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Exposure to bisphosphonates and risk of cancer: a protocol for nested caseecontrol studies using the QResearch primary care database (2012)
Journal Article
Vinogradova, Y., Coupland, C., & Hippisley-Cox, J. (2012). Exposure to bisphosphonates and risk of cancer: a protocol for nested caseecontrol studies using the QResearch primary care database. BMJ Open, 2(1), Article e000548. https://doi.org/10.1136/bmjopen-2011-000548

Introduction: Bisphosphonates are becoming
a common treatment for osteoporosis particularly after
discovery of the association between hormone
replacement therapy and increased risk of breast
cancer. As osteoporosis develops with age, treatment... Read More about Exposure to bisphosphonates and risk of cancer: a protocol for nested caseecontrol studies using the QResearch primary care database.

Who applies and who gets admitted to UK graduate entry medicine?: an analysis of UK admission statistics (2011)
Journal Article
Garrud, P. (2011). Who applies and who gets admitted to UK graduate entry medicine?: an analysis of UK admission statistics. BMC Medical Education, 11(Septem), Article 4. https://doi.org/10.1186/1472-6920-11-71

Background

Graduate-entry medicine is a recent development in the UK, intended to expand and broaden access to medical training. After eight years, it is time to evaluate its success in recruitment.

Objectives

This study aimed to compare th... Read More about Who applies and who gets admitted to UK graduate entry medicine?: an analysis of UK admission statistics.

Delayed publications of clinical trials in cystic fibrosis (2011)
Journal Article
Hurley, M., Prayle, A., & Smyth, A. R. (2011). Delayed publications of clinical trials in cystic fibrosis. Journal of Cystic Fibrosis, 11(1), https://doi.org/10.1016/j.jcf.2011.08.004

Background:

When the publication of important trial data is delayed, or data are never published, this will prevent the proper practice of evidence based medicine through robust systematic reviews. Clinical trial registries allow researchers to... Read More about Delayed publications of clinical trials in cystic fibrosis.

Maternal nutrient restriction during late gestation and early postnatal growth in sheep differentially reset the control of energy metabolism in the gastric mucosa (2011)
Journal Article
Sebert, S., Dellschaft, N., Chan, L., Street, H., Henry, M., Francois, C., Sharma, V., Fainberg, H. P., Patel, N., Roda, J., Keisler, D., Budge, H., & Symonds, M. E. (2011). Maternal nutrient restriction during late gestation and early postnatal growth in sheep differentially reset the control of energy metabolism in the gastric mucosa. Endocrinology, 152(7), https://doi.org/10.1210/en.2011-0169

Fetal growth restriction followed by accelerated postnatal growth contributes to impaired metabolic function in adulthood. The extent to which these outcomes may be mediated centrally within the hypothalamus, as opposed to in the periphery within the... Read More about Maternal nutrient restriction during late gestation and early postnatal growth in sheep differentially reset the control of energy metabolism in the gastric mucosa.

Review: The ubiquitin-proteasome system: contributions to cell death or survival in neurodegeneration (2010)
Journal Article
Rogers, N., Paine, S., Bedford, L., & Layfield, R. (2010). Review: The ubiquitin-proteasome system: contributions to cell death or survival in neurodegeneration. Neuropathology and Applied Neurobiology, 36(2), 113-124. https://doi.org/10.1111/j.1365-2990.2010.01063.x

The significance of the accumulation of ubiquitin-positive intraneuronal inclusions in the brains of those affected with different neurodegenerative diseases is currently unclear. While one interpretation is that the disease mechanism(s) involves dys... Read More about Review: The ubiquitin-proteasome system: contributions to cell death or survival in neurodegeneration.

A methodology to identify consensus classes from clustering algorithms applied to immunohistochemical data from breast cancer patients (2010)
Journal Article
Soria, D., Garibaldi, J. M., Ambrogi, F., Green, A. R., Powe, D., Rakha, E., Douglas Macmillan, R., Blamey, R. W., Ball, G., Lisboa, P. J., Etchells, T. A., Boracchi, P., Biganzoli, E. M., & Ellis, I. O. (2010). A methodology to identify consensus classes from clustering algorithms applied to immunohistochemical data from breast cancer patients. Computers in Biology and Medicine, 40(3), https://doi.org/10.1016/j.compbiomed.2010.01.003

Single clustering methods have often been used to elucidate clusters in high dimensional medical data, even though reliance on a single algorithm is known to be problematic. In this paper, we present a methodology to determine a set of ‘core classes’... Read More about A methodology to identify consensus classes from clustering algorithms applied to immunohistochemical data from breast cancer patients.

A qualitative investigation into the rehabilitation experience of patients following wrist fracture (2010)
Journal Article
Bamford, R., & Walker, D.-M. (2010). A qualitative investigation into the rehabilitation experience of patients following wrist fracture. Hand Therapy, 15(3), https://doi.org/10.1258/ht.2010.010013

Introduction. Fractures of the wrist are often highly traumatic, leading to significant pain and reduction in
an individual’s home, work and leisure roles for a considerable time. Among the studies on wrist fracture,
there is limited evidence which... Read More about A qualitative investigation into the rehabilitation experience of patients following wrist fracture.

Using the CLOX drawing task to educate the public of the effects of hearing loss (2010)
Journal Article
Quinn, S. C., Henshaw, H., Clark, D., Falck, C., & Smith, S. (2010). Using the CLOX drawing task to educate the public of the effects of hearing loss. Perception, 39(10), https://doi.org/10.1068/p6756

We describe a task used to educate the public on the importance of hearing and the experience of hearing loss. During an open day at Nottingham University, participants were presented with verbal instructions (with or without a background masker) and... Read More about Using the CLOX drawing task to educate the public of the effects of hearing loss.