Outputs (77)

Hepatitis C virus quasispecies and pseudotype analysis from acute infection to chronicity in HIV-1 co-infected individuals (2016)
Journal Article
Ferns, R. B., Tarr, A. W., Hue, S., Urbanowicz, R. A., McClure, C. P., Gilson, R., Ball, J. K., Nastouli, E., Garson, J. A., & Pillay, D. (2016). Hepatitis C virus quasispecies and pseudotype analysis from acute infection to chronicity in HIV-1 co-infected individuals. Virology, 492, 213-224. https://doi.org/10.1016/j.virol.2016.02.003

HIV-1 infected patients who acquire HCV infection have higher rates of chronicity and liver disease progression than patients with HCV mono-infection. Understanding early events in this pathogenic process is important. We applied single genome sequen... Read More about Hepatitis C virus quasispecies and pseudotype analysis from acute infection to chronicity in HIV-1 co-infected individuals.

A diverse panel of hepatitis C virus glycoproteins for use in vaccine research reveals extremes of monoclonal antibody neutralization resistance (2015)
Journal Article
Urbanowicz, R. A., McClure, P., Brown, R. J., Tsoleridis, T., Persson, M. A., Krey, T., Irving, W. L., Ball, J. K., & Tarr, A. W. (2016). A diverse panel of hepatitis C virus glycoproteins for use in vaccine research reveals extremes of monoclonal antibody neutralization resistance. Journal of Virology, 90(7), 3288-3301. https://doi.org/10.1128/JVI.02700-15

Despite significant advances in the treatment of hepatitis C virus (HCV) infection, the need to develop preventative vaccines remains. Identification of the best vaccine candidates and evaluation of their performance in preclinical and clinical devel... Read More about A diverse panel of hepatitis C virus glycoproteins for use in vaccine research reveals extremes of monoclonal antibody neutralization resistance.

Genetic diversity underlying the envelope glycoproteins of hepatitis C virus: Structural and functional consequences and the implications for vaccine design (2015)
Journal Article
Tarr, A. W., Khera, T., Hueging, K., Sheldon, J., Steinmann, E., Pietschmann, T., & Brown, R. J. (2015). Genetic diversity underlying the envelope glycoproteins of hepatitis C virus: Structural and functional consequences and the implications for vaccine design. Viruses, 7(7), 3995-4046. https://doi.org/10.3390/v7072809

© 2015 by the authors. In the 26 years since the discovery of Hepatitis C virus (HCV) a major global research effort has illuminated many aspects of the viral life cycle, facilitating the development of targeted antivirals. Recently, effective direct... Read More about Genetic diversity underlying the envelope glycoproteins of hepatitis C virus: Structural and functional consequences and the implications for vaccine design.

Non-ionic detergents facilitate non-specific binding of M13 bacteriophage to polystyrene surfaces (2015)
Journal Article
Hakami, A. R., Ball, J. K., & Tarr, A. W. (2015). Non-ionic detergents facilitate non-specific binding of M13 bacteriophage to polystyrene surfaces. Journal of Virological Methods, 221, 1-8. https://doi.org/10.1016/j.jviromet.2015.04.023

© 2015 Elsevier B.V. Phage-displayed random peptide libraries are widely used for identifying peptide interactions with proteins and other substrates. Selection of peptide ligands involves iterative rounds of affinity enrichment. The binding properti... Read More about Non-ionic detergents facilitate non-specific binding of M13 bacteriophage to polystyrene surfaces.

Human lectins and their roles in viral infections (2015)
Journal Article
Mason, C. P., & Tarr, A. W. (2015). Human lectins and their roles in viral infections. Molecules, 20(2), 2229-2271. https://doi.org/10.3390/molecules20022229

© 2015 by the authors; licensee MDPI. Innate recognition of virus proteins is an important component of the immune response to viral pathogens. A component of this immune recognition is the family of lectins; pattern recognition receptors (PRRs) that... Read More about Human lectins and their roles in viral infections.

Dramatic potentiation of the antiviral activity of HIV antibodies by cholesterol conjugation (2014)
Journal Article
Lacek, K., Urbanowicz, R. A., Troise, F., De Lorenzo, C., Severino, V., Di Maro, A., Tarr, A. W., Ferrara, F., Ploss, A., Temperton, N., Ball, J. K., Nicosia, A., Cortese, R., & Pessi, A. (2014). Dramatic potentiation of the antiviral activity of HIV antibodies by cholesterol conjugation. Journal of Biological Chemistry, 289(50), 35015-35028. https://doi.org/10.1074/jbc.M114.591826

Type I interferon rapidly restricts infectious hepatitis C virus particle genesis (2014)
Journal Article
Meredith, L. W., Farquhar, M. J., Tarr, A. W., & McKeating, J. A. (2014). Type I interferon rapidly restricts infectious hepatitis C virus particle genesis. Hepatology, 60(6), https://doi.org/10.1002/hep.27333

Interferon-alpha (IFNα) has been used to treat chronic hepatitis C virus (HCV) infection for over 20 years with varying efficacy, depending on the infecting viral genotype. The mechanism of action of IFNα is not fully understood, but is thought to ta... Read More about Type I interferon rapidly restricts infectious hepatitis C virus particle genesis.

Recombinant Human L-Ficolin Directly Neutralizes Hepatitis C Virus Entry (2014)
Journal Article
Hamed, M. R., Brown, R. J., Zothner, C., Urbanowicz, R. A., Mason, C. P., Krarup, A., McClure, C. P., Irving, W. L., Ball, J. K., Harris, M., Hickling, T. P., & Tarr, A. W. (2014). Recombinant Human L-Ficolin Directly Neutralizes Hepatitis C Virus Entry. Journal of Innate Immunity, 6(5), 676-684. https://doi.org/10.1159/000362209

L-ficolin is a soluble pattern recognition molecule expressed by the liver that contributes to innate immune defense against microorganisms. It is well described that binding of L-ficolin to specific pathogen-associated molecular patterns activates t... Read More about Recombinant Human L-Ficolin Directly Neutralizes Hepatitis C Virus Entry.

Colicin import into E. coli cells: A model system for insights into the import mechanisms of bacteriocins (2014)
Journal Article
Kim, Y. C., Tarr, A. W., & Penfold, C. N. (2014). Colicin import into E. coli cells: A model system for insights into the import mechanisms of bacteriocins. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1843(8), 1717-1731. https://doi.org/10.1016/j.bbamcr.2014.04.010

Bacteriocins are a diverse group of ribosomally synthesized protein antibiotics produced by most bacteria. They range from small lanthipeptides produced by lactic acid bacteria to much larger multi domain proteins of Gram negative bacteria such as th... Read More about Colicin import into E. coli cells: A model system for insights into the import mechanisms of bacteriocins.

The past, present and future of neutralizing antibodies for hepatitis C virus (2014)
Journal Article
Ball, J. K., Tarr, A. W., & McKeating, J. A. (2014). The past, present and future of neutralizing antibodies for hepatitis C virus. Antiviral Research, 105(1), 100-111. https://doi.org/10.1016/j.antiviral.2014.02.013

Hepatitis C virus (HCV) is a major cause of liver disease and hepatocellular carcinoma worldwide. HCV establishes a chronic infection in the majority of cases. However, some individuals clear the virus, demonstrating a protective role for the host im... Read More about The past, present and future of neutralizing antibodies for hepatitis C virus.