Outputs (3)

ROBIN: A unified nanopore-based assay integrating intraoperative methylome classification and next-day comprehensive profiling for ultra-rapid tumor diagnosis (2025)
Journal Article
Deacon, S., Cahyani, I., Holmes, N., Fox, G., Munro, R., Wibowo, S., Murray, T., Mason, H., Housley, M., Martin, D., Sharif, A., Patel, A., Goldspring, R., Brandner, S., Sahm, F., Smith, S., Paine, S., & Loose, M. (2025). ROBIN: A unified nanopore-based assay integrating intraoperative methylome classification and next-day comprehensive profiling for ultra-rapid tumor diagnosis. Neuro-Oncology, https://doi.org/10.1093/neuonc/noaf103

Background
Advances in our technological capacity to interrogate CNS tumor biology have led to the ever increasing use of genomic sequencing in diagnostic decision making. Presently, CNS tumors are classified based on their epigenetic signatures, le... Read More about ROBIN: A unified nanopore-based assay integrating intraoperative methylome classification and next-day comprehensive profiling for ultra-rapid tumor diagnosis.

An evaluation of spraying as a delivery method for human mesenchymal stem cells suspended in low-methyl pectin solutions (2025)
Journal Article
Nash, A., Lee, I.-N., Fox, G., Phillips, J., White, L. J., & Marlow, M. (2025). An evaluation of spraying as a delivery method for human mesenchymal stem cells suspended in low-methyl pectin solutions. Stem Cell Research and Therapy, 16(1), Article 246. https://doi.org/10.1186/s13287-025-04331-4

Background: Mesenchymal stem cells have shown promise in many areas of regenerative medicine due to the anti-inflammatory and pro-regenerative effects of the secreted factors. However, successful delivery remains problematic, particularly for deliver... Read More about An evaluation of spraying as a delivery method for human mesenchymal stem cells suspended in low-methyl pectin solutions.

Prospective, multicenter validation of a platform for rapid molecular profiling of central nervous system tumors (2025)
Journal Article
Patel, A., Göbel, K., Ille, S., Hinz, F., Schoebe, N., Bogumil, H., Meyer, J., Brehm, M., Kardo, H., Schrimpf, D., Lomakin, A., Ritter, M., Göller, P., Kerbs, P., Pfeifer, L., Hamelmann, S., Blume, C., Ippen, F. M., Berghaus, N., Euskirchen, P., …Sahm, F. (2025). Prospective, multicenter validation of a platform for rapid molecular profiling of central nervous system tumors. Nature Medicine, https://doi.org/10.1038/s41591-025-03562-5

Molecular data integration plays a central role in central nervous system (CNS) tumor diagnostics but currently used assays pose limitations due to technical complexity, equipment and reagent costs, as well as lengthy turnaround times. We previously... Read More about Prospective, multicenter validation of a platform for rapid molecular profiling of central nervous system tumors.