Novel Use of Manganese Gluconate as a Marker for Visualization of Tablet Dissolution in the Fed Human Stomach Using Magnetic Resonance Imaging

Akbar, Tejal; Gershkovich, Pavel; Stamatopoulos, Konstantinos; Gowland, Penny; Stolnik, Snow; Butler, James; Marciani, Luca

Abstract

Magnetic resonance imaging (MRI) of dry or solid materials in the gastrointestinal (GI) tract requires the use of contrast agents to enhance visualisation of the dosage forms. In this study, we explore the novel use of manganese gluconate added to tablets. Manganese was released during tablet dissolution, generating a bright ‘halo’ effect around the tablets, consistent with shortening of the longitudinal relaxation time of the bulk water surrounding the tablet. This is the first study to use MRI to directly image tablet dissolution in the fed stomach using a manganese gluconate contrast agent as dissolution marker.

Citation

Akbar, T., Gershkovich, P., Stamatopoulos, K., Gowland, P., Stolnik, S., Butler, J., & Marciani, L. (2024). Novel Use of Manganese Gluconate as a Marker for Visualization of Tablet Dissolution in the Fed Human Stomach Using Magnetic Resonance Imaging. Molecular Pharmaceutics, https://doi.org/10.1021/acs.molpharmaceut.4c00854

• Journal Article Type: Article
• Acceptance Date: Dec 3, 2024
• Online Publication Date: Dec 5, 2024
• Publication Date: Dec 5, 2024
• Deposit Date: Dec 4, 2024
• Publicly Available Date: Dec 6, 2025
• Journal: Molecular Pharmaceutics
• Print ISSN: 1543-8384
• Electronic ISSN: 1543-8392
• Publisher: American Chemical Society
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1021/acs.molpharmaceut.4c00854
• Public URL: https://nottingham-repository.worktribe.com/output/42814754
• Publisher URL: https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.4c00854