WILLIAM BROWN's Outputs (3)

Mutation and selection explain why many eukaryotic centromeric DNA sequences are often A+T rich (2021)
Journal Article
Barbosa, A. C., Xu, Z., Karari, K., Williams, W., Hauf, S., & Brown, W. R. A. (2022). Mutation and selection explain why many eukaryotic centromeric DNA sequences are often A+T rich. Nucleic Acids Research, 50(1), 579-596. https://doi.org/10.1093/nar/gkab1219

We have used chromosome engineering to replace native centromeric DNA with different test sequences at native centromeres in two different strains of the fission yeast Schizosaccharomyces pombe and have discovered that A + T rich DNA, whether synthet... Read More about Mutation and selection explain why many eukaryotic centromeric DNA sequences are often A+T rich.

Kinetochore assembly and heterochromatin formation occur autonomously in Schizosaccharomyces pombe (2014)
Journal Article
Brown, W. R., Thomas, G., Lee, N. C., Blythe, M., Liti, G., Warringer, J., & Loose, M. W. (2014). Kinetochore assembly and heterochromatin formation occur autonomously in Schizosaccharomyces pombe. Proceedings of the National Academy of Sciences, 111(5), https://doi.org/10.1073/pnas.1216934111

Kinetochores in multicellular eukaryotes are usually associated with heterochromatin. Whether this heterochromatin simply promotes the cohesion necessary for accurate chromosome segregation at cell division or whether it also has a role in kinetochor... Read More about Kinetochore assembly and heterochromatin formation occur autonomously in Schizosaccharomyces pombe.

A geographically diverse collection of schizosaccharomyces pombe isolates shows limited phenotypic variation but extensive karyotypic diversity (2011)
Journal Article
Brown, W. R., Litti, G., Rosa, C., James, S., Roberts, I., Robert, V., …Warringer, J. (2011). A geographically diverse collection of schizosaccharomyces pombe isolates shows limited phenotypic variation but extensive karyotypic diversity. G3, 1(7), https://doi.org/10.1534/g3.111.001123

The fission yeast Schizosaccharomyces pombe has been widely used to study eukaryotic cell
biology, but almost all of this work has used derivatives of a single strain. We have studied 81 independent
natural isolates and 3 designated laboratory stra... Read More about A geographically diverse collection of schizosaccharomyces pombe isolates shows limited phenotypic variation but extensive karyotypic diversity.