The IUPHAR/BPS Guide to PHARMACOLOGY in 2024

Harding, Simon D; Armstrong, Jane F; Faccenda, Elena; Southan, Christopher; Alexander, Stephen P H; Davenport, Anthony P; Spedding, Michael; Davies, Jamie A

Abstract

The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb; https://www.guidetopharmacology.org) is an open-access, expert-curated, online database that provides succinct overviews and key references for pharmacological targets and their recommended experimental ligands. It includes over 3039 protein targets and 12163 ligand molecules, including approved drugs, small molecules, peptidesand antibodies. Here, we report recent developments to the resource and describe expansion in content over the six database releases made during the last two years. The database update section of this paper focuses on two areas relating to important global health challenges. The first, SARS-CoV-2 COVID-19, remains a major concern and we describe our efforts to expand the database to include a new family of coronavirus proteins. The second area is antimicrobial resistance, for which we have extended our coverage of antibacterials in partnership with AntibioticDB, a collaboration that has continued through support from GARDP. We discuss other areas of curation and also focus on our external links to resources such as PubChem that bring important synergies to the resources.

Citation

Harding, S. D., Armstrong, J. F., Faccenda, E., Southan, C., Alexander, S. H., Davenport, A. P., Spedding, M., & Davies, J. A. (2024). The IUPHAR/BPS Guide to PHARMACOLOGY in 2024. Nucleic Acids Research, 52(D1), D1438-D1449. https://doi.org/10.1093/nar/gkad944

• Journal Article Type: Article
• Acceptance Date: Oct 18, 2023
• Online Publication Date: Oct 28, 2023
• Publication Date: Jan 5, 2024
• Deposit Date: Jan 4, 2024
• Publicly Available Date: Jan 4, 2024
• Journal: Nucleic Acids Research
• Print ISSN: 0305-1048
• Electronic ISSN: 1362-4962
• Publisher: Oxford University Press
• Peer Reviewed: Peer Reviewed
• Volume: 52
• Issue: D1
• Article Number: gkad944
• Pages: D1438-D1449
• DOI: https://doi.org/10.1093/nar/gkad944
• Keywords: Genetics
• Public URL: https://nottingham-repository.worktribe.com/output/27363311
• Publisher URL: https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkad944/7332061?login=false