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Psyllium reduces insulin-induced colonic gas production in irritable bowel syndrome: MRI and in vitro fermentation studies (2021)
Journal Article
Gunn, D., Abbas, Z., Harris, H., Major, G., Hoad, C., Gowland, P., …Spiller, R. (2022). Psyllium reduces insulin-induced colonic gas production in irritable bowel syndrome: MRI and in vitro fermentation studies. Gut, 71(5), 919-927. https://doi.org/10.1136/gutjnl-2021-324784

Objective: Health promoting dietary fibre including inulin often triggers gastrointestinal symptoms in patients with irritable bowel syndrome (IBS), limiting their intake. Our aim was to test if co-administering psyllium with inulin would reduce gas... Read More about Psyllium reduces insulin-induced colonic gas production in irritable bowel syndrome: MRI and in vitro fermentation studies.

Postprandial changes in gastrointestinal function and transit in cystic fibrosis assessed by Magnetic Resonance Imaging (2021)
Journal Article
Ng, C., Dellschaft, N. S., Hoad, C. L., Marciani, L., Ban, L., Prayle, A. P., …Smyth, A. R. (2021). Postprandial changes in gastrointestinal function and transit in cystic fibrosis assessed by Magnetic Resonance Imaging. Journal of Cystic Fibrosis, 20(4), 591-597. https://doi.org/10.1016/j.jcf.2020.06.004

Background: Cystic fibrosis (CF) is a multi-system genetic disorder affecting >72,000 people worldwide. Most CF patients experience gastrointestinal symptoms and can develop complications. However, the mechanisms of CF gut disease are not well unders... Read More about Postprandial changes in gastrointestinal function and transit in cystic fibrosis assessed by Magnetic Resonance Imaging.

Association of Cannabis Use During Adolescence With Neurodevelopment (2021)
Journal Article
Albaugh, M. D., Ottino-Gonzalez, J., Sidwell, A., Lepage, C., Juliano, A., Owens, M. M., …Garavan, H. (2021). Association of Cannabis Use During Adolescence With Neurodevelopment. JAMA Psychiatry, 78(9), 1031-1040. https://doi.org/10.1001/jamapsychiatry.2021.1258

IMPORTANCE Animal studies have shown that the adolescent brain is sensitive to disruptions in endocannabinoid signaling, resulting in altered neurodevelopment and lasting behavioral effects. However, few studies have investigated ties between cannabi... Read More about Association of Cannabis Use During Adolescence With Neurodevelopment.

Residual effects of cannabis-use on neuropsychological functioning (2021)
Journal Article
Wendel, L. K., Daedelow, L., Kaminski, J., Banaschewski, T., Millenet, S., Bokde, A. L., …Walter, H. (2021). Residual effects of cannabis-use on neuropsychological functioning. Cognitive Development, 59, Article 101072. https://doi.org/10.1016/j.cogdev.2021.101072

Non-acute effects of cannabis on neurocognition in adolescents remain unclear with most studies being cross-sectional. Therefore, the aim of this longitudinal, multi-center study was to examine the effects of cannabis use on cognitive abilities in pa... Read More about Residual effects of cannabis-use on neuropsychological functioning.

Test–retest assessment of non-contrast MRI sequences to characterise and quantify the small bowel wall in healthy participants (2021)
Journal Article
Alyami, A. S., Williams, H. G., Argyriou, K., Gunn, D., Wilkinson-Smith, V., White, J. R., …Hoad, C. L. (2021). Test–retest assessment of non-contrast MRI sequences to characterise and quantify the small bowel wall in healthy participants. Magnetic Resonance Materials in Physics, Biology and Medicine, 34, 791-804. https://doi.org/10.1007/s10334-021-00931-2

Objective: Quantitative Magnetic Resonance Imaging sequences have been investigated as objective imaging biomarkers of fibrosis and inflammation in Crohn’s disease. Aim: To determine the repeatability and inter- and intra-observer agreement of these... Read More about Test–retest assessment of non-contrast MRI sequences to characterise and quantify the small bowel wall in healthy participants.

Colonic Volume Changes in Paediatric Constipation Compared to Normal Values Measured Using MRI (2021)
Journal Article
Sharif, H., Hoad, C. L., Abrehart, N., Gowland, P. A., Spiller, R. C., Kirkham, S., …Marciani, L. (2021). Colonic Volume Changes in Paediatric Constipation Compared to Normal Values Measured Using MRI. Diagnostics, 11(6), Article 974. https://doi.org/10.3390/diagnostics11060974

Background: Functional constipation in children is common. Management of this condition can be challenging and is often based on symptom reports. Increased, objective knowledge of colonic volume changes in constipation compared to health could provid... Read More about Colonic Volume Changes in Paediatric Constipation Compared to Normal Values Measured Using MRI.

Orbitofrontal control of conduct problems? Evidence from healthy adolescents processing negative facial affect (2021)
Journal Article
Böttinger, B. W., Baumeister, S., Millenet, S., Barker, G. J., Bokde, A. L. W., Büchel, C., …IMAGEN Consortium. (2021). Orbitofrontal control of conduct problems? Evidence from healthy adolescents processing negative facial affect. European Child and Adolescent Psychiatry, https://doi.org/10.1007/s00787-021-01770-1

Conduct problems (CP) in patients with disruptive behavior disorders have been linked to impaired prefrontal processing of negative facial affect compared to controls. However, it is unknown whether associations with prefrontal activity during affect... Read More about Orbitofrontal control of conduct problems? Evidence from healthy adolescents processing negative facial affect.

Endocannabinoid Gene x Gene Interaction Association to Alcohol Use Disorder in two Adolescent Cohorts (2021)
Journal Article
Elkrief, L., Spinney, S., Vosberg, D. E., Banaschewski, T., Bokde, A., Quinlan, E. B., …Conrod, P. (2021). Endocannabinoid Gene x Gene Interaction Association to Alcohol Use Disorder in two Adolescent Cohorts. Frontiers in Psychiatry, 12, Article 645746. https://doi.org/10.3389/fpsyt.2021.645746

Genetic markers of endocannabinoid system have been linked to a variety of addiction-related behaviours that extend beyond cannabis use. In the current study we investigate the relationship between eCB genetic markers and AUDs in European adolescents... Read More about Endocannabinoid Gene x Gene Interaction Association to Alcohol Use Disorder in two Adolescent Cohorts.

Sex differences in neural correlates of common psychopathological symptoms in early adolescence (2021)
Journal Article
Biondo, F., Thunell, C. N., Xu, B., Chu, C., Jia, T., Ing, A., …IMAGEN Consortium. (2022). Sex differences in neural correlates of common psychopathological symptoms in early adolescence. Psychological Medicine, 52(14), 3086-3096. https://doi.org/10.1017/S0033291720005140

Background Sex-related differences in psychopathology are known phenomena, with externalizing and internalizing symptoms typically more common in boys and girls, respectively. However, the neural correlates of these sex-by-psychopathology interaction... Read More about Sex differences in neural correlates of common psychopathological symptoms in early adolescence.

Calibration-free regional RF shims for MRS (2021)
Journal Article
Berrington, A., Považan, M., Mirfin, C., Bawden, S., Park, Y. W., Marsh, D. C., …Gowland, P. A. (2021). Calibration-free regional RF shims for MRS. Magnetic Resonance in Medicine, 86(2), 611-624. https://doi.org/10.1002/mrm.28749

Purpose: Achieving a desired RF transmit field (B1+) in small regions-of-interest (ROIs) is critical for single-voxel MR spectroscopy at ultra-high field. RF shimming, using parallel transmission, requires B1+ mapping and optimisation, which limits i... Read More about Calibration-free regional RF shims for MRS.

Predicting Depression Onset in Young People Based on Clinical, Cognitive, Environmental, and Neurobiological Data (2021)
Journal Article
Toenders, Y. J., Kottaram, A., Dinga, R., Davey, C. G., Banaschewski, T., Bokde, A. L., …Schmaal, L. (2022). Predicting Depression Onset in Young People Based on Clinical, Cognitive, Environmental, and Neurobiological Data. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 7(4), 376-384. https://doi.org/10.1016/j.bpsc.2021.03.005

Background Adolescent onset of depression is associated with long-lasting negative consequences. Identifying adolescents at risk for developing depression would enable the monitoring of risk-factors and the development of early intervention strategi... Read More about Predicting Depression Onset in Young People Based on Clinical, Cognitive, Environmental, and Neurobiological Data.

Examination of the association between exposure to childhood maltreatment and brain structure in young adults: a machine learning analysis (2021)
Journal Article
Price, M., Albaugh, M., Hahn, S., Juliano, A. C., Fani, N., Brier, Z. M. F., …Garavan, H. (2021). Examination of the association between exposure to childhood maltreatment and brain structure in young adults: a machine learning analysis. Neuropsychopharmacology, 46(11), 1888-1894. https://doi.org/10.1038/s41386-021-00987-7

Exposure to maltreatment during childhood is associated with structural changes throughout the brain. However, the structural differences that are most strongly associated with maltreatment remain unclear given the limited number of whole-brain studi... Read More about Examination of the association between exposure to childhood maltreatment and brain structure in young adults: a machine learning analysis.

Acute gabapentin administration in healthy adults. A double-blind placebo-controlled study using transcranial magnetic stimulation and 7T 1H-MRS (2021)
Journal Article
Dyke, K., Pépés, S. E., Babourina-Brooks, B., Chen, C., Kim, S., Sigurdsson, H. P., …Jackson, S. R. (2021). Acute gabapentin administration in healthy adults. A double-blind placebo-controlled study using transcranial magnetic stimulation and 7T 1H-MRS. NeuroImage: Reports, 1(1), Article 100003. https://doi.org/10.1016/j.ynirp.2021.100003

Neural network involving medial orbitofrontal cortex and dorsal periaqueductal gray regulation in human alcohol abuse (2021)
Journal Article
Jia, T., Xie, C., Banaschewski, T., Barker, G. J., Bokde, A. L. W., Büchel, C., …IMAGEN Consortium. (2021). Neural network involving medial orbitofrontal cortex and dorsal periaqueductal gray regulation in human alcohol abuse. Science Advances, 7(6), 1-10. https://doi.org/10.1126/sciadv.abd4074

Prompted by recent evidence of neural circuitry in rodent models, functional magnetic resonance imaging and functional connectivity analyses were conducted for a large adolescent population at two ages, together with alcohol abuse measures, to charac... Read More about Neural network involving medial orbitofrontal cortex and dorsal periaqueductal gray regulation in human alcohol abuse.

The Human Brain Is Best Described as Being on a Female/Male Continuum: Evidence from a Neuroimaging Connectivity Study (2021)
Journal Article
Zhang, Y., Luo, Q., Huang, C., Lo, C. Z., Langley, C., Desrivières, S., …for the IMAGEN consortium. (2021). The Human Brain Is Best Described as Being on a Female/Male Continuum: Evidence from a Neuroimaging Connectivity Study. Cerebral Cortex, 31(6), 3021-3033. https://doi.org/10.1093/cercor/bhaa408

Psychological androgyny has long been associated with greater cognitive flexibility, adaptive behavior, and better mental health, but whether a similar concept can be defined using neural features remains unknown. Using the neuroimaging data from 962... Read More about The Human Brain Is Best Described as Being on a Female/Male Continuum: Evidence from a Neuroimaging Connectivity Study.

MR Measures of Small Bowel Wall T2 Are Associated With Increased Permeability (2020)
Journal Article
Scott, R. A., Williams, H. G., Hoad, C. L., Alyami, A., Ortori, C. A., Grove, J. I., …Gowland, P. A. (2021). MR Measures of Small Bowel Wall T2 Are Associated With Increased Permeability. Journal of Magnetic Resonance Imaging, 53(5), 1422-1431. https://doi.org/10.1002/jmri.27463

Background: Increased small bowel permeability leads to bacterial translocation, associated with significant morbidity and mortality. Biomarkers are needed to evaluate these changes in vivo, stratify an individual's risk, and evaluate the efficacy of... Read More about MR Measures of Small Bowel Wall T2 Are Associated With Increased Permeability.

Measurement of fasted state gastric antral motility before and after a standard bioavailability and bioequivalence 240 mL drink of water: Validation of MRI method against concomitant perfused manometry in healthy participants (2020)
Journal Article
Heissam, K., Abrehart, N., Hoad, C. L., Wright, J., Menys, A., Murray, K., …Marciani, L. (2020). Measurement of fasted state gastric antral motility before and after a standard bioavailability and bioequivalence 240 mL drink of water: Validation of MRI method against concomitant perfused manometry in healthy participants. PLoS ONE, 15(11), e0241441. https://doi.org/10.1371/journal.pone.0241441

Objective The gastrointestinal environment in which drug products need to disintegrate before the drug can dissolve and be absorbed has not been studied in detail due to limitations, especially invasiveness of existing techniques. Minimal in vivo dat... Read More about Measurement of fasted state gastric antral motility before and after a standard bioavailability and bioequivalence 240 mL drink of water: Validation of MRI method against concomitant perfused manometry in healthy participants.