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Professor KIN-CHOW CHANG's Outputs (3)

SRSF5-Mediated Alternative Splicing of M Gene is Essential for Influenza A Virus Replication: A Host-Directed Target Against Influenza Virus (2022)
Journal Article
Li, Q., Jiang, Z., Ren, S., Guo, H., Song, Z., Chen, S., Gao, X., Meng, F., Zhu, J., Liu, L., Tong, Q., Sun, H., Sun, Y., Pu, J., Chang, K. C., & Liu, J. (2022). SRSF5-Mediated Alternative Splicing of M Gene is Essential for Influenza A Virus Replication: A Host-Directed Target Against Influenza Virus. Advanced Science, 9(34), Article 2203088. https://doi.org/10.1002/advs.202203088

Splicing of influenza A virus (IAV) RNA is an essential process in the viral life cycle that involves the co-opting of host factors. Here, it is demonstrated that induction of host serine and arginine-rich splicing factor 5 (SRSF5) by IAV facilitated... Read More about SRSF5-Mediated Alternative Splicing of M Gene is Essential for Influenza A Virus Replication: A Host-Directed Target Against Influenza Virus.

Enhanced stability of M1 protein mediated by a phospho-resistant mutation promotes the replication of prevailing avian influenza virus in mammals (2022)
Journal Article
Wang, C., Qu, R., Zong, Y., Qin, C., Liu, L., Gao, X., Sun, H., Sun, Y., Chang, K. C., Zhang, R., Liu, J., & Pu, J. (2022). Enhanced stability of M1 protein mediated by a phospho-resistant mutation promotes the replication of prevailing avian influenza virus in mammals. PLoS Pathogens, 18(7), Article e1010645. https://doi.org/10.1371/journal.ppat.1010645

Avian influenza virus (AIV) can evolve multiple strategies to combat host antiviral defenses and establish efficient infectivity in mammals, including humans. H9N2 AIV and its reassortants (such as H5N6 and H7N9 viruses) pose an increasing threat to... Read More about Enhanced stability of M1 protein mediated by a phospho-resistant mutation promotes the replication of prevailing avian influenza virus in mammals.

N-linked glycosylation enhances hemagglutinin stability in avian H5N6 influenza virus to promote adaptation in mammals. (2022)
Journal Article
Sun, H., Deng, G., Sun, H., Song, J., Zhang, W., Li, H., Wei, X., Li, F., Zhang, X., Liu, J., Pu, J., Sun, Y., Tong, Q., Bi, Y., Xie, Y., Qi, J., Chang, K.-C., Gao, G. F., & Liu, J. (2022). N-linked glycosylation enhances hemagglutinin stability in avian H5N6 influenza virus to promote adaptation in mammals. PNAS Nexus, 1(3), Article pgac085. https://doi.org/10.1093/pnasnexus/pgac085

Clade 2.3.4.4 avian H5Ny viruses, namely H5N2, H5N6, and H5N8, have exhibited unprecedented intercontinental spread in poultry. Among them, only H5N6 viruses are frequently reported to infect mammals and cause serious human infections. In this study,... Read More about N-linked glycosylation enhances hemagglutinin stability in avian H5N6 influenza virus to promote adaptation in mammals..