Mrs MIRANDA CLARK's Outputs (20)

myCOtrak: an app which records smoking, nicotine use and exhaled carbon monoxide concentrations concurrently for use in smoking research (2025)
Journal Article
Huang, Y., Emery, J., McDaid, L., Naughton, F., Clark, M., Dickinson, A., Cooper, S., & Coleman, T. (2025). myCOtrak: an app which records smoking, nicotine use and exhaled carbon monoxide concentrations concurrently for use in smoking research. BMC Research Notes, 18, Article 158. https://doi.org/10.1186/s13104-025-07195-2

Objective
Smoking during pregnancy poses significant health risks, necessitating accurate continuous monitoring of pregnant women’s smoking behaviours. Existing methods relying on self-reporting lack objectivity, while biochemical measures like exha... Read More about myCOtrak: an app which records smoking, nicotine use and exhaled carbon monoxide concentrations concurrently for use in smoking research.

Smoking, nicotine and pregnancy 2 (SNAP2) trial: protocol for a randomised controlled trial of an intervention to improve adherence to nicotine replacement therapy during pregnancy (2024)
Journal Article
Clark, M. M., Cooper, S., Naughton, F., Ussher, M., Emery, J., McDaid, L., Thomson, R., Phillips, L., Bauld, L., Aveyard, P., Torgerson, D., Berlin, I., Lewis, S., Parrott, S., Hewitt, C., Welch, C., Parkinson, G., Dickinson, A., Sutton, S., Brimicombe, J., …Coleman, T. (2024). Smoking, nicotine and pregnancy 2 (SNAP2) trial: protocol for a randomised controlled trial of an intervention to improve adherence to nicotine replacement therapy during pregnancy. BMJ Open, 14(5), Article e087175. https://doi.org/10.1136/bmjopen-2024-087175

IntroductionSmoking during pregnancy is harmful to unborn babies, infants and women. Nicotine replacement therapy (NRT) is offered as the usual stop-smoking support in the UK. However, this is often used in insufficient doses, intermittently or for t... Read More about Smoking, nicotine and pregnancy 2 (SNAP2) trial: protocol for a randomised controlled trial of an intervention to improve adherence to nicotine replacement therapy during pregnancy.

Smoking, nicotine and pregnancy 2 (SNAP2) trial: protocol for a randomised controlled trial of an intervention to improve adherence to nicotine replacement therapy in pregnancy (2024)
Journal Article
Clark, M., Cooper, S., Naughton, F., Ussher, M., Emery, J., Mcdaid, L., Thomson, R., Phillips, L., Bauld, L., Aveyard, P., Torgerson, D., Berlin, I., Lewis, S., Parrott, S., Hewitt, C., Welch, C., Parkinson, G., Dickinson, A., Sutton, S., Brimicombe, J., …Coleman, T. (2024). Smoking, nicotine and pregnancy 2 (SNAP2) trial: protocol for a randomised controlled trial of an intervention to improve adherence to nicotine replacement therapy in pregnancy. BMJ Open, 14(5), Article e087175. https://doi.org/10.1136/bmjopen-2024-087175

Introduction: Smoking in pregnancy is harmful for unborn babies, infants, and women. Nicotine replacement therapy (NRT) is offered as usual stop smoking support in the UK. However, this is often used in insufficient doses, intermittently, or for too... Read More about Smoking, nicotine and pregnancy 2 (SNAP2) trial: protocol for a randomised controlled trial of an intervention to improve adherence to nicotine replacement therapy in pregnancy.

Safety of e-cigarettes and nicotine patches as stop-smoking aids in pregnancy: Secondary analysis of the Pregnancy Trial of E-cigarettes and Patches (PREP) randomized controlled trial (2024)
Journal Article
Pesola, F., Smith, K. M., Phillips‐Waller, A., Przulj, D., Griffiths, C., Walton, R., McRobbie, H., Coleman, T., Lewis, S., Whitemore, R., Clark, M., Ussher, M., Sinclair, L., Seager, E., Cooper, S., Bauld, L., Naughton, F., Sasieni, P., Manyonda, I., & Hajek, P. (2024). Safety of e-cigarettes and nicotine patches as stop-smoking aids in pregnancy: Secondary analysis of the Pregnancy Trial of E-cigarettes and Patches (PREP) randomized controlled trial. Addiction, 119(5), 875-884. https://doi.org/10.1111/add.16422

Aims: The aim of this study was to examine the safety of e-cigarettes (EC) and nicotine patches (NRT) when used to help pregnant smokers quit. Design: A recent trial of EC versus NRT reported safety outcomes in the randomized arms. We conducted a fur... Read More about Safety of e-cigarettes and nicotine patches as stop-smoking aids in pregnancy: Secondary analysis of the Pregnancy Trial of E-cigarettes and Patches (PREP) randomized controlled trial.

Safety of e-cigarettes and nicotine patches as stop-smoking aids in pregnancy: Secondary analysis of the Pregnancy Trial of E-cigarettes and Patches (PREP) randomised controlled trial (2024)
Journal Article
Pesola, F., Smith, K. M., Phillips-Waller, A., Przulj, D., Griffiths, C., Walton, R., Mcrobbie, H., Coleman, T., Lewis, S., Whitemore, R., Clark, M., Ussher, M., Sinclair, L., Seager, E., Cooper, S., Bauld, L., Naughton, F., Sasieni, P., Manyonda, I., & Hajek, P. (2024). Safety of e-cigarettes and nicotine patches as stop-smoking aids in pregnancy: Secondary analysis of the Pregnancy Trial of E-cigarettes and Patches (PREP) randomised controlled trial. Addiction, 119(5), 875-884. https://doi.org/10.1111/add.16422

Aims

To examine safety of e-cigarettes (EC) and nicotine patches (NRT) when used to help pregnant smokers quit.

Design

A recent trial of EC versus NRT reported safety outcomes in the randomised arms. We conducted a further analysis based... Read More about Safety of e-cigarettes and nicotine patches as stop-smoking aids in pregnancy: Secondary analysis of the Pregnancy Trial of E-cigarettes and Patches (PREP) randomised controlled trial.

The relationship between reported daily nicotine dose from NRT and daily cigarette consumption in pregnant women who smoke in an observational cohort study (2023)
Journal Article
Orton, S., Szatkowski, L., Naughton, F., Coleman, T., Clark, M., Cooper, S., Dickinson, A., Emery, J., Lewis, S., McDaid, L., Phillips, L., & Thomson, R. (2024). The relationship between reported daily nicotine dose from NRT and daily cigarette consumption in pregnant women who smoke in an observational cohort study. Nicotine and Tobacco Research, 26(2), 212-219. https://doi.org/10.1093/ntr/ntad140

Introduction For non-pregnant people unable to quit smoking, the NHS recommends nicotine replacement therapy (NRT) for smoking reduction. This is not recommended during pregnancy due to concerns about higher nicotine intake than smoking alone. We inv... Read More about The relationship between reported daily nicotine dose from NRT and daily cigarette consumption in pregnant women who smoke in an observational cohort study.

Helping pregnant smokers quit: a multi-centre randomised controlled trial of electronic cigarettes versus nicotine replacement therapy (2023)
Journal Article
Przulj, D., Pesola, F., Myers Smith, K., McRobbie, H., Coleman, T., Lewis, S., Griffith, C., Walton, R., Whitemore, R., Clark, M., Ussher, M., Sinclair, L., Seager, E., Cooper, S., Bauld, L., Naughton, F., Sasieni, P., Manyonda, I., & Hajek, P. (2023). Helping pregnant smokers quit: a multi-centre randomised controlled trial of electronic cigarettes versus nicotine replacement therapy. Health Technology Assessment, 27(13), https://doi.org/10.3310/AGTH6901

Background
Some pregnant smokers try e-cigarettes, but effectiveness and safety of such use are unknown.

Objectives
To compare effectiveness and safety of nicotine patches and e-cigarettes in pregnancy.

Design
A pragmatic multi-centre random... Read More about Helping pregnant smokers quit: a multi-centre randomised controlled trial of electronic cigarettes versus nicotine replacement therapy.

Comparison of a Daily Smartphone App and Retrospective Questionnaire Measures of Adherence to Nicotine Replacement Therapy Among Pregnant Women: Observational Study (2023)
Journal Article
Emery, J., Naughton, F., Huang, Y., Cooper, S., McDaid, L., Dickinson, A., Clark, M., Kinahan-Goodwin, D., Thomson, R., Phillips, L., Lewis, S., & Coleman, T. (2023). Comparison of a Daily Smartphone App and Retrospective Questionnaire Measures of Adherence to Nicotine Replacement Therapy Among Pregnant Women: Observational Study. JMIR Formative Research, 7, Article e35045. https://doi.org/10.2196/35045

Background: Few studies have investigated how to best measure adherence to smoking cessation medications, but continuous usage measures are recommended. Objective: In this first study of its kind, we compared methods for measuring adherence to nicoti... Read More about Comparison of a Daily Smartphone App and Retrospective Questionnaire Measures of Adherence to Nicotine Replacement Therapy Among Pregnant Women: Observational Study.

Development and Content Validation of a Questionnaire for Measuring Beliefs About Using Nicotine Replacement Therapy for Smoking Cessation in Pregnancy (2023)
Journal Article
Emery, J., Mcdaid, L., Coleman, T., Cooper, S., Thomson, R., Kinahan-Goodwin, D., Dickinson, A., Phillips, L., Clark, M., Bowker, K., Brown, E., & Naughton, F. (2023). Development and Content Validation of a Questionnaire for Measuring Beliefs About Using Nicotine Replacement Therapy for Smoking Cessation in Pregnancy. Nicotine and Tobacco Research, 25(7), 1310-1318. https://doi.org/10.1093/ntr/ntad030

Introduction
Improving adherence to nicotine replacement therapy (NRT) in pregnancy may result in higher smoking cessation rates. Informed by the Necessities and Concerns Framework, we developed an intervention targeting pregnancy NRT adherence. To... Read More about Development and Content Validation of a Questionnaire for Measuring Beliefs About Using Nicotine Replacement Therapy for Smoking Cessation in Pregnancy.

Electronic cigarettes versus nicotine patches for smoking cessation in pregnancy: a randomized controlled trial (2022)
Journal Article
Hajek, P., Przulj, D., Pesola, F., Griffiths, C., Walton, R., McRobbie, H., Coleman, T., Lewis, S., Whitemore, R., Clark, M., Ussher, M., Sinclair, L., Seager, E., Cooper, S., Bauld, L., Naughton, F., Sasieni, P., Manyonda, I., & Myers Smith, K. (2022). Electronic cigarettes versus nicotine patches for smoking cessation in pregnancy: a randomized controlled trial. Nature Medicine, 28(5), 958-964. https://doi.org/10.1038/s41591-022-01808-0

Nicotine replacement therapy, in the form of nicotine patches, is commonly offered to pregnant women who smoke to help them to stop smoking, but this approach has limited efficacy in this population. Electronic cigarettes (e-cigarettes) are also used... Read More about Electronic cigarettes versus nicotine patches for smoking cessation in pregnancy: a randomized controlled trial.

The development and acceptability testing of an app-based smart survey system to record smoking behaviour, use of nicotine replacement therapy (NRT) and e-cigarettes (2022)
Journal Article
Huang, Y., Emery, J., Naughton, F., Cooper, S., McDaid, L., Dickinson, A., Clark, M., Kinahan-Goodwin, D., Thomson, R., Phillips, L., Lewis, S., Orton, S., & Coleman, T. (2022). The development and acceptability testing of an app-based smart survey system to record smoking behaviour, use of nicotine replacement therapy (NRT) and e-cigarettes. BMC Research Notes, 15(1), Article 100. https://doi.org/10.1186/s13104-022-05983-8

Objective: Nicotine replacement therapy (NRT) helps people stop smoking. Monitoring treatment adherence is important as poor adherence to NRT limits its effectiveness. As e-cigarettes contain nicotine, their use (‘vaping’) is likely to affect both NR... Read More about The development and acceptability testing of an app-based smart survey system to record smoking behaviour, use of nicotine replacement therapy (NRT) and e-cigarettes.

Effectiveness of offering tailored text message, self‐help smoking cessation support to pregnant women who want information on stopping smoking: MiQuit3 randomised controlled trial (RCT) and meta‐analysis (2021)
Journal Article
Coleman, T., Clark, M., Welch, C., Whitemore, R., Leonardi‐Bee, J., Cooper, S., Hewitt, C., Jones, M., Sutton, S., Watson, J., Daykin, K., Ussher, M., Parrott, S., & Naughton, F. (2022). Effectiveness of offering tailored text message, self‐help smoking cessation support to pregnant women who want information on stopping smoking: MiQuit3 randomised controlled trial (RCT) and meta‐analysis. Addiction, 117(4), 1079-1094. https://doi.org/10.1111/add.15715

Aims: To test efficacy of “MiQuit’, a tailored, self-help, text message stop smoking programme for pregnancy, as an adjunct to usual care (UC) for smoking cessation in pregnancy.

Design: Multicentre, open, two-arm, parallel-group, superiority rand... Read More about Effectiveness of offering tailored text message, self‐help smoking cessation support to pregnant women who want information on stopping smoking: MiQuit3 randomised controlled trial (RCT) and meta‐analysis.

Pre-notification and personalisation of text messages to increase questionnaire completion in a smoking cessation pregnancy RCT: An embedded randomised factorial trial (2021)
Journal Article
Coleman, E., Whitemore, R., Clark, L., Daykin, K., & Clark, M. (2021). Pre-notification and personalisation of text messages to increase questionnaire completion in a smoking cessation pregnancy RCT: An embedded randomised factorial trial. F1000Research, 10, Article 637. https://doi.org/10.12688/f1000research.51964.2

Background: Low completion rates of questionnaires in randomised controlled trials can compromise the reliability of the results, so ways to boost questionnaire completion are often implemented. Although there is evidence to suggest that sending a te... Read More about Pre-notification and personalisation of text messages to increase questionnaire completion in a smoking cessation pregnancy RCT: An embedded randomised factorial trial.

Comparison of saliva cotinine and exhaled carbon monoxide concentrations when smoking and after being offered dual nicotine replacement therapy in pregnancy (2021)
Journal Article
Slaich, B., Claire, R., Emery, J., Lewis, S., Cooper, S., Thomson, R., Phillips, L., Kinahan-Goodwin, D., Naughton, F., McDaid, L., Clark, M., Dickinson, A., & Coleman, T. (2022). Comparison of saliva cotinine and exhaled carbon monoxide concentrations when smoking and after being offered dual nicotine replacement therapy in pregnancy. Addiction, 117(3), 751-759. https://doi.org/10.1111/add.15671

Background and Aims
Although English Stop Smoking Services routinely offer dual nicotine replacement therapy (NRT) to help pregnant women quit smoking, little is known about how nicotine and tobacco smoke exposures following this compares with that... Read More about Comparison of saliva cotinine and exhaled carbon monoxide concentrations when smoking and after being offered dual nicotine replacement therapy in pregnancy.

Pre-notification and personalisation of text-messages to retain participants in a smoking cessation pregnancy RCT: an embedded randomised factorial trial (2021)
Journal Article
Coleman, E., Whitemore, R., Clark, L., Daykin, K., & Clark, M. (2021). Pre-notification and personalisation of text-messages to retain participants in a smoking cessation pregnancy RCT: an embedded randomised factorial trial. F1000Research, 10, Article 637. https://doi.org/10.12688/f1000research.51964.1

Background: Low response rates in randomised controlled trials can compromise the reliability of the results, so ways to boost retention are often implemented. Although there is evidence to suggest that sending a text message to participants increas... Read More about Pre-notification and personalisation of text-messages to retain participants in a smoking cessation pregnancy RCT: an embedded randomised factorial trial.

A Qualitative Study of Factors Influencing Adherence among Pregnant Women Taking Part in a Trial of E-Cigarettes for Smoking Cessation (2021)
Journal Article
Ford, A., Uny, I., Lowes, J., Naughton, F., Cooper, S., Coleman, T., Hajek, P., Przulj, D., Myers Smith, K., Bauld, L., Sinclair, L., Walton, R., Clark, M., & Ussher, M. (2021). A Qualitative Study of Factors Influencing Adherence among Pregnant Women Taking Part in a Trial of E-Cigarettes for Smoking Cessation. International Journal of Environmental Research and Public Health, 18(2), Article 430. https://doi.org/10.3390/ijerph18020430

Use of e-cigarettes (vaping) has potential to help pregnant women stop smoking. This study explored factors influencing adherence among participants in the vaping arm of the first trial of vaping for smoking cessation in pregnancy. We conducted semi-... Read More about A Qualitative Study of Factors Influencing Adherence among Pregnant Women Taking Part in a Trial of E-Cigarettes for Smoking Cessation.

Examining the effectiveness of general practitioner and nurse promotion of electronic cigarettes versus standard care for smoking reduction and abstinence in hardcore smokers with smoking-related chronic disease: Protocol for a randomised controlled trial (2019)
Journal Article
Begh, R., Coleman, T., Yardley, L., Barnes, R., Naughton, F., Gilbert, H., Ferrey, A., Madigan, C., Williams, N., Hamilton, L., Warren, Y., Grabey, J., Clark, M., Dickinson, A., & Aveyard, P. (2019). Examining the effectiveness of general practitioner and nurse promotion of electronic cigarettes versus standard care for smoking reduction and abstinence in hardcore smokers with smoking-related chronic disease: Protocol for a randomised controlled trial. Trials, 20(1), Article 659. https://doi.org/10.1186/s13063-019-3850-1

© 2019 The Author(s). Background: Despite the clear harm associated with smoking tobacco, many people with smoking-related chronic diseases or serious mental illnesses (SMI) are unwilling or unable to stop smoking. In many cases, these smokers have t... Read More about Examining the effectiveness of general practitioner and nurse promotion of electronic cigarettes versus standard care for smoking reduction and abstinence in hardcore smokers with smoking-related chronic disease: Protocol for a randomised controlled trial.

Effectiveness and cost-effectiveness of a tailored text message programme (MiQuit) for smoking cessation in pregnancy: study protocol for a randomised controlled trial and meta-analysis (2019)
Journal Article
Whitemore, R., Leonardi-Bee, J., Naughton, F., Sutton, S., Cooper, S., Parrott, S., Hewitt, C., Clark, M., Ussher, M., Jones, M., Torgerson, D., & Coleman, T. (2019). Effectiveness and cost-effectiveness of a tailored text message programme (MiQuit) for smoking cessation in pregnancy: study protocol for a randomised controlled trial and meta-analysis. Trials, 20, 1-13. https://doi.org/10.1186/s13063-019-3341-4

Background: Smoking in pregnancy is a major international public health problem. Self-help support (SHS) increases the likelihood of women stopping smoking in pregnancy and delivering this kind of support by text message could be a cost-effective way... Read More about Effectiveness and cost-effectiveness of a tailored text message programme (MiQuit) for smoking cessation in pregnancy: study protocol for a randomised controlled trial and meta-analysis.

Autologous stem-cell transplantation in treatment-refractory Crohn's disease: an analysis of pooled data from the ASTIC trial (2017)
Journal Article
Lindsay, J. O., Clark, M., Allez, M., Labopin, M., Rogler, G., Rovira, M., Satsangi, J., Farge, D., Hawkey, C. J., & Ricart, E. (2017). Autologous stem-cell transplantation in treatment-refractory Crohn's disease: an analysis of pooled data from the ASTIC trial. The Lancet Gastroenterology & Hepatology, 2(6), 399-406. https://doi.org/10.1016/S2468-1253%2817%2930056-0

Background: The randomised controlled ASTIC trial showed no benefit of mobilisation and autologous haematopoietic stem-cell transplantation (HSCT) compared with mobilisation followed by conventional therapy using a stringent primary endpoint (steroid... Read More about Autologous stem-cell transplantation in treatment-refractory Crohn's disease: an analysis of pooled data from the ASTIC trial.

Autologous Hematopoetic Stem Cell Transplantation for Refractory Crohn Disease: A Randomized Clinical Trial (2015)
Journal Article
Hawkey, C. J., Allez, M., Clark, M. M., Labopin, M., Lindsay, J. O., Ricart, E., Rogler, G., Rovira, M., Satsangi, J., Danese, S., Russell, N., Gribben, J., Johnson, P., Larghero, J., Thieblemont, C., Ardizzone, S., Dierickx, D., Ibatici, A., Littlewood, T., Onida, F., …Farge, D. (2015). Autologous Hematopoetic Stem Cell Transplantation for Refractory Crohn Disease: A Randomized Clinical Trial. Journal of the American Medical Association, 314(23), 2524-2534. https://doi.org/10.1001/jama.2015.16700

Importance: Case reports and series suggest hematopoietic stem cell transplantation (HSCT) may benefit some patients with Crohn disease.

Objective: To evaluate the effect of autologous HSCT on refractory Crohn disease.

Design, Setting, and Pa... Read More about Autologous Hematopoetic Stem Cell Transplantation for Refractory Crohn Disease: A Randomized Clinical Trial.