Paula Muresan
Evaluation of cannabidiol nanoparticles and nanoemulsion biodistribution in the central nervous system after intrathecal administration for the treatment of pain
Muresan, Paula; Woodhams, Stephen; Smith, Fiona; Taresco, Vincenzo; Shah, Jaymin; Wong, Mei; Chapman, Victoria; Smith, Stuart; Hathway, Gareth; Rahman, Ruman; Gershkovich, Pavel; Marlow, Maria
Authors
STEPHEN WOODHAMS STEPHEN.WOODHAMS@NOTTINGHAM.AC.UK
Teaching Associate Neuroscience (Fixed T
Fiona Smith
VINCENZO TARESCO VINCENZO.TARESCO@NOTTINGHAM.AC.UK
Nottingham Research Fellow
Jaymin Shah
Mei Wong
Professor VICTORIA CHAPMAN VICTORIA.CHAPMAN@NOTTINGHAM.AC.UK
Professor of Neuropharmacology
STUART SMITH stuart.smith@nottingham.ac.uk
Clinical Associate Professor
GARETH HATHWAY gareth.hathway@nottingham.ac.uk
Professor of Neuroscience
RUMAN RAHMAN RUMAN.RAHMAN@NOTTINGHAM.AC.UK
Professor of Molecular Neuro-Oncology
PAVEL GERSHKOVICH PAVEL.GERSHKOVICH@NOTTINGHAM.AC.UK
Associate Professor
MARIA MARLOW Maria.Marlow@nottingham.ac.uk
Associate Professor
Abstract
We investigated how the biodistribution of cannabidiol (CBD) within the central nervous system (CNS) is influenced by two different formulations, an oil-in-water (O/W) nanoemulsion and polymer-coated nanoparticles (PCNPs). We observed that both CBD formulations administered were preferentially retained in the spinal cord, with high concentrations reaching the brain within 10 min of administration. The CBD nanoemulsion reached Cmax in the brain at 210 ng/g within 120 min (Tmax), whereas the CBD PCNPs had a Cmax of 94 ng/g at 30 min (Tmax), indicating that rapid brain delivery can be achieved through the use of PCNPs. Moreover, the AUC0–4 h of CBD in the brain was increased 3.7-fold through the delivery of the nanoemulsion as opposed to the PCNPs, indicating higher retention of CBD at this site. Both formulations exhibited immediate anti-nociceptive effects in comparison to the respective blank formulations.
Citation
Muresan, P., Woodhams, S., Smith, F., Taresco, V., Shah, J., Wong, M., …Marlow, M. (2023). Evaluation of cannabidiol nanoparticles and nanoemulsion biodistribution in the central nervous system after intrathecal administration for the treatment of pain. Nanomedicine: Nanotechnology, Biology and Medicine, 49, Article 102664. https://doi.org/10.1016/j.nano.2023.102664
Journal Article Type | Article |
---|---|
Acceptance Date | Feb 3, 2023 |
Online Publication Date | Mar 7, 2023 |
Publication Date | 2023-04 |
Deposit Date | Mar 8, 2023 |
Publicly Available Date | Mar 10, 2023 |
Journal | Nanomedicine: Nanotechnology, Biology and Medicine |
Print ISSN | 1549-9634 |
Electronic ISSN | 1549-9642 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 49 |
Article Number | 102664 |
DOI | https://doi.org/10.1016/j.nano.2023.102664 |
Keywords | Drug-delivery, Polymer-coated nanoparticles, Intrathecal, Nanoemulsion, Cannabidiol |
Public URL | https://nottingham-repository.worktribe.com/output/18229717 |
Publisher URL | https://www.sciencedirect.com/science/article/pii/S1549963423000151?via%3Dihub |
Files
1-s2.0-S1549963423000151-main
(1.3 Mb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
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