Outputs (1292)

Cross-cultural insights from two global mental health studies: self-enhancement and ingroup biases (2024)
Journal Article
Kotera, Y., Ronaldson, A., Hayes, D., Hunter-Brown, H., McPhilbin, M., Dunnett, D., …Slade, M. (in press). Cross-cultural insights from two global mental health studies: self-enhancement and ingroup biases. International Journal of Mental Health and Addiction,

This Commentary highlights two cross-cultural issues identified from our global mental health (GMH) research, RECOLLECT (Recovery Colleges Characterisation and Testing) 2: Selfenhancement and ingroup biases. Self-enhancement is a tendency to maintain... Read More about Cross-cultural insights from two global mental health studies: self-enhancement and ingroup biases.

Label-free Brillouin endo-microscopy for the quantitative 3D imaging of sub-micrometre biology (2024)
Journal Article
La Cavera III, S., Chauhan, V. M., Hardiman, W., Yao, M., Fuentes-Domínguez, R., Setchfield, K., …Clark, M. (2024). Label-free Brillouin endo-microscopy for the quantitative 3D imaging of sub-micrometre biology. Communications Biology, 7, Article 451. https://doi.org/10.1038/s42003-024-06126-4

This report presents an optical fibre-based endo-microscopic imaging tool that simultaneously measures the topographic profile and 3D viscoelastic properties of biological specimens through the phenomenon of time-resolved Brillouin scattering. This u... Read More about Label-free Brillouin endo-microscopy for the quantitative 3D imaging of sub-micrometre biology.

Design, Synthesis, and Biological Evaluation of Novel Tetrahydroacridin Hybrids with Sulfur-Inserted Linkers as Potential Multitarget Agents for Alzheimer’s Disease (2024)
Journal Article
Wu, X., Ze, X., Qin, S., Zhang, B., Li, X., Gong, Q., …Xu, J. (2024). Design, Synthesis, and Biological Evaluation of Novel Tetrahydroacridin Hybrids with Sulfur-Inserted Linkers as Potential Multitarget Agents for Alzheimer’s Disease. Molecules, 29(8), Article 1782. https://doi.org/10.3390/molecules29081782

Alzheimer’s disease (AD) is a complex neurodegenerative disease that can lead to the loss of cognitive function. The progression of AD is regulated by multiple signaling pathways and their associated targets. Therefore, multitarget strategies theoret... Read More about Design, Synthesis, and Biological Evaluation of Novel Tetrahydroacridin Hybrids with Sulfur-Inserted Linkers as Potential Multitarget Agents for Alzheimer’s Disease.

A facile one step route that introduces functionality to polymer powders for laser sintering (2024)
Journal Article
Krumins, E., Crawford, L. A., Rogers, D. M., Machado, F., Taresco, V., East, M., …Howdle, S. M. (2024). A facile one step route that introduces functionality to polymer powders for laser sintering. Nature Communications, 15(1), Article 3137. https://doi.org/10.1038/s41467-024-47376-4

Laser Sintering (LS) is a type of Additive Manufacturing (AM) exploiting laser processing of polymeric particles to produce 3D objects. Because of its ease of processability and thermo-physical properties, polyamide-12 (PA-12) represents ~95% of the... Read More about A facile one step route that introduces functionality to polymer powders for laser sintering.

Mechano-sensitivity of β2-adrenoceptors enhances constitutive activation of cAMP generation that is inhibited by inverse agonists (2024)
Journal Article
Cullum, S. A., Platt, S., Dale, N., Isaac, O. C., Wragg, E. S., Soave, M., …Hill, S. J. (2024). Mechano-sensitivity of β2-adrenoceptors enhances constitutive activation of cAMP generation that is inhibited by inverse agonists. Communications Biology, 7(1), Article 417. https://doi.org/10.1038/s42003-024-06128-2

The concept of agonist-independent signalling that can be attenuated by inverse agonists is a fundamental element of the cubic ternary complex model of G protein-coupled receptor (GPCR) activation. This model shows how a GPCR can exist in two conform... Read More about Mechano-sensitivity of β2-adrenoceptors enhances constitutive activation of cAMP generation that is inhibited by inverse agonists.

Salt-Dependent Self-Association of Trinucleotide Repeat RNA Sequences (2024)
Journal Article
Maity, H., Nguyen, H. T., Hori, N., & Thirumalai, D. (in press). Salt-Dependent Self-Association of Trinucleotide Repeat RNA Sequences. Journal of Physical Chemistry Letters, 15(14), 3820–3827. https://doi.org/10.1021/acs.jpclett.3c03553

Repeat RNA sequences self-associate to form condensates. Simulations of a coarse-grained single-interaction site model for (CAG)n (n = 30 and 31) show that the salt-dependent free energy gap, ΔGS, between the ground (perfect hairpin) and the excited... Read More about Salt-Dependent Self-Association of Trinucleotide Repeat RNA Sequences.

Discovery of α-Amidobenzylboronates as Highly Potent Covalent Inhibitors of Plasma Kallikrein (2024)
Journal Article
Allison, M., Davie, R. L., Mogg, A. J., Hampton, S. L., Emsley, J., & Stocks, M. J. (2024). Discovery of α-Amidobenzylboronates as Highly Potent Covalent Inhibitors of Plasma Kallikrein. ACS Medicinal Chemistry Letters, 15(4), 501–509. https://doi.org/10.1021/acsmedchemlett.3c00572

Hereditary angioedema (HAE), a rare genetic disorder, is associated with uncontrolled plasma kallikrein (PKa) enzyme activity leading to the generation of bradykinin swelling in subcutaneous and submucosal membranes in various locations of the body.... Read More about Discovery of α-Amidobenzylboronates as Highly Potent Covalent Inhibitors of Plasma Kallikrein.

CXCL17 is an allosteric inhibitor of CXCR4 through a mechanism of action involving glycosaminoglycans (2024)
Journal Article
White, C. W., Platt, S., Kilpatrick, L. E., Dale, N., Abhayawardana, R. S., Dekkers, S., …Hill, S. J. (2024). CXCL17 is an allosteric inhibitor of CXCR4 through a mechanism of action involving glycosaminoglycans. Science Signaling, 17(828), Article abl3758. https://doi.org/10.1126/scisignal.abl3758

CXCL17 is a chemokine principally expressed by mucosal tissues, where it facilitates chemotaxis of monocytes, dendritic cells, and macrophages and has antimicrobial properties. CXCL17 is also implicated in the pathology of inflammatory disorders and... Read More about CXCL17 is an allosteric inhibitor of CXCR4 through a mechanism of action involving glycosaminoglycans.

Competition between stacking and divalent cation mediated electrostatic interactions determines the conformations of short DNA sequences (2024)
Journal Article
Mondal, B., Chakraborty, D., Hori, N., Nguyen, H. T., & Thirumalai, D. (2024). Competition between stacking and divalent cation mediated electrostatic interactions determines the conformations of short DNA sequences. Journal of Chemical Theory and Computation, https://doi.org/10.1021/acs.jctc.3c01193

Interplay between divalent cations (Mg2+ and Ca2+) and single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA), as well as stacking interactions, is important in nucleosome stability and phase separation in nucleic acids. Quantitative techniques... Read More about Competition between stacking and divalent cation mediated electrostatic interactions determines the conformations of short DNA sequences.

Deep Learning‐Driven Exploration of Pyrroloquinoline Quinone Neuroprotective Activity in Alzheimer's Disease (2024)
Journal Article
Li, X., Sun, Y., Zhou, Z., Li, J., Liu, S., Chen, L., …Lu, Q. (2024). Deep Learning‐Driven Exploration of Pyrroloquinoline Quinone Neuroprotective Activity in Alzheimer's Disease. Advanced Science, https://doi.org/10.1002/advs.202308970

Alzheimer's disease (AD) is a pressing concern in neurodegenerative research. To address the challenges in AD drug development, especially those targeting Aβ, this study uses deep learning and a pharmacological approach to elucidate the potential of... Read More about Deep Learning‐Driven Exploration of Pyrroloquinoline Quinone Neuroprotective Activity in Alzheimer's Disease.