Advances in malaria pharmacology and the online guide to MALARIA PHARMACOLOGY: IUPHAR review 38

Armstrong, Jane F.; Campo, Brice; Alexander, Stephen P.H.; Arendse, Lauren B.; Cheng, Xiu; Davenport, Anthony P.; Faccenda, Elena; Fidock, David A.; Godinez‐Macias, Karla P.; Harding, Simon D.; Kato, Nobutaka; Lee, Marcus C.S.; Luth, Madeline R.; Mazitschek, Ralph; Mittal, Nimisha; Niles, Jacquin C.; Okombo, John; Ottilie, Sabine; Pasaje, Charisse Flerida A.; Probst, Alexandra S.; Rawat, Mukul; Rocamora, Frances; Sakata‐Kato, Tomoyo; Southan, Christopher; Spedding, Michael; Tye, Mark A.; Yang, Tuo; Zhao, Na; Davies, Jamie A.

Abstract

Antimalarial drug discovery has until recently been driven by high-throughput phenotypic cellular screening, allowing millions of compounds to be assayed and delivering clinical drug candidates. In this review, we will focus on target-based approaches, describing recent advances in our understanding of druggable targets in the malaria parasite. Targeting multiple stages of the Plasmodium lifecycle, rather than just the clinically symptomatic asexual blood stage, has become a requirement for new antimalarial medicines, and we link pharmacological data clearly to the parasite stages to which it applies. Finally, we highlight the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY, a web resource developed for the malaria research community that provides open and optimized access to published data on malaria pharmacology.

Citation

Armstrong, J. F., Campo, B., Alexander, S. P., Arendse, L. B., Cheng, X., Davenport, A. P., Faccenda, E., Fidock, D. A., Godinez‐Macias, K. P., Harding, S. D., Kato, N., Lee, M. C., Luth, M. R., Mazitschek, R., Mittal, N., Niles, J. C., Okombo, J., Ottilie, S., Pasaje, C. F. A., Probst, A. S., …Davies, J. A. (2023). Advances in malaria pharmacology and the online guide to MALARIA PHARMACOLOGY: IUPHAR review 38. British Journal of Pharmacology, 180(15), 1899-1929. https://doi.org/10.1111/bph.16144

• Journal Article Type: Article
• Acceptance Date: May 15, 2023
• Online Publication Date: May 17, 2023
• Publication Date: 2023-08
• Deposit Date: May 19, 2023
• Publicly Available Date: May 30, 2023
• Journal: British Journal of Pharmacology
• Print ISSN: 0007-1188
• Electronic ISSN: 1476-5381
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 180
• Issue: 15
• Pages: 1899-1929
• DOI: https://doi.org/10.1111/bph.16144
• Keywords: Bioinformatics; database; drug discovery; malaria; molecular target; Plasmodium
• Public URL: https://nottingham-repository.worktribe.com/output/20841941
• Publisher URL: https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16144
• Additional Information: © 2023 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.