CovidNeuroOnc: a UK multi-centre, prospective cohort study of the impact of the COVID-19 pandemic on the neuro-oncology service

Fountain, Daniel M; Piper, Rory J; Poon, Michael T C; Solomou, Georgios; Brennan, Paul M; Chowdhury, Yasir A; Colombo, Francesca; Elmoslemany, Tarek; Ewbank, Frederick G; Grundy, Paul L; Hasan, Md Tanvir; Karabatsou, Konstantina; Hilling, Molly; Hutchinson, Peter J; Kolias, Angelos G; McSorley, Nathan J; Millward, Christopher P; Phang, Isaac; Plaha, Puneet; Price, Stephen J; Rominiyi, Ola; Sage, William; Shumon, Syed; Silva, Ines L; Smith, Stuart J; Surash, Surash; Thomson, Simon; Lau, Jun Yi; Watts, Colin; Jenkinson, Michael D

Abstract

Background: The COVID-19 pandemic has profoundly affected cancer services. Our objective was to determine the effect of the COVID-19 pandemic on decision making and the resulting outcomes for patients with newly diagnosed or recurrent intracranial tumours.

Methods: We performed a multi-centre prospective study of all adult patients discussed in weekly neuro-oncology and skull base multidisciplinary team meetings who had a newly diagnosed or recurrent intracranial (excluding pituitary) tumour between 01 April and 31 May 2020. All patients had at least 30-day follow-up data. Descriptive statistical reporting was used.

Results: There were 1357 referrals for newly diagnosed or recurrent intracranial tumours across fifteen neuro-oncology centres. Of centres with all intracranial tumours, a change in initial management was reported in 8.6% of cases (n=104/1210). Decisions to change the management plan reduced over time from a peak of 19% referrals at the start of the study to 0% by the end of the study period. Changes in management were reported in 16% (n=75/466) of cases previously recommended for surgery and 28% of cases previously recommended for chemotherapy (n=20/72). The reported SARS-CoV-2 infection rate was similar in surgical and non-surgical patients (2.6% vs. 2.4%, p>0.9).

Conclusions: Disruption to neuro-oncology services in the UK caused by the COVID-19 pandemic was most marked in the first month, affecting all diagnoses. Patients considered for chemotherapy were most affected. In those recommended surgical treatment this was successfully completed. Longer-term outcome data will evaluate oncological treatments received by these patients and overall survival.

Citation

Fountain, D. M., Piper, R. J., Poon, M. T. C., Solomou, G., Brennan, P. M., Chowdhury, Y. A., Colombo, F., Elmoslemany, T., Ewbank, F. G., Grundy, P. L., Hasan, M. T., Karabatsou, K., Hilling, M., Hutchinson, P. J., Kolias, A. G., McSorley, N. J., Millward, C. P., Phang, I., Plaha, P., Price, S. J., …Jenkinson, M. D. (2021). CovidNeuroOnc: a UK multi-centre, prospective cohort study of the impact of the COVID-19 pandemic on the neuro-oncology service. Neuro-Oncology Advances, 3(1), Article vdab014. https://doi.org/10.1093/noajnl/vdab014

• Journal Article Type: Article
• Acceptance Date: Jan 19, 2021
• Online Publication Date: Jan 28, 2021
• Publication Date: 2021
• Deposit Date: Apr 27, 2021
• Publicly Available Date: Apr 29, 2021
• Journal: Neuro-Oncology Advances
• Electronic ISSN: 2632-2498
• Publisher: Oxford University Press (OUP)
• Peer Reviewed: Peer Reviewed
• Volume: 3
• Issue: 1
• Article Number: vdab014
• DOI: https://doi.org/10.1093/noajnl/vdab014
• Public URL: https://nottingham-repository.worktribe.com/output/5498344
• Publisher URL: https://academic.oup.com/noa/advance-article/doi/10.1093/noajnl/vdab014/6121868