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Professor DILEEP LOBO's Outputs (109)

A phase 1 trial of human telomerase reverse transcriptase (hTERT) vaccination combined with therapeutic strategies to control immune-suppressor mechanisms (2024)
Journal Article
Zareian, N., Eremin, O., Pandha, H., Baird, R., Kwatra, V., Funingana, G., Verma, C., Choy, D., Hargreaves, S., Moghimi, P., Shepherd, A., Lobo, D. N., Eremin, J., Farzaneh, F., Kordasti, S., & Spicer, J. (2024). A phase 1 trial of human telomerase reverse transcriptase (hTERT) vaccination combined with therapeutic strategies to control immune-suppressor mechanisms. Experimental Biology and Medicine, 249(1), https://doi.org/10.3389/ebm.2024.10021

The presence of inhibitory immune cells and difficulty in generating activated effector T cells remain obstacles to development of effective cancer vaccines. We designed a vaccine regimen combining human telomerase reverse transcriptase (hTERT) pepti... Read More about A phase 1 trial of human telomerase reverse transcriptase (hTERT) vaccination combined with therapeutic strategies to control immune-suppressor mechanisms.

Association between prealbumin, all-cause mortality, and response to nutrition treatment in patients at nutrition risk. Secondary analysis of a randomized controlled trial (2023)
Journal Article
Bretscher, C., Buergin, M., Gurzeler, G., Kägi-Braun, N., Gressies, C., Tribolet, P., Lobo, D. N., Evans, D. C., Stanga, Z., Mueller, B., Schuetz, P., & for the EFFORT study team. (2023). Association between prealbumin, all-cause mortality, and response to nutrition treatment in patients at nutrition risk. Secondary analysis of a randomized controlled trial. Journal of Parenteral and Enteral Nutrition, 47(3), 408-419. https://doi.org/10.1002/jpen.2470

Background: Because of the shorter half-life as compared with albumin, serum prealbumin concentrations have been proposed to be useful nutrition biomarkers for the assessment of patients at nutrition risk. In a post hoc analysis of patients at nutrit... Read More about Association between prealbumin, all-cause mortality, and response to nutrition treatment in patients at nutrition risk. Secondary analysis of a randomized controlled trial.

Three Centuries of Appendicectomy (2022)
Journal Article
Herrod, P. J. J., Kwok, A. T., & Lobo, D. N. (2023). Three Centuries of Appendicectomy. World Journal of Surgery, 47(4), 928-936. https://doi.org/10.1007/s00268-022-06874-6

Background
Save for the contribution of Charles McBurney, who described his eponymous point and the appendicectomy incision, the history of appendicectomy is largely unknown among the medical profession. This review traces the history from the first... Read More about Three Centuries of Appendicectomy.

Nascent to novel methods to evaluate malnutrition and frailty in the surgical patient (2022)
Journal Article
Prado, C. M., Ford, K. L., Gonzalez, M. C., Murnane, L. C., Gillis, C., Wischmeyer, P. E., Morrison, C. A., & Lobo, D. N. (2023). Nascent to novel methods to evaluate malnutrition and frailty in the surgical patient. Journal of Parenteral and Enteral Nutrition, 47(S1), S54-S68. https://doi.org/10.1002/jpen.2420

Preoperative nutrition status is an important determinant of surgical outcomes, yet malnutrition assessment is not integrated into all surgical pathways. Given its importance and the high prevalence of malnutrition in patients undergoing surgical pro... Read More about Nascent to novel methods to evaluate malnutrition and frailty in the surgical patient.

Digital Informed Consent: Modernising Information Sharing in Surgery to Empower Patients (2022)
Journal Article
Parsons, S. L., Daliya, P., Evans, P., & Lobo, D. N. (2023). Digital Informed Consent: Modernising Information Sharing in Surgery to Empower Patients. World Journal of Surgery, 47(3), 649-657. https://doi.org/10.1007/s00268-022-06846-w

Background Despite the 2015 Montgomery Ruling highlighting key requisites for informed consent, little has changed to modernise data-sharing and documentation of the consent process. It can be difficult to gauge patient understanding and address all... Read More about Digital Informed Consent: Modernising Information Sharing in Surgery to Empower Patients.

Prehabilitation: high-quality evidence is still required (2022)
Journal Article
Lobo, D. N., Skořepa, P., Gomez, D., & Greenhaff, P. L. (2022). Prehabilitation: high-quality evidence is still required. British Journal of Anaesthesia, https://doi.org/10.1016/j.bja.2022.09.016

Prehabilitation comprises multidisciplinary healthcare interventions, including exercise, nutritional optimisation, and psychological preparation, which aim to dampen the metabolic response to surgery, shorten the period of recovery, reduce complicat... Read More about Prehabilitation: high-quality evidence is still required.

Identification of Surgeon Burnout via a Single-Item Measure (2022)
Journal Article
Houdmont, J., Daliya, P., Adiamah, A., Theophilidou, E., Hassard, J., Lobo, D. N., Ahmed, J., Babu, V., Baker, D., Bartlett, D., Beckingham, I., Bhatti, I., Brooks, A., Brown, S., Burke, J., Byrne, H., Chetter, I., Cook, H., Coulston, J., Cruddas, L., …Young, L. (2022). Identification of Surgeon Burnout via a Single-Item Measure. Occupational Medicine, 72(9), 641-643. https://doi.org/10.1093/occmed/kqac116

Background
Burnout is endemic in surgeons in the UK and linked with poor patient safety and quality of care, mental health problems, and workforce sustainability. Mechanisms are required to facilitate the efficient identification of burnout in this... Read More about Identification of Surgeon Burnout via a Single-Item Measure.

M1 macrophages evoke an increase in polymeric immunoglobulin receptor (PIGR) expression in MDA-MB468 breast cancer cells through secretion of interleukin-1β (2022)
Journal Article
Asanprakit, W., Lobo, D. N., Eremin, O., & Bennett, A. J. (2022). M1 macrophages evoke an increase in polymeric immunoglobulin receptor (PIGR) expression in MDA-MB468 breast cancer cells through secretion of interleukin-1β. Scientific Reports, 12(1), Article 16842. https://doi.org/10.1038/s41598-022-20811-6

High expression of polymeric immunoglobulin receptor (PIGR) in breast cancer is associated with increased 5-year survival rate. However, the factors influencing PIGR expression in breast cancer have not been elucidated. The aim of this study was to d... Read More about M1 macrophages evoke an increase in polymeric immunoglobulin receptor (PIGR) expression in MDA-MB468 breast cancer cells through secretion of interleukin-1β.

Human adaptation to immobilization: Novel insights of impacts on glucose disposal and fuel utilization (2022)
Journal Article
Shur, N. F., Simpson, E. J., Crossland, H., Chivaka, P. K., Constantin, D., Cordon, S. M., Constantin-Teodosiu, D., Stephens, F. B., Lobo, D. N., Szewczyk, N., Narici, M., Prats, C., Macdonald, I. A., & Greenhaff, P. L. (2022). Human adaptation to immobilization: Novel insights of impacts on glucose disposal and fuel utilization. Journal of Cachexia, Sarcopenia and Muscle, 13(6), 2999-3013. https://doi.org/10.1002/jcsm.13075

Background: Bed rest (BR) reduces whole-body insulin-stimulated glucose disposal (GD) and alters muscle fuel metabolism, but little is known about metabolic adaptation from acute to chronic BR nor the mechanisms involved, particularly when volunteers... Read More about Human adaptation to immobilization: Novel insights of impacts on glucose disposal and fuel utilization.

Randomised clinical trials comparing antibiotic therapy with appendicectomy for uncomplicated acute appendicitis: meta-analysis (2022)
Journal Article
Herrod, P. J. J., Kwok, A. T., & Lobo, D. N. (2022). Randomised clinical trials comparing antibiotic therapy with appendicectomy for uncomplicated acute appendicitis: meta-analysis. BJS Open, 6(4), Article zrac100

Background
This aim of this study was to provide an updated meta-analysis comparing antibiotic therapy with appendicectomy in adults (16 years or older) with uncomplicated acute appendicitis.

Methods
A search for randomized clinical trials compa... Read More about Randomised clinical trials comparing antibiotic therapy with appendicectomy for uncomplicated acute appendicitis: meta-analysis.

Digital Follow-Up After Elective Laparoscopic Cholecystectomy: A Feasibility Study (2022)
Journal Article
Daliya, P., Carvell, J., Rozentals, J., Lobo, D. N., & Parsons, S. L. (2022). Digital Follow-Up After Elective Laparoscopic Cholecystectomy: A Feasibility Study. World Journal of Surgery, 46, 2648-2658. https://doi.org/10.1007/s00268-022-06684-w

Background: Although recommendations exist for patients to be offered a post-operative helpline or telephone follow-up appointment at discharge after cholecystectomy, implementation of these is resource-intensive. Whilst the benefits of telephone fol... Read More about Digital Follow-Up After Elective Laparoscopic Cholecystectomy: A Feasibility Study.

O038 Digital consent: modernising data-sharing in surgery and empowering patients (2022)
Journal Article
Daliya, P., Lobo, D., & Parsons, S. (2022). O038 Digital consent: modernising data-sharing in surgery and empowering patients. British Journal of Surgery, 109(Supplement_4), Article znac242.038. https://doi.org/10.1093/bjs/znac242.038

Introduction Despite the 2015 Montgomery Ruling highlighting key requisites for informed consent, little has changed to modernise data-sharing and documentation of the consent process. Although many practitioners provide supplementary information to... Read More about O038 Digital consent: modernising data-sharing in surgery and empowering patients.

Utilising Electronic PROMs to Measure a Change in Health Following Elective Laparoscopic Cholecystectomy: A Feasibility Study (2022)
Journal Article
Daliya, P., Lobo, D. N., & Parsons, S. L. (2022). Utilising Electronic PROMs to Measure a Change in Health Following Elective Laparoscopic Cholecystectomy: A Feasibility Study. World Journal of Surgery, 46(9), 2155-2165. https://doi.org/10.1007/s00268-022-06588-9

Background
The collection of patient-reported outcome measures (PROMs) has many benefits for clinical practice. However, there are many barriers that prevent them from becoming a part of routine clinical care. The aim of this feasibility study was t... Read More about Utilising Electronic PROMs to Measure a Change in Health Following Elective Laparoscopic Cholecystectomy: A Feasibility Study.

Unresolved issues in perioperative nutrition: A narrative review (2022)
Journal Article
Ford, K. L., Prado, C. M., Weimann, A., Schuetz, P., & Lobo, D. N. (2022). Unresolved issues in perioperative nutrition: A narrative review. Clinical Nutrition, 41(7), 1578-1590. https://doi.org/10.1016/j.clnu.2022.05.015

Surgical patients are at an increased risk of negative outcomes if they are malnourished or at risk of malnutrition preoperatively. Optimisation of nutritional status should be a focus throughout the perioperative continuum to promote improved surgic... Read More about Unresolved issues in perioperative nutrition: A narrative review.

Prospective validation of five malnutrition screening and assessment instruments among medical inpatients: Secondary analysis of a randomized clinical trial (2022)
Journal Article
Stalder, L., Kaegi-Braun, N., Gressies, C., Gregoriano, C., Tribolet, P., Lobo, D. N., Gomes, F., Hoess, C., Pavlicek, V., Bilz, S., Sigrist, S., Brändle, M., Henzen, C., Thomann, R., Rutishauser, J., Aujesky, D., Rodondi, N., Donzé, J., Stanga, Z., Mueller, B., & Schuetz, P. (2022). Prospective validation of five malnutrition screening and assessment instruments among medical inpatients: Secondary analysis of a randomized clinical trial. Clinical Nutrition, 41(6), 1307-1315. https://doi.org/10.1016/j.clnu.2022.04.025

Background & aims: Screening for malnutrition upon hospital admission is the first crucial step for proper nutritional assessment and treatment. While several nutritional screening and assessment instruments exist, there is a lack of head-to-head val... Read More about Prospective validation of five malnutrition screening and assessment instruments among medical inpatients: Secondary analysis of a randomized clinical trial.

Misappropriation of the 1986 WHO analgesic ladder: the pitfalls of labelling opioids as weak or strong (2022)
Journal Article
Crush, J., Levy, N., Knaggs, R. D., & Lobo, D. N. (2022). Misappropriation of the 1986 WHO analgesic ladder: the pitfalls of labelling opioids as weak or strong. British Journal of Anaesthesia, 129(2), 137-142. https://doi.org/10.1016/j.bja.2022.03.004

Opioids have a vital role in alleviating pain from cancer and surgery. Despite good intentions, it is now recognised that the original WHO Cancer Pain Relief guidance from 1986, in which opioids were classified as either weak or strong, has been both... Read More about Misappropriation of the 1986 WHO analgesic ladder: the pitfalls of labelling opioids as weak or strong.

Early Postoperative Supplementary Parenteral Nutrition (2022)
Journal Article
Ljungqvist, O., Gustafsson, U. O., & Lobo, D. N. (2022). Early Postoperative Supplementary Parenteral Nutrition. JAMA Surgery, 209, Article 118333. https://doi.org/10.1001/jamasurg.2022.0266

Molten salts have been used in solar thermal energy storage due to their high energy storage density, low cost and excellent chemical stability. However, their application is limited by “bad days” such as cloudy days and winter because the weak conce... Read More about Early Postoperative Supplementary Parenteral Nutrition.