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Professor MAARTEN TAAL's Outputs (76)

Acute kidney injury associated with COVID-19: A retrospective cohort study (2020)
Journal Article
Kolhe, N. V., Fluck, R. J., Selby, N. M., & Taal, M. W. (2020). Acute kidney injury associated with COVID-19: A retrospective cohort study. PLoS Medicine, 17(10), Article e1003406. https://doi.org/10.1371/journal.pmed.1003406

Background Initial reports indicate a high incidence of acute kidney injury (AKI) in Coronavirus Disease 2019 (COVID-19), but more data are required to clarify if COVID-19 is an independent risk factor for AKI and how COVID-19–associated AKI may diff... Read More about Acute kidney injury associated with COVID-19: A retrospective cohort study.

Symptom-burden in people living with frailty and chronic kidney disease (2020)
Journal Article
Nixon, A. C., Wilkinson, T. J., Young, H. M. L., Taal, M. W., Pendleton, N., Mitra, S., Brady, M. E., Dhaygude, A. P., & Smith, A. C. (2020). Symptom-burden in people living with frailty and chronic kidney disease. BMC Nephrology, 21, Article 411. https://doi.org/10.1186/s12882-020-02063-6

Background: Frailty is independently associated with worse health-related quality of life (HRQOL) in chronic kidney disease (CKD). However, the relationship between frailty and symptom experience is not well described in people living with CKD. This... Read More about Symptom-burden in people living with frailty and chronic kidney disease.

Nutritional status assessment: a neglected biomarker in persons with end- stage kidney disease (2020)
Journal Article
Viramontes-Hörner, D., & Taal, M. W. (2020). Nutritional status assessment: a neglected biomarker in persons with end- stage kidney disease. Current Opinion in Nephrology and Hypertension, 29(6), 547-554. https://doi.org/10.1097/MNH.0000000000000651

Purpose of review: Malnutrition is a frequent complication and risk factor for adverse outcomes in the dialysis population that is often underrecognized and neglected. This article reviews published literature on the associations between malnutrition... Read More about Nutritional status assessment: a neglected biomarker in persons with end- stage kidney disease.

The PrEscription of intraDialytic exercise to improve quAlity of Life in patients with chronic kidney disease trial: study design and baseline data for a multicentre randomized controlled trial (2020)
Journal Article
Greenwood, S. A., Koufaki, P., Macdonald, J., Bhandari, S., Burton, J., Dasgupta, I., Farrington, K., Ford, I., Kalra, P. A., Kean, S., Kumwenda, M., Macdougall, I. C., Messow, C.-M., Mitra, S., Reid, C., Smith, A. C., Taal, M. W., Thomson, P. C., Wheeler, D. C., White, C., …Mercer, T. H. (2021). The PrEscription of intraDialytic exercise to improve quAlity of Life in patients with chronic kidney disease trial: study design and baseline data for a multicentre randomized controlled trial. Clinical Kidney Journal, 14(5), 1345–1355. https://doi.org/10.1093/ckj/sfaa107

Background
Exercise interventions designed to improve physical function and reduce sedentary behaviour in haemodialysis (HD) patients might improve exercise capacity, reduce fatigue and lead to improved quality of life (QOL). The PrEscription of int... Read More about The PrEscription of intraDialytic exercise to improve quAlity of Life in patients with chronic kidney disease trial: study design and baseline data for a multicentre randomized controlled trial.

Prevalence of chronic kidney disease in adults in England: comparison of nationally representative cross-sectional surveys from 2003 to 2016 (2020)
Journal Article
Hounkpatin, H. O., Harris, S., Fraser, S. D., Day, J., Mindell, J. S., Taal, M. W., O’Donoghue, D., & Roderick, P. J. (2020). Prevalence of chronic kidney disease in adults in England: comparison of nationally representative cross-sectional surveys from 2003 to 2016. BMJ Open, 10(8), Article e038423. https://doi.org/10.1136/bmjopen-2020-038423

Objectives: To identify recent trends in chronic kidney disease (CKD) prevalence in England and explore their association with changes in sociodemographic, behavioural and clinical factors.
Design: Pooled cross-sectional analysis.
Setting: Health... Read More about Prevalence of chronic kidney disease in adults in England: comparison of nationally representative cross-sectional surveys from 2003 to 2016.

Health-related quality of life, functional impairment and comorbidity in people with mild-to-moderate chronic kidney disease: a cross-sectional study (2020)
Journal Article
Fraser, S. D., Barker, J., Roderick, P. J., Yuen, H. M., Shardlow, A., Morris, J. E., McIntyre, N. J., Fluck, R. J., McIntyre, C. W., & Taal, M. W. (2020). Health-related quality of life, functional impairment and comorbidity in people with mild-to-moderate chronic kidney disease: a cross-sectional study. BMJ Open, 10, Article e040286. https://doi.org/10.1136/bmjopen-2020-040286

Objectives: To determine the associations between comorbidities, health-related quality of life (HRQoL) and functional impairment in people with mild-to-moderate chronic kidney disease (CKD) in primary care.

Design: Cross-sectional analysis at 5-y... Read More about Health-related quality of life, functional impairment and comorbidity in people with mild-to-moderate chronic kidney disease: a cross-sectional study.

The association of skin autofluorescence with cardiovascular events and all-cause mortality in persons with chronic kidney disease stage 3: A prospective cohort study (2020)
Journal Article
Shardlow, A., McIntyre, N. J., Kolhe, N. V., Nellums, L. B., Fluck, R. J., McIntyre, C. W., & Taal, M. W. (2020). The association of skin autofluorescence with cardiovascular events and all-cause mortality in persons with chronic kidney disease stage 3: A prospective cohort study. PLoS Medicine, 17(7), e1003163. https://doi.org/10.1371/journal.pmed.1003163

Helping people to live well with chronic kidney disease (2020)
Journal Article
Fraser, S., & Taal, M. (2020). Helping people to live well with chronic kidney disease. British Journal of Hospital Medicine, 81(6), https://doi.org/10.12968/hmed.2020.0069

Reduced glomerular filtration rate and presence of albuminuria are both associated with increased risk of several poor outcomes. People with chronic kidney disease also commonly suffer from lower quality of life than their age-matched peers. The expe... Read More about Helping people to live well with chronic kidney disease.

Skin autofluorescence and malnutrition as predictors of mortality in persons receiving dialysis: a prospective cohort study (2020)
Journal Article
Viramontes Hörner, D., Selby, N. M., & Taal, M. W. (2020). Skin autofluorescence and malnutrition as predictors of mortality in persons receiving dialysis: a prospective cohort study. Journal of Human Nutrition and Dietetics, 33(6), 852-861. https://doi.org/10.1111/jhn.12764

Background

Skin autofluorescence (SAF), which is a measure of accumulation of advanced glycation end‐products (AGE), and malnutrition are each associated with higher mortality in dialysis populations, although no studies have investigated these po... Read More about Skin autofluorescence and malnutrition as predictors of mortality in persons receiving dialysis: a prospective cohort study.

Factors associated with change in skin autofluorescence in persons receiving dialysis (2020)
Journal Article
Viramontes Hörner, D., Selby, N. M., & Taal, M. W. (2020). Factors associated with change in skin autofluorescence in persons receiving dialysis. Kidney International Reports, 5(5), 654-662. https://doi.org/10.1016/j.ekir.2020.02.003

Introduction

An increase over time in skin autofluorescence (SAF), a measure of accumulation of advanced glycation end products (AGE), predicts higher mortality on hemodialysis (HD). However, evidence is lacking regarding factors that contribute t... Read More about Factors associated with change in skin autofluorescence in persons receiving dialysis.

SGLT‐2 Inhibitor Renal Outcome Modification in Type‐2 Diabetes: Evidence from Studies in Patients with High or Low Renal Risk (2020)
Journal Article
Schernthaner, G., Groop, P.-H., Kalra, P. A., Ronco, C., & Taal, M. W. (2020). SGLT‐2 Inhibitor Renal Outcome Modification in Type‐2 Diabetes: Evidence from Studies in Patients with High or Low Renal Risk. Diabetes, Obesity and Metabolism, 22(7), 1024-1034. https://doi.org/10.1111/dom.13994

Data from three completed cardiovascular outcome trials (CVOTs), EMPA‐REG OUTCOME, CANVAS Program and DECLARE‐TIMI 58, add to the evidence supporting the potential renoprotective effects of sodium‐glucose linked transporter‐2 (SGLT2) inhibitors in pa... Read More about SGLT‐2 Inhibitor Renal Outcome Modification in Type‐2 Diabetes: Evidence from Studies in Patients with High or Low Renal Risk.

Impact of Dietetic Intervention on Skin Autofluorescence and Nutritional Status in Persons Receiving Dialysis: A Proof of Principle Study (2020)
Journal Article
Hörner, D. V., Willingham, F. C., Selby, N. M., & Taal, M. W. (2020). Impact of Dietetic Intervention on Skin Autofluorescence and Nutritional Status in Persons Receiving Dialysis: A Proof of Principle Study. Journal of Renal Nutrition, 30(6), 540-547. https://doi.org/10.1053/j.jrn.2019.12.006

Objective: Advanced glycation end-products (AGEs) are uremic toxins that result from oxidative stress and food consumption. We have previously reported that markers of malnutrition are more important determinants of increased skin autofluorescence (S... Read More about Impact of Dietetic Intervention on Skin Autofluorescence and Nutritional Status in Persons Receiving Dialysis: A Proof of Principle Study.

Biological Variation of Cardiac Troponins in Chronic Kidney Disease (2020)
Journal Article
Jones, R., Barrett, J., Brettell, E., Cockwell, P., Dalton, R. N., Deeks, J., Eaglestone, G., Pellatt-Higgins, T., Kalra, P. A., Khunti, K., Morris, F., Ottridge, R., Sitch, A., Stevens, P. E., Sharpe, C., Sutton, A., Taal, M., & Lamb, E. J. (2020). Biological Variation of Cardiac Troponins in Chronic Kidney Disease. Annals of Clinical Biochemistry, 57(2), 162-169. https://doi.org/10.1177/0004563220906431

Background
Patients with chronic kidney disease often have increased plasma cardiac troponin concentration in the absence of myocardial infarction. Incidence of myocardial infarction is high in this population, and diagnosis, particularly of non ST-... Read More about Biological Variation of Cardiac Troponins in Chronic Kidney Disease.

Association between non-malignant monoclonal gammopathy and adverse outcomes in chronic kidney disease: Acohort study (2020)
Journal Article
Fenton, A., Chinnadurai, R., Gullapudi, L., Kampanis, P., Dasgupta, I., Ritchie, J., Harding, S., Ferro, C. J., Kalra, P. A., Taal, M. W., & Cockwell, P. (2020). Association between non-malignant monoclonal gammopathy and adverse outcomes in chronic kidney disease: Acohort study. PLoS Medicine, 17(2), Article e1003050. https://doi.org/10.1371/journal.pmed.1003050

BACKGROUND: In studies including the general population, the presence of non-malignant monoclonal gammopathy (MG) can be causally associated with kidney damage and shorter survival. We assessed whether the presence of an MG is associated with a highe... Read More about Association between non-malignant monoclonal gammopathy and adverse outcomes in chronic kidney disease: Acohort study.

A Paradigm to Discover Biomarkers Associated With Chronic Kidney Disease Progression (2020)
Journal Article
Ali, I., Ibrahim, S. T., Chinnadurai, R., Green, D., Taal, M., Whetton, T. D., & Kalra, P. A. (2020). A Paradigm to Discover Biomarkers Associated With Chronic Kidney Disease Progression. Biomarker Insights, 15, 117727192097614. https://doi.org/10.1177/1177271920976146

Biomarker discovery in the field of risk prediction in chronic kidney disease (CKD) embraces the prospect of improving our ability to risk stratify future adverse outcomes and thereby guide patient care in a new era of personalised medicine. However,... Read More about A Paradigm to Discover Biomarkers Associated With Chronic Kidney Disease Progression.

Coffee Consumption and Kidney Function: A Mendelian Randomization Study (2019)
Journal Article
Kennedy, O. J., Pirastu, N., Poole, R., Fallowfield, J. A., Hayes, P. C., Grzeszkowiak, E. J., Taal, M. W., Wilson, J. F., Parkes, J., & Roderick, P. J. (2020). Coffee Consumption and Kidney Function: A Mendelian Randomization Study. American Journal of Kidney Diseases, 75(5), 753-761. https://doi.org/10.1053/j.ajkd.2019.08.025

Rationale & Objective

Chronic kidney disease (CKD) is a leading cause of morbidity and mortality worldwide, with limited strategies for prevention and treatment. Coffee is a complex mixture of chemicals, and consumption has been associated with mo... Read More about Coffee Consumption and Kidney Function: A Mendelian Randomization Study.

Determinants of change in arterial stiffness over 5 years in early chronic kidney disease (2019)
Journal Article
Mcintyre, N., Shardlow, A., Fluck, R., Mcintyre, C., & Taal, M. (2021). Determinants of change in arterial stiffness over 5 years in early chronic kidney disease. Nephrology Dialysis Transplantation, 36(2), 281-288. https://doi.org/10.1093/ndt/gfz170

Background
Arterial stiffness is an established and potentially modifiable risk factor for cardiovascular disease, associated with chronic kidney disease. There have been few studies to evaluate progression of arterial stiffness over time or factors... Read More about Determinants of change in arterial stiffness over 5 years in early chronic kidney disease.

Skin autofluorescence: an emerging biomarker in persons with kidney disease (2019)
Journal Article
Viramontes Horner, D., & Taal, M. W. (2019). Skin autofluorescence: an emerging biomarker in persons with kidney disease. Current Opinion in Nephrology and Hypertension, 28(6), 507–512. https://doi.org/10.1097/MNH.0000000000000549

Purpose of review: Skin autofluorescence (SAF) is a measure of the accumulation of advanced glycation end-products (AGEs) proposed to act as a marker of “cumulative metabolic stress”. This paper discusses mechanisms of AGE formation and reviews publi... Read More about Skin autofluorescence: an emerging biomarker in persons with kidney disease.

Chronic Kidney Disease: call for an age-adapted definition (2019)
Journal Article
Delanaye, P., Jager, K. J., Bökenkamp, A., Christensson, A., Dubourg, L., Eriksen, B. O., Gaillard, F., Gambaro, G., Van Der Giet, M., Glassock, R. J., Indridason, O. S., van Londen, M., Mariat, C., Melsom, T., Moranne, O., Nordin, G., Palsson, R., Pottel, H., Rule, A. D., Schaeffner, E., …van den Brand, J. A. (2019). Chronic Kidney Disease: call for an age-adapted definition. Journal of the American Society of Nephrology, 30(9), 1785-1805. https://doi.org/10.1681/ASN.2019030238

Current criteria for the diagnosis of chronic kidney disease (CKD) in adults include persistent signs of kidney damage; for example, increased urine albumin-to-creatinine ratio or a glomerular filtration rate (GFR) below the threshold of 60 mL/min pe... Read More about Chronic Kidney Disease: call for an age-adapted definition.