Outputs (47)

Characterising the Concentration-Dependent Behaviour of Heat-Treated Sunflower Oleosomes at an Air-Water Interface (2024)
Journal Article
Aliyari, A., di Bari, V., Ratcliffe, L. P., Borah, P. K., Dong, Y., & Gray, D. (2025). Characterising the Concentration-Dependent Behaviour of Heat-Treated Sunflower Oleosomes at an Air-Water Interface. Food Hydrocolloids, 162, Article 110896. https://doi.org/10.1016/j.foodhyd.2024.110896

The behaviour of fresh and heat-treated sunflower oleosomes (oil bodies) at the air-water interface was studied using a force tensiometer with a conventional method and a new approach based on the fresh interface formation. Oleosomes were recovered u... Read More about Characterising the Concentration-Dependent Behaviour of Heat-Treated Sunflower Oleosomes at an Air-Water Interface.

Rapeseed oleosomes facilitate intestinal lymphatic delivery and oral bioavailability of cannabidiol (2024)
Journal Article
Ji, L., Feng, W., Chen, H., Chu, Y., Wong, A., Zhu, Y., Sinatra, G., Bramante, F., Carrière, F., Stocks, M. J., di Bari, V., Gray, D. A., & Gershkovich, P. (2025). Rapeseed oleosomes facilitate intestinal lymphatic delivery and oral bioavailability of cannabidiol. International Journal of Pharmaceutics, 668, Article 124947. https://doi.org/10.1016/j.ijpharm.2024.124947

Due to high lipophilicity and extensive first-pass metabolic loss, cannabidiol (CBD) has low oral bioavailability. Co-administration of CBD and long-chain lipids facilitates the intestinal lymphatic delivery, resulting in higher systemic bioavailabil... Read More about Rapeseed oleosomes facilitate intestinal lymphatic delivery and oral bioavailability of cannabidiol.

Evaluation of Chlamydomonas reinhardtii Microalgae as a Sustainable Feed Supplement and Fishmeal Substitute in Aquaculture with a Positive Impact on Human Nutrition (2023)
Journal Article
Darwish, R. M., Magee, K. J., Gedi, M. A., Farmanfarmaian, A., Zaky, A. S., Young, I., & Gray, D. A. (2023). Evaluation of Chlamydomonas reinhardtii Microalgae as a Sustainable Feed Supplement and Fishmeal Substitute in Aquaculture with a Positive Impact on Human Nutrition. Fermentation, 9(7), Article 682. https://doi.org/10.3390/fermentation9070682

Currently, there is an urgent need for the growing aquaculture sector to rely on sustainable ingredients which can achieve optimal growth while maintaining fish’s nutritional value (especially omega-3 fatty acid content) for human consumption. Here,... Read More about Evaluation of Chlamydomonas reinhardtii Microalgae as a Sustainable Feed Supplement and Fishmeal Substitute in Aquaculture with a Positive Impact on Human Nutrition.

In situ monitoring of galactolipid digestion by infrared spectroscopy in both model micelles and spinach chloroplasts (2023)
Journal Article
Sahaka, M., Mateos-Diaz, E., Amara, S., Wattanakul, J., Gray, D., Lafont, D., Gontero, B., Launay, H., & Carrière, F. (2023). In situ monitoring of galactolipid digestion by infrared spectroscopy in both model micelles and spinach chloroplasts. Chemistry and Physics of Lipids, 252, 105291. https://doi.org/10.1016/j.chemphyslip.2023.105291

Galactolipids are the main lipids from plant photosynthetic membranes and they can be digested by pancreatic lipase related protein 2 (PLRP2), an enzyme found in the pancreatic secretion in many animal species. Here, we used transmission Fourier-tran... Read More about In situ monitoring of galactolipid digestion by infrared spectroscopy in both model micelles and spinach chloroplasts.

Chloroplast/thylakoid-rich material: A possible alternative to the chemically synthesised flow enhancer polyglycerol polyricinoleate in oil-based systems (2023)
Journal Article
Sutcharit, P., Wattanakul, J., Price, R., Di Bari, V., Gould, J., Yakubov, G., Wolf, B., & Gray, D. A. (2023). Chloroplast/thylakoid-rich material: A possible alternative to the chemically synthesised flow enhancer polyglycerol polyricinoleate in oil-based systems. Food Research International, 165, Article 112472. https://doi.org/10.1016/j.foodres.2023.112472

Chloroplasts are abundant organelles in a diverse range of plant materials; they are predominantly composed of multicomponent thylakoid membranes which are lipid and protein rich. Intact or unravelled thylakoid membranes should, in principle, have in... Read More about Chloroplast/thylakoid-rich material: A possible alternative to the chemically synthesised flow enhancer polyglycerol polyricinoleate in oil-based systems.

Linking the yield stress functionality of polyglycerol polyricinoleate in a highly filled suspension to its molecular properties (2022)
Journal Article
Price, R., Gray, D., Watson, N., Vieira, J., & Wolf, B. (2022). Linking the yield stress functionality of polyglycerol polyricinoleate in a highly filled suspension to its molecular properties. LWT - Food Science and Technology, 165, Article 113704. https://doi.org/10.1016/j.lwt.2022.113704

Polyglycerol polyricinoleate (PGPR) is a food emulsifier with a unique yield stress reducing efficacy in fat-based suspensions. There are many commercially available PGPRs, and the different products vary in their impact on the yield stress. Choosing... Read More about Linking the yield stress functionality of polyglycerol polyricinoleate in a highly filled suspension to its molecular properties.

Vegetable oils composition affects the intestinal lymphatic transport and systemic bioavailability of co-administered lipophilic drug cannabidiol (2022)
Journal Article
Feng, W., Qin, C., Abdelrazig, S., Bai, Z., Raji, M., Darwish, R., Chu, Y., Ji, L., Gray, D. A., Stocks, M. J., Constantinescu, C. S., Barrett, D. A., Fischer, P. M., & Gershkovich, P. (2022). Vegetable oils composition affects the intestinal lymphatic transport and systemic bioavailability of co-administered lipophilic drug cannabidiol. International Journal of Pharmaceutics, 624, Article 121947. https://doi.org/10.1016/j.ijpharm.2022.121947

Although natural sesame oil has been shown to facilitate the lymphatic delivery and oral bioavailability of the highly lipophilic drug cannabidiol (CBD), considerable variability remains an unresolved challenge. Vegetable oils differ substantially in... Read More about Vegetable oils composition affects the intestinal lymphatic transport and systemic bioavailability of co-administered lipophilic drug cannabidiol.

Bioaccessibility of essential lipophilic nutrients in a chloroplast-rich fraction (CRF) from agricultural green waste during simulated human gastrointestinal tract digestion (2022)
Journal Article
Wattanakul, J., Syamila, M., Darwish, R., Gedi, M. A., Sutcharit, P., Chi, C., Akepach, P., Sahaka, M., Gontero, B., Carrière, F., & Gray, D. A. (2022). Bioaccessibility of essential lipophilic nutrients in a chloroplast-rich fraction (CRF) from agricultural green waste during simulated human gastrointestinal tract digestion. Food and Function, 13(9), 5365-5380. https://doi.org/10.1039/d2fo00604a

An in vitro gastrointestinal human digestion model, with and without additional rapeseed oil, was used to measure the bioaccessibility of the major lipophilic nutrients enriched in chloroplasts: β-carotene; lutein; α-tocopherol; and α-linolenic acid.... Read More about Bioaccessibility of essential lipophilic nutrients in a chloroplast-rich fraction (CRF) from agricultural green waste during simulated human gastrointestinal tract digestion.

Bioaccessibility of carotenoids (β-carotene and lutein) from intact and disrupted microalgae (Chlamydomonas reinhardtii) (2022)
Journal Article
Akepach, P., Ribeiro-Filho, N., Wattanakul, J., Darwish, R., Gedi, M. A., & Gray, D. A. (2022). Bioaccessibility of carotenoids (β-carotene and lutein) from intact and disrupted microalgae (Chlamydomonas reinhardtii). LWT - Food Science and Technology, 160, Article 113292. https://doi.org/10.1016/j.lwt.2022.113292

Chlamydomonas reinhardtii (C. reinhardtii) has a potential as a novel source for food/feed because it contains several constituents including bioactive compounds. However, its multilayer cell wall (hydroxyproline-rich glycoprotein [HRPGs]) may restri... Read More about Bioaccessibility of carotenoids (β-carotene and lutein) from intact and disrupted microalgae (Chlamydomonas reinhardtii).

Is oral lipid-based delivery for drug targeting to the brain feasible? (2022)
Journal Article
Brookes, A., Ji, L., Bradshaw, T. D., Stocks, M., Gray, D., Butler, J., & Gershkovich, P. (2022). Is oral lipid-based delivery for drug targeting to the brain feasible?. European Journal of Pharmaceutics and Biopharmaceutics, 172, 112-122. https://doi.org/10.1016/j.ejpb.2022.02.004

This review outlines the feasibility of oral lipid-based targeted delivery of drugs to the brain, including permeation of the central nervous system's (CNS) protective blood–brain barrier (BBB). The structure of the BBB and disruption caused by varyi... Read More about Is oral lipid-based delivery for drug targeting to the brain feasible?.