Saad Jbabdi
Model-based analysis of multishell diffusion MR data for tractography: how to get over fitting problems
Jbabdi, Saad; Sotiropoulos, Stamatios N.; Savio, Alexander M.; Gra�a, Manuel; Behrens, Timothy E.J.
Authors
Stamatios N. Sotiropoulos
Alexander M. Savio
Manuel Gra�a
Timothy E.J. Behrens
Abstract
In this article, we highlight an issue that arises when using multiple b‐values in a model‐based analysis of diffusion MR data for tractography. The non‐monoexponential decay, commonly observed in experimental data, is shown to induce overfitting in the distribution of fiber orientations when not considered in the model. Extra fiber orientations perpendicular to the main orientation arise to compensate for the slower apparent signal decay at higher b‐values. We propose a simple extension to the ball and stick model based on a continuous gamma distribution of diffusivities, which significantly improves the fitting and reduces the overfitting. Using in vivo experimental data, we show that this model outperforms a simpler, noise floor model, especially at the interfaces between brain tissues, suggesting that partial volume effects are a major cause of the observed non‐monoexponential decay. This model may be helpful for future data acquisition strategies that may attempt to combine multiple shells to improve estimates of fiber orientations in white matter and near the cortex.
Citation
Jbabdi, S., Sotiropoulos, S. N., Savio, A. M., Graña, M., & Behrens, T. E. (2012). Model-based analysis of multishell diffusion MR data for tractography: how to get over fitting problems. Magnetic Resonance in Medicine, 68(6), https://doi.org/10.1002/mrm.24204
Journal Article Type | Article |
---|---|
Acceptance Date | Jan 17, 2012 |
Online Publication Date | Feb 14, 2012 |
Publication Date | Nov 21, 2012 |
Deposit Date | Jul 12, 2018 |
Publicly Available Date | Jul 12, 2018 |
Journal | Magnetic Resonance in Medicine |
Print ISSN | 0740-3194 |
Electronic ISSN | 1522-2594 |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
Volume | 68 |
Issue | 6 |
DOI | https://doi.org/10.1002/mrm.24204 |
Public URL | https://nottingham-repository.worktribe.com/output/712138 |
Publisher URL | https://onlinelibrary.wiley.com/doi/abs/10.1002/mrm.24204 |
Contract Date | Jul 12, 2018 |
Files
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