Davis Tucis
The Role of Extracellular Vesicles in Allergic Sensitization: A Systematic Review
Tucis, Davis; Hopkins, Georgina; Browne, William; James, Victoria; Onion, David; Fairclough, Lucy C.
Authors
GEORGINA HOPKINS Georgina.Hopkins@nottingham.ac.uk
Research Fellow
William Browne
VICTORIA JAMES VICTORIA.JAMES@NOTTINGHAM.AC.UK
Professor of Molecular Biology
Dr DAVID ONION david.onion@nottingham.ac.uk
Advanced Technical Specialist (Flow Cytometry)
LUCY FAIRCLOUGH LUCY.FAIRCLOUGH@NOTTINGHAM.AC.UK
Professor of Immunology
Abstract
Allergies affect approximately 10–30% of people worldwide, with an increasing number of cases each year; however, the underlying mechanisms are still poorly understood. In recent years, extracellular vesicles (EVs) have been suggested to play a role in allergic sensitization and skew to a T helper type 2 (Th2) response. The aim of this review is to highlight the existing evidence of EV involvement in allergies. A total of 22 studies were reviewed; 12 studies showed EVs can influence a Th2 response, while 10 studies found EVs promoted a Th1 or Treg response. EVs can drive allergic sensitization through up-regulation of pro-Th2 cytokines, such as IL-4 and IL-13. In addition, EVs from MRSA can induce IgE hypersensitivity in mice towards MRSA. On the other hand, EVs can induce tolerance in the immune system; for example, pre-exposing OVA-loaded EVs prevented OVA sensitization in mice. The current literature thus suggests that EVs play an essential role in allergy. Further research utilizing human in vitro models and clinical studies is needed to give a reliable account of the role of EVs in allergy.
Citation
Tucis, D., Hopkins, G., Browne, W., James, V., Onion, D., & Fairclough, L. C. (2024). The Role of Extracellular Vesicles in Allergic Sensitization: A Systematic Review. International Journal of Molecular Sciences, 25(8), Article 4492. https://doi.org/10.3390/ijms25084492
| Journal Article Type | Review |
|---|---|
| Acceptance Date | Apr 18, 2024 |
| Online Publication Date | Apr 19, 2024 |
| Publication Date | Apr 19, 2024 |
| Deposit Date | May 30, 2024 |
| Publicly Available Date | May 30, 2024 |
| Journal | International Journal of Molecular Sciences |
| Print ISSN | 1661-6596 |
| Electronic ISSN | 1422-0067 |
| Publisher | MDPI |
| Peer Reviewed | Peer Reviewed |
| Volume | 25 |
| Issue | 8 |
| Article Number | 4492 |
| DOI | https://doi.org/10.3390/ijms25084492 |
| Keywords | allergy; extracellular vesicles; sensitization; tolerance; Th2 |
| Public URL | https://nottingham-repository.worktribe.com/output/33838675 |
| Publisher URL | https://www.mdpi.com/1422-0067/25/8/4492 |
Files
Tucis et al, 2024
(639 Kb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
You might also like
The Role of Extracellular Vesicles in Atopic Dermatitis
(2024)
Journal Article
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: discovery-access-systems@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search