Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease

Selvarajah, Senthooran; Todd, Ian; Tighe, Patrick J.; John, Michelle; Bolton, Charlotte E.; Harrison, Timothy W.; Fairclough, Lucy C.

Abstract

Inflammatory biomarkers, including cytokines, are associated with COPD, but the association of particular circulating cytokines with systemic pathology remains equivocal. To investigate this, we developed a protein microarray system to detect multiple cytokines in small volumes of serum. Fourteen cytokines were measured in serum from never-smokers, ex-smokers, current smokers, and COPD patients (GOLD stages 1–3). Certain individual circulating cytokines (particularly TNFa and IL-1b) were significantly elevated in concentration in the serum of particular COPD patients (and some current/ex-smokers without COPD) and may serve as markers of particularly significant systemic inflammation. However, numerous circulating cytokines were raised such that their combined, but not individual, elevation was significantly associated with severity of disease, and these may be further indicators of, and contributors to, the systemic inflammatory manifestations of COPD. The coelevation of numerous circulating cytokines in COPD is consistent with the insidious development, chronic nature, and systemic comorbidities of the disease.

Citation

Selvarajah, S., Todd, I., Tighe, P. J., John, M., Bolton, C. E., Harrison, T. W., & Fairclough, L. C. (2016). Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease. Mediators of Inflammation, 2016, 1-9. https://doi.org/10.1155/2016/3604842

• Journal Article Type: Article
• Acceptance Date: Jun 23, 2016
• Online Publication Date: Jun 23, 2016
• Publication Date: 2016
• Deposit Date: Sep 23, 2016
• Publicly Available Date: Sep 23, 2016
• Journal: Mediators of Inflammation
• Print ISSN: 0962-9351
• Electronic ISSN: 1466-1861
• Publisher: Hindawi
• Peer Reviewed: Peer Reviewed
• Volume: 2016
• Article Number: 3604842
• Pages: 1-9
• DOI: https://doi.org/10.1155/2016/3604842
• Public URL: https://nottingham-repository.worktribe.com/output/799673
• Publisher URL: https://www.hindawi.com/journals/mi/2016/3604842/
• Contract Date: Sep 23, 2016