Professor CAROL COUPLAND's Outputs (26)

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV-2 infection (2021)
Journal Article
Patone, M., Mei, X. W., Handunnetthi, L., Dixon, S., Zaccardi, F., Shankar-Hari, M., Watkinson, P., Khunti, K., Harnden, A., Coupland, C. A., Channon, K. M., Mills, N. L., Sheikh, A., & Hippisley-Cox, J. (2022). Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV-2 infection. Nature Medicine, 28(2), 410-422. https://doi.org/10.1038/s41591-021-01630-0

Although myocarditis and pericarditis were not observed as adverse events in coronavirus disease 2019 (COVID-19) vaccine trials, there have been numerous reports of suspected cases following vaccination in the general population. We undertook a self-... Read More about Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV-2 infection.

Neurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infection (2021)
Journal Article
Patone, M., Handunnetthi, L., Saatci, D., Pan, J., Katikireddi, S. V., Razvi, S., Hunt, D., Mei, X. W., Dixon, S., Zaccardi, F., Khunti, K., Watkinson, P., Coupland, C. A. C., Doidge, J., Harrison, D. A., Ravanan, R., Sheikh, A., Robertson, C., & Hippisley-Cox, J. (2021). Neurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infection. Nature Medicine, 27(12), 2144-2153. https://doi.org/10.1038/s41591-021-01556-7

Emerging reports of rare neurological complications associated with COVID-19 infection and vaccinations are leading to regulatory, clinical and public health concerns. We undertook a self-controlled case series study to investigate hospital admission... Read More about Neurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infection.

Use of menopausal hormone therapy and risk of dementia: Nested case-control studies using QResearch and CPRD databases (2021)
Journal Article
Vinogradova, Y., Dening, T., Hippisley-Cox, J., Taylor, L., Moore, M., & Coupland, C. (2021). Use of menopausal hormone therapy and risk of dementia: Nested case-control studies using QResearch and CPRD databases. British Medical Journal, 374, Article n2182. https://doi.org/10.1136/bmj.n2182

Objective To assess the risks of developing dementia associated with different types and durations of menopausal hormone therapy. Design Two nested case-control studies. Setting UK general practices contributing to QResearch or the Clinical Practice... Read More about Use of menopausal hormone therapy and risk of dementia: Nested case-control studies using QResearch and CPRD databases.

Identifying symptoms associated with diagnosis of pancreatic exocrine and neuroendocrine neoplasms: A nested case-control study of the UK primary care population (2021)
Journal Article
Liao, W., Clift, A. K., Patone, M., Coupland, C., González-Izquierdo, A., Pereira, S., & Cox, J. H. (2021). Identifying symptoms associated with diagnosis of pancreatic exocrine and neuroendocrine neoplasms: A nested case-control study of the UK primary care population. British Journal of General Practice, 71(712), e836-e845. https://doi.org/10.3399/bjgp.2021.0153

Background: Pancreatic cancer has the worst survival rate among all cancers. Almost 70% of patients were diagnosed at Stage IV.

Aim: This study aimed to investigate the symptoms associated with the diagnoses of pancreatic ductal adenocarcinoma (P... Read More about Identifying symptoms associated with diagnosis of pancreatic exocrine and neuroendocrine neoplasms: A nested case-control study of the UK primary care population.

Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: National prospective cohort study (2021)
Journal Article
Hippisley-Cox, J., Coupland, C. A., Mehta, N., Keogh, R. H., Diaz-Ordaz, K., Khunti, K., Lyons, R. A., Kee, F., Sheikh, A., Rahman, S., Valabhji, J., Harrison, E. M., Sellen, P., Haq, N., Semple, M. G., Johnson, P. W. M., Hayward, A., & Nguyen-Van-Tam, J. S. (2021). Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: National prospective cohort study. BMJ, 374, Article n2244. https://doi.org/10.1136/bmj.n2244

Objectives To derive and validate risk prediction algorithms to estimate the risk of covid-19 related mortality and hospital admission in UK adults after one or two doses of covid-19 vaccination. Design Prospective, population based cohort study usin... Read More about Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: National prospective cohort study.

Mental health and other factors associated with work productivity after injury in the UK: multicentre cohort study (2021)
Journal Article
Kellezi, B., Dhiman, P., Coupland, C., Whitehead, J., Morriss, R., Joseph, S., Beckett, K., Sleney, J., Barnes, J., & Kendrick, D. (2022). Mental health and other factors associated with work productivity after injury in the UK: multicentre cohort study. Injury Prevention, 28(2), 131-140. https://doi.org/10.1136/injuryprev-2021-044311

Introduction: Mental health conditions are a major contributor to productivity loss and are common post-injury. This study quantifies post-injury productivity loss and its association with pre and post-injury mental health, injury, demographic, healt... Read More about Mental health and other factors associated with work productivity after injury in the UK: multicentre cohort study.

Risk of thrombocytopenia and thromboembolism after covid-19 vaccination and SARS-CoV-2 positive testing: self-controlled case series study (2021)
Journal Article
Hippisley-Cox, J., Patone, M., Mei, X. W., Saatci, D., Dixon, S., Khunti, K., Zaccardi, F., Watkinson, P., Shankar-Hari, M., Doidge, J., Harrison, D. A., Griffin, S. J., Sheikh, A., & Coupland, C. A. C. (2021). Risk of thrombocytopenia and thromboembolism after covid-19 vaccination and SARS-CoV-2 positive testing: self-controlled case series study. BMJ, 374, Article n1931. https://doi.org/10.1136/bmj.n1931

Objective: To assess the association between covid-19 vaccines and risk of thrombocytopenia and thromboembolic events in England among adults.

Design: Self-controlled case series study using national data on covid-19 vaccination and hospital adm... Read More about Risk of thrombocytopenia and thromboembolism after covid-19 vaccination and SARS-CoV-2 positive testing: self-controlled case series study.

Hormone replacement therapy and cancer survival: a longitudinal cohort study: protocol paper (2021)
Journal Article
Ranger, T. A., Burchardt, J., Clift, A. K., Mei, W. X., Coupland, C., Tan, P. S., Dixon, S., Cardwell, C. R., & Hippisley-Cox, J. (2021). Hormone replacement therapy and cancer survival: a longitudinal cohort study: protocol paper. BMJ Open, 11(8), Article e046701. https://doi.org/10.1136/bmjopen-2020-046701

Introduction Hormone replacement therapy (HRT) can help women experiencing menopausal symptoms, but usage has declined due to uncertainty around risks of cancer and some cardiovascular diseases (CVD). Moreover, improved cancer survival rates mean tha... Read More about Hormone replacement therapy and cancer survival: a longitudinal cohort study: protocol paper.

Prospective examination of mental health in university students during the COVID-19 pandemic (2021)
Preprint / Working Paper
Jia, R., Knight, H., Ayling, K., Coupland, C., Corner, J., Denning, C., Ball, J., Bolton, K., Morling, J. R., Figueredo, G., Morris, D. E., Tighe, P., Villalon, A., Blake, H., & Vedhara, K. Prospective examination of mental health in university students during the COVID-19 pandemic

Background The impact of changing social restrictions on the mental health of students during the COVID-19 pandemic warrants exploration.

Aims To prospectively examine changes to university students’ mental health during the pandemic.

Methods S... Read More about Prospective examination of mental health in university students during the COVID-19 pandemic.

Sickle Cell Disorders and Severe COVID-19 Outcomes: A Cohort Study (2021)
Journal Article
Clift, A. K., Saatci, D., Coupland, C. A., Dambha-Miller, H., Hippisley-Cox, J., & International Investigator Group for Ethnicity and COVID-19. (2021). Sickle Cell Disorders and Severe COVID-19 Outcomes: A Cohort Study. Annals of Internal Medicine, 174(10), 1483-1487. https://doi.org/10.7326/M21-1375

Background: Sickle cell disease is a collection of compound heterozygote hemoglobinopathies, including sickle cell anemia (1). The heterozygote hemoglobinopathies are characterized by erythrocyte deformation with hemolysis; immune and coagulation dys... Read More about Sickle Cell Disorders and Severe COVID-19 Outcomes: A Cohort Study.

Implementation fidelity of the Falls Management Exercise Programme: a mixed methods analysis using a conceptual framework for implementation fidelity (2021)
Journal Article
Orton, E., Lafond, N., Skelton, D. A., Coupland, C., Gladman, J. R., Iliffe, S., Logan, P. A., Masud, T., Timblin, C., Timmons, S., & Kendrick, D. (2021). Implementation fidelity of the Falls Management Exercise Programme: a mixed methods analysis using a conceptual framework for implementation fidelity. Public Health, 197, 11-18. https://doi.org/10.1016/j.puhe.2021.05.038

Objectives: Falls in older adults cause significant morbidity and mortality and incur cost to health and care services. The Falls Management Exercise (FaME) programme is a 24-week intervention for older adults that, in clinical trials, improves balan... Read More about Implementation fidelity of the Falls Management Exercise Programme: a mixed methods analysis using a conceptual framework for implementation fidelity.

An external validation of the QCovid risk prediction algorithm for risk of mortality from COVID-19 in adults: a national validation cohort study in England (2021)
Journal Article
Nafilyan, V., Humberstone, B., Mehta, N., Diamond, I., Coupland, C., Lorenzi, L., Pawelek, P., Schofield, R., Morgan, J., Brown, P., Lyons, R., Sheikh, A., & Hippisley-Cox, J. (2021). An external validation of the QCovid risk prediction algorithm for risk of mortality from COVID-19 in adults: a national validation cohort study in England. The Lancet. Digital Health, 3(7), E425-E433. https://doi.org/10.1016/S2589-7500%2821%2900080-7

Background: Public policy measures and clinical risk assessments relevant to COVID-19 need to be aided by risk prediction models that are rigorously developed and validated. We aimed to externally validate a risk prediction algorithm (QCovid) to esti... Read More about An external validation of the QCovid risk prediction algorithm for risk of mortality from COVID-19 in adults: a national validation cohort study in England.

Mortality and critical care unit admission associated with the SARS-CoV-2 lineage B.1.1.7 in England: an observational cohort study (2021)
Journal Article
Patone, M., Thomas, K., Hatch, R., Tan, P. S., Coupland, C., Liao, W., Mouncey, P., Harrison, D., Rowan, K., Horby, P., Watkinson, P., & Hippisley-Cox, J. (2021). Mortality and critical care unit admission associated with the SARS-CoV-2 lineage B.1.1.7 in England: an observational cohort study. Lancet Infectious Diseases, 21(11), 1518-1528. https://doi.org/10.1016/s1473-3099%2821%2900318-2

Background: A more transmissible variant of SARS-CoV-2, the variant of concern 202012/01 or lineage B.1.1.7, has emerged in the UK. We aimed to estimate the risk of critical care admission, mortality in patients who are critically ill, and overall mo... Read More about Mortality and critical care unit admission associated with the SARS-CoV-2 lineage B.1.1.7 in England: an observational cohort study.

Impact of the national home safety equipment scheme ‘Safe At Home’ on hospital admissions for unintentional injury in children under 5: controlled interrupted time series analysis (2021)
Journal Article
Hill, T., Coupland, C., Kendrick, D., Jones, M., Akbari, A., Rodgers, S., Watson, M. C., Tyrrell, E., Merrill, S., & Orton, E. (2022). Impact of the national home safety equipment scheme ‘Safe At Home’ on hospital admissions for unintentional injury in children under 5: controlled interrupted time series analysis. Journal of Epidemiology and Community Health, 76(1), 53-59. https://doi.org/10.1136/jech-2021-216613

Background: Unintentional home injuries are a leading cause of preventable death in young children. Safety education and equipment provision improve home safety practices, but their impact on injuries is less clear. Between 2009 and 2011 a national h... Read More about Impact of the national home safety equipment scheme ‘Safe At Home’ on hospital admissions for unintentional injury in children under 5: controlled interrupted time series analysis.

Association Between Race and COVID-19 Outcomes Among 2.6 Million Children in England (2021)
Journal Article
Saatci, D., Ranger, T. A., Garriga, C., Clift, A. K., Zaccardi, F., Tan, P. S., Patone, M., Coupland, C., Harnden, A., Griffin, S. J., Khunti, K., Dambha-Miller, H., & Hippisley-Cox, J. (2021). Association Between Race and COVID-19 Outcomes Among 2.6 Million Children in England. JAMA Pediatrics, 175(9), 928-938. https://doi.org/10.1001/jamapediatrics.2021.1685

Importance: Although children mainly experience mild COVID-19 disease, hospitalization rates are increasing, with limited understanding of underlying factors. There is an established association between race and severe COVID-19 outcomes in adults in... Read More about Association Between Race and COVID-19 Outcomes Among 2.6 Million Children in England.

Anticholinergic drugs and risk of dementia: Time for action? (2021)
Journal Article
Bell, B., Avery, A., Bishara, D., Coupland, C., Ashcroft, D., & Orrell, M. (2021). Anticholinergic drugs and risk of dementia: Time for action?. Pharmacology Research and Perspectives, 9(3), Article e00793. https://doi.org/10.1002/prp2.793

Evidence suggests that the prescription of bladder anticholinergics is increasing. Recent studies have accentuated concerns about whether certain prescribed medications could increase risk of dementia, including anticholinergic drugs, and specificall... Read More about Anticholinergic drugs and risk of dementia: Time for action?.

Depression, anxiety and stress during the COVID-19 pandemic: results from a New Zealand cohort study on mental well-being (2021)
Journal Article
Gasteiger, N., Vedhara, K., Massey, A., Jia, R., Ayling, K., Chalder, T., Coupland, C., & Broadbent, E. (2021). Depression, anxiety and stress during the COVID-19 pandemic: results from a New Zealand cohort study on mental well-being. BMJ Open, 11(5), Article e045325. https://doi.org/10.1136/bmjopen-2020-045325

Objectives: The COVID-19 pandemic has caused unprecedented disruption to daily life. This study investigated depression, anxiety and stress in New Zealand (NZ) during the first ten weeks of the COVID-19 pandemic, and associated psychological and beha... Read More about Depression, anxiety and stress during the COVID-19 pandemic: results from a New Zealand cohort study on mental well-being.

Predicting the risk of prostate cancer in asymptomatic men: a cohort study to develop and validate a novel algorithm (2021)
Journal Article
Coupland, C., & Hippisley-Cox, J. (2021). Predicting the risk of prostate cancer in asymptomatic men: a cohort study to develop and validate a novel algorithm. British Journal of General Practice, 71(706), e364-e371. https://doi.org/10.3399/bjgp20x714137

Background: Diagnosis of prostate cancer at an early stage can potentially identify tumours when intervention may improve treatment options and survival.

Aim: To develop and validate an equation to predict absolute risk of prostate cancer in asymp... Read More about Predicting the risk of prostate cancer in asymptomatic men: a cohort study to develop and validate a novel algorithm.

Quantifying the association between ethnicity and COVID-19 mortality: a national cohort study protocol (2021)
Journal Article
Dambha-Miller, H., San Tan, P., Saatci, D., Kieran Clift, A., Zaccardi, F., Coupland, C., Locufier, P., Davies, F., Khunti, K., Griffin, S. J., & Hippisley-Cox, J. (2021). Quantifying the association between ethnicity and COVID-19 mortality: a national cohort study protocol. BMJ Open, 11(4), Article e045286. https://doi.org/10.1136/bmjopen-2020-045286

Introduction: Recent evidence suggests that ethnic minority groups are disproportionately at increased risk of hospitalisation and death from SARS-CoV-2 infection. Population-based evidence on potential explanatory factors across minority groups and... Read More about Quantifying the association between ethnicity and COVID-19 mortality: a national cohort study protocol.

Association between pre-existing respiratory disease and its treatments and severe COVID-19: population cohort study (2021)
Journal Article
Aveyard, P., Gao, M., Lindson, N., Hartmann-Boyce, J., Watkinson, P., Young, D., Coupland, C. A., San Tan, P., Clift, A. K., Harrison, D., Gould, D. W., Pavord, I. D., & Hippisley-Cox, J. (2021). Association between pre-existing respiratory disease and its treatments and severe COVID-19: population cohort study. Lancet Respiratory Medicine, 9(8), 909-923. https://doi.org/10.1016/S2213-2600%2821%2900095-3

Background: The aim was to assess whether chronic lung disease or use of inhaled corticosteroids (ICS) affect the risk of contracting severe COVID-19.

Methods: English general practice records from the QResearch database were linked to Public Hea... Read More about Association between pre-existing respiratory disease and its treatments and severe COVID-19: population cohort study.