Outputs (7)

General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy (2019)
Journal Article
Li, Z., Mirams, G. R., Yoshinaga, T., Ridder, B. J., Han, X., Chen, J. E., Stockbridge, N. L., Wisialowski, T. A., Damiano, B., Severi, S., Morissette, P., Kowey, P. R., Holbrook, M., Smith, G., Rasmusson, R. L., Liu, M., Song, Z., Qu, Z., Leishman, D. J., Steidl‐Nichols, J., …Strauss, D. G. (2020). General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy. Clinical Pharmacology and Therapeutics, 107(1), 102-111. https://doi.org/10.1002/cpt.1647

This white paper presents principles for validating proarrhythmia risk prediction models for regulatory use as discussed at the In Silico Breakout Session of a Cardiac Safety Research Consortium/Health and Environmental Sciences Institute/US Food and... Read More about General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy.

Lacan's May '68: Analysing the Institution in the Wake of the University Discourse (2019)
Book Chapter
Wright, C. (in press). Lacan's May '68: Analysing the Institution in the Wake of the University Discourse. In A. Vidal, K. Shingler, & A. Sharman (Eds.), Other ‘68s: Lineages and Legacies of May ‘68

This chapter tracks the psychoanalyst Jacques Lacan’s evolving position on the French experi-ence of May 1968. Lacanian notions around structure and desire were clearly at play in the run up to the May events and initially Lacan was supportive of bot... Read More about Lacan's May '68: Analysing the Institution in the Wake of the University Discourse.

Sulfadiazine Sodium Ameliorates the Metabolomic Perturbation in Mice Infected with Toxoplasma gondii (2019)
Journal Article
Zhu, X.-Q., Zhou, C.-X., Liu, Q., Gan, Y., Cong, H., Elsheikha, H. M., & Chen, X.-Q. (2019). Sulfadiazine Sodium Ameliorates the Metabolomic Perturbation in Mice Infected with Toxoplasma gondii. Antimicrobial Agents and Chemotherapy, 63(10), Article e00312-19. https://doi.org/10.1128/AAC.00312-19

In this study, we analyzed the global metabolomic changes associated with Toxoplasma gondii infection in mice in the presence or absence of sulfadiazine sodium (SDZ) treatment. BALB/c mice were infected with T. gondii GT1 strain and treated orally wi... Read More about Sulfadiazine Sodium Ameliorates the Metabolomic Perturbation in Mice Infected with Toxoplasma gondii.

Education Program for Carers in Facilities with Neuro Disabled Subjects EPoCFiNDS (2019)
Journal Article
Dionyssiotis, Y., Vellidou, E., Konstantinidis, S. T., Sarafis, P., Artemi, S., Stergiopoulou, K., Vind, A. M., Birsanu, N., Duport, S., & Koutsouris, D. (2019). Education Program for Carers in Facilities with Neuro Disabled Subjects EPoCFiNDS. Journal of Frailty, Sarcopenia and Falls, 4(2), 45-50. https://doi.org/10.22540/JFSF-04-045

The prevalence of chronic illness and the disabilities they cause are strongly associated with age. According to
the United Nations, in most countries around the world, 8-10% of the population has some form of disability.
Carers are helping subject... Read More about Education Program for Carers in Facilities with Neuro Disabled Subjects EPoCFiNDS.

Simvastatin inhibits L-type Ca 2+ -channel activity through impairment of mitochondrial function (2019)
Journal Article
Curry, L., Almukhtar, H., Alahmed, J., Roberts, R., & Smith, P. A. (2019). Simvastatin inhibits L-type Ca 2+ -channel activity through impairment of mitochondrial function. Toxicological Sciences, 169(2), 543–552. https://doi.org/10.1093/toxsci/kfz068

Plasma membrane ion channels and mitochondrial electron transport complexes (mETC) are recognised “off-targets” for certain drugs. Simvastatin is one such drug, a lipophilic statin used to treat hypercholesterolaemia, but which is also associated wit... Read More about Simvastatin inhibits L-type Ca 2+ -channel activity through impairment of mitochondrial function.

Tactical authenticity in the production of mad narratives (2019)
Journal Article
WRIGHT, C., & CLARKE, S. (2019). Tactical authenticity in the production of mad narratives. Social Theory and Health, 17(2), 15. https://doi.org/10.1057/s41285-019-00092-2

First-person accounts of madness and of encountering psychiatric services provide important sociocultural and psychological knowledge about the subjectivity of distress. The importance of such accounts is often based upon a claim of the authenticity... Read More about Tactical authenticity in the production of mad narratives.

Discrimination of gain increments in speech-shaped noises (2019)
Journal Article
Caswell-Midwinter, B., & Whitmer, W. (2019). Discrimination of gain increments in speech-shaped noises. Trends in Hearing, 23, 1-12. https://doi.org/10.1177/2331216518820220

Frequency-dependent gain adjustments are routine in hearing-aid fittings, whether in matching to real-ear targets or fine-tuning to patient feedback. Patient feedback may be unreliable and fittings inefficient if adjustments are not discriminable. To... Read More about Discrimination of gain increments in speech-shaped noises.