All Outputs (116)

Heterogeneity of Tumour Infiltrating Lymphocytes (TILs) in breast cancer and its prognostic significance (2018)
Journal Article
Althobiti, M., Aleskandarany, M. A., Joseph, C., Toss, M., Mongan, N., Diez-Rodriguez, M., …Rakha, E. A. (2018). Heterogeneity of Tumour Infiltrating Lymphocytes (TILs) in breast cancer and its prognostic significance. Histopathology, 73(6), 887-896. https://doi.org/10.1111/his.13695

Background: Tumour-infiltrating lymphocytes (TILs) in breast cancer (BC) confer prognostic and predictive information. This study aims to assess the spatial and temporal heterogeneity of TILs in BC and its relationship with immune cell subtypes. Met... Read More about Heterogeneity of Tumour Infiltrating Lymphocytes (TILs) in breast cancer and its prognostic significance.

The dog as an animal model for bladder and urethral urothelial carcinoma: comparative epidemiology and histology (2018)
Journal Article
de Brot, S., Robinson, B. D., Scase, T., Grau‑Roma, L., Wilkinson, E., Boorjian, S. A., …Mongan, N. P. (2018). The dog as an animal model for bladder and urethral urothelial carcinoma: comparative epidemiology and histology. Oncology Letters, 16(2), https://doi.org/10.3892/ol.2018.8837

Despite the recent approval of several novel agents for patients with metastatic urothelial carcinoma (UC), survival in this setting remains poor. As such, continued investigation into novel therapeutic options remains warranted. Pre clinical develop... Read More about The dog as an animal model for bladder and urethral urothelial carcinoma: comparative epidemiology and histology.

Peri-conception and first trimester diet modifies reproductive development in bulls (2017)
Journal Article
Copping, K. J., Ruiz-Diaz, M. D., Rutland, C. S., Mongan, N. P., Callaghan, M., McMillen, I. C., …Perry, V. (in press). Peri-conception and first trimester diet modifies reproductive development in bulls. Reproduction, Fertility and Development, https://doi.org/10.1071/RD17102

Nutritional perturbation during gestation alters male reproductive development in rodents and sheep. In cattle both the developmental trajectory of the feto–placental unit and its response to dietary perturbations is dissimilar to that of these speci... Read More about Peri-conception and first trimester diet modifies reproductive development in bulls.

Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics (2017)
Journal Article
Simpson, S., Dunning, M. D., de Brot, S., Grau-Roma, L., Mongan, N. P., & Rutland, C. S. (2017). Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics. Acta Veterinaria Scandinavica, 59, Article 71. https://doi.org/10.1186/s13028-017-0341-9

Osteosarcoma (OSA) is a rare cancer in people. However OSA incidence rates in dogs are 27 times higher than in people. Prognosis in both species is poor, with five year osteosarcoma survival rates in people not having improved in decades. For dogs, o... Read More about Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics.

Epigenetic control of microRNA expression and cancer (2017)
Book Chapter
De Brot, S., Rutland, C. S., Mongan, N. P., & James, V. (2018). Epigenetic control of microRNA expression and cancer. In J. Chakrabarti, & S. Mitra (Eds.), Cancer and Noncoding RNAs, 373-380. Elsevier. doi:10.1016/B978-0-12-811022-5.00020-6

MicroRNAs (miRNAs or miRs) are involved in pathways central to homeostasis and cellular function, including proliferation, differentiation, and apoptosis; processes which when aberrantly regulated contribute to the hallmarks of cancer. The contributi... Read More about Epigenetic control of microRNA expression and cancer.

Heterochromatin modulation and PCG control of gene expression mediated by noncoding RNA in cancer (2017)
Book Chapter
Rutland, C. S., de Brot, S., James, V., & Mongan, N. P. (2018). Heterochromatin modulation and PCG control of gene expression mediated by noncoding RNA in cancer. In J. Chakrabarti, & S. Mitra (Eds.), Cancer and Noncoding RNAs, 359-372. Elsevier. doi:10.1016/b978-0-12-811022-5.00019-x

In eukaryotes, the packaging of DNA and proteins, termed chromatin, is an essential determinant of transcription. The basic unit of chromatin, the nucleosome, is composed of ?146 base pairs of DNA spooled around a dense protein core containing two co... Read More about Heterochromatin modulation and PCG control of gene expression mediated by noncoding RNA in cancer.

Parental protein malnutrition programmes of offspring growth and vasculature to increase risk of cardiovascular, pancreatic, and metabolic disease: lessons learned from animal studies (2017)
Journal Article
Ruiz-Diaz, M. D., Partridge, H., Davidson, F., Mongan, N. P., Gardner, D. S., & Rutland, C. S. (2017). Parental protein malnutrition programmes of offspring growth and vasculature to increase risk of cardiovascular, pancreatic, and metabolic disease: lessons learned from animal studies. European Medical Journal Reproductive Health, 3(1),

It is well known that consumption of a balanced diet throughout adulthood is key toward maintenance of optimal body weight and cardiovascular health. Research using animal models can provide insights into the programming of short and long-term health... Read More about Parental protein malnutrition programmes of offspring growth and vasculature to increase risk of cardiovascular, pancreatic, and metabolic disease: lessons learned from animal studies.

Cytochalasin B-induced membrane vesicles convey angiogenic activity of parental cells (2017)
Journal Article
Gomzikova, M., Zhuravleva, M., Miftakhova, R., Arkhipova, S., Evtugin, V., Khaiboullina, S., …Rizvanov, A. A. (2017). Cytochalasin B-induced membrane vesicles convey angiogenic activity of parental cells. Oncotarget, 8(41), https://doi.org/10.18632/oncotarget.19723

Naturally occurring extracellular vesicles (EVs) play essential roles in intracellular communication and delivery of bioactive molecules. Therefore it has been suggested that EVs could be used for delivery of therapeutics. However, to date the therap... Read More about Cytochalasin B-induced membrane vesicles convey angiogenic activity of parental cells.

Expression of NAD(P)H quinone dehydrogenase 1 (NQO1) is increased in the endometrium of women with endometrial cancer and women with Polycystic Ovary Syndrome (2017)
Journal Article
Atiomo, W., Shafiee, M. N., Chapman, C., Metzler, V. M., Abouzeid, J., Latif, A., …Mongan, N. P. (2017). Expression of NAD(P)H quinone dehydrogenase 1 (NQO1) is increased in the endometrium of women with endometrial cancer and women with Polycystic Ovary Syndrome. Clinical Endocrinology, 87(5), 557-565. https://doi.org/10.1111/cen.13436

OBJECTIVE: Women with a prior history of polycystic ovary syndrome (PCOS) have an increased risk of endometrial cancer (EC). AIM: To investigate whether the endometrium of women with PCOS possess gene expression changes similar to those found in EC.... Read More about Expression of NAD(P)H quinone dehydrogenase 1 (NQO1) is increased in the endometrium of women with endometrial cancer and women with Polycystic Ovary Syndrome.

Identification of factors required for m6A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI (2017)
Journal Article
Růžička, K., Zhang, M., Campilho, A., Bodi, Z., Kashif, M., Saleh, M., …Fray, R. G. (2017). Identification of factors required for m6A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI. New Phytologist, 215(1), 157-172. https://doi.org/10.1111/nph.14586

N6-adenosine methylation (m6A) of mRNA is an essential process in most eukaryotes, but its role and the status of factors accompanying this modification are still poorly understood. Using combined methods of genetics, proteomics and RNA biochemis... Read More about Identification of factors required for m6A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI.

Heterodimers of photoreceptor-specific nuclear receptor (PNR/NR2E3) and peroxisome proliferator-activated receptor (PPAR?) are disrupted by retinal disease-associated mutations (2017)
Journal Article
Fulton, J., Mazumder, B., Whitchurch, J., Monteiro, C. J., Collins, H. M., Chan, C. M., …Heery, D. M. (2017). Heterodimers of photoreceptor-specific nuclear receptor (PNR/NR2E3) and peroxisome proliferator-activated receptor (PPARγ) are disrupted by retinal disease-associated mutations. Cell Death and Disease, 8, Article e2677. https://doi.org/10.1038/cddis.2017.98

Photoreceptor-specific nuclear receptor (PNR/NR2E3) and Tailless homolog (TLX/NR2E1) are human orthologs of the NR2E group, a subgroup of phylogenetically related members of the Nuclear Receptor (NR) superfamily of transcription factors. We assessed... Read More about Heterodimers of photoreceptor-specific nuclear receptor (PNR/NR2E3) and peroxisome proliferator-activated receptor (PPAR?) are disrupted by retinal disease-associated mutations.

Androgen dependent mechanisms of pro-angiogenic networks in placental and tumor development (2017)
Journal Article
Metzler, V. M., de Brot, S., Robinson, R. S., Jeyapalan, J. N., Rakha, E., Walton, T., …Mongan, N. P. (2017). Androgen dependent mechanisms of pro-angiogenic networks in placental and tumor development. Placenta, 56, 79-85. https://doi.org/10.1016/j.placenta.2017.02.018

The placenta and tumors share important characteristics, including a requirement to establish effective angiogenesis. In the case of the placenta, optimal angiogenesis is required to sustain the blood flow required to maintain a successful pregnancy,... Read More about Androgen dependent mechanisms of pro-angiogenic networks in placental and tumor development.

HOXC8 regulates self-renewal, differentiation and transformation of breast cancer stem cells (2017)
Journal Article
Shah, M., Cardenas, R., Wang, B., Persson, J., Mongan, N. P., Grabowska, A. M., & Allegrucci, C. (2017). HOXC8 regulates self-renewal, differentiation and transformation of breast cancer stem cells. Molecular Cancer, 16(38), https://doi.org/10.1186/s12943-017-0605-z

Background: Homeobox genes are master regulators of cell fate during embryonic development and their expression is altered in cancer. By regulating the balance between cell proliferation and differentiation, they maintain homeostasis of normal tissue... Read More about HOXC8 regulates self-renewal, differentiation and transformation of breast cancer stem cells.

Sterol regulatory element binding protein-1 (SREBP1) gene expression is similarly increased in polycystic ovary syndrome and endometrial cancer (2017)
Journal Article
Shafiee, M. N., Mongan, N. P., Seedhouse, C., Chapman, C., Deen, S., Abu, J., & Atiomo, W. (2017). Sterol regulatory element binding protein-1 (SREBP1) gene expression is similarly increased in polycystic ovary syndrome and endometrial cancer. Acta Obstetricia et Gynecologica Scandinavica, 96(5), 556-562. https://doi.org/10.1111/aogs.13106

Introduction: Women with polycystic ovary syndrome (PCOS) have a 3-fold higher risk of endometrial cancer (EC). Insulin resistance and hyperlipidaemia may be pertinent factors in the pathogenesis of both conditions. The aim of this study was to inves... Read More about Sterol regulatory element binding protein-1 (SREBP1) gene expression is similarly increased in polycystic ovary syndrome and endometrial cancer.

Multiple genetic associations with Irish wolfhound dilated cardiomyopathy (2016)
Journal Article
Simpson, S., Dunning, M. D., Brownlie, S., Patel, J., Godden, M., Cobb, M., …Rutland, C. S. (2016). Multiple genetic associations with Irish wolfhound dilated cardiomyopathy. BioMed Research International, 2016(637408), https://doi.org/10.1155/2016/6374082

Cardiac disease is a leading cause of morbidity and mortality in dogs and humans, with dilated cardiomyopathy being a large contributor to this. The Irish Wolfhound (IWH) is one of the most commonly affected breeds and one of the few breeds with gene... Read More about Multiple genetic associations with Irish wolfhound dilated cardiomyopathy.

m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination (2016)
Journal Article
Haussmann, I. U., Bodi, Z., Sanchez-Moran, E., Mongan, N. P., Archer, N., Fray, R. G., & Soller, M. (2016). m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination. Nature, 540(7632), 301-304. https://doi.org/10.1038/nature20577

N6-methyladenosine (m6A) is the most common internal modification of eukaryotic messenger RNA (mRNA) and is decoded by YTH domain proteins1, 2, 3, 4, 5, 6, 7. The mammalian mRNA m6A methylosome is a complex of nuclear proteins that includes METTL3 (m... Read More about m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination.

Malignant inflammation in cutaneous T-cell lymphoma: a hostile takeover (2016)
Journal Article
Krejsgaard, T., Lindahl, L. M., Mongan, N. P., Wasik, M. A., Litvinov, I. V., Iversen, L., …Odum, N. (in press). Malignant inflammation in cutaneous T-cell lymphoma: a hostile takeover. Seminars in Immunopathology, https://doi.org/10.1007/s00281-016-0594-9

Cutaneous T-cell lymphomas (CTCL) are characterized by the presence of chronically inflamed skin lesions containing malignant T cells. Early disease presents as limited skin patches or plaques and exhibits an indolent behavior. For many patients, the... Read More about Malignant inflammation in cutaneous T-cell lymphoma: a hostile takeover.

TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants (2016)
Journal Article
Sulak, M., Fong, L., Mika, K., Chigurupati, S., Yon, L., Mongan, N. P., …Lynch, V. J. (2016). TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants. eLife, 5(2016), Article e11994. https://doi.org/10.7554/eLife.11994.001

A major constraint on the evolution of large body sizes in animals is an increased risk of developing cancer. There is no correlation, however, between body size and cancer risk. This lack of correlation is often referred to as 'Peto's Paradox'. Here... Read More about TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants.

TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants (2016)
Journal Article
Michael, S., Lindsey, F., Katelyn, M., Sravanthi, C., Lisa, Y., Nigel P, M., …Vincent J, L. (2016). TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants. eLife, 5, Article e11994. https://doi.org/10.7554/eLife.11994.001

A major constraint on the evolution of large body sizes in animals is an increased risk of developing cancer. There is no correlation, however, between body size and cancer risk. This lack of correlation is often referred to as 'Peto's Paradox'. Here... Read More about TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants.

Targeted suppression of AR-V7 using PIP5K1? inhibitor overcomes enzalutamide resistance in prostate cancer cells (2016)
Journal Article
Sarwar, M., Semenas, J., Miftakhova, R., Simoulis, A., Robinson, B., Wingren, A. G., …Persson, J. L. (2016). Targeted suppression of AR-V7 using PIP5K1α inhibitor overcomes enzalutamide resistance in prostate cancer cells. Oncotarget, 7(39), 63065-63081. https://doi.org/10.18632/oncotarget.11757

One mechanism of resistance of prostate cancer (PCa) to enzalutamide (MDV3100) treatment is the increased expression of AR variants lacking the ligand binding-domain, the best characterized of which is AR-V7. We have previously reported that Phosphat... Read More about Targeted suppression of AR-V7 using PIP5K1? inhibitor overcomes enzalutamide resistance in prostate cancer cells.