Professor CAROL COUPLAND's Outputs (148)

Risk prediction of covid-19 related death or hospital admission in adults testing positive for SARS-CoV-2 infection during the omicron wave in England (QCOVID4): cohort study (2023)
Journal Article
Hippisley-Cox, J., Khunti, K., Sheikh, A., Nguyen-Van-Tam, J. S., & Coupland, C. A. (2023). Risk prediction of covid-19 related death or hospital admission in adults testing positive for SARS-CoV-2 infection during the omicron wave in England (QCOVID4): cohort study. British Medical Journal, 381, Article e072976. https://doi.org/10.1136/bmj-2022-072976

Objectives To derive and validate risk prediction algorithms (QCOVID4) to estimate the risk of covid-19 related death and hospital admission in people with a positive SARS-CoV-2 test result during the period when the omicron variant of the virus was... Read More about Risk prediction of covid-19 related death or hospital admission in adults testing positive for SARS-CoV-2 infection during the omicron wave in England (QCOVID4): cohort study.

Disparities in care and outcomes for primary liver cancer in England during 2008–2018: a cohort study of 8.52 million primary care population using the QResearch database (2023)
Journal Article
Liao, W., Coupland, C. A., Innes, H., Jepsen, P., Matthews, P. C., Campbell, C., Barnes, E., Hippisley-Cox, J., Barnes, E., Culver, E., Fischer, R., Hippisley-Cox, J., Innes, H., Irving, W. L., Jepsen, P., Kelly, M., Klenerman, P., Liao, W., Mann, D., Marshall, A., …Welberry, C. (2023). Disparities in care and outcomes for primary liver cancer in England during 2008–2018: a cohort study of 8.52 million primary care population using the QResearch database. eClinicalMedicine, 59, Article 101969. https://doi.org/10.1016/j.eclinm.2023.101969

Background: Liver cancer has one of the fastest rising incidence and mortality rates among all cancers in the UK, but it receives little attention. This study aims to understand the disparities in epidemiology and clinical pathways of primary liver c... Read More about Disparities in care and outcomes for primary liver cancer in England during 2008–2018: a cohort study of 8.52 million primary care population using the QResearch database.

Predicting the future risk of lung cancer: development, and internal and external validation of the CanPredict (lung) model in 19·67 million people and evaluation of model performance against seven other risk prediction models (2023)
Journal Article
Liao, W., Coupland, C., Burchardt, J., Baldwin, D. R., Gleeson, F. V., Hippisley-Cox, J., & DART initiative. (2023). Predicting the future risk of lung cancer: development, and internal and external validation of the CanPredict (lung) model in 19·67 million people and evaluation of model performance against seven other risk prediction models. Lancet Respiratory Medicine, https://doi.org/10.1016/S2213-2600%2823%2900050-4

Background: Lung cancer is the second most common cancer in incidence and the leading cause of cancer deaths worldwide. Meanwhile, lung cancer screening with low-dose CT can reduce mortality. The UK National Screening Committee recommended targeted l... Read More about Predicting the future risk of lung cancer: development, and internal and external validation of the CanPredict (lung) model in 19·67 million people and evaluation of model performance against seven other risk prediction models.

Ethnic disparities in COVID-19 outcomes: a multinational cohort study of 20 million individuals from England and Canada (2023)
Journal Article
Zaccardi, F., Tan, P. S., Shah, B. R., Everett, K., Clift, A. K., Patone, M., Saatci, D., Coupland, C., Griffin, S. J., Khunti, K., Dambha-Miller, H., & Hippisley-Cox, J. (2023). Ethnic disparities in COVID-19 outcomes: a multinational cohort study of 20 million individuals from England and Canada. BMC Public Health, 23(1), Article 399. https://doi.org/10.1186/s12889-023-15223-8

Background: Heterogeneous studies have demonstrated ethnic inequalities in the risk of SARS-CoV-2 infection and adverse COVID-19 outcomes. This study evaluates the association between ethnicity and COVID-19 outcomes in two large population-based coho... Read More about Ethnic disparities in COVID-19 outcomes: a multinational cohort study of 20 million individuals from England and Canada.

Impact of the COVID-19 pandemic on incidence of tics in children and young people: a population-based cohort study (2023)
Journal Article
Jack, R. H., Joseph, R. M., Coupland, C. A., Hall, C. L., & Hollis, C. (2023). Impact of the COVID-19 pandemic on incidence of tics in children and young people: a population-based cohort study. eClinicalMedicine, 57, Article 101857. https://doi.org/10.1016/j.eclinm.2023.101857

Background: Since the onset of the coronavirus (COVID-19) pandemic, clinicians have reported an increase in presentations of sudden and new onset tics particularly affecting teenage girls. This population-based study aimed to describe and compare the... Read More about Impact of the COVID-19 pandemic on incidence of tics in children and young people: a population-based cohort study.

Uptake of COVID-19 vaccination in people with blood cancer: Population-level cohort study of 12 million patients in England (2023)
Journal Article
Hirst, J., Mi, E., Copland, E., Patone, M., Coupland, C., & Hippisley-Cox, J. (2023). Uptake of COVID-19 vaccination in people with blood cancer: Population-level cohort study of 12 million patients in England. European Journal of Cancer, 183, 162-170. https://doi.org/10.1016/j.ejca.2023.02.001

Background: People with blood cancers have increased risk of severe outcomes from COVID-19 and were prioritised for vaccination. Methods: Individuals in the QResearch database aged 12 years and above on 1st December 2020 were included in the analysis... Read More about Uptake of COVID-19 vaccination in people with blood cancer: Population-level cohort study of 12 million patients in England.

Effectiveness of systematically delivered evidence-based home safety promotion to improve child home safety practices: a controlled before-and-after study (2023)
Journal Article
Taylor, M. J., Orton, E., Patel, T., Timblin, C., Clarke, R., Watson, M. C., Hayes, M., Jones, M., Coupland, C., & Kendrick, D. (2023). Effectiveness of systematically delivered evidence-based home safety promotion to improve child home safety practices: a controlled before-and-after study. Injury Prevention, 29(3), 227-233. https://doi.org/10.1136/ip-2022-044745

Objective: Evaluate the effectiveness of systematically delivered evidence-based home safety promotion for improving child home safety practices. Design: Controlled before-and-after study. Setting: Nine electoral wards in Nottingham, UK. Participants... Read More about Effectiveness of systematically delivered evidence-based home safety promotion to improve child home safety practices: a controlled before-and-after study.

Increases in stress hormone levels in a UK population during the COVID-19 pandemic: A prospective cohort study (2022)
Journal Article
Jia, R., Ayling, K., Coupland, C., Chalder, T., Massey, A., Nater, U., Broadbent, E., Gasteiger, N., Gao, W., Kirschbaum, C., & Vedhara, K. (2023). Increases in stress hormone levels in a UK population during the COVID-19 pandemic: A prospective cohort study. Psychoneuroendocrinology, 148, Article 105992. https://doi.org/10.1016/j.psyneuen.2022.105992

Background: Research suggests that psychological factors may influence vulnerability to SARS-CoV-2 infection, although the mechanisms are unclear. Purpose: We examined whether the hypothalamic-pituitary-adrenal axis may be a possible mechanism, by me... Read More about Increases in stress hormone levels in a UK population during the COVID-19 pandemic: A prospective cohort study.

Cost-effectiveness of England's national 'Safe At Home' scheme for reducing hospital admissions for unintentional injury in children aged under 5 (2022)
Journal Article
Jones, M., Hill, T., Coupland, C., Kendrick, D., Akbari, A., Rodgers, S., Watson, M. C., Tyrrell, E., Merrill, S., Martin, A., & Orton, E. (2022). Cost-effectiveness of England's national 'Safe At Home' scheme for reducing hospital admissions for unintentional injury in children aged under 5. Injury Prevention, https://doi.org/10.1136/ip-2022-044698

Background: Injuries in children aged under 5 years most commonly occur in the home and disproportionately affect those living in the most disadvantaged communities. The 'Safe at Home' (SAH) national home safety equipment scheme, which ran in England... Read More about Cost-effectiveness of England's national 'Safe At Home' scheme for reducing hospital admissions for unintentional injury in children aged under 5.

Preexisting Neuropsychiatric Conditions and Associated Risk of Severe COVID-19 Infection and Other Acute Respiratory Infections (2022)
Journal Article
Ranger, T. A., Clift, A. K., Patone, M., Coupland, C. A. C., Hatch, R., Thomas, K., Watkinson, P., & Hippisley-Cox, J. (2022). Preexisting Neuropsychiatric Conditions and Associated Risk of Severe COVID-19 Infection and Other Acute Respiratory Infections. JAMA Psychiatry, 80(1), 57-65. https://doi.org/10.1001/jamapsychiatry.2022.3614

Importance Evidence indicates that preexisting neuropsychiatric conditions confer increased risks of severe outcomes from COVID-19 infection. It is unclear how this increased risk compares with risks associated with other severe acute respiratory inf... Read More about Preexisting Neuropsychiatric Conditions and Associated Risk of Severe COVID-19 Infection and Other Acute Respiratory Infections.

Design decisions and data completeness for experience sampling methods used in psychosis: systematic review (2022)
Journal Article
Deakin, E., Ng, F., Young, E., Thorpe, N., Newby, C., Coupland, C., Craven, M., & Slade, M. (2022). Design decisions and data completeness for experience sampling methods used in psychosis: systematic review. BMC Psychiatry, 22, Article 669. https://doi.org/10.1186/s12888-022-04319-x

Background: The experience sampling method (ESM) is an intensive longitudinal research method. Participants complete questionnaires at multiple times about their current or very recent state. The design of ESM studies is complex. People with psychosi... Read More about Design decisions and data completeness for experience sampling methods used in psychosis: systematic review.

Risk Factors and Changes in Depression and Anxiety over Time in New Zealand during COVID-19: A Longitudinal Cohort Study (2022)
Journal Article
Law, M., Gasteiger, N., Vedhara, K., Massey, A., Jia, R., Ayling, K., Chalder, T., Coupland, C., & Broadbent, E. (2022). Risk Factors and Changes in Depression and Anxiety over Time in New Zealand during COVID-19: A Longitudinal Cohort Study. Psych, 4(4), 706-716. https://doi.org/10.3390/psych4040052

This longitudinal study investigated changes in and risk factors for anxiety and depression during the COVID-19 pandemic in a New Zealand cohort. Online surveys were distributed to 681 participants at three time-points: May 2020 (Time 1), August–Sept... Read More about Risk Factors and Changes in Depression and Anxiety over Time in New Zealand during COVID-19: A Longitudinal Cohort Study.

Associations of BMI with COVID-19 vaccine uptake, vaccine effectiveness, and risk of severe COVID-19 outcomes after vaccination in England: a population-based cohort study (2022)
Journal Article
Piernas, C., Patone, M., Astbury, N. M., Gao, M., Sheikh, A., Khunti, K., Shankar-Hari, M., Dixon, S., Coupland, C., Aveyard, P., Hippisley-Cox, J., & Jebb, S. A. (2022). Associations of BMI with COVID-19 vaccine uptake, vaccine effectiveness, and risk of severe COVID-19 outcomes after vaccination in England: a population-based cohort study. Lancet Diabetes and Endocrinology, 10(8), 571-580. https://doi.org/10.1016/s2213-8587%2822%2900158-9

Background: A high BMI has been associated with a reduced immune response to vaccination against influenza. We aimed to investigate the association between BMI and COVID-19 vaccine uptake, vaccine effectiveness, and risk of severe COVID-19 outcomes a... Read More about Associations of BMI with COVID-19 vaccine uptake, vaccine effectiveness, and risk of severe COVID-19 outcomes after vaccination in England: a population-based cohort study.

Temporality of body mass index, blood tests, comorbidities and medication use as early markers for pancreatic ductal adenocarcinoma (PDAC): a nested case–control study (2022)
Journal Article
Tan, P. S., Garriga, C., Clift, A., Liao, W., Patone, M., Coupland, C., Bashford-Rogers, R., Sivakumar, S., & Hippisley-Cox, J. (2023). Temporality of body mass index, blood tests, comorbidities and medication use as early markers for pancreatic ductal adenocarcinoma (PDAC): a nested case–control study. Gut, 72(3), 512-521. https://doi.org/10.1136/gutjnl-2021-326522

Objective Prior studies identified clinical factors associated with increased risk of pancreatic ductal adenocarcinoma (PDAC). However, little is known regarding their time-varying nature, which could inform earlier diagnosis. This study assessed tem... Read More about Temporality of body mass index, blood tests, comorbidities and medication use as early markers for pancreatic ductal adenocarcinoma (PDAC): a nested case–control study.

Common protocol for validation of the QCOVID algorithm across the four UK nations (2022)
Journal Article
Kerr, S., Robertson, C., Nafilyan, V., Lyons, R. A., Kee, F., Cardwell, C. R., Coupland, C., Lyons, J., Humberstone, B., Hippisley-Cox, J., & Sheikh, A. (2022). Common protocol for validation of the QCOVID algorithm across the four UK nations. BMJ Open, 12(6), Article e050994. https://doi.org/10.1136/bmjopen-2021-050994

Introduction The QCOVID algorithm is a risk prediction tool for infection and subsequent hospitalisation/death due to SARS-CoV-2. At the time of writing, it is being used in important policy-making decisions by the UK and devolved governments for com... Read More about Common protocol for validation of the QCOVID algorithm across the four UK nations.

Comorbidities in osteoarthritis (ComOA): a combined cross-sectional, case–control and cohort study using large electronic health records in four European countries (2022)
Journal Article
Swain, S., Kamps, A., Runhaar, J., Dell ‘Isola, A., Turkiewicz, A., Robinson, D., Strauss, V. Y., Mallen, C., Kuo, C. F., Coupland, C., Doherty, M., Sarmanova, A., Prieto Alhambra, D., Englund, M., Bierma-Zeinstra, S., & Zhang, W. (2022). Comorbidities in osteoarthritis (ComOA): a combined cross-sectional, case–control and cohort study using large electronic health records in four European countries. BMJ Open, 12(4), Article e052816. https://doi.org/10.1136/bmjopen-2021-052816

Introduction: Osteoarthritis (OA) is one of the leading chronic conditions in the older population. People with OA are more likely to have one or more other chronic conditions than those without. However, the temporal associations, clusters of the co... Read More about Comorbidities in osteoarthritis (ComOA): a combined cross-sectional, case–control and cohort study using large electronic health records in four European countries.

The prevalence, incidence, prognosis and risk factors for symptoms of depression and anxiety in a UK cohort during the COVID-19 pandemic (2022)
Journal Article
Jia, R., Ayling, K., Chalder, T., Massey, A., Gasteiger, N., Broadbent, E., Coupland, C., & Vedhara, K. (2022). The prevalence, incidence, prognosis and risk factors for symptoms of depression and anxiety in a UK cohort during the COVID-19 pandemic. BJPsych Open, 8(2), Article e64. https://doi.org/10.1192/bjo.2022.34

Background The COVID-19 pandemic has had profound consequences for population mental health. However, it is less clear for whom these effects are sustained. Aims To investigate the prevalence, incidence, prognosis and risk factors for symptoms of dep... Read More about The prevalence, incidence, prognosis and risk factors for symptoms of depression and anxiety in a UK cohort during the COVID-19 pandemic.

Association between mirtazapine use and serious self-harm in people with depression: an active comparator cohort study using UK electronic health records (2022)
Journal Article
Joseph, R. M., Jack, R. H., Morriss, R., Knaggs, R. D., Butler, D., Hollis, C., Hippisley-Cox, J., & Coupland, C. (2022). Association between mirtazapine use and serious self-harm in people with depression: an active comparator cohort study using UK electronic health records. Evidence-Based Mental Health, 25(4), 169-176. https://doi.org/10.1136/ebmental-2021-300355

BACKGROUND: Studies report an increased risk of self-harm or suicide in people prescribed mirtazapine compared with other antidepressants. OBJECTIVES: To compare the risk of serious self-harm in people prescribed mirtazapine versus other antidepressa... Read More about Association between mirtazapine use and serious self-harm in people with depression: an active comparator cohort study using UK electronic health records.

Association between smoking, e-cigarette use and severe COVID-19: A cohort study (2022)
Journal Article
Gao, M., Aveyard, P., Lindson, N., Hartmann-Boyce, J., Watkinson, P., Young, D., Coupland, C., Clift, A. K., Harrison, D., Gould, D., Pavord, I. D., Smith, M., & Hippisley-Cox, J. (2022). Association between smoking, e-cigarette use and severe COVID-19: A cohort study. International Journal of Epidemiology, 51(4), 1062-1072. https://doi.org/10.1093/ije/dyac028

Background: Smoking is a risk factor for most respiratory infections, but it may protect against SARS-CoV-2 infection. The objective was to assess whether smoking and e-cigarette use were associated with severe COVID-19. Methods: This cohort ran from... Read More about Association between smoking, e-cigarette use and severe COVID-19: A cohort study.

Recruitment to a large scale randomised controlled clinical trial in primary care: the Helicobacter Eradication Aspirin Trial (HEAT) (2022)
Journal Article
Stevenson, D. J., Avery, A. J., Coupland, C., Hobbs, F. D. R., Kendrick, D., Moore, M. V., Morris, C., Rubin, G. P., Smith, M. D., Hawkey, C. J., & Dumbleton, J. S. (2022). Recruitment to a large scale randomised controlled clinical trial in primary care: the Helicobacter Eradication Aspirin Trial (HEAT). Trials, 23(1), Article 140. https://doi.org/10.1186/s13063-022-06054-w

Background: The Helicobacter Eradication Aspirin Trial (HEAT) is a multicentre, double blind, randomised controlled trial investigating whether Helicobacter (H.) pylori eradication reduces hospitalisation for peptic ulcer bleeding. Recruited particip... Read More about Recruitment to a large scale randomised controlled clinical trial in primary care: the Helicobacter Eradication Aspirin Trial (HEAT).