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Tri-axial rubidium and helium optically pumped magnetometers for on-scalp magnetoencephalography recording of interictal epileptiform discharges: a case study

Feys, Odile; Corvilain, Pierre; Labyt, Etienne; Mahmoudzadeh, Mahdi; Routier, Laura; Sculier, Claudine; Holmes, Niall; Brookes, Matthew; Goldman, Serge; Romain, Rudy; Mitryukovskiy, Sergey; Palacios-Laloy, Agustin; Schwartz, Denis; Betrouni, Nacim; Derambure, Philippe; Wallois, Fabrice; Wens, Vincent; De Tiège, Xavier

Tri-axial rubidium and helium optically pumped magnetometers for on-scalp magnetoencephalography recording of interictal epileptiform discharges: a case study Thumbnail


Authors

Odile Feys

Pierre Corvilain

Etienne Labyt

Mahdi Mahmoudzadeh

Laura Routier

Claudine Sculier

Serge Goldman

Rudy Romain

Sergey Mitryukovskiy

Agustin Palacios-Laloy

Denis Schwartz

Nacim Betrouni

Philippe Derambure

Fabrice Wallois

Vincent Wens

Xavier De Tiège



Abstract

Cryogenic magnetoencephalography (MEG) enhances the presurgical assessment of refractory focal epilepsy (RFE). Optically pumped magnetometers (OPMs) are cryogen-free sensors that enable on-scalp MEG recordings. Here, we investigate the application of tri-axial OPMs [87Rb (Rb-OPM) and 4He gas (He-OPM)] for the detection of interictal epileptiform discharges (IEDs). IEDs were recorded simultaneously with 4 tri-axial Rb- and 4 tri-axial He-OPMs in a child with RFE. IEDs were identified visually, isolated from magnetic background noise using independent component analysis (ICA) and were studied following their optimal magnetic field orientation thanks to virtual sensors. Most IEDs (>1,000) were detectable by both He- and Rb-OPM recordings. IEDs were isolated by ICA and the resulting magnetic field oriented mostly tangential to the scalp in Rb-OPMs and radial in He-OPMs. Likely due to differences in sensor locations, the IED amplitude was higher with Rb-OPMs. This case study shows comparable ability of Rb-OPMs and He-OPMs to detect IEDs and the substantial benefits of triaxial OPMs to detect IEDs from different sensor locations. Tri-axial OPMs allow to maximize spatial brain sampling for IEDs detection with a limited number of sensors.

Citation

Feys, O., Corvilain, P., Labyt, E., Mahmoudzadeh, M., Routier, L., Sculier, C., Holmes, N., Brookes, M., Goldman, S., Romain, R., Mitryukovskiy, S., Palacios-Laloy, A., Schwartz, D., Betrouni, N., Derambure, P., Wallois, F., Wens, V., & De Tiège, X. (2023). Tri-axial rubidium and helium optically pumped magnetometers for on-scalp magnetoencephalography recording of interictal epileptiform discharges: a case study. Frontiers in Neuroscience, 17, Article 1284262. https://doi.org/10.3389/fnins.2023.1284262

Journal Article Type Article
Acceptance Date Oct 26, 2023
Online Publication Date Nov 27, 2023
Publication Date Nov 27, 2023
Deposit Date Jan 15, 2024
Publicly Available Date Jan 15, 2024
Journal Frontiers in Neuroscience
Print ISSN 1662-4548
Electronic ISSN 1662-453X
Publisher Frontiers Media
Peer Reviewed Peer Reviewed
Volume 17
Article Number 1284262
DOI https://doi.org/10.3389/fnins.2023.1284262
Keywords refractory epilepsy, optically pumped magnetometers, magnetoencephalography, on-scalp magnetoencephalography, focal epilepsy
Public URL https://nottingham-repository.worktribe.com/output/28702240
Publisher URL https://www.frontiersin.org/articles/10.3389/fnins.2023.1284262/full

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