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Outputs (170)

The evolution of the duckweed ionome mirrors losses in structural complexity (2024)
Journal Article
Smith, K. E., Zhou, M., Flis, P., Jones, D. H., Bishopp, A., & Yant, L. (2024). The evolution of the duckweed ionome mirrors losses in structural complexity. Annals of Botany, 133(7), 997-1006. https://doi.org/10.1093/aob/mcae012

• Background and Aims The duckweeds (Lemnaceae) consist of 36 species exhibiting impressive phenotypic variation, including the progressive evolutionary loss of a fundamental plant organ, the root. Loss of roots and reduction of vascular tissues in r... Read More about The evolution of the duckweed ionome mirrors losses in structural complexity.

Non-canonical endogenous expression of voltage-gated sodium channel NaV1.7 subtype by the TE671 rhabdomyosarcoma cell line (2024)
Preprint / Working Paper
Ngum, N., Aziz, M., Wall, R., Duce, I., & Mellor, I. (2024). Non-canonical endogenous expression of voltage-gated sodium channel NaV1.7 subtype by the TE671 rhabdomyosarcoma cell line

Background and Purpose: The human TE671 cell line was originally used as a model of medulloblastoma but has since been reassigned as rhabdomyosarcoma. Despite the characterised endogenous expression of voltage-sensitive sodium currents in these cells... Read More about Non-canonical endogenous expression of voltage-gated sodium channel NaV1.7 subtype by the TE671 rhabdomyosarcoma cell line.

The Role of Lipids in Allergic Sensitization: A Systematic Review (2024)
Preprint / Working Paper
Fairclough, L., Hopkins V, G., Cochrane, S., & Onion, D. (2024). The Role of Lipids in Allergic Sensitization: A Systematic Review

Background
Immunoglobulin E (IgE)-mediated allergies are increasing in prevalence, with IgE-mediated food allergies currently affecting up to 10% of children and 6% of adults worldwide. The mechanisms underpinning the first phase of IgE-mediated all... Read More about The Role of Lipids in Allergic Sensitization: A Systematic Review.

Ciprofloxacin poly(β-amino ester) conjugates enhance antibiofilm activity and slow the development of resistance (2024)
Journal Article
Kasza, K., Richards, B., Jones, S., Romero, M., Robertson, S. N., Hardie, K. R., Gurnani, P., Cámara, M., & Alexander, C. (2024). Ciprofloxacin poly(β-amino ester) conjugates enhance antibiofilm activity and slow the development of resistance. ACS Applied Materials and Interfaces, 16(5), 5412-5425. https://doi.org/10.1021/acsami.3c14357

To tackle the emerging antibiotic resistance crisis, novel antimicrobial approaches are urgently needed. Bacterial biofilms are a particular concern in this context as they are responsible for over 80% of bacterial infections and are inherently more... Read More about Ciprofloxacin poly(β-amino ester) conjugates enhance antibiofilm activity and slow the development of resistance.

Whole-genome resource sequences of 57 indigenous Ethiopian goats (2024)
Journal Article
Belay, S., Belay, G., Nigussie, H., Jian-Lin, H., Tijjani, A., Ahbara, A. M., Tarekegn, G. M., Woldekiros, H. S., Mor, S., Dobney, K., Lebrasseur, O., Hanotte, O., & Mwacharo, J. M. (2024). Whole-genome resource sequences of 57 indigenous Ethiopian goats. Scientific Data, 11(1), Article 139. https://doi.org/10.1038/s41597-024-02973-2

Domestic goats are distributed worldwide, with approximately 35% of the one billion world goat population occurring in Africa. Ethiopia has 52.5 million goats, ~99.9% of which are considered indigenous landraces deriving from animals introduced to th... Read More about Whole-genome resource sequences of 57 indigenous Ethiopian goats.

Genomic analysis of Nigerian indigenous chickens reveals their genetic diversity and adaptation to heat-stress (2024)
Journal Article
Rachman, M. P., Bamidele, O., Dessie, T., Smith, J., Hanotte, O., & Gheyas, A. A. (2024). Genomic analysis of Nigerian indigenous chickens reveals their genetic diversity and adaptation to heat-stress. Scientific Reports, 14(1), Article 2209. https://doi.org/10.1038/s41598-024-52569-4

Indigenous poultry breeds from Africa can survive in harsh tropical environments (such as long arid seasons, excessive rain and humidity, and extreme heat) and are resilient to disease challenges, but they are not productive compared to their commerc... Read More about Genomic analysis of Nigerian indigenous chickens reveals their genetic diversity and adaptation to heat-stress.

Age-related impact of social isolation in mice: Young vs middle-aged (2024)
Journal Article
Magalhães, D. M., Mampay, M., Sebastião, A. M., Sheridan, G. K., & Valente, C. A. (2024). Age-related impact of social isolation in mice: Young vs middle-aged. Neurochemistry International, 174, Article 105678. https://doi.org/10.1016/j.neuint.2024.105678

Social isolation is a chronic mild stressor and a significant risk factor for mental health disorders. Herein we explored the impact of social isolation on depression- and anxiety-like behaviours, as well as spatial memory impairments, in middle-aged... Read More about Age-related impact of social isolation in mice: Young vs middle-aged.

Botulinum neurotoxins exploit host digestive proteases to boost their oral toxicity via activating OrfXs/P47 (2024)
Journal Article
Gao, L., Nowakowska, M. B., Selby, K., Przykopanski, A., Chen, B., Krüger, M., Douillard, F. P., Lam, K. H., Chen, P., Huang, T., Minton, N. P., Dorner, M. B., Dorner, B. G., Rummel, A., Lindström, M., & Jin, R. (2025). Botulinum neurotoxins exploit host digestive proteases to boost their oral toxicity via activating OrfXs/P47. Nature Structural and Molecular Biology, 32, 864–875. https://doi.org/10.1038/s41594-024-01479-0

Botulinum neurotoxins (BoNTs) rank among the most potent toxins and many of them are produced by bacteria carrying the orfX gene cluster that also encodes four nontoxic proteins (OrfX1, OrfX2, OrfX3 and P47). The orfX gene cluster is also found in th... Read More about Botulinum neurotoxins exploit host digestive proteases to boost their oral toxicity via activating OrfXs/P47.

Heat-not-burn technology affects plasma testosterone levels and markers of inflammation, oxidative stress in the testes of rats (2024)
Journal Article
Granata, S., Morosini, C., Valerii, M. C., Fagiolino, I., Sangiorgi, S., Ghini, S., Spisni, E., Vivarelli, F., Fairclough, L. C., Paolini, M., & Canistro, D. (2024). Heat-not-burn technology affects plasma testosterone levels and markers of inflammation, oxidative stress in the testes of rats. Frontiers in Toxicology, 6, Article 1515850. https://doi.org/10.3389/ftox.2024.1515850

Introduction: Heating tobacco products (HTPs) are advanced electronic cigarette models. Classified by the FDA as a modified-risk tobacco product and can be used as part of efforts to quit smoking. Using heat-not-burn (HnB) technology, these devices h... Read More about Heat-not-burn technology affects plasma testosterone levels and markers of inflammation, oxidative stress in the testes of rats.

Polymer-Coated Urinary Catheter Reduces Biofilm Formation and Biomineralization: A First-in-Man, Prospective Pilot Study (2024)
Journal Article
Kalenderski, K., Dubern, J.-F., Lewis-Lloyd, C., Jeffery, N., Heeb, S., Irvine, D. J., Sloan, T. J., Birch, B., Andrich, D., Humes, D., Alexander, M. R., & Williams, P. (2024). Polymer-Coated Urinary Catheter Reduces Biofilm Formation and Biomineralization: A First-in-Man, Prospective Pilot Study. Journal of Urology Open PLus, 2(1), Article e00005. https://doi.org/10.1097/JU9.0000000000000097

Purpose: Biofilm formation and biomineralization on urinary catheters may cause severe complications including infection and obstruction. Here, we describe an in vitro evaluation and prospective pilot clinical study of a silicone catheter coated with... Read More about Polymer-Coated Urinary Catheter Reduces Biofilm Formation and Biomineralization: A First-in-Man, Prospective Pilot Study.