Professor CAROL COUPLAND's Outputs (26)

Hormone replacement therapy in women with cancer and risk of cancer-specific mortality and cardiovascular disease: A protocol for a cohort study from Scotland and Wales (2021)
Journal Article
McMenamin, Ú., Hicks, B., Hughes, C., Murchie, P., Hippisley-Cox, J., Ranger, T., Coupland, C., & Cardwell, C. (in press). Hormone replacement therapy in women with cancer and risk of cancer-specific mortality and cardiovascular disease: A protocol for a cohort study from Scotland and Wales. BMC Cancer, 21, Article 313. https://doi.org/10.1186/s12885-021-08065-3

Background: Hormone replacement therapy (HRT) is widely used and has proven benefits for women with menopausal symptoms. An increasing number of women with cancer experience menopausal symptoms but the safety of HRT use in women with cancer is uncl... Read More about Hormone replacement therapy in women with cancer and risk of cancer-specific mortality and cardiovascular disease: A protocol for a cohort study from Scotland and Wales.

Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting (2021)
Journal Article
Swain, S., Coupland, C., Mallen, C., Kuo, C. F., Sarmanova, A., Bierma-Zeinstra, S. M., Englund, M., Prieto-Alhambra, D., Doherty, M., & Zhang, W. (2021). Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting. Rheumatology, 60(9), 4327-4339. https://doi.org/10.1093/rheumatology/keab067

OBJECTIVE: To determine the burden of comorbidities in OA and their temporal relationships in the UK.

METHODS: The Clinical Practice Research Datalink (CPRD) GOLD was used to identify people with incident OA and age, gender and practice matched n... Read More about Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting.

Hormone replacement therapy and dementia risk: nested case-control studies using CPRD and QResearch (2021)
Journal Article
Vinogradova, Y., Dening, T., Hippisley-Cox, J., Taylor, L., Moore, M., & Coupland, C. (2021). Hormone replacement therapy and dementia risk: nested case-control studies using CPRD and QResearch. East Midlands Research into Ageing Network (EMRAN) Discussion Paper Series, 38, 1-16

Introduction: Research from clinical trials of hormone replacement therapy (HRT) has produced conflicting findings about possible risks of dementia after receiving these treatments, and further research on HRT and dementia risk has been identified as... Read More about Hormone replacement therapy and dementia risk: nested case-control studies using CPRD and QResearch.

PROTOCOL: A cohort study examining the association between mirtazapine and mortality risk in adults with a diagnosis of depression (2021)
Preprint / Working Paper
Joseph, R. M., Jack, R. H., Morriss, R., Knaggs, R. D., Hollis, C., Hippisley-Cox, J., & Coupland, C. PROTOCOL: A cohort study examining the association between mirtazapine and mortality risk in adults with a diagnosis of depression

This protocol describes a cohort study comparing the risks of mortality and serious self-harm (suicide or near-fatal deliberate self-harm) between adults with depression prescribed mirtazapine, a selective serotonin reuptake inhibitor (SSRI), amitrip... Read More about PROTOCOL: A cohort study examining the association between mirtazapine and mortality risk in adults with a diagnosis of depression.

‘Real world’ effectiveness of the Falls Management Exercise (FaME) programme: an implementation study (2021)
Journal Article
Orton, E., Audsley, S., Coupland, C., Gladman, J. R., Iliffe, S., Lafond, N., Logan, P., Masud, T., Skelton, D. A., Timblin, C., Timmons, S., Ward, D., & Kendrick, D. (2021). ‘Real world’ effectiveness of the Falls Management Exercise (FaME) programme: an implementation study. Age and Ageing, 50(4), 1290-1297. https://doi.org/10.1093/ageing/afaa288

Background
Falls incidence increases with age alongside declines in strength and balance. Clinical trials show that the Falls Management Exercise (FaME) programme improves strength and balance, which can reduce falls and improve physical functioning... Read More about ‘Real world’ effectiveness of the Falls Management Exercise (FaME) programme: an implementation study.

Prostate-specific antigen testing and opportunistic prostate cancer screening: a cohort study in England, 1998–2017 (2021)
Journal Article
Clift, A. K., Coupland, C. A., & Hippisley-Cox, J. (2021). Prostate-specific antigen testing and opportunistic prostate cancer screening: a cohort study in England, 1998–2017. British Journal of General Practice, 71(703), e157-e165. https://doi.org/10.3399/bjgp20X713957

Background: Prostate cancer is a leading cause of cancer-related death. Interpretation of results from trials of screening with prostate-specific antigen (PSA) are complex in terms of defining optimal prostate cancer screening policy.

Aims: Assess... Read More about Prostate-specific antigen testing and opportunistic prostate cancer screening: a cohort study in England, 1998–2017.