Professor PHIL WILLIAMS's Outputs (33)

Teleoperated Astropharmaceutical Payload for Long-Duration Space Missions: Project VITA! (2024)
Presentation / Conference Contribution
Izcan, S., Tsinidis, M., Pushparaj, N., Williams, P., & Cappelletti, C. (2024, October). Teleoperated Astropharmaceutical Payload for Long-Duration Space Missions: Project VITA!. Presented at 75th International Astronautical Congress, Milan, Italy

The VITA (Visualizing In-space Tx-Tl Astropharmaceuticals) mission is a teleoperated Astropharmaceutical cube-payload that will launch a biological experiment to the ICE Cubes Facility (ICF) on board the International Space Station (ISS) as a selecte... Read More about Teleoperated Astropharmaceutical Payload for Long-Duration Space Missions: Project VITA!.

Cosmic-Ray Radiation Effects on Ibuprofen Tablet Formulation Inside and Outside of the International Space Station (2024)
Journal Article
Tran, Q. D., Spooner, N., Geoghehan, S., Thavarajah, S. R., Rahman, S., Tran, N. N., Williams, P. M., Jarquin, S. M., Kim, D., Davey, K., Buell, J., Shumbera, M., Gittleman, M., Clements, T., Stoudemire, J., Fisk, I., & Hessel, V. (2024). Cosmic-Ray Radiation Effects on Ibuprofen Tablet Formulation Inside and Outside of the International Space Station. Advanced Healthcare Materials, https://doi.org/10.1002/adhm.202402361

In extreme environments people will have different needs for medicine(s), making it crucial to understand how such environments affect drug efficacy. Ibuprofen, commonly used in tablet formulation on Earth, could fail in space despite standard pharma... Read More about Cosmic-Ray Radiation Effects on Ibuprofen Tablet Formulation Inside and Outside of the International Space Station.

Cosmic-Ray Radiation Effects on Ibuprofen Tablet Formulation Inside and Outside of the International Space Station (2024)
Preprint / Working Paper
Fisk, I., Tran, Q., Spooner, N., Geoghehan, S., Thavarajah, S., Rahman, S., Tran, N., Williams, P., Jarquin, S., Kim, D.-H., Davey, K., Buell, J., Shumbera, M., Gittleman, M., Clements, T., Stoudemire, J., & Hessel, V. (2024). Cosmic-Ray Radiation Effects on Ibuprofen Tablet Formulation Inside and Outside of the International Space Station

In extreme environments people will have different needs for medicine(s). It is important, therefore, to know how medicine efficacy will be impacted by the environment. Ibuprofen is very widely used in tablet formulation in temperate climates on Eart... Read More about Cosmic-Ray Radiation Effects on Ibuprofen Tablet Formulation Inside and Outside of the International Space Station.

Discovery and Computational Modelling of Adsorbent Polymers that Effectively Immobilize SARS-CoV-2 with Potential Practical Applications (2024)
Journal Article
Xue, X., Duncan, J. D., Coleman, C. M., Contreas, L., Blackburn, C., Vivero-Lopez, M., Williams, P. M., Ball, J. K., Alexander, C., & Alexander, M. R. (2024). Discovery and Computational Modelling of Adsorbent Polymers that Effectively Immobilize SARS-CoV-2 with Potential Practical Applications. Cell Reports Physical Science, 5(9), Article 102204. https://doi.org/10.1016/j.xcrp.2024.102204

Viral translocation is considered a common way for respiratory viruses to spread and contaminate the surrounding environment. Thus, the discovery of non-eluting polymers that immobilize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) upo... Read More about Discovery and Computational Modelling of Adsorbent Polymers that Effectively Immobilize SARS-CoV-2 with Potential Practical Applications.

Advancing insights into microgravity induced muscle changes using Caenorhabditis elegans as a model organism (2024)
Journal Article
Beckett, L. J., Williams, P. M., Toh, L. S., Hessel, V., Gerstweiler, L., Fisk, I., Toronjo-Urquiza, L., & Chauhan, V. M. (2024). Advancing insights into microgravity induced muscle changes using Caenorhabditis elegans as a model organism. npj Microgravity, 10(1), Article 79. https://doi.org/10.1038/s41526-024-00418-z

Spaceflight presents significant challenges to the physiological state of living organisms. This can be due to the microgravity environment experienced during long-term space missions, resulting in alterations in muscle structure and function, such a... Read More about Advancing insights into microgravity induced muscle changes using Caenorhabditis elegans as a model organism.

Esterification and volatile compound manipulation using radiofrequency cold plasma (2024)
Journal Article
Warne, G. R., Lim, M., Lamichhane, P., Machala, Z., Hessel, V., Williams, P. M., & Fisk, I. D. (2024). Esterification and volatile compound manipulation using radiofrequency cold plasma. Innovative Food Science and Emerging Technologies, 95, Article 103726. https://doi.org/10.1016/j.ifset.2024.103726

Esters are vital in many industries, including food; however, there are still significant opportunities to improve production efficiency, sustainability, and cost. Cold plasma was trialled as a novel tool to induce esterification. Cold plasma increas... Read More about Esterification and volatile compound manipulation using radiofrequency cold plasma.

Bacillus subtilis engineered for aerospace medicine: a platform for on-demand production of pharmaceutical peptides (2023)
Journal Article
Vallota-Eastman, A., Bui, C., Williams, P. M., Valentine, D. L., Loftus, D., & Rothschild, L. (2023). Bacillus subtilis engineered for aerospace medicine: a platform for on-demand production of pharmaceutical peptides. Frontiers in Space Technologies, 4, Article 1181843. https://doi.org/10.3389/frspt.2023.1181843

Biologics, such as pharmaceutical peptides, have notoriously short shelf lives, insufficient for long-duration space flight missions to the Moon or Mars. To enable the sustainable presence of humans on the Moon or Mars, we must develop methods for on... Read More about Bacillus subtilis engineered for aerospace medicine: a platform for on-demand production of pharmaceutical peptides.

Modelled-Microgravity Reduces Virulence Factor Production in Staphylococcus aureus through Downregulation of agr-Dependent Quorum Sensing (2023)
Journal Article
Green, M. J., Murray, E. J., Williams, P., Ghaemmaghami, A. M., Aylott, J. W., & Williams, P. M. (2023). Modelled-Microgravity Reduces Virulence Factor Production in Staphylococcus aureus through Downregulation of agr-Dependent Quorum Sensing. International Journal of Molecular Sciences, 24(21), Article 15997. https://doi.org/10.3390/ijms242115997

Bacterial contamination during space missions is problematic for human health and damages filters and other vital support systems. Staphylococcus aureus is both a human commensal and an opportunistic pathogen that colonizes human tissues and causes a... Read More about Modelled-Microgravity Reduces Virulence Factor Production in Staphylococcus aureus through Downregulation of agr-Dependent Quorum Sensing.

Spaceflight Induces Strength Decline in Caenorhabditis elegans (2023)
Journal Article
Soni, P., Edwards, H., Anupom, T., Rahman, M., Lesanpezeshki, L., Blawzdziewicz, J., Cope, H., Gharahdaghi, N., Scott, D., Toh, L. S., Williams, P. M., Etheridge, T., Szewczyk, N., Willis, C. R. G., & Vanapalli, S. A. (2023). Spaceflight Induces Strength Decline in Caenorhabditis elegans. Cells, 12(20), Article 2470. https://doi.org/10.3390/cells12202470

Background: Understanding and countering the well-established negative health consequences of spaceflight remains a primary challenge preventing safe deep space exploration. Targeted/personalized therapeutics are at the forefront of space medicine st... Read More about Spaceflight Induces Strength Decline in Caenorhabditis elegans.

Radiofrequency cold plasma – A novel tool for flavour modification in fresh and freeze-dried strawberries (2023)
Journal Article
Warne, G. R., Lim, M., Wilkinson, K., Hessel, V., Williams, P. M., & Fisk, I. D. (2023). Radiofrequency cold plasma – A novel tool for flavour modification in fresh and freeze-dried strawberries. Innovative Food Science and Emerging Technologies, 90, Article 103497. https://doi.org/10.1016/j.ifset.2023.103497

Cold plasma treatment is an emerging non-thermal food processing tool. This study aimed to identify how cold plasma can improve the aroma of a model space food system (freeze-dried strawberries) by mitigating freeze-drying aroma losses. Cold plasma s... Read More about Radiofrequency cold plasma – A novel tool for flavour modification in fresh and freeze-dried strawberries.

Microflow synthesis of a formulation of phosphorus fertiliser to enhance the P content in soil and P uptake in wheat (2023)
Journal Article
Nguyen Quang Le, T., Robertson, K., Escribà-Gelonch, M., Marschner, P., Nghiep Tran, N., Williams, P. M., Fisk, I., & Hessel, V. (2023). Microflow synthesis of a formulation of phosphorus fertiliser to enhance the P content in soil and P uptake in wheat. Green Chemistry, 25(22), 9422-9437. https://doi.org/10.1039/d3gc02859c

Highly soluble commercial phosphorus (P) fertilisers have been the most common form of P applied in agriculture for decades, but their releasing efficiency can be low because phosphate ions can easily bind with cations in the soil to form precipitate... Read More about Microflow synthesis of a formulation of phosphorus fertiliser to enhance the P content in soil and P uptake in wheat.

Patch area and uniform sampling on the surface of any ellipsoid (2023)
Journal Article
Marples, C. R., & Williams, P. M. (2024). Patch area and uniform sampling on the surface of any ellipsoid. Numerical Algorithms, 95(4), 1801-1827. https://doi.org/10.1007/s11075-023-01628-4

Algorithms for generating uniform random points on a triaxial ellipsoid are non-trivial to verify because of the non-analytical form of the surface area. In this paper, a formula for the surface area of an ellipsoidal patch is derived in the form of... Read More about Patch area and uniform sampling on the surface of any ellipsoid.

Linear Binary Classifier to Predict Bacterial Biofilm Formation on Polyacrylates (2023)
Journal Article
Contreas, L., Hook, A. L., Winkler, D. A., Figueredo, G., Williams, P., Laughton, C. A., Alexander, M. R., & Williams, P. M. (2023). Linear Binary Classifier to Predict Bacterial Biofilm Formation on Polyacrylates. ACS Applied Materials and Interfaces, 15(11), 14155-14163. https://doi.org/10.1021/acsami.2c23182

Bacterial infections are increasingly problematic due to the rise of antimicrobial resistance. Consequently, the rational design of materials naturally resistant to biofilm formation is an important strategy for preventing medical device-associated i... Read More about Linear Binary Classifier to Predict Bacterial Biofilm Formation on Polyacrylates.

The Golden Ratio in Nature: A Tour across Length Scales (2022)
Journal Article
Marples, C. R., & Williams, P. M. (2022). The Golden Ratio in Nature: A Tour across Length Scales. Symmetry, 14(10), Article 2059. https://doi.org/10.3390/sym14102059

The Golden ratio is an irrational number that has a tendency to appear in many different scientific and artistic fields. It may be found in natural phenomena across a vast range of length scales; from galactic to atomic. In this review, the mathemati... Read More about The Golden Ratio in Nature: A Tour across Length Scales.

Routine omics collection is a golden opportunity for European human research in space and analog environments (2022)
Journal Article
Cope, H., Willis, C. R., MacKay, M. J., Rutter, L. A., Toh, L. S., Williams, P. M., Herranz, R., Borg, J., Bezdan, D., Giacomello, S., Muratani, M., Mason, C. E., Etheridge, T., & Szewczyk, N. J. (2022). Routine omics collection is a golden opportunity for European human research in space and analog environments. Patterns, 3(10), Article 100550. https://doi.org/10.1016/j.patter.2022.100550

Widespread generation and analysis of omics data have revolutionized molecular medicine on Earth, yet its power to yield new mechanistic insights and improve occupational health during spaceflight is still to be fully realized in humans. Nevertheless... Read More about Routine omics collection is a golden opportunity for European human research in space and analog environments.

Space Medicines for Space Health (2022)
Journal Article
Tran, Q. D., Tran, V., Toh, L. S., Williams, P. M., Tran, N. N., & Hessel, V. (2022). Space Medicines for Space Health. ACS Medicinal Chemistry Letters, 13(8), 1231–1247. https://doi.org/10.1021/acsmedchemlett.1c00681

Scientists from around the world are studying the effects of microgravity and cosmic radiation via the “off-Earth” International Space Station (ISS) laboratory platform. The ISS has helped scientists make discoveries that go beyond the basic understa... Read More about Space Medicines for Space Health.

Astropharmacy: Pushing the boundaries of the pharmacists’ role for sustainable space exploration (2022)
Journal Article
Sawyers, L., Anderson, C., Boyd, M. J., Hessel, V., Wotring, V., Williams, P. M., & Toh, L. S. (2022). Astropharmacy: Pushing the boundaries of the pharmacists’ role for sustainable space exploration. Research in Social and Administrative Pharmacy, https://doi.org/10.1016/j.sapharm.2022.02.002

Background: Human physiology undergoes extensive changes in space potentially leading to alterations in the way a medication functions. Understanding the efficacy behind Pharmacological Countermeasures (PCMs) and deliverable pharmacy services is impe... Read More about Astropharmacy: Pushing the boundaries of the pharmacists’ role for sustainable space exploration.

Generation and Characterization of a Library of Novel Biologically Active Functional Surfactants (Surfmers) Using Combined High-Throughput Methods (2021)
Journal Article
Cuzzucoli Crucitti, V., Contreas, L., Taresco, V., Howard, S. C., Dundas, A. A., Limo, M. J., Nisisako, T., Williams, P. M., Williams, P., Alexander, M. R., Wildman, R. D., Muir, B. W., & Irvine, D. J. (2021). Generation and Characterization of a Library of Novel Biologically Active Functional Surfactants (Surfmers) Using Combined High-Throughput Methods. ACS Applied Materials and Interfaces, 13(36), 43290-43300. https://doi.org/10.1021/acsami.1c08662

We report the first successful combination of three distinct high-throughput techniques to deliver the accelerated design, synthesis, and property screening of a library of novel, bio-instructive, polymeric, comb-graft surfactants. These three-dimens... Read More about Generation and Characterization of a Library of Novel Biologically Active Functional Surfactants (Surfmers) Using Combined High-Throughput Methods.

Impact of cold plasma on the biomolecules and organoleptic properties of foods: A review (2021)
Journal Article
Warne, G. R., Williams, P. M., Quoc Pho, H., Nghiep Tran, N., Hessel, V., & Fisk, I. D. (2021). Impact of cold plasma on the biomolecules and organoleptic properties of foods: A review. Journal of Food Science, 86(9), 3762-3777. https://doi.org/10.1111/1750-3841.15856

Cold plasma is formed by the nonthermal ionisation of gas into free electrons, ions, reactive atomic and molecular species, and UV radiation. This cold plasma can be used to alter the surface of solid and liquid foods, and it offers multiple advantag... Read More about Impact of cold plasma on the biomolecules and organoleptic properties of foods: A review.

Droplet Microfluidic Optimisation Using Micropipette Characterisation of Bio-Instructive Polymeric Surfactants (2021)
Journal Article
Henshaw, C. A., Dundas, A. A., Cuzzucoli Crucitti, V., Alexander, M. R., Wildman, R., Rose, F. R. A. J., Irvine, D. J., & Williams, P. M. (2021). Droplet Microfluidic Optimisation Using Micropipette Characterisation of Bio-Instructive Polymeric Surfactants. Molecules, 26(11), Article 3302. https://doi.org/10.3390/molecules26113302

Droplet microfluidics can produce highly tailored microparticles whilst retaining monodispersity. However, these systems often require lengthy optimisation, commonly based on a trial-and-error approach, particularly when using bio-instructive, polyme... Read More about Droplet Microfluidic Optimisation Using Micropipette Characterisation of Bio-Instructive Polymeric Surfactants.