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Outputs (721)

Eradication of Helicobacter pylori for prevention of aspirin-associated peptic ulcer bleeding in adults over 65 years: the HEAT RCT (2025)
Journal Article
Hawkey, C., J Avery, A., AC Coupland, C., Crooks, C. J., S Dumbleton, J., Richard Hobbs, F., Kendrick, D., Moore, M., Morris, C., Rubin, G., Smith, M., & Stevenson, D. (2025). Eradication of Helicobacter pylori for prevention of aspirin-associated peptic ulcer bleeding in adults over 65 years: the HEAT RCT. Health Technology Assessment, 29(42), https://doi.org/10.3310/LLKF7871

Background
Peptic ulcers in patients on aspirin are associated with Helicobacter pylori infection. We investigated whether H. pylori eradication would protect against aspirin-associated ulcer bleeding.

Methods
The Helicobacter Eradication Aspiri... Read More about Eradication of Helicobacter pylori for prevention of aspirin-associated peptic ulcer bleeding in adults over 65 years: the HEAT RCT.

The Experiences of Endometriosis Patients During Primary Healthcare Encounters: A Systematic Review of Qualitative Evidence (2025)
Journal Article
Harris, S., J. Tata, L., Qureshi, N., Read, K., & Bains, M. (2025). The Experiences of Endometriosis Patients During Primary Healthcare Encounters: A Systematic Review of Qualitative Evidence. Women's Reproductive Health, https://doi.org/10.1080/23293691.2025.2545308

Endometriosis affects 10% of those assigned-female-at-birth worldwide. Diagnosis typically takes between 5–12 years. This qualitative systematic review explored endometriosis patients’ experiences with primary healthcare professionals from presentati... Read More about The Experiences of Endometriosis Patients During Primary Healthcare Encounters: A Systematic Review of Qualitative Evidence.

Co-prescribing of antidepressants and opioids for non-cancer pain in England, 2010–2019: a descriptive study using CPRD primary care electronic health records (2025)
Journal Article
Butler, J., Joseph, R. M., Coupland, C., Knaggs, R. D., Avery, A. J., Morriss, R., Butler, D., Gerrard, L., Waldram, D., & Jack, R. H. (2025). Co-prescribing of antidepressants and opioids for non-cancer pain in England, 2010–2019: a descriptive study using CPRD primary care electronic health records. BMC Primary Care, 26, Article 254. https://doi.org/10.1186/s12875-025-02956-1

Background

There is a complex relationship between pain and mood disorders, and interactions between opioids and antidepressants can affect the effectiveness and adverse effects of these medicines when taken together. However, little is known abou... Read More about Co-prescribing of antidepressants and opioids for non-cancer pain in England, 2010–2019: a descriptive study using CPRD primary care electronic health records.

Temporal Trends in Medical and Surgical Management of Ulcerative Colitis in England: 2003–2020 (2025)
Journal Article
Couch, J., Thomas, K., Card, T. R., & Humes, D. J. (2025). Temporal Trends in Medical and Surgical Management of Ulcerative Colitis in England: 2003–2020. Alimentary Pharmacology and Therapeutics, https://doi.org/10.1111/apt.70319

Background
The medical management of ulcerative colitis (UC) is evolving. However, colectomy may be required in severe or refractory cases.

Aim
To provide contemporary evidence on medication usage and surgery for UC.

Methods
An incident coho... Read More about Temporal Trends in Medical and Surgical Management of Ulcerative Colitis in England: 2003–2020.

All-cause and non-colorectal cancer 1-year mortality among people having a faecal immunochemical test in primary care for investigation of symptoms of suspected colorectal cancer: an English cohort study (2025)
Journal Article
Malcolm, F. L., Crooks, C. J., West, J., Humes, D. J., & Langan, S. M. (2025). All-cause and non-colorectal cancer 1-year mortality among people having a faecal immunochemical test in primary care for investigation of symptoms of suspected colorectal cancer: an English cohort study. The Lancet Primary Care, Article 100007. https://doi.org/10.1016/j.lanprc.2025.100007

Background
High blood concentrations in stool, as determined by the faecal immunochemical test (FIT), in individuals screened for colorectal cancer are associated with increased mortality. To our knowledge, no studies to date have assessed whether t... Read More about All-cause and non-colorectal cancer 1-year mortality among people having a faecal immunochemical test in primary care for investigation of symptoms of suspected colorectal cancer: an English cohort study.

Determining the most frequent combinations of drugs prescribed prior to bullous pemphigoid diagnosis using association rule mining: a UK population-based case-control study (2025)
Journal Article
Swiderski, M. A., Figueredo, G., Vinogradova, Y., Knaggs, R. D., Harman, K. E., Harwood, R. H., Prasad, V., Persson, M. S., Layfield, C., & Gran, S. (2025). Determining the most frequent combinations of drugs prescribed prior to bullous pemphigoid diagnosis using association rule mining: a UK population-based case-control study. Clinical and Experimental Dermatology, https://doi.org/10.1093/ced/llaf362

Background

Bullous pemphigoid (BP) is a serious autoimmune skin disease affecting older people. Given the highly prevalent polypharmacy in older people, identifying drug combinations associated with high BP risk is needed.

Objectives

To iden... Read More about Determining the most frequent combinations of drugs prescribed prior to bullous pemphigoid diagnosis using association rule mining: a UK population-based case-control study.

Development of a digital, self-guided return-to-work toolkit for stroke survivors and employers using intervention mapping (2025)
Journal Article
Craven, K., Holmes, J., Kettlewell, J., & Radford, K. (2025). Development of a digital, self-guided return-to-work toolkit for stroke survivors and employers using intervention mapping. PLOS Digital Health, 4(8), Article e0000971. https://doi.org/10.1371/journal.pdig.0000971

Stroke incidence is rising among working-age adults in high-income countries. Employers often lack knowledge and skills to support return-to-work post-stroke. In the United Kingdom, nearly 40% of stroke survivors stop working. Vocational rehabilitati... Read More about Development of a digital, self-guided return-to-work toolkit for stroke survivors and employers using intervention mapping.

Examining variations in the prevalence of hazardous opioid prescribing across general practices in England: a cross-sectional study (2025)
Journal Article
Chen, T.-C., Trafford, A. M., Carr, M. J., Bansal, N., Kontopantelis, E., Avery, A., Chen, L.-C., & Ashcroft, D. M. (2025). Examining variations in the prevalence of hazardous opioid prescribing across general practices in England: a cross-sectional study. BMJ Quality and Safety, https://doi.org/10.1136/bmjqs-2025-018794

Background Prescribed opioids are potent analgesics associated with high safety risks due to their adverse effects, drug-drug and drug-disease interactions and potential for dependency. To support the implementation of prescribing indicators for furt... Read More about Examining variations in the prevalence of hazardous opioid prescribing across general practices in England: a cross-sectional study.