Outputs (196)

Widefield, Spatiotemporal Mapping of Spontaneous Activity of Mouse Cultured Neuronal Networks Using Quantum Diamond Sensors (2020)
Journal Article
Price, J. C., Mesquita-Ribeiro, R., Dajas-Bailador, F., & Mather, M. L. (2020). Widefield, Spatiotemporal Mapping of Spontaneous Activity of Mouse Cultured Neuronal Networks Using Quantum Diamond Sensors. Frontiers in Physics, 8, Article 255. https://doi.org/10.3389/fphy.2020.00255

Quantum diamond sensors containing Nitrogen Vacancy (NV) centers were integrated into the culture of spontaneously electrically active cultures of live mouse primary cortical neurons. Two diamond formats were used enabling extracellular studies of ce... Read More about Widefield, Spatiotemporal Mapping of Spontaneous Activity of Mouse Cultured Neuronal Networks Using Quantum Diamond Sensors.

Using singular perturbation theory to determine kinetic parameters in a non-standard coupled enzyme assay (2020)
Journal Article
Dalwadi, M. P., Orol, D., Walter, F., Minton, N. P., King, J. R., & Kovács, K. (2020). Using singular perturbation theory to determine kinetic parameters in a non-standard coupled enzyme assay. Journal of Mathematical Biology, 81(2), 649-690. https://doi.org/10.1007/s00285-020-01524-8

We investigate how to characterize the kinetic parameters of an aminotransaminase using a non-standard coupled (or auxiliary) enzyme assay, where the peculiarity arises for two reasons. First, one of the products of the auxiliary enzyme is a substrat... Read More about Using singular perturbation theory to determine kinetic parameters in a non-standard coupled enzyme assay.

Adjuvant formulated virus-like particles expressing native-like forms of the Lassa virus envelope surface glycoprotein are immunogenic and induce antibodies with broadly neutralizing activity (2020)
Journal Article
Müller, H., Fehling, S. K., Dorna, J., Urbanowicz, R. A., Oestereich, L., Krebs, Y., Kolesnikova, L., Schauflinger, M., Krähling, V., Magassouba, N., Fichet-Calvet, E., Ball, J. K., Kaufmann, A., Bauer, S., Becker, S., von Messling, V., & Strecker, T. (2020). Adjuvant formulated virus-like particles expressing native-like forms of the Lassa virus envelope surface glycoprotein are immunogenic and induce antibodies with broadly neutralizing activity. npj Vaccines, 5, Article 71. https://doi.org/10.1038/s41541-020-00219-x

Lassa mammarenavirus (LASV) is a rodent-borne arenavirus endemic to several West African countries. It is the causative agent of human Lassa fever, an acute viral hemorrhagic fever disease. To date, no therapeutics or vaccines against LASV have obtai... Read More about Adjuvant formulated virus-like particles expressing native-like forms of the Lassa virus envelope surface glycoprotein are immunogenic and induce antibodies with broadly neutralizing activity.

PDCD4 regulates axonal growth by translational repression of neurite growth-related genes and is modulated during nerve injury responses (2020)
Journal Article
Di Paolo, A. P., Eastman, G., Mesquita Ribeiro, R., Farias, J., Macklin, A., Kislinger, T., Colburn, N., Munroe, D., Sotelo Sosa, J. R., Dajas Bailador, F., & Sotelo Silveira, J. R. (2020). PDCD4 regulates axonal growth by translational repression of neurite growth-related genes and is modulated during nerve injury responses. RNA, 26(11), 1637-1653. https://doi.org/10.1261/rna.075424.120

© 2020 Di Paolo et al. Programmed cell death 4 (PDCD4) protein is a tumor suppressor that inhibits translation through the mTOR-dependent initiation factor EIF4A, but its functional role and mRNA targets in neurons remain largely unknown. Our work id... Read More about PDCD4 regulates axonal growth by translational repression of neurite growth-related genes and is modulated during nerve injury responses.

Gaussia luciferase as a reporter for quorum sensing in staphylococcus aureus (2020)
Journal Article
Blower, I., Tong, C., Sun, X., Murray, E., Luckett, J., Chan, W., Williams, P., & Hill, P. (2020). Gaussia luciferase as a reporter for quorum sensing in staphylococcus aureus. Sensors, 20(15), 1-12. https://doi.org/10.3390/s20154305

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Gaussia luciferase (GLuc) is a secreted protein with significant potential for use as a reporter of gene expression in bacterial pathogenicity studies. To date there are relatively few example... Read More about Gaussia luciferase as a reporter for quorum sensing in staphylococcus aureus.

The impaired quorum sensing response of Pseudomonas aeruginosa MexAB-OprM efflux pump overexpressing mutants is not due to non-physiological efflux of 3-oxo-C12-HSL (2020)
Journal Article
Alcalde‐Rico, M., Olivares‐Pacheco, J., Halliday, N., Cámara, M., & Martínez, J. L. (2020). The impaired quorum sensing response of Pseudomonas aeruginosa MexAB-OprM efflux pump overexpressing mutants is not due to non-physiological efflux of 3-oxo-C12-HSL. Environmental Microbiology, 22(12), 5167-5188. https://doi.org/10.1111/1462-2920.15177

Multidrug (MDR) efflux pumps are ancient and conserved molecular machineries with relevant roles in different aspects of the bacterial physiology, besides antibiotic resistance. In the case of the environmental opportunistic pathogen Pseudomonas aeru... Read More about The impaired quorum sensing response of Pseudomonas aeruginosa MexAB-OprM efflux pump overexpressing mutants is not due to non-physiological efflux of 3-oxo-C12-HSL.

Philanthotoxin-343 attenuates retinal and optic nerve injury, and protects visual function in rats with N-methyl-D-aspartate-induced excitotoxicity (2020)
Journal Article
Fazel, M. F., Abu, I. F., Mohamad, M. H. N., Agarwal, R., Iezhitsa, I., Bakar, N. S., Juliana, N., Mellor, I. R., & Franzyk, H. (2020). Philanthotoxin-343 attenuates retinal and optic nerve injury, and protects visual function in rats with N-methyl-D-aspartate-induced excitotoxicity. PLoS ONE, 15(7), Article e0236450. https://doi.org/10.1371/journal.pone.0236450

Retinal ganglion cell (RGC) loss and optic neuropathy, both hallmarks of glaucoma, have been shown to involve N-methyl-D-aspartate receptor (NMDAR)-mediated excitotoxicity. This study investigated the neuroprotective effects of Philanthotoxin (PhTX)-... Read More about Philanthotoxin-343 attenuates retinal and optic nerve injury, and protects visual function in rats with N-methyl-D-aspartate-induced excitotoxicity.

The clinical usefulness of muscle mass and strength measures in older people: a systematic review (2020)
Journal Article
Lunt, E., Ong, T., Gordon, A. L., Greenhaff, P. L., & Gladman, J. R. F. (2021). The clinical usefulness of muscle mass and strength measures in older people: a systematic review. Age and Ageing, 50(1), 88-95. https://doi.org/10.1093/ageing/afaa123

Background: Sarcopenia is the loss of muscle mass and quality and is diagnosed using measures of muscle strength, size and mass. We evaluated the literature on whether sarcopenia measures are predictive of motor outcomes in older people in clinical... Read More about The clinical usefulness of muscle mass and strength measures in older people: a systematic review.

aMAP risk score predicts hepatocellular carcinoma development in patients with chronic hepatitis (2020)
Journal Article
Fan, R., Papatheodoridis, G., Sun, J., Innes, H., Toyoda, H., Xie, Q., Mo, S., Sypsa, V., Guha, I. N., Kumada, T., Niu, J., Dalekos, G., Yasuda, S., Barnes, E., Lian, J., Suri, V., Idilman, R., Barclay, S. T., Dou, X., Berg, T., …Hou, J. (2020). aMAP risk score predicts hepatocellular carcinoma development in patients with chronic hepatitis. Journal of Hepatology, 73(6), 1368-1378. https://doi.org/10.1016/j.jhep.2020.07.025

© 2020 European Association for the Study of the Liver Background & Aims: Hepatocellular carcinoma (HCC) is the leading cause of death in patients with chronic hepatitis. In this international collaboration, we sought to develop a global universal HC... Read More about aMAP risk score predicts hepatocellular carcinoma development in patients with chronic hepatitis.

A rational roadmap for SARS-CoV-2/COVID-19 pharmacotherapeutic research and development. IUPHAR Review 29 (2020)
Journal Article
Alexander, S. P., Armstrong, J., Davenport, A., Davies, J. A., Faccenda, E., Harding, S. D., Levi‐Schaffer, F., Maguire, J. J., Pawson, A. J., Southan, C., & Spedding, M. (2020). A rational roadmap for SARS-CoV-2/COVID-19 pharmacotherapeutic research and development. IUPHAR Review 29. British Journal of Pharmacology, 177(21), 4942-4966. https://doi.org/10.1111/bph.15094

This article is protected by copyright. All rights reserved. In this review, we identify opportunities for drug discovery in the treatment of COVID-19 and in so doing, provide a rational roadmap whereby pharmacology and pharmacologists can mitigate a... Read More about A rational roadmap for SARS-CoV-2/COVID-19 pharmacotherapeutic research and development. IUPHAR Review 29.