Neuromedin U
(2013)
Book Chapter
Jethwa, P. H., Small, C. J., Patterson, M., & Bloom, S. R. (2013). Neuromedin U. In A. Kastin (Ed.), Handbook of Biologically Active Peptides (Second Edition) (856-862). Elsevier. https://doi.org/10.1016/B978-0-12-385095-9.00114-7
Outputs (33)
Peripheral administration of prokineticin 2 potently reduces food intake and body weight in mice via the brainstem (2012)
Journal Article
Beale, K., Gardiner, J., Bewick, G., Hostomska, K., Patel, N., Hussain, S., Jayasena, C., Ebling, F., Jethwa, P., Prosser, H., Lattanzi, R., Negri, L., Ghatei, M., Bloom, S., & Dhillo, W. (2013). Peripheral administration of prokineticin 2 potently reduces food intake and body weight in mice via the brainstem. British Journal of Pharmacology, 168(2), 403-410. https://doi.org/10.1111/j.1476-5381.2012.02191.xBackground and Purpose Prokineticin 2 (PK2) has recently been shown to acutely reduce food intake in rodents. We aimed to determine the CNS sites and receptors that mediate the anorectic effects of peripherally administered PK2 and its chronic effect... Read More about Peripheral administration of prokineticin 2 potently reduces food intake and body weight in mice via the brainstem.
Effects of manipulating hypothalamic triiodothyronine concentrations on seasonal body weight and torpor cycles in Siberian hamsters (2012)
Journal Article
Murphy, M., Jethwa, P. H., Warner, A., Barrett, P., Nilaweera, K. N., Brameld, J. M., & Ebling, F. J. (2012). Effects of manipulating hypothalamic triiodothyronine concentrations on seasonal body weight and torpor cycles in Siberian hamsters. Endocrinology, 153(1), 101-112. https://doi.org/10.1210/en.2011-1249Siberian hamsters display photoperiodically regulated annual cycles in body weight, appetite, and reproduction. Previous studies have revealed a profound up-regulation of type 3 deiodinase (DIO3) mRNA in the ventral ependyma of the hypothalamus assoc... Read More about Effects of manipulating hypothalamic triiodothyronine concentrations on seasonal body weight and torpor cycles in Siberian hamsters.
Histaminergic regulation of seasonal metabolic rhythms in Siberian hamsters (2011)
Journal Article
I'Anson, H., Jethwa, P. H., Warner, A., & Ebling, F. J. (2011). Histaminergic regulation of seasonal metabolic rhythms in Siberian hamsters. Physiology and Behavior, 103(3-4), 268-278. https://doi.org/10.1016/j.physbeh.2011.02.035We investigated whether histaminergic tone contributes to the seasonal catabolic state in Siberian hamsters by determining the effect of ablation of histaminergic neurons on food intake, metabolic rate and body weight. A ribosomal toxin (saporin) con... Read More about Histaminergic regulation of seasonal metabolic rhythms in Siberian hamsters.
Effects of photoperiod on daily locomotor activity, energy expenditure, and feeding behavior in a seasonal mammal (2010)
Journal Article
Warner, A., Jethwa, P. H., Wyse, C. A., I'Anson, H., Brameld, J. M., & Ebling, F. J. (2010). Effects of photoperiod on daily locomotor activity, energy expenditure, and feeding behavior in a seasonal mammal. AJP - Regulatory, Integrative and Comparative Physiology, 298(5), R1409-R1416. https://doi.org/10.1152/ajpregu.00279.2009The objective of this study was to determine whether the previously observed effects of photoperiod on body weight in Siberian hamsters were due to changes in the daily patterns of locomotor activity, energy expenditure, and/or feeding behavior. Adul... Read More about Effects of photoperiod on daily locomotor activity, energy expenditure, and feeding behavior in a seasonal mammal.
Short-days induce weight loss in siberian hamsters despite overexpression of the agouti-related peptide gene (2010)
Journal Article
Jethwa, P. H., Warner, A., Fowler, M. J., Murphy, M., de Backer, M. W., Adan, R. A., Barrett, P., Brameld, J. M., & Ebling, F. J. (2010). Short-days induce weight loss in siberian hamsters despite overexpression of the agouti-related peptide gene. Journal of Neuroendocrinology, 22(6), 564-575. https://doi.org/10.1111/j.1365-2826.2010.02001.xMany vertebrates express profound annual cycles of body fattening, although it is not clear whether these represent differential activity of the central pathways known to mediate homeostatic control of food intake and energy expenditure, or whether t... Read More about Short-days induce weight loss in siberian hamsters despite overexpression of the agouti-related peptide gene.
Prokineticin 2 is a hypothalamic neuropeptide that potently inhibits food intake (2009)
Journal Article
Gardiner, J. V., Bataveljic, A., Patel, N. A., Bewick, G. A., Roy, D., Campbell, D., Greenwood, H. C., Murphy, K. G., Hameed, S., Jethwa, P. H., Ebling, F. J., Vickers, S. P., Cheetham, S., Ghatei, M. A., Bloom, S. R., & Dhillo, W. S. (2010). Prokineticin 2 is a hypothalamic neuropeptide that potently inhibits food intake. Diabetes, 59(2), 397-406. https://doi.org/10.2337/db09-1198OBJECTIVE-Prokineticin 2 (PK2) is a hypothalamic neuropeptide expressed in central nervous system areas known to be involved in food intake. We therefore hypothesized that PK2 plays a role in energy homeostasis. RESEARCH DESIGN AND METHODS - We inves... Read More about Prokineticin 2 is a hypothalamic neuropeptide that potently inhibits food intake.
The role of histamine 3 receptors in the control of food intake in a seasonal model of obesity: The Siberian hamster (2009)
Journal Article
Jethwa, P. H., Barrett, P., Turnbull, Y., Enright, R. A., Warner, A., Murphy, M., & Ebling, F. J. (2009). The role of histamine 3 receptors in the control of food intake in a seasonal model of obesity: The Siberian hamster. Behavioural Pharmacology, 20(2), 155-165. https://doi.org/10.1097/FBP.0b013e32832a8099Siberian hamsters develop hypophagia and increase catabolism of fat reserves in response to short photoperiods resulting in a natural loss of body weight in winter. We previously found that histamine 3 receptor (H3R) mRNA in the posterior hypothalamu... Read More about The role of histamine 3 receptors in the control of food intake in a seasonal model of obesity: The Siberian hamster.
Loss of prokineticin receptor 2 signaling predisposes mice to torpor (2008)
Journal Article
Jethwa, P. H., I'Anson, H., Warner, A., Prosser, H. M., Hastings, M. H., Maywood, E. S., & Ebling, F. J. (2008). Loss of prokineticin receptor 2 signaling predisposes mice to torpor. AJP - Regulatory, Integrative and Comparative Physiology, 294(6), R1968-R1979. https://doi.org/10.1152/ajpregu.00778.2007The genes encoding prokineticin 2 polypeptide (Prok2) and its cognate receptor (Prokr2/Gpcr73l1) are widely expressed in both the suprachiasmatic nucleus and its hypothalamic targets, and this signaling pathway has been implicated in the circadian re... Read More about Loss of prokineticin receptor 2 signaling predisposes mice to torpor.
Role of VGF-derived peptides in the control of food intake, body weight and reproduction (2008)
Journal Article
Jethwa, P. H., & Ebling, F. J. P. (2008). Role of VGF-derived peptides in the control of food intake, body weight and reproduction. Neuroendocrinology, 88(2), 80-87. https://doi.org/10.1159/000127319VGF is a 68-kDa polypeptide synthesized in neuronal and neuroendocrine cells. It is cleaved into a number of smaller peptides which are stored in dense core vesicles and are likely to be secreted products. The VGF gene is expressed abundantly in the... Read More about Role of VGF-derived peptides in the control of food intake, body weight and reproduction.