Professor MAARTEN TAAL's Outputs (76)

Multiparametric Renal Magnetic Resonance Imaging for Prediction and Annual Monitoring of the Progression of Chronic Kidney Disease over Two Years (2023)
Journal Article
Buchanan, C. E., Mahmoud, H., Cox, E. F., Prestwich, B. L., Noble, R. A., Selby, N. M., Taal, M. W., & Francis, S. T. (2023). Multiparametric Renal Magnetic Resonance Imaging for Prediction and Annual Monitoring of the Progression of Chronic Kidney Disease over Two Years. Journal of Clinical Medicine, 12(23), Article 7282. https://doi.org/10.3390/jcm12237282

Background: Multiparametric renal Magnetic Resonance Imaging (MRI) provides a non-invasive method to assess kidney structure and function, but longitudinal studies are limited. Methods: A total of 22 patients with CKD category G3-4 (estimated glomeru... Read More about Multiparametric Renal Magnetic Resonance Imaging for Prediction and Annual Monitoring of the Progression of Chronic Kidney Disease over Two Years.

Evaluating the effect of a digital health intervention to enhance physical activity in people with chronic kidney disease (Kidney BEAM): a multicentre, randomised controlled trial in the UK (2023)
Journal Article
Greenwood, S. A., Young, H. M., Briggs, J., Castle, E. M., Walklin, C., Haggis, L., Balkin, C., Asgari, E., Bhandari, S., Burton, J. O., Billany, R. E., Bishop, N. C., Bramham, K., Campbell, J., Chilcot, J., Cooper, N. J., Deelchand, V., Graham-Brown, M. M., Hamilton, A., Jesky, M., …Macdonald, J. H. (2024). Evaluating the effect of a digital health intervention to enhance physical activity in people with chronic kidney disease (Kidney BEAM): a multicentre, randomised controlled trial in the UK. Lancet Digital Health, 6(1), E23-E32. https://doi.org/10.1016/S2589-7500%2823%2900204-2

Background: Remote digital health interventions to enhance physical activity provide a potential solution to improve the sedentary behaviour, physical inactivity, and poor health-related quality of life that are typical of chronic conditions, particu... Read More about Evaluating the effect of a digital health intervention to enhance physical activity in people with chronic kidney disease (Kidney BEAM): a multicentre, randomised controlled trial in the UK.

Blood Pressure targets in Chronic Kidney Disease: still no consensus (2023)
Journal Article
Lucas, B., & Taal, M. W. (2023). Blood Pressure targets in Chronic Kidney Disease: still no consensus. Current Opinion in Nephrology and Hypertension, 32(6), 497-501. https://doi.org/10.1097/MNH.0000000000000920

Purpose of review
Despite a strong consensus that treatment of hypertension is fundamental to strategies seeking to slow chronic kidney disease (CKD) progression and reduce the associated risk of cardiovascular events (CVE), controversy persists re... Read More about Blood Pressure targets in Chronic Kidney Disease: still no consensus.

Risk-stratified monitoring for thiopurine toxicity in immune-mediated inflammatory diseases: prognostic model development, validation, and, health economic evaluation (2023)
Journal Article
Nakafero, G., Card, T., Grainge, M. J., Williams, H. C., Taal, M. W., Aithal, G. P., Fox, C. P., Mallen, C. D., van der Windt, D. A., Stevenson, M. D., Riley, R. D., & Abhishek, A. (2023). Risk-stratified monitoring for thiopurine toxicity in immune-mediated inflammatory diseases: prognostic model development, validation, and, health economic evaluation. eClinicalMedicine, 64, Article 102213. https://doi.org/10.1016/j.eclinm.2023.102213

Background: Patients established on thiopurines (e.g., azathioprine) are recommended to undergo three-monthly blood tests for the early detection of blood, liver, or kidney toxicity. These side-effects are uncommon during long-term treatment. We deve... Read More about Risk-stratified monitoring for thiopurine toxicity in immune-mediated inflammatory diseases: prognostic model development, validation, and, health economic evaluation.

Randomised trial comparing standard versus thermocontrolled haemodialysis using intradialytic cardiac, brain and renal magnetic resonance imaging (2023)
Journal Article
Gullapudi, V. R. L., Cox, E. F., Buchanan, C. E., Canaud, B., White, K., Taal, M. W., Selby, N. M., & Francis, S. T. (2024). Randomised trial comparing standard versus thermocontrolled haemodialysis using intradialytic cardiac, brain and renal magnetic resonance imaging. Nephrology Dialysis Transplantation, 39(2), 233–241. https://doi.org/10.1093/ndt/gfad150

Background
Ischaemic end-organ damage during haemodialysis (HD) is a significant problem that may be ameliorated by intradialytic cooling. A randomised trial was performed to compare standard HD (SHD; dialysate temperature 37°C) and programmed cooli... Read More about Randomised trial comparing standard versus thermocontrolled haemodialysis using intradialytic cardiac, brain and renal magnetic resonance imaging.

Risk stratified monitoring for methotrexate toxicity in immune mediated inflammatory diseases: prognostic model development and validation using primary care data from the UK (2023)
Journal Article
Nakafero, G., Grainge, M. J., Williams, H. C., Card, T., Taal, M. W., Aithal, G. P., Fox, C. P., Mallen, C. D., van der Windt, D. A., Stevenson, M. D., Riley, R. D., & Abhishek, A. (2023). Risk stratified monitoring for methotrexate toxicity in immune mediated inflammatory diseases: prognostic model development and validation using primary care data from the UK. BMJ, 381, Article e074678. https://doi.org/10.1136/bmj-2022-074678

OBJECTIVE: To develop and validate a prognostic model to inform risk stratified decisions on frequency of monitoring blood tests during long term methotrexate treatment. DESIGN: Retrospective cohort study. SETTING: Electronic health records within th... Read More about Risk stratified monitoring for methotrexate toxicity in immune mediated inflammatory diseases: prognostic model development and validation using primary care data from the UK.

Associations with age and glomerular filtration rate in a referred population with chronic kidney disease: Methods and baseline data from a UK multicentre cohort study (NURTuRE-CKD) (2023)
Journal Article
Taal, M. W., Lucas, B., Roderick, P., Cockwell, P., Wheeler, D. C., Saleem, M. A., Fraser, S. D. S., Banks, R. E., Johnson, T., Hale, L. J., Andag, U., Skroblin, P., Bayerlova, M., Unwin, R., Vuilleumier, N., Dusaulcy, R., Robertson, F., Colby, E., Pitcher, D., Braddon, F., …Kalra, P. A. (2023). Associations with age and glomerular filtration rate in a referred population with chronic kidney disease: Methods and baseline data from a UK multicentre cohort study (NURTuRE-CKD). Nephrology Dialysis Transplantation, 38(11), 2617–2626. https://doi.org/10.1093/ndt/gfad110

Background
Chronic kidney disease (CKD) is common but heterogenous and is associated with multiple adverse outcomes. The National Unified Renal Translational Research Enterprise (NURTuRE)-CKD cohort was established to investigate risk factors for cl... Read More about Associations with age and glomerular filtration rate in a referred population with chronic kidney disease: Methods and baseline data from a UK multicentre cohort study (NURTuRE-CKD).

Magnetic Resonance Imaging to Evaluate Kidney Structure, Function, and Pathology: Moving Toward Clinical Application (2023)
Journal Article
Francis, S. T., Selby, N. M., & Taal, M. W. (2023). Magnetic Resonance Imaging to Evaluate Kidney Structure, Function, and Pathology: Moving Toward Clinical Application. American Journal of Kidney Diseases, 82(4), 491-504. https://doi.org/10.1053/j.ajkd.2023.02.007

Recent advances in multiparametric magnetic resonance imaging (MRI) allow multiple quantitative measures to assess kidney morphology, tissue microstructure, oxygenation, kidney blood flow, and perfusion to be collected in a single scan session. Anima... Read More about Magnetic Resonance Imaging to Evaluate Kidney Structure, Function, and Pathology: Moving Toward Clinical Application.

Potential clinical value of catheters impregnated with antimicrobials for the prevention of infections associated with peritoneal dialysis (2023)
Journal Article
Taal, M. W., Dukka, H., & Bayston, R. (2023). Potential clinical value of catheters impregnated with antimicrobials for the prevention of infections associated with peritoneal dialysis. Expert Review of Medical Devices, 20(6), 459-466. https://doi.org/10.1080/17434440.2023.2205587

Introduction
Peritoneal dialysis (PD) is a widely used dialysis modality, which offers the advantage of being a home therapy but is associated with a risk of potentially serious infections, including exit site infection, catheter tunnel infection, a... Read More about Potential clinical value of catheters impregnated with antimicrobials for the prevention of infections associated with peritoneal dialysis.

Quality of life in older adults with chronic kidney disease and transient changes in renal function: Findings from the Oxford Renal cohort (2022)
Journal Article
Busa, I., Ordóñez-Mena, J. M., Yang, Y., Wolstenholme, J., Petrou, S., Taylor, C. J., O’Callaghan, C. A., Fraser, S. D., Taal, M. W., McManus, R. J., Hirst, J. A., & Hobbs, F. R. (2022). Quality of life in older adults with chronic kidney disease and transient changes in renal function: Findings from the Oxford Renal cohort. PLoS ONE, 17(10), Article e0275572. https://doi.org/10.1371/journal.pone.0275572

BACKGROUND: Quality of life (QoL) is an important measure of disease burden and general health perception. The relationship between early chronic kidney disease (CKD) and QoL remains poorly understood. The Oxford Renal Study (OxRen) cohort comprises... Read More about Quality of life in older adults with chronic kidney disease and transient changes in renal function: Findings from the Oxford Renal cohort.

Room for improvement: diagnosing and managing acute coronary syndromes in persons with reduced eGFR (2022)
Journal Article
Horne, K. L., Taal, M. W., & Selby, N. M. (2022). Room for improvement: diagnosing and managing acute coronary syndromes in persons with reduced eGFR. Kidney International, 102(1), 20-22. https://doi.org/10.1016/j.kint.2022.04.017

Cardiovascular events are the leading cause of death in chronic kidney disease. A recent analysis from the High-Sensitivity Troponin in the Evaluation of Patients With Suspected Acute Coronary Syndrome trial focused on results in those with reduced e... Read More about Room for improvement: diagnosing and managing acute coronary syndromes in persons with reduced eGFR.

Defining improvement in chronic kidney disease: regression and remission (2022)
Journal Article
Taal, M. W. (2022). Defining improvement in chronic kidney disease: regression and remission. Current Opinion in Nephrology and Hypertension, 31(6), 517-521. https://doi.org/10.1097/MNH.0000000000000830

Purpose of review: International definitions exist for chronic kidney disease (CKD) progression and kidney failure but despite evidence that kidney function may improve, there are no agreed definitions for regression and remission of CKD. In the ligh... Read More about Defining improvement in chronic kidney disease: regression and remission.

Simple, high-throughput measurement of gut-derived short-chain fatty acids in clinically relevant biofluids using gas chromatography-mass spectrometry (2022)
Journal Article
Bain, J. T., Taal, M. W., Selby, N. M., Reynolds, J. C., & Heaney, L. M. (2022). Simple, high-throughput measurement of gut-derived short-chain fatty acids in clinically relevant biofluids using gas chromatography-mass spectrometry. Journal of Mass Spectrometry & Advances in the Clinical Lab, 25, 36-43. https://doi.org/10.1016/j.jmsacl.2022.07.002

Introduction

The quantitative measurement of circulating gut bacteria-derived metabolites has increased in recent years due to their associations with health and disease. While much of the previous attention has been placed on metabolites consider... Read More about Simple, high-throughput measurement of gut-derived short-chain fatty acids in clinically relevant biofluids using gas chromatography-mass spectrometry.

Development and validation of a prognostic model for leflunomide discontinuation with abnormal blood tests during long-term treatment: cohort study using data from the Clinical Practice Research Datalink Gold and Aurum (2021)
Journal Article
Nakafero, G., Grainge, M. J., Card, T., Taal, M. W., Aithal, G. P., Zhang, W., Doherty, M., Fox, C. P., Mallen, C. D., & Abhishek, A. (2022). Development and validation of a prognostic model for leflunomide discontinuation with abnormal blood tests during long-term treatment: cohort study using data from the Clinical Practice Research Datalink Gold and Aurum. Rheumatology, 61(7), 2783-2791. https://doi.org/10.1093/rheumatology/keab790

OBJECTIVE: To develop and validate a prognostic model for LEF discontinuation with abnormal blood test results. METHODS: Data from the Clinical Practice Research Datalink Gold and Aurum were used for model development and external validation, respect... Read More about Development and validation of a prognostic model for leflunomide discontinuation with abnormal blood tests during long-term treatment: cohort study using data from the Clinical Practice Research Datalink Gold and Aurum.

Impact of malnutrition on health-related quality of life in persons receiving dialysis: a prospective study (2021)
Journal Article
Viramontes-Hörner, D., Pittman, Z., Selby, N. M., & Taal, M. W. (2022). Impact of malnutrition on health-related quality of life in persons receiving dialysis: a prospective study. British Journal of Nutrition, 127(11), 1647-1655. https://doi.org/10.1017/S000711452100249X

Health-related quality of life (HRQoL) is severely impaired in persons receiving dialysis. Malnutrition has been associated with some measures of poor HRQoL in cross-sectional analyses in dialysis populations, but no studies have assessed the impact... Read More about Impact of malnutrition on health-related quality of life in persons receiving dialysis: a prospective study.

What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline? (2021)
Journal Article
Nakafero, G., Grainge, M. J., Card, T., Mallen, C. D., Zhang, W., Doherty, M., Taal, M. W., Aithal, G. P., & Abhishek, A. (2021). What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline?. Rheumatology, 60(12), 5785-5794. https://doi.org/10.1093/rheumatology/keab254

Objectives: To examine incidence of treatment changes due to abnormal blood-test results and, to explore rates of treatment changes due to liver, kidney and haematological blood-test abnormalities in autoimmune rheumatic diseases (AIRD) treated with... Read More about What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline?.

Multiparametric MRI assessment of renal structure and function in acute kidney injury and renal recovery (2021)
Journal Article
Buchanan, C., Mahmoud, H., Cox, E., Noble, R., Prestwich, B., Kasmi, I., Taal, M. W., Francis, S., & Selby, N. M. (2021). Multiparametric MRI assessment of renal structure and function in acute kidney injury and renal recovery. Clinical Kidney Journal, 14(8), 1969-1976. https://doi.org/10.1093/ckj/sfaa221

Background: Acute Kidney Injury (AKI) is associated with a marked increase in mortality as well as subsequent chronic kidney disease (CKD) and end stage kidney disease. We performed multiparametric MRI with the aim of identifying potential non-invasi... Read More about Multiparametric MRI assessment of renal structure and function in acute kidney injury and renal recovery.

Patients' and kidney care team's perspectives of treatment burden and capacity in older people with chronic kidney disease: A qualitative study (2020)
Journal Article
Hounkpatin, H. O., Leydon, G. M., Veighey, K., Armstrong, K., Santer, M., Taal, M. W., Annells, P., May, C., Roderick, P. J., & Fraser, S. D. (2020). Patients' and kidney care team's perspectives of treatment burden and capacity in older people with chronic kidney disease: A qualitative study. BMJ Open, 10(12), Article e042548. https://doi.org/10.1136/bmjopen-2020-042548

Objective Chronic kidney disease (CKD) is often a multimorbid condition and progression to more severe disease is commonly associated with increased management requirements, including lifestyle change, more medication and greater clinician involvemen... Read More about Patients' and kidney care team's perspectives of treatment burden and capacity in older people with chronic kidney disease: A qualitative study.

Iterative Run-to-Run Learning Model to Derive Continuous Brachial Pressure Estimates from Arterial and Venous Lines During Dialysis Treatment (2020)
Journal Article
Stewart, J., Stewart, P., Walker, T., Viramontes Horner, D., Lucas, B., White, K., Taal, M. W., Selby, N. M., & Morris, M. (2021). Iterative Run-to-Run Learning Model to Derive Continuous Brachial Pressure Estimates from Arterial and Venous Lines During Dialysis Treatment. Biomedical Signal Processing and Control, 65, Article 102346. https://doi.org/10.1016/j.bspc.2020.102346

Objective: Non-invasive continuous blood pressure monitoring is not yet part of routine practice in renal dialysis units but could be a valuable tool in the detection and prevention of significant variations in patient blood pressure during treatment... Read More about Iterative Run-to-Run Learning Model to Derive Continuous Brachial Pressure Estimates from Arterial and Venous Lines During Dialysis Treatment.

A Feasibility Study of Non-Invasive Continuous Estimation of Brachial Pressure Derived from Arterial and Venous Lines During Dialysis (2020)
Journal Article
Stewart, J., Stewart, P., Walker, T., Horner, D. V., Lucas, B., White, K., Muggleton, A., Morris, M., Selby, N. M., & Taal, M. W. (2021). A Feasibility Study of Non-Invasive Continuous Estimation of Brachial Pressure Derived from Arterial and Venous Lines During Dialysis. IEEE Journal of Translational Engineering in Health and Medicine, 9, 1-1. https://doi.org/10.1109/JTEHM.2020.3035988

Objective: Intradialytic haemodynamic instability is a significant clinical problem, leading to end-organ ischaemia and contributing to morbidity and mortality in haemodialysis patients. Non-invasive continuous blood pressure monitoring is not curren... Read More about A Feasibility Study of Non-Invasive Continuous Estimation of Brachial Pressure Derived from Arterial and Venous Lines During Dialysis.