Outputs (11)

Superspreaders have lower gut microbial alpha-diversity and distinct gut microbial composition in a natural rodent population (2025)
Journal Article
Wanelik, K. M., Begon, M., Bradley, J. E., Fenn, J., Jackson, J. A., & Paterson, S. (2025). Superspreaders have lower gut microbial alpha-diversity and distinct gut microbial composition in a natural rodent population. Animal Microbiome, 7, Article 42. https://doi.org/10.1186/s42523-025-00411-1

The microbiome is well known to drive variation in host states (e.g. behaviour, immunity) that would be expected to modulate the spread of infectious disease—but the role of microbiotal interactions in promoting superspreading is poorly understood. S... Read More about Superspreaders have lower gut microbial alpha-diversity and distinct gut microbial composition in a natural rodent population.

The adaptive immune response to Trichuris in wild versus laboratory mice: An established model system in context (2024)
Journal Article
Mair, I., Fenn, J., Wolfenden, A., Lowe, A. E., Bennett, A., Muir, A., Thompson, J., Dieumerci, O., Logunova, L., Shultz, S., Bradley, J. E., & Else, K. J. (2024). The adaptive immune response to Trichuris in wild versus laboratory mice: An established model system in context. PLoS Pathogens, 20(4), Article e1012119. https://doi.org/10.1371/journal.ppat.1012119

Laboratory model organisms have provided a window into how the immune system functions. An increasing body of evidence, however, suggests that the immune responses of naive laboratory animals may differ substantially to those of their wild counterpar... Read More about The adaptive immune response to Trichuris in wild versus laboratory mice: An established model system in context.

Sex drives colonic mucin sialylation in wild mice (2024)
Journal Article
Bennett, A. R., Mair, I., Muir, A., Smith, H., Logunova, L., Wolfenden, A., Fenn, J., Lowe, A. E., Bradley, J. E., Else, K. J., & Thornton, D. J. (in press). Sex drives colonic mucin sialylation in wild mice. Scientific Reports, 14, Article 6954. https://doi.org/10.1038/s41598-024-57249-x

Mucin protein glycosylation is important in determining biological properties of mucus gels, which form protective barriers at mucosal surfaces of the body such as the intestine. Ecological factors including: age, sex, and diet can change mucus barri... Read More about Sex drives colonic mucin sialylation in wild mice.

Understanding conceptus-maternal interactions: what tools do we need to develop? (2023)
Journal Article
Butt, Z., Tinning, H., O'Connell, M. J., Fenn, J., Alberio, R., & Forde, N. (2023). Understanding conceptus-maternal interactions: what tools do we need to develop?. Reproduction, Fertility and Development, 36(2), 81-92. https://doi.org/10.1071/RD23181

Communication between the maternal endometrium and developing embryo/conceptus is critical to support successful pregnancy to term. Studying the peri-implantation period of pregnancy is critical as this is when most pregnancy loss occurs in cattle. O... Read More about Understanding conceptus-maternal interactions: what tools do we need to develop?.

The wild mouse bone marrow has a unique myeloid and lymphoid composition and phenotype (2023)
Journal Article
Muir, A., Bennett, A., Smith, H., Logunova, L., Wolfenden, A., Fenn, J., Lowe, A. E., Brass, A., Grainger, J. R., Konkel, J. E., Bradley, J. E., Mair, I., & Else, K. J. (2023). The wild mouse bone marrow has a unique myeloid and lymphoid composition and phenotype. Discovery Immunology, 2(1), Article kyad005. https://doi.org/10.1093/discim/kyad005

The murine bone marrow has a central role in immune function and health as the primary source of leukocytes in adult mice. Laboratory mice provide a human-homologous, genetically manipulable and reproducible model that has enabled an immeasurable vol... Read More about The wild mouse bone marrow has a unique myeloid and lymphoid composition and phenotype.

Discrete patterns of microbiome variability across timescales in a wild rodent population (2023)
Journal Article
Fenn, J., Taylor, C., Goertz, S., Wanelik, K. M., Paterson, S., Begon, M., Jackson, J., & Bradley, J. (2023). Discrete patterns of microbiome variability across timescales in a wild rodent population. BMC Microbiology, 23, Article 87. https://doi.org/10.1186/s12866-023-02824-x

Mammalian gastrointestinal microbiomes are highly variable, both within individuals and across populations, with changes linked to time and ageing being widely reported. Discerning patterns of change in wild mammal populations can therefore prove cha... Read More about Discrete patterns of microbiome variability across timescales in a wild rodent population.

Parasitic nematodes of the genus Syphacia Seurat, 1916 infecting Cricetidae in the British Isles: The enigmatic status of Syphacia nigeriana (2021)
Journal Article
Behnke, J. M., Stewart, A., Smales, L., Cooper, G., Lowe, A., Kinsella, J. M., Bajer, A., Dwużnik-Szarek, D., Herman, J., Fenn, J., Catalano, S., Diagne, C. A., & Webster, J. P. (2022). Parasitic nematodes of the genus Syphacia Seurat, 1916 infecting Cricetidae in the British Isles: The enigmatic status of Syphacia nigeriana. Parasitology, 149(1), 76-94. https://doi.org/10.1017/S0031182021001578

Oxyurid nematodes (Syphacia spp.) from bank (Myodes glareolus) and field/common (Microtus spp.) voles, from disparate geographical sites in the British Isles, were examined morphologically and genetically. The genetic signatures of 118 new isolates a... Read More about Parasitic nematodes of the genus Syphacia Seurat, 1916 infecting Cricetidae in the British Isles: The enigmatic status of Syphacia nigeriana.

A lesson from the wild: The natural state of eosinophils is Ly6Ghi (2021)
Journal Article
Mair, I., Wolfenden, A., Lowe, A. E., Bennett, A., Muir, A., Smith, H., Fenn, J., Bradley, J. E., & Else, K. J. (2021). A lesson from the wild: The natural state of eosinophils is Ly6Ghi. Immunology, 164(4), 766-776. https://doi.org/10.1111/imm.13413

With a long history of promoting pathological inflammation, eosinophils are now emerging as important regulatory cells. Yet, findings from controlled laboratory experiments so far lack translation to animals, including humans, in their natural enviro... Read More about A lesson from the wild: The natural state of eosinophils is Ly6Ghi.

Relationships between immune gene expression and circulating cytokine levels in wild house mice (2020)
Journal Article
Young, S., Fenn, J., Arriero, E., Lowe, A., Poulin, B., MacColl, A. D., & Bradley, J. E. (2020). Relationships between immune gene expression and circulating cytokine levels in wild house mice. Ecology and Evolution, 10(24), 13860-13871. https://doi.org/10.1002/ece3.6976

Quantitative PCR (qPCR) has been commonly used to measure gene expression in a number of research contexts, but the measured RNA concentrations do not always represent the concentrations of active proteins which they encode. This can be due to transc... Read More about Relationships between immune gene expression and circulating cytokine levels in wild house mice.

Geographical location influences the composition of the gut microbiota in wild house mice (Mus musculus domesticus) at a fine spatial scale (2019)
Journal Article
Goertz, S., de Menezes, A. B., Birtles, R. J., Fenn, J., Lowe, A. E., MacColl, A. D., Poulin, B., Young, S., Bradley, J. E., & Taylor, C. H. (2019). Geographical location influences the composition of the gut microbiota in wild house mice (Mus musculus domesticus) at a fine spatial scale. PLoS ONE, 14(9), Article e0222501. https://doi.org/10.1371/journal.pone.0222501

The composition of the mammalian gut microbiota can be influenced by a multitude of environmental variables such as diet and infections. Studies investigating the effect of these variables on gut microbiota composition often sample across multiple se... Read More about Geographical location influences the composition of the gut microbiota in wild house mice (Mus musculus domesticus) at a fine spatial scale.