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Professor ANDREW BRADLEY's Outputs (33)

Using Object-Oriented Simulation to Assess the Impact of the Frequency and Accuracy of Mobility Scoring on the Estimation of Epidemiological Parameters for Lameness in Dairy Herds (2024)
Journal Article
Clifton, R., Hyde, R., Can, E., Barden, M., Manning, A., Bradley, A., Green, M., & O’Grady, L. (2024). Using Object-Oriented Simulation to Assess the Impact of the Frequency and Accuracy of Mobility Scoring on the Estimation of Epidemiological Parameters for Lameness in Dairy Herds. Animals, 14(12), 1760. https://doi.org/10.3390/ani14121760

Mobility scoring data can be used to estimate the prevalence, incidence, and duration of lameness in dairy herds. Mobility scoring is often performed infrequently with variable sensitivity, but how this impacts the estimation of lameness parameters i... Read More about Using Object-Oriented Simulation to Assess the Impact of the Frequency and Accuracy of Mobility Scoring on the Estimation of Epidemiological Parameters for Lameness in Dairy Herds.

Quantification of the effect of in utero events on lifetime resilience in dairy cows (2024)
Journal Article
Lewis, K., Shewbridge Carter, L., Bradley, A., Dewhurst, R., Forde, N., Hyde, R., Kaler, J., March, M. D., Mason, C., O'Grady, L., Strain, S., Thompson, J., & Green, M. (2024). Quantification of the effect of in utero events on lifetime resilience in dairy cows. Journal of Dairy Science, 107(7), 4616-4633. https://doi.org/10.3168/jds.2023-24215

Currently, the dairy industry is facing many challenges that could affect its sustainability, including climate change and public perception of the industry. As a result, interest is increasing in the concept of identifying resilient animals, those w... Read More about Quantification of the effect of in utero events on lifetime resilience in dairy cows.

Improvement of mammary gland health in 81 'sentinel herds' in England and Scotland between 2012 and 2021. (2023)
Journal Article
Leach, K. A., Holsey, H. J., Bradley, A. J., & Green, M. J. (2023). Improvement of mammary gland health in 81 'sentinel herds' in England and Scotland between 2012 and 2021. Veterinary Record, Article e3605. https://doi.org/10.1002/vetr.3605

Background: Achieving a reduction in mastitis in dairy cows is a common industry goal, but there is no recent peer-reviewed record of progress in the UK. Methods: A convenience sample of 125 herds in England and Scotland was recruited based on the qu... Read More about Improvement of mammary gland health in 81 'sentinel herds' in England and Scotland between 2012 and 2021..

Associations between Johne’s disease and fertility in UK dairy herds (2023)
Journal Article
Reynolds, J. A., Bradley, A. J., Sherwin, V. E., Remnant, J. G., & Hudson, C. D. (2023). Associations between Johne’s disease and fertility in UK dairy herds. Veterinary Journal, 298-299, Article 106015. https://doi.org/10.1016/j.tvjl.2023.106015

The objective of this observational study was to quantify associations between Mycobacterium avium subspecies paratuberculosis (MAP) antibody status and a variety of fertility outcomes, in UK dairy cattle. Longitudinal milk recording, fertility and M... Read More about Associations between Johne’s disease and fertility in UK dairy herds.

Potential of ESBL-producing Escherichia coli selection in bovine feces after intramammary administration of first generation cephalosporins using in vitro experiments (2022)
Journal Article
Speksnijder, D. C., Hopman, N. E. M., Kusters, N. E., Timmerman, A., Swinkels, J. M., Penterman, P. A. A., Krömker, V., Bradley, A. J., Botteldoorn, N., Gehring, R., & Zomer, A. L. (2022). Potential of ESBL-producing Escherichia coli selection in bovine feces after intramammary administration of first generation cephalosporins using in vitro experiments. Scientific Reports, 12, Article 15083. https://doi.org/10.1038/s41598-022-15558-z

Selection and spread of Extended Spectrum Beta-Lactamase (ESBL) -producing Enterobacteriaceae within animal production systems and potential spillover to humans is a major concern. Intramammary treatment of dairy cows with first-generation cephalospo... Read More about Potential of ESBL-producing Escherichia coli selection in bovine feces after intramammary administration of first generation cephalosporins using in vitro experiments.

Mass spectrometry and machine learning for the accurate diagnosis of benzylpenicillin and multidrug resistance of Staphylococcus aureus in bovine mastitis (2021)
Journal Article
Esener, N., Guerra, A. M., Giebel, K., Lea, D., Green, M. J., Bradley, A. J., & Dottorini, T. (2021). Mass spectrometry and machine learning for the accurate diagnosis of benzylpenicillin and multidrug resistance of Staphylococcus aureus in bovine mastitis. PLoS Computational Biology, 17(6), Article e1009108. https://doi.org/10.1371/journal.pcbi.1009108

Staphylococcus aureus is a serious human and animal pathogen threat exhibiting extraordinary capacity for acquiring new antibiotic resistance traits in the pathogen population worldwide.

The development of fast, affordable and effective diagnostic... Read More about Mass spectrometry and machine learning for the accurate diagnosis of benzylpenicillin and multidrug resistance of Staphylococcus aureus in bovine mastitis.

Randomized controlled field trial comparing quarter and cow level selective dry cow treatment using the California Mastitis Test (2021)
Journal Article
Swinkels, J., Leach, K., Breen, J., Payne, B., White, V., Green, M., & Bradley, A. (2021). Randomized controlled field trial comparing quarter and cow level selective dry cow treatment using the California Mastitis Test. Journal of Dairy Science, 104(8), 9063-9081. https://doi.org/10.3168/jds.2020-19258

Selective use of antibiotic dry cow treatment can be implemented at the cow or quarter level, with the latter having the potential to further reduce antibiotic use. Our objective was to compare these 2 approaches in 6 herds in the United Kingdom in w... Read More about Randomized controlled field trial comparing quarter and cow level selective dry cow treatment using the California Mastitis Test.

Prediction of Streptococcus uberis clinical mastitis treatment success in dairy herds by means of mass spectrometry and machine-learning (2021)
Journal Article
Maciel-Guerra, A., Esener, N., Giebel, K., Lea, D., Green, M. J., Bradley, A. J., & Dottorini, T. (2021). Prediction of Streptococcus uberis clinical mastitis treatment success in dairy herds by means of mass spectrometry and machine-learning. Scientific Reports, 11(1), Article 7736. https://doi.org/10.1038/s41598-021-87300-0

Streptococcus uberis is one of the leading pathogens causing mastitis worldwide. Identification of S. uberis strains that fail to respond to treatment with antibiotics is essential for better decision making and treatment selection. We demonstrate th... Read More about Prediction of Streptococcus uberis clinical mastitis treatment success in dairy herds by means of mass spectrometry and machine-learning.

Automated prediction of mastitis infection patterns in dairy herds using machine learning (2020)
Journal Article
Hyde, R. M., Down, P. M., Bradley, A. J., Breen, J. E., Hudson, C., Leach, K. A., & Green, M. J. (2020). Automated prediction of mastitis infection patterns in dairy herds using machine learning. Scientific Reports, 10(1), Article 4289. https://doi.org/10.1038/s41598-020-61126-8

© 2020, The Author(s). Mastitis in dairy cattle is extremely costly both in economic and welfare terms and is one of the most significant drivers of antimicrobial usage in dairy cattle. A critical step in the prevention of mastitis is the diagnosis o... Read More about Automated prediction of mastitis infection patterns in dairy herds using machine learning.

Discrimination of contagious and environmental strains of Streptococcus uberis in dairy herds by means of mass spectrometry and machine-learning (2018)
Journal Article
Esener, N., Green, M. J., Emes, R. D., Jowett, B., Davies, P. L., Bradley, A. J., & Dottorini, T. (2018). Discrimination of contagious and environmental strains of Streptococcus uberis in dairy herds by means of mass spectrometry and machine-learning. Scientific Reports, 8(1), Article 17517. https://doi.org/10.1038/s41598-018-35867-6

Streptococcus uberis is one of the most common pathogens of clinical mastitis in the dairy industry. Knowledge of pathogen transmission route is essential for the selection of the most suitable intervention. Here we show that spectral profiles acquir... Read More about Discrimination of contagious and environmental strains of Streptococcus uberis in dairy herds by means of mass spectrometry and machine-learning.

Short- and long-term association between individual levels of milk antibody against Ostertagia ostertagi and first-lactation heifer’s production performances (2018)
Journal Article
Bellet, C., Green, M., Bradley, A., & Kaler, J. (2018). Short- and long-term association between individual levels of milk antibody against Ostertagia ostertagi and first-lactation heifer’s production performances. Veterinary Parasitology, 256, 1-8. https://doi.org/10.1016/j.vetpar.2018.04.008

It is agreed that exposure of adult dairy cattle to helminths on pasture can negatively affect production performances as milking herd. Young animals, especially replacement heifers, represent the future of a dairy farm and are among the most vulnera... Read More about Short- and long-term association between individual levels of milk antibody against Ostertagia ostertagi and first-lactation heifer’s production performances.

Quantitative analysis of antimicrobial use on British dairy farms (2017)
Journal Article
Hyde, R. M., Remnant, J. G., Bradley, A. J., Breen, J. E., Hudson, C. D., Davies, P. L., Clarke, T., Critchell, Y., Hylands, M., Linton, E., Wood, E., & Green, M. J. (in press). Quantitative analysis of antimicrobial use on British dairy farms. Veterinary Record, 181(25), https://doi.org/10.1136/vr.104614

Antimicrobial resistance has been reported to represent a growing threat to both human and animal health, and concerns have been raised around levels of antimicrobial usage (AMU) within the livestock industry. To provide a benchmark for dairy cattle... Read More about Quantitative analysis of antimicrobial use on British dairy farms.

The impact of dairy cows' bedding material and its microbial content on the quality and safety of milk: a cross sectional study of UK farms (2017)
Journal Article
Bradley, A. J., Leach, K. A., Green, M. J., Gibbons, J., Ohnstad, I. C., Black, D. H., Payne, B., Prout, V. E., & Breen, J. E. (in press). The impact of dairy cows' bedding material and its microbial content on the quality and safety of milk: a cross sectional study of UK farms. International Journal of Food Microbiology, https://doi.org/10.1016/j.ijfoodmicro.2017.12.022

The introduction of bedding dairy cows on recycled manure solids (RMS) in the UK led to concern by competent authorities that there could be an increased, unacceptable risk to animal and human health. A cross-sectional study was designed to evaluate... Read More about The impact of dairy cows' bedding material and its microbial content on the quality and safety of milk: a cross sectional study of UK farms.

A longitudinal study of gastrointestinal parasites in English dairy farms: practices and factors associated with first lactation heifer exposure to Ostertagia ostertagi on pasture (2017)
Journal Article
Bellet, C., Green, M. J., Bradley, A. J., & Kaler, J. (2018). A longitudinal study of gastrointestinal parasites in English dairy farms: practices and factors associated with first lactation heifer exposure to Ostertagia ostertagi on pasture. Journal of Dairy Science, 101(1), https://doi.org/10.3168/jds.2017-12952

The gastrointestinal nematode Ostertagia ostertagi is an important cause of lost production, health, and welfare in cattle. Detailed records were obtained over a 5-yr period (2010–2015) by questionnaires and qualitative interviews to investigate the... Read More about A longitudinal study of gastrointestinal parasites in English dairy farms: practices and factors associated with first lactation heifer exposure to Ostertagia ostertagi on pasture.

Factors affecting the cost-effectiveness of on-farm culture prior to the treatment of clinical mastitis in dairy cows (2017)
Journal Article
Down, P., Bradley, A. J., Breen, J., & Green, M. J. (2017). Factors affecting the cost-effectiveness of on-farm culture prior to the treatment of clinical mastitis in dairy cows. Preventive Veterinary Medicine, 145, https://doi.org/10.1016/j.prevetmed.2017.07.006

The objective of this study was to use probabilistic sensitivity analysis to evaluate the cost-effectiveness of using an on-farm culture (OFC) approach to the treatment of clinical mastitis in dairy cows and compare this to a ‘standard’ treatment app... Read More about Factors affecting the cost-effectiveness of on-farm culture prior to the treatment of clinical mastitis in dairy cows.

Prediction of Streptococcus uberis clinical mastitis risk using Matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS) in dairy herds (2017)
Journal Article
Archer, S. C., Bradley, A. J., Cooper, S., Davies, P., & Green, M. J. (2017). Prediction of Streptococcus uberis clinical mastitis risk using Matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS) in dairy herds. Preventive Veterinary Medicine, 144, https://doi.org/10.1016/j.prevetmed.2017.05.015

The purpose of this study was to evaluate whether the risk of Streptococcus uberis clinical mastitis at cow level could be predicted from the historical presence of specific strains of S. uberis on dairy farms. Matrix-assisted laser desorption ioniza... Read More about Prediction of Streptococcus uberis clinical mastitis risk using Matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS) in dairy herds.

A Bayesian micro-simulation to evaluate the cost-effectiveness of interventions for mastitis control during the dry period in UK dairy herds (2016)
Journal Article
Down, P., Bradley, A., Breen, J., Browne, W., Kypraios, T., & Green, M. (2016). A Bayesian micro-simulation to evaluate the cost-effectiveness of interventions for mastitis control during the dry period in UK dairy herds. Preventive Veterinary Medicine, 133, 64-72. https://doi.org/10.1016/j.prevetmed.2016.09.012

Importance of the dry period with respect to mastitis control is now well established although the precise interventions that reduce the risk of acquiring intramammary infections during this time are not clearly understood. There are very few interve... Read More about A Bayesian micro-simulation to evaluate the cost-effectiveness of interventions for mastitis control during the dry period in UK dairy herds.

Prediction of intramammary infection status across the dry period from lifetime cow records (2016)
Journal Article
Henderson, A., Hudson, C., Bradley, A. J., Sherwin, V., & Green, M. J. (2016). Prediction of intramammary infection status across the dry period from lifetime cow records. Journal of Dairy Science, 99(7), https://doi.org/10.3168/jds.2015-10684

The dry period is very important for mammary gland health, with the aim not only to cure existing intramammary infections (IMI) but also to prevent new IMI. Although it is known that the dry period is an important time for optimizing udder health, th... Read More about Prediction of intramammary infection status across the dry period from lifetime cow records.

Current management practices and interventions prioritised as part of a nationwide mastitis control plan (2016)
Journal Article
Down, P., Bradley, A. J., Breen, J., Hudson, C., & Green, M. J. (2016). Current management practices and interventions prioritised as part of a nationwide mastitis control plan. Veterinary Record, 178(449), https://doi.org/10.1136/vr.103203

The objectives of this study were to report performance and management data taken from a sample of UK dairy farms that have participated in the Agriculture and Horticulture Development Board Dairy Mastitis Control Plan (DMCP) and to identify importan... Read More about Current management practices and interventions prioritised as part of a nationwide mastitis control plan.