Developing a self-healing supramolecular nucleoside hydrogel

Skilling, K. J.; Kellam, B.; Ashford, M.; Bradshaw, Tracey D.; Marlow, Maria

Abstract

© 2016 The Royal Society of Chemistry. Low molecular weight gelator hydrogels provide a viable alternative to traditional polymer based drug delivery platforms, owing to their tunable stability and in most cases inherent biocompatibility. Here we report the first self-healing nucleoside hydrogel using N4-octanoyl-2′-deoxycytidine (0.5% w/v) for drug delivery. The hydrogel's cross-linked nanofibrillar structure, was characterised using oscillatory rheology and confirmed using SEM and TEM imaging. The potential of this gel for drug delivery was explored in vitro using fluorescently labelled tracers. Cell viability assays were conducted using pancreatic cell lines which tolerated the gels well; whilst no adverse effects on the viability or proliferation of cells were observed for fibroblast cell lines.

Citation

Skilling, K. J., Kellam, B., Ashford, M., Bradshaw, T. D., & Marlow, M. (2016). Developing a self-healing supramolecular nucleoside hydrogel. Soft Matter, 12(43), 8950-8957. https://doi.org/10.1039/c6sm01779g

• Journal Article Type: Article
• Acceptance Date: Sep 19, 2016
• Online Publication Date: Sep 21, 2016
• Publication Date: Nov 21, 2016
• Deposit Date: Oct 4, 2016
• Publicly Available Date: Oct 4, 2016
• Journal: Soft Matter
• Print ISSN: 1744-683X
• Electronic ISSN: 1744-6848
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 12
• Issue: 43
• Pages: 8950-8957
• DOI: https://doi.org/10.1039/c6sm01779g
• Public URL: https://nottingham-repository.worktribe.com/output/810073
• Publisher URL: http://pubs.rsc.org/en/Content/ArticleLanding/2016/SM/C6SM01779G#!divAbstract
• Contract Date: Oct 4, 2016