The Regulation of m6A Modification in Glioblastoma: Functional Mechanisms and Therapeutic Approaches

Deacon, Simon; Walker, Lauryn; Radhi, Masar; Smith, Stuart

Abstract

Glioblastoma is the most prevalent primary brain tumour and invariably confers a poor prognosis. The immense intra-tumoral heterogeneity of glioblastoma and its ability to rapidly develop treatment resistance are key barriers to successful therapy. As such, there is an urgent need for the greater understanding of the tumour biology in order to guide the development of novel therapeutics in this field. N6-methyladenosine (m6A) is the most abundant of the RNA modifications in eukaryotes. Studies have demonstrated that the regulation of this RNA modification is altered in glioblastoma and may serve to regulate diverse mechanisms including glioma stem-cell self-renewal, tumorigenesis, invasion and treatment evasion. However, the precise mechanisms by which m6A modifications exert their functional effects are poorly understood. This review summarises the evidence for the disordered regulation of m6A in glioblastoma and discusses the downstream functional effects of m6A modification on RNA fate. The wide-ranging biological consequences of m6A modification raises the hope that novel cancer therapies can be targeted against this mechanism.

Citation

Deacon, S., Walker, L., Radhi, M., & Smith, S. (2023). The Regulation of m6A Modification in Glioblastoma: Functional Mechanisms and Therapeutic Approaches. Cancers, 15(13), Article 3307. https://doi.org/10.3390/cancers15133307

• Journal Article Type: Article
• Acceptance Date: Jun 20, 2023
• Online Publication Date: Jun 23, 2023
• Publication Date: Jul 1, 2023
• Deposit Date: Jul 3, 2023
• Publicly Available Date: Jul 5, 2023
• Journal: Cancers
• Electronic ISSN: 2072-6694
• Publisher: MDPI
• Peer Reviewed: Peer Reviewed
• Volume: 15
• Issue: 13
• Article Number: 3307
• DOI: https://doi.org/10.3390/cancers15133307
• Keywords: RNA methylation, glioblastoma, epitranscriptomics
• Public URL: https://nottingham-repository.worktribe.com/output/22455118
• Publisher URL: https://www.mdpi.com/2072-6694/15/13/3307