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Outputs (4)

Do turtles get cancer? (2025)
Journal Article
Glaberman, S., Bulls, S. E., Platner, L., Wagner, P., Dreyer, S., McCain, S., Burgstaller, S., Davis, L. R., Turner, H., Bruins-van Sonsbeek, L. G. R., Fischer, D., & Chiari, Y. (2025). Do turtles get cancer?. BioScience, 1-7. https://doi.org/10.1093/biosci/biaf100

Turtles are renowned for their extreme longevity and tremendous range in body size. Theoretically, large, long-lived organisms should face higher cancer risks because of increased cell numbers and lifetime cellular turnover, yet cancer appears to be... Read More about Do turtles get cancer?.

Assessing CometChip technology for DNA damage studies in non-model species: distinct UV-induced responses in turtles and mammals (2025)
Journal Article
Bulls, S. E., Finn, E., Sykora, P., Lynch, V. J., Pramanik, P., Glaberman, S., & Chiari, Y. (2025). Assessing CometChip technology for DNA damage studies in non-model species: distinct UV-induced responses in turtles and mammals. BMC Research Notes, 18(1), Article 243. https://doi.org/10.1186/s13104-025-07285-1

Objective: We evaluated the feasibility of using the high-throughput CometChip to assess DNA damage in non-model species. Specifically, we measured UVA-induced damage in fibroblasts from five turtle and four mammalian species with diverse life histor... Read More about Assessing CometChip technology for DNA damage studies in non-model species: distinct UV-induced responses in turtles and mammals.

Signaling dynamics in coexisting monoclonal cell subpopulations unveil mechanisms of resistance to anti-cancer compounds (2024)
Journal Article
Blanchard, C. E., Gomeiz, A. T., Avery, K., Gazzah, E. E., Alsubaie, A. M., Sikaroodi, M., Chiari, Y., Ward, C., Sanchez, J., Espina, V., Petricoin, E., Baldelli, E., & Pierobon, M. (2024). Signaling dynamics in coexisting monoclonal cell subpopulations unveil mechanisms of resistance to anti-cancer compounds. Cell Communication and Signaling, 22(1), Article 377. https://doi.org/10.1186/s12964-024-01742-3

Background: Tumor heterogeneity is a main contributor of resistance to anti-cancer targeted agents though it has proven difficult to study. Unfortunately, model systems to functionally characterize and mechanistically study dynamic responses to treat... Read More about Signaling dynamics in coexisting monoclonal cell subpopulations unveil mechanisms of resistance to anti-cancer compounds.

Thermal tolerance plasticity and dynamics of thermal tolerance in Eublepharis macularius: Implications for future climate-driven heat stress (2024)
Journal Article
White, E., Kim, S., Wegh, G., & Chiari, Y. (2024). Thermal tolerance plasticity and dynamics of thermal tolerance in Eublepharis macularius: Implications for future climate-driven heat stress. Journal of Thermal Biology, 123, Article 103912. https://doi.org/10.1016/j.jtherbio.2024.103912

The intensity and duration of heat waves, as well as average global temperatures, are expected to increase due to climate change. Heat waves can cause physiological stress and reduce fitness in animals. Species can reduce overheating risk through phe... Read More about Thermal tolerance plasticity and dynamics of thermal tolerance in Eublepharis macularius: Implications for future climate-driven heat stress.