Outputs (828)

Helicobacter pylori down-regulates expression of human ß-defensin 1 in the gastric mucosa in a type IV secretion dependent fashion (2013)
Journal Article
Patel, S., Smith, K., Letley, D., Cook, K., Memon, A., Ingram, R., Staples, E., Backert, S., Zaltoun, A., Atherton, J., & Robinson, K. (2013). Helicobacter pylori down-regulates expression of human ß-defensin 1 in the gastric mucosa in a type IV secretion dependent fashion. Cellular Microbiology, 15(12), https://doi.org/10.1111/cmi.12174

Helicobacter pylori establishes a chronic lifelong infection in the human gastric mucosa, which may lead to peptic ulcer disease or gastric adenocarcinoma. The human beta-defensins (hβDs) are antimicrobial peptides, hβD1 being constitutively expresse... Read More about Helicobacter pylori down-regulates expression of human ß-defensin 1 in the gastric mucosa in a type IV secretion dependent fashion.

Evaluation of the acoustic coordinated reset (CR ®) neuromodulation therapy for tinnitus: study protocol for a double-blind randomized placebo-controlled trial (2013)
Journal Article
Hoare, D. J., Pierzycki, R. H., Thomas, H., McAlpine, D., & Hall, D. A. (2013). Evaluation of the acoustic coordinated reset (CR ®) neuromodulation therapy for tinnitus: study protocol for a double-blind randomized placebo-controlled trial. Trials, 14(July), Article 8. https://doi.org/10.1186/1745-6215-14-207

Background
Current theories of tinnitus assume that the phantom sound is generated either through increased spontaneous activity of neurons in the auditory brain, or through pathological temporal firing patterns of the spontaneous neuronal discharge... Read More about Evaluation of the acoustic coordinated reset (CR ®) neuromodulation therapy for tinnitus: study protocol for a double-blind randomized placebo-controlled trial.

Changes in medical student and doctor attitudes toward older adults after an intervention: a systematic review (2013)
Journal Article
Samra, R., Griffiths, A., Cox, T., Conroy, S., & Knight, A. (2013). Changes in medical student and doctor attitudes toward older adults after an intervention: a systematic review. Journal of the American Geriatrics Society, 61(7), https://doi.org/10.1111/jgs.12312

Research investigating the effects of attitude-focused interventions on doctors' and medical students' attitudes toward older adults has produced mixed results. The objective of this systematic review was to determine whether factors pertaining to st... Read More about Changes in medical student and doctor attitudes toward older adults after an intervention: a systematic review.

A quantifier-based fuzzy classification system for breast cancer patients (2013)
Journal Article
Soria, D., Garibaldi, J. M., Green, A. R., Powe, D. G., Nolan, C. C., Lemetre, C., Ball, G. R., & Ellis, I. O. (2013). A quantifier-based fuzzy classification system for breast cancer patients. Artificial Intelligence in Medicine, 58(3), https://doi.org/10.1016/j.artmed.2013.04.006

Objectives:Recent studies of breast cancer data have identified seven distinct clinical phenotypes (groups) using immunohistochemical analysis and a range of different clustering techniques. Consensus between unsupervised classification algorithms ha... Read More about A quantifier-based fuzzy classification system for breast cancer patients.

Delayed gastric emptying and reduced postprandial small bowel water content of equicaloric whole meal bread versus rice meals in healthy subjects: novel MRI insights (2013)
Journal Article
Marciani, L., Pritchard, S. E., Hellier-Woods, C., Costigan, C., Hoad, C., Gowland, P. A., & Spiller, R. C. (2013). Delayed gastric emptying and reduced postprandial small bowel water content of equicaloric whole meal bread versus rice meals in healthy subjects: novel MRI insights. European Journal of Clinical Nutrition, 67(7), https://doi.org/10.1038/ejcn.2013.78

BACKGROUND/OBJECTIVES: Postprandial bloating is a common symptom in patients with functional gastrointestinal (GI) diseases. Whole meal bread (WMB) often aggravates such symptoms though the mechanisms are unclear. We used magnetic resonance imaging (... Read More about Delayed gastric emptying and reduced postprandial small bowel water content of equicaloric whole meal bread versus rice meals in healthy subjects: novel MRI insights.

Efficacy of RNA polymerase II inhibitors in targeting dormant leukaemia cells (2013)
Journal Article
Pallis, M., Burrows, F., Whittall, A., Boddy, N., Seedhouse, C., & Russell, N. (2013). Efficacy of RNA polymerase II inhibitors in targeting dormant leukaemia cells. BMC Pharmacology and Toxicology, 14(June), Article 11. https://doi.org/10.1186/2050-6511-14-32

Background
Dormant cells are characterised by low RNA synthesis. In contrast, cancer cells can be addicted to high RNA synthesis, including synthesis of survival molecules. We hypothesised that dormant cancer cells, already low in RNA, might be sens... Read More about Efficacy of RNA polymerase II inhibitors in targeting dormant leukaemia cells.

Occupational health professionals’ knowledge, understanding and use of work ability (2013)
Journal Article
Coomer, K., & Houdmont, J. (2013). Occupational health professionals’ knowledge, understanding and use of work ability. Occupational Medicine, 63(6), https://doi.org/10.1093/occmed/kqt070

BACKGROUND:
The concept of work ability (WA) has a 30-year history in Finland, where it has been used extensively in occupational health (OH) research and practice. The extent to which WA has been integrated into UK OH practice is unclear.
AIMS:
(... Read More about Occupational health professionals’ knowledge, understanding and use of work ability.

Safety of fluconazole in paediatrics: a systematic review (2013)
Journal Article
Egunsola, O., Adefurin, A., Fakis, A., Jacqz-Aigrain, E., Choonara, I., & Sammons, H. (2013). Safety of fluconazole in paediatrics: a systematic review. European Journal of Clinical Pharmacology, 69(6), https://doi.org/10.1007/s00228-012-1468-2

Purpose:
To determine the safety of fluconazole in neonates and other paediatric age groups by identifying adverse events (AEs) and drug interactions associated with treatment.

Methods:
A search of EMBASE (1950–January 2012), MEDLINE (1946–Jan... Read More about Safety of fluconazole in paediatrics: a systematic review.

The role of the WNT/β-catenin pathway in central nervous system primitive neuroectodermal tumours (CNS PNETs) (2013)
Journal Article
Rogers, H., Ward, J., Miller, S., Lowe, J., Coyle, B., & Grundy, R. G. (2013). The role of the WNT/β-catenin pathway in central nervous system primitive neuroectodermal tumours (CNS PNETs). British Journal of Cancer, 108, https://doi.org/10.1038/bjc.2013.170

Background: Central nervous system primitive neuroectodermal tumours (CNS PNETs) are embryonal tumours occurring predominantly in children. Current lack of knowledge regarding their underlying biology hinders development of more effective treatments... Read More about The role of the WNT/β-catenin pathway in central nervous system primitive neuroectodermal tumours (CNS PNETs).

Evaluation and development of a novel binocular treatment (I-BiT™) system using video clips and interactive games to improve vision in children with amblyopia (‘lazy eye’): study protocol for a randomised controlled trial (2013)
Journal Article
Foss, A. J., Gregson, R. M., MacKeith, D., Herbison, N., Ash, I. M., Cobb, S. V., Eastgate, R. M., Hepburn, T., Vivian, A., Moore, D., & Haworth, S. M. (2013). Evaluation and development of a novel binocular treatment (I-BiT™) system using video clips and interactive games to improve vision in children with amblyopia (‘lazy eye’): study protocol for a randomised controlled trial. Trials, 14(145), Article 145. https://doi.org/10.1186/1745-6215-14-145

Background: Amblyopia (lazy eye) affects the vision of approximately 2% of all children. Traditional treatment
consists of wearing a patch over their ‘good’ eye for a number of hours daily, over several months. This treatment is
unpopular and compl... Read More about Evaluation and development of a novel binocular treatment (I-BiT™) system using video clips and interactive games to improve vision in children with amblyopia (‘lazy eye’): study protocol for a randomised controlled trial.