements to be made during recording. The small dynamic range of these sensors however... Read More about A bi-planar coil system for nulling background magnetic fields in scalp mounted magnetoencephalography.

Mapping the topological organisation of beta oscillations in motor cortex using MEG (2018)
Journal Article
Barratt, E., Francis, S. T., Morris, P. G., & Brookes, M. J. (2018). Mapping the topological organisation of beta oscillations in motor cortex using MEG. NeuroImage, https://doi.org/10.1016/j.neuroimage.2018.06.041

The spatial topology of the human motor cortex has been well studied, particularly using functional Magnetic Resonance Imaging (fMRI) which allows spatial separation of haemodynamic responses arising from stimulation of different body parts, individu... Read More about Mapping the topological organisation of beta oscillations in motor cortex using MEG.

Glutathione and glutamate in schizophrenia: a 7T MRS study (2018)
Journal Article
Kumar, J., Liddle, E. B., Fernandes, C. C., Palaniyappan, L., Hall, E. L., Robson, S. E., Simmonite, M., Fiesal, J., Katshu, M. Z., Qureshi, A., Skelton, M., Christodoulou, N. G., Brookes, M. J., Morris, P. G., & Liddle, P. F. (2018). Glutathione and glutamate in schizophrenia: a 7T MRS study. Molecular Psychiatry, 25(4), 873–882. https://doi.org/10.1038/s41380-018-0104-7

© 2018 The Author(s) In schizophrenia, abnormal neural metabolite concentrations may arise from cortical damage following neuroinflammatory processes implicated in acute episodes. Inflammation is associated with increased glutamate, whereas the antio... Read More about Glutathione and glutamate in schizophrenia: a 7T MRS study.

Relationships Between Neuronal Oscillatory Amplitude and Dynamic Functional Connectivity (2018)
Journal Article
Tewarie, P., Hunt, B. A. E., O'Neill, G. C., Byrne, A., Aquino, K., Bauer, M., …Brookes, M. J. (2019). Relationships Between Neuronal Oscillatory Amplitude and Dynamic Functional Connectivity. Cerebral Cortex, 29(6), 2668-2681. https://doi.org/10.1093/cercor/bhy136

Event related fluctuations of neural oscillatory amplitude are reported widely in the context of cognitive processing and are typically interpreted as a marker of brain ‘activity’. However, the precise nature of these effects remains unclear; in part... Read More about Relationships Between Neuronal Oscillatory Amplitude and Dynamic Functional Connectivity.

Moving magnetoencephalography towards real-world applications with a wearable system (2018)
Journal Article
Boto, E., Holmes, N., Leggett, J., Roberts, G., Shah, V., Meyer, S. S., …Brookes, M. J. (2018). Moving magnetoencephalography towards real-world applications with a wearable system. Nature, 555, 657-661. https://doi.org/10.1038/nature26147

Imaging human brain function with techniques such as magnetoencephalography1 (MEG) typically requires a subject to perform tasks whilst their head remains still within a restrictive scanner. This artificial environment makes the technique inaccessibl... Read More about Moving magnetoencephalography towards real-world applications with a wearable system.

Altered temporal stability in dynamic neural networks underlies connectivity changes in neurodevelopment (2018)
Journal Article
Brookes, M. J., Groom, M. J., Liuzzi, L., Hill, R. M., Smith, H. J., Briley, P. M., Hall, E. L., Hunt, B. A., Gascoyne, L. E., Taylor, M. J., Liddle, P. F., Morris, P. G., Woolrich, M. W., & Liddle, E. B. (2018). Altered temporal stability in dynamic neural networks underlies connectivity changes in neurodevelopment. NeuroImage, 174, https://doi.org/10.1016/j.neuroimage.2018.03.008

Network connectivity is an integral feature of human brain function, and characterising its maturational trajectory is a critical step towards understanding healthy and atypical neurodevelopment. Here, we used magnetoencephalography (MEG) to investig... Read More about Altered temporal stability in dynamic neural networks underlies connectivity changes in neurodevelopment.

A biophysical model of dynamic balancing of excitation and inhibition in fast oscillatory large-scale networks (2018)
Journal Article
Abeysuriya, R. G., Hadida, J., Sotiropoulos, S. N., Jbabdi, S., Becker, R., Hunt, B. A., Brookes, M. J., & Woolrich, M. W. (in press). A biophysical model of dynamic balancing of excitation and inhibition in fast oscillatory large-scale networks. PLoS Computational Biology, 14(2), Article e1006007. https://doi.org/10.1371/journal.pcbi.1006007

Over long timescales, neuronal dynamics can be robust to quite large perturbations, such as changes in white matter connectivity and grey matter structure through processes including learning, aging, development and certain disease processes. One pos... Read More about A biophysical model of dynamic balancing of excitation and inhibition in fast oscillatory large-scale networks.

Comparing multilayer brain networks between groups: Introducing graph metrics and recommendations (2017)
Journal Article
Mandke, K., Meier, J., Brookes, M. J., O'Dea, R. D., Van Mieghem, P., Stam, C. J., …Tewarie, P. K. (2018). Comparing multilayer brain networks between groups: Introducing graph metrics and recommendations. NeuroImage, 166, https://doi.org/10.1016/j.neuroimage.2017.11.016

There is an increasing awareness of the advantages of multi-modal neuroimaging. Networks obtained from different modalities are usually treated in isolation, which is however contradictory to accumulating evidence that these networks show non-trivial... Read More about Comparing multilayer brain networks between groups: Introducing graph metrics and recommendations.

Dynamics of large-scale electrophysiological networks: a technical review (2017)
Journal Article
O'Neill, G. C., Tewarie, P. K., Vidaurre, D., Liuzzi, L., Woolrich, M. W., & Brookes, M. J. (2017). Dynamics of large-scale electrophysiological networks: a technical review. NeuroImage, https://doi.org/10.1016/j.neuroimage.2017.10.003

For several years it has been argued that neural synchronisation is crucial for cognition. The idea that synchronised temporal patterns between different neural groups carries information above and beyond the isolated activity of these groups has ins... Read More about Dynamics of large-scale electrophysiological networks: a technical review.

A mean field model for movement induced changes in the beta rhythm (2017)
Journal Article
Byrne, Á., Brookes, M. J., & Coombes, S. (2017). A mean field model for movement induced changes in the beta rhythm. Journal of Computational Neuroscience, 43(2), https://doi.org/10.1007/s10827-017-0655-7

In electrophysiological recordings of the brain, the transition from high amplitude to low amplitude signals are most likely caused by a change in the synchrony of underlying neuronal population firing patterns. Classic examples of such modulations... Read More about A mean field model for movement induced changes in the beta rhythm.

An intra-neural microstimulation system for ultra-high field magnetic resonance imaging and magnetoencephalography (2017)
Journal Article
Glover, P. M., Watkins, R. H., O’Neill, G. C., Ackerley, R. M., Sánchez-Panchuelo, R.-M., McGlone, F., Brookes, M. J., Wessberg, J., & Francis, S. T. (2017). An intra-neural microstimulation system for ultra-high field magnetic resonance imaging and magnetoencephalography. Journal of Neuroscience Methods, 290, 69-78. https://doi.org/10.1016/j.jneumeth.2017.07.016

Background

Intra-neural microstimulation (INMS) is a technique that allows the precise delivery of low-current electrical pulses into human peripheral nerves. Single unit INMS can be used to stimulate individual afferent nerve fibres during micron... Read More about An intra-neural microstimulation system for ultra-high field magnetic resonance imaging and magnetoencephalography.

Abnormal task driven neural oscillations in multiple sclerosis: a visuomotor MEG study (2017)
Journal Article
Barratt, E. L., Tewarie, P. K., Clarke, M. A., Hall, E. L., Gowland, P. A., Morris, P. G., …Brookes, M. J. (2017). Abnormal task driven neural oscillations in multiple sclerosis: a visuomotor MEG study. Human Brain Mapping, 38(5), 2441-2453. https://doi.org/10.1002/hbm.23531

Multiple sclerosis (MS) is a debilitating disease commonly attributed to degradation of white matter myelin. Symptoms include fatigue, as well as problems associated with vision and movement. Although areas of demyelination in white matter are observ... Read More about Abnormal task driven neural oscillations in multiple sclerosis: a visuomotor MEG study.

The effect of physical fatigue on oscillatory dynamics of the sensorimotor cortex (2017)
Journal Article
Fry, A., Mullinger, K. J., O'Neill, G. C., Brookes, M. J., & Folland, J. P. (2018). The effect of physical fatigue on oscillatory dynamics of the sensorimotor cortex. Acta Physiologica, 220(3), 370-381. https://doi.org/10.1111/apha.12843

Aim: While physical fatigue is known to arise in part from supraspinal mechanisms within the brain exactly how brain activity is modulated during fatigue is not well understood. Therefore, this study examined how typical neural oscillatory responses... Read More about The effect of physical fatigue on oscillatory dynamics of the sensorimotor cortex.

A new generation of magnetoencephalography: Room temperature measurements using optically-pumped magnetometers (2017)
Journal Article
Boto, E., Meyer, S. S., Shah, V., Alem, O., Knappe, S., Kruger, P., …Brookes, M. J. (2017). A new generation of magnetoencephalography: Room temperature measurements using optically-pumped magnetometers. NeuroImage, 149, 404-414. https://doi.org/10.1016/j.neuroimage.2017.01.034

© 2017 The Authors Advances in the field of quantum sensing mean that magnetic field sensors, operating at room temperature, are now able to achieve sensitivity similar to that of cryogenically cooled devices (SQUIDs). This means that room temperatur... Read More about A new generation of magnetoencephalography: Room temperature measurements using optically-pumped magnetometers.

Optimising experimental design for MEG resting state functional connectivity measurement (2016)
Journal Article
Liuzzi, L., Gascoyne, L. E., Tewarie, P. K., Barratt, E. L., Boto, E., & Brookes, M. J. (2017). Optimising experimental design for MEG resting state functional connectivity measurement. NeuroImage, 155, 565-576. https://doi.org/10.1016/j.neuroimage.2016.11.064

The study of functional connectivity using magnetoencephalography (MEG) is an expanding area of neuroimaging, and adds an extra dimension to the more common assessments made using fMRI. The importance of such metrics is growing, with recent demonstra... Read More about Optimising experimental design for MEG resting state functional connectivity measurement.

Relationships between cortical myeloarchitecture and electrophysiological networks (2016)
Journal Article
Hunt, B. A. E., Tewarie, P. K., Mougin, O. E., Geades, N., Jones, D. K., Singh, K. D., …Brookes, M. J. (2016). Relationships between cortical myeloarchitecture and electrophysiological networks. Proceedings of the National Academy of Sciences, 113(47), 13510-13515. https://doi.org/10.1073/pnas.1608587113

The human brain relies upon the dynamic formation and dissolution of a hierarchy of functional networks to support ongoing cognition. However, how functional connectivities underlying such networks are supported by cortical microstructure remains poo... Read More about Relationships between cortical myeloarchitecture and electrophysiological networks.

Measurement of dynamic task related functional networks using MEG (2016)
Journal Article
O’Neill, G. C., Tewarie, P. K., Colclough, G. L., Gascoyne, L. E., Hunt, B. A., Morris, P. G., …Brookes, M. J. (2017). Measurement of dynamic task related functional networks using MEG. NeuroImage, 146, 667-678. https://doi.org/10.1016/j.neuroimage.2016.08.061

The characterisation of dynamic electrophysiological brain networks, which form and dissolve in order to support ongoing cognitive function, is one of the most important goals in neuroscience. Here, we introduce a method for measuring such networks i... Read More about Measurement of dynamic task related functional networks using MEG.

On the potential of a new generation of magnetometers for MEG: A beamformer simulation study (2016)
Journal Article
Boto, E., Bowtell, R. W., Kruger, P., Fromhold, T. M., Morris, P. G., Meyer, S. S., …Brookes, M. J. (2016). On the potential of a new generation of magnetometers for MEG: A beamformer simulation study. PLoS ONE, 11(8), Article e0157655. https://doi.org/10.1371/journal.pone.0157655

Magnetoencephalography (MEG) is a sophisticated tool which yields rich information on the spatial, spectral and temporal signatures of human brain function. Despite unique potential, MEG is limited by a low signal-to-noise ratio (SNR) which is caused... Read More about On the potential of a new generation of magnetometers for MEG: A beamformer simulation study.

Integrating cross-frequency and within band functional networks in resting-state MEG: A multi-layer network approach (2016)
Journal Article
Van Mieghem, P., Tewarie, P., Hillebrand, A., van Dijk, B. W., Stam, C. J., O'Neill, G. C., …Brookes, M. J. (2016). Integrating cross-frequency and within band functional networks in resting-state MEG: A multi-layer network approach. NeuroImage, 142, 324-336. https://doi.org/10.1016/j.neuroimage.2016.07.057

Neuronal oscillations exist across a broad frequency spectrum, and are thought to provide a mechanism of interaction between spatially separated brain regions. Since ongoing mental activity necessitates the simultaneous formation of multiple networks... Read More about Integrating cross-frequency and within band functional networks in resting-state MEG: A multi-layer network approach.

The UK National Quantum Technologies Hub in sensors and metrology (Keynote Paper) (2016)
Presentation / Conference Contribution
Bongs, K., Boyer, V., Cruise, M., Freise, A., Holynski, M., Hughes, J., Kaushik, A., Lien, Y.-H., Niggebaum, A., Perea-Ortiz, M., Petrov, P., Plant, S., Singh, Y., Stabrawa, A., Paul, D., Sorel, M., Cumming, D., Marsh, J., Bowtell, R. W., Bason, M., …John, P. (2016, April). The UK National Quantum Technologies Hub in sensors and metrology (Keynote Paper). Presented at SPIE Photonics Europe, 2016, Brussels, Belgium

The UK National Quantum Technology Hub in Sensors and Metrology is one of four flagship initiatives in the UK National of Quantum Technology Program. As part of a 20-year vision it translates laboratory demonstrations to deployable practical devices,... Read More about The UK National Quantum Technologies Hub in sensors and metrology (Keynote Paper).

How reliable are MEG resting-state connectivity metrics? (2016)
Journal Article
Colclough, G., Woolrich, M., Tewarie, P., Brookes, M., Quinn, A., & Smith, S. (2016). How reliable are MEG resting-state connectivity metrics?. NeuroImage, 138, 284-293. https://doi.org/10.1016/j.neuroimage.2016.05.070

MEG offers dynamic and spectral resolution for resting-state connectivity which is unavailable in fMRI. However, there are a wide range of available network estimation methods for MEG, and little in the way of existing guidance on which ones to emplo... Read More about How reliable are MEG resting-state connectivity metrics?.

Modulation of post-movement beta rebound by contraction force and rate of force development (2016)
Journal Article
Fry, A., Mullinger, K. J., O'Neill, G. C., Barratt, E. L., Morris, P. G., Bauer, M., …Brookes, M. J. (2016). Modulation of post-movement beta rebound by contraction force and rate of force development. Human Brain Mapping, 37(7), https://doi.org/10.1002/hbm.23189

Movement induced modulation of the beta rhythm is one of the most robust neural oscillatory phenomena in the brain. In the preparation and execution phases of movement, a loss in beta amplitude is observed (movement related beta decrease (MRBD)). Thi... Read More about Modulation of post-movement beta rebound by contraction force and rate of force development.

A multi-layer network approach to MEG connectivity analysis (2016)
Journal Article
Brookes, M. J., Tewarie, P. K., Hunt, B. A. E., Robson, S. E., Gascoyne, L. E., Liddle, E. B., …Morris, P. G. (2016). A multi-layer network approach to MEG connectivity analysis. NeuroImage, 132, 425-438. https://doi.org/10.1016/j.neuroimage.2016.02.045

© 2016 The Authors. Recent years have shown the critical importance of inter-regional neural network connectivity in supporting healthy brain function. Such connectivity is measurable using neuroimaging techniques such as MEG, however the richness of... Read More about A multi-layer network approach to MEG connectivity analysis.

Abnormal salience signaling in schizophrenia: The role of integrative beta oscillations: Salience Signaling in Schizophrenia (2016)
Journal Article
Liddle, E. B., Price, D., Palaniyappan, L., Brookes, M. J., Robson, S. E., Hall, E. L., …Liddle, P. F. (2016). Abnormal salience signaling in schizophrenia: The role of integrative beta oscillations: Salience Signaling in Schizophrenia. Human Brain Mapping, 37(4), 1361-1374. https://doi.org/10.1002/hbm.23107

Aberrant salience attribution and cerebral dysconnectivity both have strong evidential support as core dysfunctions in schizophrenia. Aberrant salience arising from an excess of dopamine activity has been implicated in delusions and hallucinations, e... Read More about Abnormal salience signaling in schizophrenia: The role of integrative beta oscillations: Salience Signaling in Schizophrenia.

Measuring electrophysiological connectivity by power envelope correlation: a technical review on MEG methods (2015)
Journal Article
O'Neill, G. C., Barratt, E. L., Hunt, B. A. E., Tewarie, P. K., & Brookes, M. J. (2015). Measuring electrophysiological connectivity by power envelope correlation: a technical review on MEG methods. Physics in Medicine and Biology, 60(21), Article R271-R295. https://doi.org/10.1088/0031-9155/60/21/R271

The human brain can be divided into multiple areas, each responsible for different aspects of behaviour. Healthy brain function relies upon efficient connectivity between these areas and, in recent years, neuroimaging has been revolutionised by an ab... Read More about Measuring electrophysiological connectivity by power envelope correlation: a technical review on MEG methods.

Abnormal visuomotor processing in schizophrenia (2015)
Journal Article
Robson, S. E., Brookes, M. J., Hall, E. L., Palaniyappan, L., Kumar, J., Skelton, M., …Morris, P. G. (2016). Abnormal visuomotor processing in schizophrenia. NeuroImage: Clinical, 12, 869-878. https://doi.org/10.1016/j.nicl.2015.08.005

Subtle disturbances of visual and motor function are known features of schizophrenia and can greatly impact quality of life; however, few studies investigate these abnormalities using simple visuomotor stimuli. In healthy people, electrophysiological... Read More about Abnormal visuomotor processing in schizophrenia.

Dynamic recruitment of resting state sub-networks (2015)
Journal Article
O'Neill, G. C., Bauer, M., Woolrich, M. W., Morris, P. G., Barnes, G. R., & Brookes, M. J. (2015). Dynamic recruitment of resting state sub-networks. NeuroImage, 115, https://doi.org/10.1016/j.neuroimage.2015.04.030

Resting state networks (RSNs) are of fundamental importance in human systems neuroscience with evidence suggesting that they are integral to healthy brain function and perturbed in pathology. Despite rapid progress in this area, the temporal dynamics... Read More about Dynamic recruitment of resting state sub-networks.

The effect of isocapnic hyperoxia on neurophysiology as measured with MRI and MEG (2015)
Journal Article
Croal, P. L., Hall, E. L., Driver, I. D., Brookes, M. J., Gowland, P. A., & Francis, S. T. (2015). The effect of isocapnic hyperoxia on neurophysiology as measured with MRI and MEG. NeuroImage, 105, https://doi.org/10.1016/j.neuroimage.2014.10.036

The physiological effect of hyperoxia has been poorly characterised, with studies reporting conflicting results on the role of hyperoxia as a vasoconstrictor. It is not clear whether hyperoxia is the primary contributor to vasoconstriction or whether... Read More about The effect of isocapnic hyperoxia on neurophysiology as measured with MRI and MEG.

Fast transient networks in spontaneous human brain activity (2014)
Journal Article
Baker, A. P., Brookes, M. J., Rezek, I. A., Smith, S. M., Behrens, T., Probert Smith, P. J., & Woolrich, M. W. (2014). Fast transient networks in spontaneous human brain activity. eLife, 3, Article e01867. https://doi.org/10.7554/eLife.01867

To provide an effective substrate for cognitive processes, functional brain networks should be able to reorganize and coordinate on a sub-second temporal scale. We used magnetoencephalography recordings of spontaneous activity to characterize whole-b... Read More about Fast transient networks in spontaneous human brain activity.

Measuring temporal, spectral and spatial changes in electrophysiological brain network connectivity (2014)
Journal Article
Brookes, M. J., O'Neill, G. C., Hall, E. L., Woolrich, M. W., Baker, A., Palazzo Corner, S., …Barnes, G. R. (2014). Measuring temporal, spectral and spatial changes in electrophysiological brain network connectivity. NeuroImage, 91, 282-299. https://doi.org/10.1016/j.neuroimage.2013.12.066

The topic of functional connectivity in neuroimaging is expanding rapidly and many studies now focus on coupling between spatially separate brain regions. These studies show that a relatively small number of large scale networks exist within the brai... Read More about Measuring temporal, spectral and spatial changes in electrophysiological brain network connectivity.

The relationship between MEG and fMRI (2013)
Journal Article
Hall, E. L., Robson, S., Morris, P., & Brookes, M. J. (2014). The relationship between MEG and fMRI. NeuroImage, 102(1), https://doi.org/10.1016/j.neuroimage.2013.11.005

In recent years functional neuroimaging techniques such as fMRI, MEG, EEG and PET have provided researchers with a wealth of information on human brain function. However none of these modalities can measure directly either the neuro-electrical or ne... Read More about The relationship between MEG and fMRI.